Long non-coding RNA PVT1 promotes cell proliferation in ERα+ breast cancer through the ERα-BTG2 axis
Available online 7 April 2026
Plasmacytoma variant translocation 1 (PVT1) is recognized as an oncogenic long non-coding RNA (lncRNA) in multiple cancer types including breast cancer (BC). Estrogen receptor alpha-positive (ERα+)...
Systematically investigating the pharmacological mechanism of Guizhi Gancao decoction in promoting thermogenesis during cold exposure by integrating HPLC-Q-TOF/MS analysis and network pharmacology
Available online 6 April 2026
Guizhi Gancao Decoction (GGD), a classic formula in Traditional Chinese Medicine (TCM), is composed of Ramulus Cinnamomi (RC) and Radix Glycyrrhizae (RG). It is traditionally used to restore heart Yang...
Reverse MIC drift of nemonoxacin and its advantages against Gram-positive bacteria: A 10-year multicenter surveillance study
Available online 5 April 2026
Antimicrobial resistance (AMR) threatens global health. Conventional fluoroquinolones have experienced accelerated resistance due to target‑enzyme mutations and are further constrained by safety concerns....
Role of nemonoxacin as a therapeutic option for community-acquired pneumonia in the era of atypical pathogens
Available online 5 April 2026
To systematically summarize the clinical data from phase II–IV studies of nemonoxacin malate and comprehensively evaluate the clinical efficacy of nemonoxacin in treating pneumonia caused by atypical...
Spatiotemporal trends in the global burden of drug-induced chronic liver diseases in thirty years
Available online 26 March 2026
Drug-induced chronic liver disease (DICLD) is concerned due to its threat to health, but there are few data about its global burden. We evaluated the trends in the burden of DICLD in 204 countries in...
Epithelial-mesenchymal transition in cancer metastasis: Molecular mechanisms, microenvironmental regulation, and therapeutic targeting
Available online 25 March 2026
Epithelial-mesenchymal transition is a crucial driver of cancer metastasis, enabling cancer cells to acquire invasive and migratory characteristics. This review synthesizes the molecular mechanisms...
Challenges in utilizing the FAERS database for adverse drug reaction data mining: A critical analysis
Available online 25 March 2026
The FAERS database is a vital tool for identifying adverse drug reactions (ADRs). However, data mining in FAERS faces significant challenges, including data quality issues (e.g., integrity, consistency,...
Integrating precision medicine and artificial intelligence to prevent cardiotoxicity in cardiovascular drug therapy
Available online 25 March 2026
Precision medicine refers to tailoring therapeutic interventions to an individual’s genetic, molecular and phenotypic characteristics, while multi-omics integrates genomics, proteomics and metabolomics...
Blebbisomes: isolation, characterization, and functional role of organelle-rich giant vesicles
Available online 24 March 2026
Cells secrete a diverse array of extracellular vesicles (EVs) to mediate intercellular communication, profoundly influencing both physiological and pathological processes through the transfer of proteins,...
Molecular aspects of metformin’s anti-aging properties for muscle function and longevity in Drosophila melanogaster
December 2025
Muscle aging, characterized by the progressive loss of muscle mass and function, presents a significant clinical challenge, contributing to sarcopenia and age-related frailty. Recent research highlights...
Predictive potential of five genes of cuproptosis for survival in LGG
December 2025
Low-grade glioma (LGG) is a common primary tumor in the central nervous system. The function of several types of cell death has been proved in tumorigenesis of low-grade glioma (LGG). Cuproptosis, a...
Anti-platelet aggregation effect of Compound Danshen dripping pill: An integrated study of meta-analysis, network pharmacology, and in vivo and vitro experiments
December 2025
Compound Danshen Dripping Pill (CDDP) is a marketed Chinese patent medicine, primarily efficacious in “promoting blood circulation to remove blood stasis, regulating Qi to relieve pain”. CDDP, as an...
Multi-omics mendelian randomization identifies ferroptosis-related genetic variants linked to NAFLD risk
December 2025
Ferroptosis, an iron-dependent cell death, contributes to non-alcoholic fatty liver disease (NAFLD), but causal genes remain unclear. This study identifies ferroptosis-related genes driving NAFLD to...
Adverse drug event signal detection and risk factor analysis of blinatumomab in ten years of post-marketing use
December 2025
To analyze factors influencing the safety of blinatumomab based on real-world adverse drug event (ADE) reports collected from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS)...
Efficacy and safety of semaglutide in patients with heart failure: A meta-analysis
December 2025
The pleiotropic effects of semaglutide make it a breakthrough therapy for managing diabetes and obesity, particularly in patients with comorbid cardiovascular diseases. However, its clinical application...
Evaluation of the efficacy, safety and economy of different amphotericin B formulations in invasive fungal disease: A retrospective cohort study
September 2025
Fungal infections have emerged as an increasingly serious public health challenge globally. Four Formulations of amphotericin B are widely used in antifungal therapy. Despite the same active ingredient,...
Advances and challenges in personalized diagnosis and therapies for the management of recurrent glioblastoma
September 2025
Recurrent glioblastoma (rGBM) remains one of the most formidable challenges in neuro-oncology due to its aggressive evolution, treatment resistance, and profound intratumoral heterogeneity. Despite...
A bibliometric analysis of mechanisms and linkage studies on neurological disorders and statins over the past 20 years
September 2025
Neurological disorders are one of the major contributors to the burden of disease, affecting the quality of life of the global population.Statins, known for their cholesterol-lowering properties, have...
A micro review on the role of recently emerged Artificial Intelligence (AI) tools and algorithms in microbiome-gut-brain-axis associated disease therapy via psychobiotics
September 2025
The microbiome-gut-brain axis involves the bidirectional connection between the gastrointestinal tract, gut microbiome, and central nervous system, and it is pivotal for mental well-being. Imbalances...
Integrative multi-omics approach for drug repositioning in Alzheimer's disease
September 2025
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an insidious onset, and effective therapeutic agents are urgently needed....
Quality evaluation of the guidelines for vericiguat treatment of heart failure with reduced ejection fraction
June 2025
Heart failure (HF) bears a heavy disease burden, and vericiguat is the only guanylate cyclase stimulator proved to improve its prognosis. However, its clinical use needs a further improvement....
Biologic therapy for immune-mediated inflammatory diseases during pregnancy and lactation: Efficacy, safety, and challenges
June 2025
Immune-mediated inflammatory diseases (IMIDs) commonly affect women of reproductive age, and concerns regarding the impact of therapeutic drugs on pregnancy outcomes, fetal development, and infant health...
Exploring the mechanism of Simiao Yong’an decoction in treating diabetic foot based on metabolomics
June 2025
In recent years, diabetic foot has become a significant cause of disability and mortality among individuals with diabetes. With the progression of time and technology, both modern medicine and traditional...
Evidence-based pharmacological investigation of the clinical practice and rational use of metformin in prediabetes mellitus
June 2025
Prediabetes is a condition where blood glucose levels have deviated from the normal range but have not yet reached the diagnostic criteria for diabetes. It represents a transitional phase between health...
Current status of the potentially inappropriate medications and omissions of medicines among older adults in Hubei Province
June 2025
Potentially inappropriate medications (PIMs) and omissions of medicines among older adults are increasingly popular with the aging population in China....