Special issue on exercise and muscle wasting

Published 20 April, 2022


Skeletal muscle wasting can result from various stimuli, ranging from disuse and ageing to disease conditions such as cancer and sepsis. Decreased muscle mass leads to lower quality of life and increased mortality rates; for example, cancer-induced cachexia is responsible for 20-40% of cancer-related deaths. Unfortunately, mechanisms inducing muscle mass loss can vary depending on the underlying disease, activity level, biological sex, age and other factors. Many therapeutic approaches have been suggested to prevent and treat muscle wasting, including nutritional, pharmacologic and exercise-based approaches.

For this special issue, we welcome original and review articles with a preclinical or human focus that examine exercise approaches to prevent or treat muscle wasting induced by various stimuli including, but not limited to, cancer cachexia, disuse, ageing and other chronic conditions. Studies investigating how disuse or inactivity can exacerbate muscle wasting are also encouraged, as are studies examining the interaction of either nutritional or pharmacological interventions with exercise.

Topics covered:

  • How exercise or inactivity impacts the progression of muscle wasting
  • Biological sex differences in mechanisms of muscle wasting that occur with specific underlying conditions that could impact treatment
  • Novel modes or doses of exercise to prevent or treat muscle wasting
  • Exercise interactions with nutrition or pharmacological approaches to prevent or treat muscle wasting
  • How biological sex impacts exercise interventions to treat or prevent muscle wasting

Submission deadline: 1 December 2022 

Submission instructions:

Please read the Guide for Authors before submitting. All articles should be submitted online via the submission system; please contact the Guest Editors before submitting. Special issue manuscripts will be processed via a fast review channel.

Guest Editors:

Dr. Nicholas Greene

University of Arkansas, USA.

Email: npgreene@uark.edu

Dr. James Carson

The University of Tennessee Health Science Center, USA.

Email: jcarso16@uthsc.edu

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