Leveraging mitochondrial stress to improve healthy aging
Available online 24 October 2025
Aging is characterized by a progressive decline in physiological function, driven by intrinsic mechanisms (primary aging) and modifiable factors (secondary aging), ultimately leading to multimorbidity,...
Impact of exercise on the 21st century epidemic of heart failure
September 2025
Heart failure (HF) poses a serious threat to public health in an aging population. HF with reduced ejection fraction (HFrEF) historically was the focus for developing prevention and management strategies,...
Two-legged medicine: Exercise-mediated health benefits
September 2025
The role of resistance training in mitigating cancer-induced cachexia: A systematic review
September 2025
Cancer induced cachexia, the involuntary loss of lean body mass and adipose tissue, is a debilitating syndrome experienced in up to 80% of all cancer patients. Cachexia is associated with poor treatment...
Episodic denervation as a driver of loss of skeletal muscle redox homeostasis and muscle weakness in sarcopenia: Possible amelioration by exercise
September 2025
Substantial reductions in muscle motor unit numbers accompany ageing and occur in parallel the age-related changes in skeletal muscle mass and fibre number. These motor unit changes are reflected in...
Exercise-induced cardioprotection: From endogenous to exogenous mechanisms
September 2025
Acute myocardial infarction (AMI) remains the leading form of cardiovascular morbidity and mortality, while exercise is a preventative and therapeutic countermeasure. The collective benefits of exercise...
Evolution of resistance training in women: History and mechanisms for health and performance
September 2025
Throughout history, cultural norms and stereotypes have discouraged resistance training in women. Today, as awareness and acceptance of resistance training in women has grown, supported by scientific...
Importance, unique aspects and guidelines, and building blocks of early childhood physical activity from a socioecological perspective
September 2025
Although the benefits of physical activity are established across all age groups, researchers have recently noted that there is uncertainty as to which correlates and determinants of physical activity...
Perspectives on enhancing human performance in the heat: Is the solution to simply “just add water”?
September 2025
Human exercise performance is influenced by factors related to inherent individual characteristics along with other modifiable factors. During exercise in the heat, sweating provides the major avenue...
Health benefits of physical activity: What role does skeletal muscle-organ crosstalk play?
September 2025
The observation that physical activity (PA) reduces the risk of coronary heart disease dates back more than 70 years ago and it is now established that regular PA reduces all-cause mortality, in part,...
Effects of amount, intensity, and mode of exercise training on the metabolic syndrome: A narrative review
September 2025
The purpose of this narrative review is to: 1) summarize findings from the three Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) randomized trials regarding the...
Impact of the administration type for normobaric hypoxia on the maximal aerobic capacity: A systematic review and meta-analysis
Available online 30 September 2025
Normobaric hypoxia (NH) is a frequent strategy for training under hypoxic conditions that can be administered through different equipment, including face masks or hypoxic chambers/tents. Nonetheless,...
Physiological basis for recommending changes to the physical activity guidelines
Available online 23 September 2025
The rapid drop in mortality risk as people become more active has been known for some time. While the public health message is clear (i.e., that any physical activity [PA] is better than no PA), no...
Mechanisms of exercise against anxiety disorder: A review of the research progress
Available online 23 September 2025
This review aims to explore the efficacy of exercise in the treatment of anxiety disorders and its underlying mechanisms, summarizing recent research advances and focusing on the potential biological...
Cardiorespiratory fitness and mortality risk in women - public health implications for cardiovascular health promotion
Available online 16 September 2025
Cardiovascular health in women is global concern. The study aimed to assess the risk association between cardiorespiratory fitness (CRF), an established surrogate-metric for cardiovascular health and...
Pulmonary function, respiratory muscle strength, and core strength: A comparative study of paralympic and Olympic athletes
Available online 16 September 2025
The significance of pulmonary function, respiratory muscles, and core muscle strength in athletes is extensively studied, however the correlation between these variables remains unexplored in athletes...
Pan-cancer multi-omics analysis reveals dysregulation and prognostic significance of exercise-responsive factors
Available online 5 September 2025
Exerkines are exercise-responsive factors that contribute to systemic homeostasis and have emerging roles in tumor regulation. However, their molecular characteristics and clinical implications at the...
Impact of nutrition on long COVID
Available online 5 September 2025
Long COVID is characterized by a group of persistent symptoms following the acute SARS-COV2 infection, which presented a multifaceted challenge to the healthcare systems all over the globe. The long...
Warming up to improved performance? Effects of different specific warm-up protocols on neuromuscular performance in trained individuals
Available online 22 August 2025
This study investigated the effects of varying the set number and loads in specific warm-up (SWU) protocols on resistance training (RT) session performance....
Swimming-induced pulmonary oedema in triathletes: A narrative review of epidemiology, risk factors and prevention
Available online 21 August 2025
Swimming-induced pulmonary oedema (SIPO) has predominantly been reported in swimmers. However, to date, no review has specifically explored the scientific literature concerning the occurrence and characteristics...
Postural stability and muscle function responses to acute brisk walking in young and middle-aged women
Available online 19 August 2025
Age-related research on postural stability and muscle function responses following fatiguing tasks representative of everyday life is limited to older adults, despite the high prevalence of injurious...
Motor cortex inhibition and facilitation changes within two weeks of anterior cruciate ligament reconstruction (ACLR): A case series
Available online 19 August 2025
Anterior cruciate ligament reconstruction (ACLR) can cause arthrogenic muscle inhibition (AMI) or persistent muscle weakness that impairs physical function and return to sport. Deficits in voluntary...
Neuromotor function following lower-limb muscle or tendon injury: Systematic review and meta-analysis
Available online 6 August 2025
Alterations in neuromotor function occur following lower-limb injuries and might be a factor in recurrent injury. We evaluated if adults with previous lower-limb muscle or tendon injury demonstrate...
Brain resting state functional connectivity changes with aerobic exercise, and mindfulness: A narrative review
Available online 6 August 2025
Neuroimaging studies show that the functional connectivity of the brain changes with age. Resting state functional connectivity (rsFC) in the brain appears to decrease with aging in key networks associated...
Assessing fundamental movement skills using the Test of Gross Motor Development (TGMD): Challenges and solutions to comparability and standardization
July 2025
Proficiency in fundamental movement skills in children is linked to numerous positive physical, behavioral, and cognitive outcomes. The Test of Gross Motor Development is a widely used tool in research...