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ISSN: 2468-5011

Tuning up an aged clock: Circadian clock regulation in metabolism and aging

Circadian rhythms provide temporal variation of a broad range of behavioral and physiological functions, which is precisely controlled by the internal molecular gear, the circadian clock. However, circadian...

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Targeting senescent cell clearance: An approach to delay aging and age-associated disorders

Cellular senescence is the occurrence of irreversible cell cycle arrest resulting from accumulated DNA damage and the loss of proteostasis over time. Senescent cells contribute to age-related diseases...

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High calorie diet background alters the expression of sirtuins in the testes of mice under caloric restriction

Caloric restriction (CR) is considered one of the most efficient interventions that extend lifespan and healthspan by delaying the onset of many age-related diseases in a variety of organisms. CR appears...

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The regulation of healthspan and lifespan by dietary amino acids

As a key macronutrient and source of essential macromolecules, dietary protein plays a significant role in health. For many years, protein-rich diets have been recommended as healthy due to the satiety-inducing...

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Transcription errors in aging and disease

Accurate transcription is required for the faithful expression of genetic information. However, little is known about the fidelity of RNA synthesis or the biological consequences of transcription errors...

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Validation of a new frailty scale in primary care: The simplified Zulfiqar frailty scale

Evaluate the ability of the “simplified Zulfiqar frailty scale” (sZFS) tool to detect frailty as defined by Fried's criteria among a group of patients aged 65 and older....

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A single oral supplementation of nicotinamide within the daily tolerable upper level increases blood NAD+ levels in healthy subjects

A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple species, including humans. Our previous clinical trial showed that supplementation of 200 mg nicotinamide,...

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A chronic low dosage of taurine induces muscle weakness in castrated-aged mice

Taurine is an abundant metabolite associated with regulation of cell volume. Several signaling pathways are stimulated at a micromolar concentrations of taurine. However, most of the experimental studies...

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Heart failure risk remote monitoring program in the very elderly patients with COVID-19 disease

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The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate

We used classical methods of biochemistry, chromolithography, atomic adsorption spectrometry for the determination of copper ions and MALDI-TOF mass spectrometry for the determination of metallothioneins....

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A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects

A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose...

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Maintaining a scientific community while social distancing

The “Aging Science Talks: Science for the Community” daily online seminar series was established in reaction to the cancellation of a myriad of regional, national, and international meetings focused...

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Caenorhabditis elegans as a model system for studying aging-associated neurodegenerative diseases

Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated disorders characterized by the disruption of cellular proteostasis machinery and the misfolding of distinct protein species...

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Automation of C. elegans lifespan measurement

Aging is a fundamental biological process that is still not fully understood. As many of the most significant human diseases have aging as their greatest risk factor, a better understanding of aging...

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RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial

The biopharmaceutical company resTORbio, Inc. Recently announced termination of a phase 3 clinical trial evaluating the ability of the drug RTB101 to improve immune function in the elderly. The company...

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Aging Science Talks: The role of miR-181a in age-related loss of muscle mass and function

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Extracellular vesicles and extracellular RNA in aging and age-related disease

Circulating factors are well known to influence aging and age-related disease. As part of the Aging Science Talks: Science for the Community series, data was presented on two types of circulating functional...

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Mito-Omics and immune function: Applying novel mitochondrial omic techniques to the context of the aging immune system

Recent advancements in genomic, transcriptomic, proteomic, and metabolomic techniques have prompted fresh inquiry in the field of aging. Here, we outline the application of these techniques in the context...

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Role of hematopoietic aging in cognitive decline

We recently demonstrated that transplantation of young bone marrow cells rescued hippocampal learning and memory in old recipient mice. Our study also implicated CCL11/eotaxin-1 in microglial reactivity...

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SPOCK, an R based package for high-throughput analysis of growth rate, survival, and chronological lifespan in yeast

Plate-reader based methods for high-throughput measurement of growth rate, cellular survival, and chronological lifespan are a compelling addition to the already powerful toolbox of budding yeast Saccharomyces...

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A high throughput drug screening paradigm using transgenic Caenorhabditis elegans model of Alzheimer’s disease

Alzheimer’s disease (AD), characterized by memory loss and cognitive decline, is one of the diseases with the highest attrition rate in drug development. As with other neurodegenerative diseases, AD...

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Mitochondrial hyperactivity as a potential therapeutic target in Parkinson’s disease

Mitochondrial dysfunction is thought to contribute to neurodegeneration in Parkinson’s disease (PD), yet the cellular events that lead to mitochondrial disruption remain unclear. Post-mortem studies...

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The heat shock transcription factor HSF-1 protects Caenorhabditis elegans from peroxide stress

Cells induce conserved defense mechanisms that protect them from oxidative stress. How these defenses are regulated in multicellular organisms is incompletely understood. Here, we show that the heat...

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Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae

Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of age-related ailments such as neurodegenerative...

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