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ISSN: 2468-5011

Young and old animals “use” different strategies for adapting to the chronic effects of ethanol

The study of the young and old animals’ adaptation characteristics to the chronic effect of ethyl alcohol provides a quick solution of problems in biomedicine and gerontology, such as the formation...

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The gerontological saga of antidiabetic biguanides: From ignorance to prudence via high hopes

The history of the discoveries that shaped the current attitudes to the use of antidiabetic biguanides, mainly metformin, as antiaging agents is reviewed. An emphasis is made on the mounting evidence...

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Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model

Follicle-stimulation hormone (FSH) and FSH receptor (FSHR) signaling is essential for lifelong ovarian and endocrine functions in females. Previous studies have reported that Fshr haploinsufficiency...

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The collaborative peer review framework as a model for training biomedical graduate students to perform rigorous, ethical peer review

Peer review is an essential component of the academic publishing process, critical for the dissemination of new scientific information. Peer reviewers ensure that scientific assertions made in manuscripts...

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The efficacy and tolerability of intermittent prandial acarbose to reduce glucose spikes in healthy individuals

Acarbose is an α-glucosidase inhibitor that slows the digestion of carbohydrates and can prevent sharp increases in blood sugar levels after meals (spikes). Excessive postprandial blood glucose spikes...

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Age-related changes of GAD1 mRNA expression in the central inferior colliculus

Encoding sounds with a high degree of temporal precision is an essential task for the inferior colliculus (IC) to perform and maintain the accurate processing of sounds and speech. However, the age-related...

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Psychological stress and epigenetic aging in older men: The VA normative aging study

Psychological stress remains an important risk factor for morbidity and mortality throughout the life course. However, there have been counterintuitive findings reported in previous studies of older...

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Treatment mechanism of immune triad from the repurposing drug against COVID-19

COVID-19 is an immune-mediated disease whose pathophysiology uses SAMHD1 tetramerization and cGAS–STING signaling, toll-like receptor 4 (TLR4) cascade, spike protein– inflammasome activation, and neuropilin...

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An updated landscape of cellular senescence heterogeneity: Mechanisms, technologies and senotherapies

Chronic aging represents the leading risk factor for the vast majority of age-related diseases, which together contribute to increased morbidities and elevated mortalities in late life. Senescent cells...

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Body composition, fear of falling and balance performance in community-dwelling older adults

We aimed to 1) assess body composition using a portable technology, bioelectrical impedance analysis, (BIA) and 2) examine the associations between body composition and the discrepancy of fear of falling...

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Recent developments in the role of DNA damage response and understanding its implications for new therapeutic approaches in Alzheimer's disease

The underlying molecular mechanisms associated with sporadic Alzheimer's disease (AD), a progressive neurodegenerative disease, are not yet fully understood. Adult neurons are post-mitotic cells that...

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The protective role of cognitive reserve on sleeping disorders on an aging population. A cross-sectional study

Sleep disorders and depression have been identified as risk factors for aging-related problems. This cross-sectional studiy explored the protective role of the cognitive reserve on a sample of 377 healthy...

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Proteostasis defects: Medicinal challenges of imperfect aging & neurodegeneration

A prolonged healthy life is based on the optimal activity of an organism’s organ systems, and healthy cells are at the core of this proper functioning. Cellular homeostasis is of utmost importance,...

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Mitochondrial cardiomyopathy and emerging therapeutics

Genetic mitochondrial cardiomyopathy (MCM) is a myocardial condition characterized by abnormal cardiac structure and function secondary to genetic defects. Severity can vary from asymptomatic to severe...

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Rationale and design of STAMINA: Senolytics to alleviate mobility issues and neurological impairments in aging, a geroscience feasibility study

The process of cellular senescence is hypothesized to play a critical role in the development of age-related mobility and cognitive impairments, both of which precede the development of Alzheimer's...

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Adrenergic innervation of thoracic lymphatic duct in postnatal ontogenesis

The adrenergic innervation of the thoracic lymphatic duct was studied in young, mature and old animals. Adrenergic innervation of lymphatic system in postnatal ontogenesis, especially in its late period,...

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B and T cell subsets in elderly with frailty syndrome

Aging is related to changes in functional reserve that progressively lead to increased morbidity and mortality. Frailty syndrome, a common entity in older adults, is characterized by increased vulnerability...

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Impact of frailty status on clinical outcomes in patients receiving peritoneal dialysis

A cross-sectional analytical study was conducted for 88 patients receiving peritoneal dialysis (PD) in our centre over 13-months, to evaluate the ssociations between frailty and clinical outcomes within...

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Subjective cognitive decline and cerebral-cognitive reserve in late age

Determining the boundaries of the norm and pathology of mental aging is an urgent scientific task. We have formulated a hypothesis about the presence of a transitional period within the cognitive continuum,...

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Tuning up an aged clock: Circadian clock regulation in metabolism and aging

Circadian rhythms provide temporal variation of a broad range of behavioral and physiological functions, which is precisely controlled by the internal molecular gear, the circadian clock. However, circadian...

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Effects of cocoa on altered metabolite levels in purine metabolism pathways and urea cycle in Alzheimer's disease in C. elegans

Dietary interventions have gained much attention as alternative therapies in aging-associated diseases. Epidemiological studies suggest that polyphenols (PPs) play an important role in this regard....

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Targeting senescent cell clearance: An approach to delay aging and age-associated disorders

Cellular senescence is the occurrence of irreversible cell cycle arrest resulting from accumulated DNA damage and the loss of proteostasis over time. Senescent cells contribute to age-related diseases...

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High calorie diet background alters the expression of sirtuins in the testes of mice under caloric restriction

Caloric restriction (CR) is considered one of the most efficient interventions that extend lifespan and healthspan by delaying the onset of many age-related diseases in a variety of organisms. CR appears...

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The regulation of healthspan and lifespan by dietary amino acids

As a key macronutrient and source of essential macromolecules, dietary protein plays a significant role in health. For many years, protein-rich diets have been recommended as healthy due to the satiety-inducing...

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Transcription errors in aging and disease

Accurate transcription is required for the faithful expression of genetic information. However, little is known about the fidelity of RNA synthesis or the biological consequences of transcription errors...

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