Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model
2023
Follicle-stimulation hormone (FSH) and FSH receptor (FSHR) signaling is essential for lifelong ovarian and endocrine functions in females. Previous studies have reported that Fshr haploinsufficiency...
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The collaborative peer review framework as a model for training biomedical graduate students to perform rigorous, ethical peer review
2023
Peer review is an essential component of the academic publishing process, critical for the dissemination of new scientific information. Peer reviewers ensure that scientific assertions made in manuscripts...
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The efficacy and tolerability of intermittent prandial acarbose to reduce glucose spikes in healthy individuals
2023
Acarbose is an α-glucosidase inhibitor that slows the digestion of carbohydrates and can prevent sharp increases in blood sugar levels after meals (spikes). Excessive postprandial blood glucose spikes...
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Age-related changes of GAD1 mRNA expression in the central inferior colliculus
2023
Encoding sounds with a high degree of temporal precision is an essential task for the inferior colliculus (IC) to perform and maintain the accurate processing of sounds and speech. However, the age-related...
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Tuning up an aged clock: Circadian clock regulation in metabolism and aging
2022
Circadian rhythms provide temporal variation of a broad range of behavioral and physiological functions, which is precisely controlled by the internal molecular gear, the circadian clock. However, circadian...
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Effects of cocoa on altered metabolite levels in purine metabolism pathways and urea cycle in Alzheimer's disease in C. elegans
2022
Dietary interventions have gained much attention as alternative therapies in aging-associated diseases. Epidemiological studies suggest that polyphenols (PPs) play an important role in this regard....
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Targeting senescent cell clearance: An approach to delay aging and age-associated disorders
2021
Cellular senescence is the occurrence of irreversible cell cycle arrest resulting from accumulated DNA damage and the loss of proteostasis over time. Senescent cells contribute to age-related diseases...
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High calorie diet background alters the expression of sirtuins in the testes of mice under caloric restriction
2021
Caloric restriction (CR) is considered one of the most efficient interventions that extend lifespan and healthspan by delaying the onset of many age-related diseases in a variety of organisms. CR appears...
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The regulation of healthspan and lifespan by dietary amino acids
2021
As a key macronutrient and source of essential macromolecules, dietary protein plays a significant role in health. For many years, protein-rich diets have been recommended as healthy due to the satiety-inducing...
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Transcription errors in aging and disease
2021
Accurate transcription is required for the faithful expression of genetic information. However, little is known about the fidelity of RNA synthesis or the biological consequences of transcription errors...
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Validation of a new frailty scale in primary care: The simplified Zulfiqar frailty scale
2021
Evaluate the ability of the “simplified Zulfiqar frailty scale” (sZFS) tool to detect frailty as defined by Fried's criteria among a group of patients aged 65 and older....
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A single oral supplementation of nicotinamide within the daily tolerable upper level increases blood NAD+ levels in healthy subjects
2021
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple species, including humans. Our previous clinical trial showed that supplementation of 200 mg nicotinamide,...
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A chronic low dosage of taurine induces muscle weakness in castrated-aged mice
2021
Taurine is an abundant metabolite associated with regulation of cell volume. Several signaling pathways are stimulated at a micromolar concentrations of taurine. However, most of the experimental studies...
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Heart failure risk remote monitoring program in the very elderly patients with COVID-19 disease
2021
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The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate
2021
We used classical methods of biochemistry, chromolithography, atomic adsorption spectrometry for the determination of copper ions and MALDI-TOF mass spectrometry for the determination of metallothioneins....
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A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects
2020
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose...
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Maintaining a scientific community while social distancing
2020
The “Aging Science Talks: Science for the Community” daily online seminar series was established in reaction to the cancellation of a myriad of regional, national, and international meetings focused...
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Caenorhabditis elegans as a model system for studying aging-associated neurodegenerative diseases
2020
Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated disorders characterized by the disruption of cellular proteostasis machinery and the misfolding of distinct protein species...
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Automation of C. elegans lifespan measurement
2020
Aging is a fundamental biological process that is still not fully understood. As many of the most significant human diseases have aging as their greatest risk factor, a better understanding of aging...
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RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial
2020
The biopharmaceutical company resTORbio, Inc. Recently announced termination of a phase 3 clinical trial evaluating the ability of the drug RTB101 to improve immune function in the elderly. The company...
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Extracellular vesicles and extracellular RNA in aging and age-related disease
2020
Circulating factors are well known to influence aging and age-related disease. As part of the Aging Science Talks: Science for the Community series, data was presented on two types of circulating functional...
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Mito-Omics and immune function: Applying novel mitochondrial omic techniques to the context of the aging immune system
2020
Recent advancements in genomic, transcriptomic, proteomic, and metabolomic techniques have prompted fresh inquiry in the field of aging. Here, we outline the application of these techniques in the context...
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Role of hematopoietic aging in cognitive decline
2020
We recently demonstrated that transplantation of young bone marrow cells rescued hippocampal learning and memory in old recipient mice. Our study also implicated CCL11/eotaxin-1 in microglial reactivity...
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