Neural stem cells in aging
2025
Aging is intricately linked to cognitive decline and neurodegenerative diseases, with neural stem cells (NSCs) playing a crucial role in brain function maintenance and repair. We examine the age-related...
Exploring Nintendo Wii Balance Board as a tool to assess lower limb muscle strength for fall risk screening in elderly women
2025
The aging process and declining muscle strength and function are known to increase the risk of falls in older adults. The Nintendo Wii Balance Board (NWBB) is a cost-effective and easily accessible...
Overweight effects on metabolic rate, time perception, diseases, aging, and lifespan: A systematic review with meta-regression analysis
2025
The hypothesis that metabolic rate (MR) is inversely correlated with lifespan has long been debating. Another area of controversy is the relationship between MR and time-flow perception (TFP), and aging....
Multi-ancestry GWAS reveals loci linked to human variation in LINE-1- and Alu-insertion numbers
2025
LINE-1 (L1) and Alu are two families of transposable elements (TEs) occupying ∼17 % and ∼11 % of the human genome, respectively. Though only a small fraction of L1 copies is able to produce the machinery...
Curli protein: A potential contributor to α-synucleopathy in Parkinson's disease
2025
Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by the gradual loss of dopaminergic neurons in the substantia nigra, resulting in both motor and non-motor symptoms. A defining...
Age in aortic disease: The path towards atrial fibrillation
2025
Aging induces structural remodeling, altering atrial electrogram morphology. Over time, structural and consequently electrical remodeling creates a substrate for atrial fibrillation. In structural heart...
Predictive model of small vessel vascular dementia based on comorbidities, cytokines and claudin-1 genetic polymorphisms
2025
Although small vessel vascular dementia (SmVD) remains a significant contributor to global disease burden, its aetiology and pathogenesis are not fully understood. Past research has highlighted an association...
Comprehensive behavioural study of senescence-accelerated mouse prone 8 and senescence-accelerated mouse prone 10
2025
Aging is the strongest risk factor for neurodegenerative diseases and has been implicated in important changes in the brain. Rodents, such as mice, have been used to understand age-related changes in...
The Role of Diet, Gut Microbiome, and Inflammation in Vascular Dementia: a mini review
Available online 6 September 2025
Vascular dementia (VaD) is the second most common form of dementia after Alzheimer’s disease and results from cerebrovascular pathology leading to brain tissue damage. This mini-review synthesizes current...
A comprehensive Review of the Multi-System Benefits of Anti-Diabetic Drug Classes in Aging Beyond Glycemic Control
Available online 29 August 2025
Diabetes management has evolved beyond glycemic control, with emerging evidence demonstrating the multi-system benefits of various anti-diabetic drug classes. This review examines the mechanisms, pharmacokinetics,...
Time-varying lifestyle and mental-ill health risk factors for the longitudinal development of daily activity limitations among middle-aged and older adults in Thailand
2024
The aim of this study was to assess the longitudinal association between lifestyle factors, mental ill-health indicators and activities of daily living (ADL) disability among ageing adults in Thailand....
Osmotic stressors confer age-dependent resistance to heat stress in wild-type and daf-2 Caenorhabditis elegans
2024
Glucose has been shown to shorten lifespan in Caenorhabditis elegans. The connection of glucose to stress resistance in C. elegans, however, appears to be complex. We have shown glucose to be protective...
Young and old animals “use” different strategies for adapting to the chronic effects of ethanol
2024
The study of the young and old animals’ adaptation characteristics to the chronic effect of ethyl alcohol provides a quick solution of problems in biomedicine and gerontology, such as the formation...
The gerontological saga of antidiabetic biguanides: From ignorance to prudence via high hopes
2024
The history of the discoveries that shaped the current attitudes to the use of antidiabetic biguanides, mainly metformin, as antiaging agents is reviewed. An emphasis is made on the mounting evidence...
Role of the endoplasmic reticulum in mechanisms of aging and formation of senescent cells
2024
The role of the endoplasmic reticulum (ER) in aging processes has not attracted much attention of researchers, while this structure plays one of the central roles in the processes of intracellular synthesis....
Are you feeling comfortable? – Measuring clinical hormesis
2024
Hormesis is a biological phenomenon where exposure to a low dose of a stressor or toxin induces a beneficial adaptive response, whereas higher doses may have detrimental effects. The concept of hormesis...
Erlec1 controls bone metabolism by affecting osteoblast type I collagen synthesis
2024
Erlec1 gene has been suggested to be involved in the regulation of bone development. However, the underlying mechanism remains largely unknown. In this study, we showed that loss of Erlec1 leads to...
Mechanistic insights of the anti-ageing dietary plant secondary metabolites vis-à-vis the modern hallmarks of ageing: Implications for developing novel anti-ageing foods
2024
Plant secondary metabolites (PSM) including polyphenols, alkaloids, and terpenes are diverse dietary influencers of human health that are also emerging as potent longevity modulators. However, the mechanistic...
Body composition, fear of falling and balance performance in community-dwelling older adults
2023
We aimed to 1) assess body composition using a portable technology, bioelectrical impedance analysis, (BIA) and 2) examine the associations between body composition and the discrepancy of fear of falling...
Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model
2023
Follicle-stimulation hormone (FSH) and FSH receptor (FSHR) signaling is essential for lifelong ovarian and endocrine functions in females. Previous studies have reported that Fshr haploinsufficiency...
The protective role of cognitive reserve on sleeping disorders on an aging population. A cross-sectional study
2023
Sleep disorders and depression have been identified as risk factors for aging-related problems. This cross-sectional studiy explored the protective role of the cognitive reserve on a sample of 377 healthy...
Age-related changes of GAD1 mRNA expression in the central inferior colliculus
2023
Encoding sounds with a high degree of temporal precision is an essential task for the inferior colliculus (IC) to perform and maintain the accurate processing of sounds and speech. However, the age-related...
Psychological stress and epigenetic aging in older men: The VA normative aging study
2023
Psychological stress remains an important risk factor for morbidity and mortality throughout the life course. However, there have been counterintuitive findings reported in previous studies of older...
Mitochondrial cardiomyopathy and emerging therapeutics
2023
Genetic mitochondrial cardiomyopathy (MCM) is a myocardial condition characterized by abnormal cardiac structure and function secondary to genetic defects. Severity can vary from asymptomatic to severe...
Proteostasis defects: Medicinal challenges of imperfect aging & neurodegeneration
2023
A prolonged healthy life is based on the optimal activity of an organism’s organ systems, and healthy cells are at the core of this proper functioning. Cellular homeostasis is of utmost importance,...
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