Recent Articles

Open access

ISSN: 2468-5011

Time-varying lifestyle and mental-ill health risk factors for the longitudinal development of daily activity limitations among middle-aged and older adults in Thailand

The aim of this study was to assess the longitudinal association between lifestyle factors, mental ill-health indicators and activities of daily living (ADL) disability among ageing adults in Thailand....

Share article

Osmotic stressors confer age-dependent resistance to heat stress in wild-type and daf-2 Caenorhabditis elegans

Glucose has been shown to shorten lifespan in Caenorhabditis elegans. The connection of glucose to stress resistance in C. elegans, however, appears to be complex. We have shown glucose to be protective...

Share article

Young and old animals “use” different strategies for adapting to the chronic effects of ethanol

The study of the young and old animals’ adaptation characteristics to the chronic effect of ethyl alcohol provides a quick solution of problems in biomedicine and gerontology, such as the formation...

Share article

The gerontological saga of antidiabetic biguanides: From ignorance to prudence via high hopes

The history of the discoveries that shaped the current attitudes to the use of antidiabetic biguanides, mainly metformin, as antiaging agents is reviewed. An emphasis is made on the mounting evidence...

Share article

Role of the endoplasmic reticulum in mechanisms of aging and formation of senescent cells

The role of the endoplasmic reticulum (ER) in aging processes has not attracted much attention of researchers, while this structure plays one of the central roles in the processes of intracellular synthesis....

Share article

Are you feeling comfortable? – Measuring clinical hormesis

Hormesis is a biological phenomenon where exposure to a low dose of a stressor or toxin induces a beneficial adaptive response, whereas higher doses may have detrimental effects. The concept of hormesis...

Share article

Erlec1 controls bone metabolism by affecting osteoblast type I collagen synthesis

Erlec1 gene has been suggested to be involved in the regulation of bone development. However, the underlying mechanism remains largely unknown. In this study, we showed that loss of Erlec1 leads to...

Share article

Mechanistic insights of the anti-ageing dietary plant secondary metabolites vis-à-vis the modern hallmarks of ageing: implications for developing novel anti-ageing foods

Plant secondary metabolites (PSM) including polyphenols, alkaloids, and terpenes are diverse dietary influencers of human health that are also emerging as potent longevity modulators. However, the mechanistic...

Share article

Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals

To evaluate the relationship between metformin and the outcome of COVID-19 infection....

Share article

Body composition, fear of falling and balance performance in community-dwelling older adults

We aimed to 1) assess body composition using a portable technology, bioelectrical impedance analysis, (BIA) and 2) examine the associations between body composition and the discrepancy of fear of falling...

Share article

Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model

Follicle-stimulation hormone (FSH) and FSH receptor (FSHR) signaling is essential for lifelong ovarian and endocrine functions in females. Previous studies have reported that Fshr haploinsufficiency...

Share article

The protective role of cognitive reserve on sleeping disorders on an aging population. A cross-sectional study

Sleep disorders and depression have been identified as risk factors for aging-related problems. This cross-sectional studiy explored the protective role of the cognitive reserve on a sample of 377 healthy...

Share article

Age-related changes of GAD1 mRNA expression in the central inferior colliculus

Encoding sounds with a high degree of temporal precision is an essential task for the inferior colliculus (IC) to perform and maintain the accurate processing of sounds and speech. However, the age-related...

Share article

Psychological stress and epigenetic aging in older men: The VA normative aging study

Psychological stress remains an important risk factor for morbidity and mortality throughout the life course. However, there have been counterintuitive findings reported in previous studies of older...

Share article

Mitochondrial cardiomyopathy and emerging therapeutics

Genetic mitochondrial cardiomyopathy (MCM) is a myocardial condition characterized by abnormal cardiac structure and function secondary to genetic defects. Severity can vary from asymptomatic to severe...

Share article

Proteostasis defects: Medicinal challenges of imperfect aging & neurodegeneration

A prolonged healthy life is based on the optimal activity of an organism’s organ systems, and healthy cells are at the core of this proper functioning. Cellular homeostasis is of utmost importance,...

Share article

Treatment mechanism of immune triad from the repurposing drug against COVID-19

COVID-19 is an immune-mediated disease whose pathophysiology uses SAMHD1 tetramerization and cGAS–STING signaling, toll-like receptor 4 (TLR4) cascade, spike protein– inflammasome activation, and neuropilin...

Share article

An updated landscape of cellular senescence heterogeneity: Mechanisms, technologies and senotherapies

Chronic aging represents the leading risk factor for the vast majority of age-related diseases, which together contribute to increased morbidities and elevated mortalities in late life. Senescent cells...

Share article

Adrenergic innervation of thoracic lymphatic duct in postnatal ontogenesis

The adrenergic innervation of the thoracic lymphatic duct was studied in young, mature and old animals. Adrenergic innervation of lymphatic system in postnatal ontogenesis, especially in its late period,...

Share article

Subjective cognitive decline and cerebral-cognitive reserve in late age

Determining the boundaries of the norm and pathology of mental aging is an urgent scientific task. We have formulated a hypothesis about the presence of a transitional period within the cognitive continuum,...

Share article

The efficacy and tolerability of intermittent prandial acarbose to reduce glucose spikes in healthy individuals

Acarbose is an α-glucosidase inhibitor that slows the digestion of carbohydrates and can prevent sharp increases in blood sugar levels after meals (spikes). Excessive postprandial blood glucose spikes...

Share article

Impact of frailty status on clinical outcomes in patients receiving peritoneal dialysis

A cross-sectional analytical study was conducted for 88 patients receiving peritoneal dialysis (PD) in our centre over 13-months, to evaluate the ssociations between frailty and clinical outcomes within...

Share article

The collaborative peer review framework as a model for training biomedical graduate students to perform rigorous, ethical peer review

Peer review is an essential component of the academic publishing process, critical for the dissemination of new scientific information. Peer reviewers ensure that scientific assertions made in manuscripts...

Share article

B and T cell subsets in elderly with frailty syndrome

Aging is related to changes in functional reserve that progressively lead to increased morbidity and mortality. Frailty syndrome, a common entity in older adults, is characterized by increased vulnerability...

Share article

Rationale and design of STAMINA: Senolytics to alleviate mobility issues and neurological impairments in aging, a geroscience feasibility study

The process of cellular senescence is hypothesized to play a critical role in the development of age-related mobility and cognitive impairments, both of which precede the development of Alzheimer's...

Share article

Stay Informed

Register your interest and receive email alerts tailored to your needs. Sign up below.

Production and hosting by Elsevier on behalf of KeAi Communications Co. Ltd