A single oral supplementation of nicotinamide within the daily tolerable upper level increases blood NAD+ levels in healthy subjects
2021
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple species, including humans. Our previous clinical trial showed that supplementation of 200 mg nicotinamide,...
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Therapeutic potential of boosting NAD+ in aging and age-related diseases
January 2018
Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in all living cells that is involved in fundamental biological processes. NAD+ depletion has been associated with hallmarks of aging...
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Amino acids in the regulation of aging and aging-related diseases
2019
Amino acids are the building blocks of protein, but also play important cellular signaling roles. The mechanisms through which altered levels of many amino acids are sensed and the signals transmitted...
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The microbiome: An emerging key player in aging and longevity
2020
Revolutionary advancements of high-throughput sequencing and metagenomic tools have provided new insights to microbiome function, including a bidirectional relationship between the microbiome and host...
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Transcription errors in aging and disease
2021
Accurate transcription is required for the faithful expression of genetic information. However, little is known about the fidelity of RNA synthesis or the biological consequences of transcription errors...
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A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects
2020
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose...
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RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial
2020
The biopharmaceutical company resTORbio, Inc. Recently announced termination of a phase 3 clinical trial evaluating the ability of the drug RTB101 to improve immune function in the elderly. The company...
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Tuning up an aged clock: Circadian clock regulation in metabolism and aging
2022
Circadian rhythms provide temporal variation of a broad range of behavioral and physiological functions, which is precisely controlled by the internal molecular gear, the circadian clock. However, circadian...
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Genome instability and aging: Cause or effect?
October 2017
Genome instability, i.e., the tendency of the genome to undergo alterations in DNA information content through mutation, is considered a hallmark of aging. While mutations can be analyzed in clonal...
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Senescence in aging and disorders of the central nervous system
2019
Aging can be defined as the natural process of accumulating time during the life of an organism. Advancing age correlates with tissue dysfunction, including frailty, malignancies, immobility, and cognitive...
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The regulation of healthspan and lifespan by dietary amino acids
2021
As a key macronutrient and source of essential macromolecules, dietary protein plays a significant role in health. For many years, protein-rich diets have been recommended as healthy due to the satiety-inducing...
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Targeting senescent cell clearance: An approach to delay aging and age-associated disorders
2021
Cellular senescence is the occurrence of irreversible cell cycle arrest resulting from accumulated DNA damage and the loss of proteostasis over time. Senescent cells contribute to age-related diseases...
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Drosophila melanogaster as a model system in the study of pharmacological interventions in aging
2019
Drosophila melanogaster has been used as a model system in biological studies for a long time, and those studies have contributed to elucidating the principal mechanisms of life and aging. The notable...
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Caenorhabditis elegans as a model system for studying aging-associated neurodegenerative diseases
2020
Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated disorders characterized by the disruption of cellular proteostasis machinery and the misfolding of distinct protein species...
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Alternative splicing in aging and age-related diseases
October 2017
Alternative splicing (AS) of mRNA generates multiple protein isoforms from a single gene. This greatly expands proteome diversity and plays important roles in most biological processes. Global changes...
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Alcohol and aging: From epidemiology to mechanism
October 2017
Alcohol is one of the most widely encountered drugs in the world and is credited with a wealth of health interactions. Light to moderate regular consumption (14–28 g daily) can promote heart health,...
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Recent progresses on anti-aging compounds and their targets in Caenorhabditis elegans
2019
Searching for drugs that extend healthy lifespan and the subsequent analysis of their mechanisms of action is a crucial aspect for aging research. However, identifying both longevity-enhancing drugs...
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Recent studies on anti-aging compounds with Saccharomyces cerevisiae as a model organism
2019
Extension of lifespan and amelioration of aging-associated phenotypes have been targets of many studies. Some of the established methods of increasing lifespan including dietary restriction and genetic...
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Effects of cocoa on altered metabolite levels in purine metabolism pathways and urea cycle in Alzheimer's disease in C. elegans
2022
Dietary interventions have gained much attention as alternative therapies in aging-associated diseases. Epidemiological studies suggest that polyphenols (PPs) play an important role in this regard....
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Hypothesis: Plant stem cells hold the key to extreme longevity
2019
Theories of ageing explain how multicellular organisms age by means of an immortal germ line and a perishable soma, whereby accumulated damage is preferentially distributed to the soma. Plants do not...
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A high throughput drug screening paradigm using transgenic Caenorhabditis elegans model of Alzheimer’s disease
2020
Alzheimer’s disease (AD), characterized by memory loss and cognitive decline, is one of the diseases with the highest attrition rate in drug development. As with other neurodegenerative diseases, AD...
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Nutrition, sarcopenia and frailty: An Asian perspective
2019
Despite a growing body of evidence that nutrition plays a key role in the pathophysiology, prevention and intervention programs of frailty and sarcopenia, as well as in promoting brain health, the awareness...
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A chronic low dosage of taurine induces muscle weakness in castrated-aged mice
2021
Taurine is an abundant metabolite associated with regulation of cell volume. Several signaling pathways are stimulated at a micromolar concentrations of taurine. However, most of the experimental studies...
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Translational geroscience: From invertebrate models to companion animal and human interventions
January 2018
Translational geroscience is an interdisciplinary field descended from basic gerontology that seeks to identify, validate, and clinically apply interventions to maximize healthy, disease-free lifespan....
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Automation of C. elegans lifespan measurement
2020
Aging is a fundamental biological process that is still not fully understood. As many of the most significant human diseases have aging as their greatest risk factor, a better understanding of aging...
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