A single oral supplementation of nicotinamide within the daily tolerable upper level increases blood NAD+ levels in healthy subjects
2021
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple species, including humans. Our previous clinical trial showed that supplementation of 200 mg nicotinamide,...
Amino acids in the regulation of aging and aging-related diseases
2019
Amino acids are the building blocks of protein, but also play important cellular signaling roles. The mechanisms through which altered levels of many amino acids are sensed and the signals transmitted...
Therapeutic potential of boosting NAD+ in aging and age-related diseases
January 2018
Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in all living cells that is involved in fundamental biological processes. NAD+ depletion has been associated with hallmarks of aging...
Ubiquinol-mediated NRF2 activation enhances mitochondrial function and attenuates cellular senescence
2026
Aging is closely associated with mitochondrial dysfunction, oxidative stress, and impaired activation of the Nrf2 signaling pathway and all of these contribute to cellular senescence and subsequent...
The efficacy and tolerability of intermittent prandial acarbose to reduce glucose spikes in healthy individuals
2023
Acarbose is an α-glucosidase inhibitor that slows the digestion of carbohydrates and can prevent sharp increases in blood sugar levels after meals (spikes). Excessive postprandial blood glucose spikes...
Senescence in aging and disorders of the central nervous system
2019
Aging can be defined as the natural process of accumulating time during the life of an organism. Advancing age correlates with tissue dysfunction, including frailty, malignancies, immobility, and cognitive...
A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects
2020
A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose...
Transcription errors in aging and disease
2021
Accurate transcription is required for the faithful expression of genetic information. However, little is known about the fidelity of RNA synthesis or the biological consequences of transcription errors...
Genome instability and aging: Cause or effect?
October 2017
Genome instability, i.e., the tendency of the genome to undergo alterations in DNA information content through mutation, is considered a hallmark of aging. While mutations can be analyzed in clonal...
Overweight effects on metabolic rate, time perception, diseases, aging, and lifespan: A systematic review with meta-regression analysis
2025
The hypothesis that metabolic rate (MR) is inversely correlated with lifespan has long been debating. Another area of controversy is the relationship between MR and time-flow perception (TFP), and aging....
Neural stem cells in aging
2025
Aging is intricately linked to cognitive decline and neurodegenerative diseases, with neural stem cells (NSCs) playing a crucial role in brain function maintenance and repair. We examine the age-related...
Mitochondrial cardiomyopathy and emerging therapeutics
2023
Genetic mitochondrial cardiomyopathy (MCM) is a myocardial condition characterized by abnormal cardiac structure and function secondary to genetic defects. Severity can vary from asymptomatic to severe...
The microbiome: An emerging key player in aging and longevity
2020
Revolutionary advancements of high-throughput sequencing and metagenomic tools have provided new insights to microbiome function, including a bidirectional relationship between the microbiome and host...
Curli protein: A potential contributor to α-synucleopathy in Parkinson's disease
2025
Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by the gradual loss of dopaminergic neurons in the substantia nigra, resulting in both motor and non-motor symptoms. A defining...
Drosophila melanogaster as a model system in the study of pharmacological interventions in aging
2019
Drosophila melanogaster has been used as a model system in biological studies for a long time, and those studies have contributed to elucidating the principal mechanisms of life and aging. The notable...
ELOVL2: Not just a biomarker of aging
2020
DNA methylation of the ELOVL2 (Elongation Of Very Long Chain Fatty Acids-Like 2) promoter is one of the most robust molecular biomarkers for chronological age, but whether ELOVL2 plays a functional...
A comprehensive review of the multisystem benefits of antidiabetic drugs in aging beyond glycemic control
2025
Diabetes management has evolved beyond glycemic control, with emerging evidence demonstrating the multi-system benefits of various anti-diabetic drug classes. This review examines the mechanisms, pharmacokinetics,...
The regulation of healthspan and lifespan by dietary amino acids
2021
As a key macronutrient and source of essential macromolecules, dietary protein plays a significant role in health. For many years, protein-rich diets have been recommended as healthy due to the satiety-inducing...
Caenorhabditis elegans as a model system for studying aging-associated neurodegenerative diseases
2020
Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated disorders characterized by the disruption of cellular proteostasis machinery and the misfolding of distinct protein species...
Multi-ancestry GWAS reveals loci linked to human variation in LINE-1- and Alu-insertion numbers
2025
LINE-1 (L1) and Alu are two families of transposable elements (TEs) occupying ∼17 % and ∼11 % of the human genome, respectively. Though only a small fraction of L1 copies is able to produce the machinery...
Comprehensive behavioural study of senescence-accelerated mouse prone 8 and senescence-accelerated mouse prone 10
2025
Aging is the strongest risk factor for neurodegenerative diseases and has been implicated in important changes in the brain. Rodents, such as mice, have been used to understand age-related changes in...
Proteostasis defects: Medicinal challenges of imperfect aging & neurodegeneration
2023
A prolonged healthy life is based on the optimal activity of an organism’s organ systems, and healthy cells are at the core of this proper functioning. Cellular homeostasis is of utmost importance,...
Exploring Nintendo Wii Balance Board as a tool to assess lower limb muscle strength for fall risk screening in elderly women
2025
The aging process and declining muscle strength and function are known to increase the risk of falls in older adults. The Nintendo Wii Balance Board (NWBB) is a cost-effective and easily accessible...
Are you feeling comfortable? – Measuring clinical hormesis
2024
Hormesis is a biological phenomenon where exposure to a low dose of a stressor or toxin induces a beneficial adaptive response, whereas higher doses may have detrimental effects. The concept of hormesis...
Targeting senescent cell clearance: An approach to delay aging and age-associated disorders
2021
Cellular senescence is the occurrence of irreversible cell cycle arrest resulting from accumulated DNA damage and the loss of proteostasis over time. Senescent cells contribute to age-related diseases...
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