Evaluation of toxicity and antioxidant activities of various crude extracts of leaves and stems of Zygophyllumsimplex
2025
Zygophyllum simplex (Z. simplex) is a plant that has been used for a long time for the treatment of human diseases. Therefore, this present research study aims to prepare various plant extracts and...
Etiological connections between initial COVID-19 and two rare infectious diseases
2025
The origin of COVID-19 remains unclear despite extensive research. Theoretical models can simplify complex epigenetic landscapes by reducing vast methylation sites into manageable sets, revealing fundamental...
Unraveling ankylosing spondylitis: Exploring the genetic and immunological factors and latest treatment innovations
2025
Ankylosing spondylitis (AS) is a chronic inflammatory arthritis primarily affecting the spine and sacroiliac joints. Gut microbiota significantly affects ankylosing spondylitis (AS) pathophysiology....
Bringing lab to the field: Exploring innovations in point-of-care diagnostics for the rapid detection and management of tropical diseases in resource-limited settings
2025
Tropical diseases present major health challenges in regions with limited resources, where access to advanced laboratory facilities is often scarce. This study explores the innovative techniques emerging...
Application of Generative Adversarial Networks on RNASeq data to uncover COVID-19 severity biomarkers
2025
The COVID-19 pandemic has highlighted the need for reliable biomarkers to predict disease severity and guide treatment strategies. However, the analysis of RNASeq data for biomarker discovery using...
“MiRNA based target identification of TNFα gene in nephrotic syndrome”
2025
Nephrotic syndrome (NS) can be caused by various underlying kidney conditions. In most cases, the exact cause of NS is unknown, although it may be related to the body's immune system malfunctioning....
Genomic analysis identifies an incipient signature to forecast imatinib resistance before start of treatment in patients with chronic myeloid leukemia
2025
The unprecedented success of tyrosine kinase inhibitor (TKI), imatinib, to induce remission in 86 % of chronic phase (CP) patients of chronic myeloid leukemia (CML) is undermined by drug resistance....
Clinical features and predictive model for invasive pulmonary fungal infections in hematologic disorders
2025
This study was to investigate the clinical features of hematological disorders complicated by invasive pulmonary fungal infections and identify factors affecting treatment outcomes, with the aim of...
A mini review: Role of novel biomarker for kidney disease of future study
2025
In the world, kidney disease is most common cause of death. Primary care physicians must conduct appropriate diagnosis, and management in order to avoid detrimental consequences linked to death as well...
Procalcitonin and C-reactive protein as alternative salivary biomarkers in infection and inflammatory diseases detection and patient care: A scoping review
2025
In ambulatory and hospital settings, inflammatory diseases stand a significant challenge for both patients and clinicians. These conditions, often serve as precursors to sepsis, necessitate effective...
Biomarkers in immunology: Their impact on immune function and response
2025
The immune system is a complex network of organs, tissues, and cells that plays a critical role in defending the body against life-threatening diseases such as infections, cancer, Alzheimer's, and Crohn's...
CAR-T and nanotechnology: A comparative Perspective on autoimmune disease and cancer
2025
Nanotechnology has emerged as a key transformative force in upgrading Chimeric Antigen Receptor T-cell (CAR-T) from generation to generation in cancer and autoimmune treatment. Nanotechnology-aided...
Investigations of solid waste biosorbents for eliminations of total hardness from water: An experimental study of conversion of waste into valuable products
2025
Hard water is a serious problem in the village areas. Alkaline hardness can cause eye pain, respiratory tract collapse, liver difficulties, and skin concerns. Human biological hardness after the extreme...
Urine PD-L1 as a non-invasive biomarker for immune checkpoint inhibitor (ICI) therapy in bladder cancer
2025
Bladder cancer (BCa) is a common urological malignancy with a high recurrence rate, often within 2 years of initial diagnosis and treatment. Due to this high recurrence, near all patients require cystoscopic...
Machine learning-driven discovery of anoikis-related biomarkers in Adult T-Cell Leukemia/Lymphoma subtypes
2025
Adult T-Cell Leukemia/Lymphoma (ATLL) is a malignancy that arises from T-cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1). The disease is characterized by uncontrolled proliferation...
Implementation of a disease trigger prediction model using AIML for early diagnosis of epilepsy
2025
Epilepsy is one of the most prevalent neurological disorders that negatively impacts patients' quality of life and poses a severe health risk. It is often characterized by recurrent brain seizures....
Decoding inflammatory signaling networks: From molecular mechanisms to therapeutic targets
2025
This review aims to provide a comprehensive overview of inflammatory signalling pathways and their pharmacological significance in human health and disease. Inflammation signifies a basic biological...
The role of TGF-β in the development of lung cancer in patients with chronic obstructive pulmonary disease
2025
Lung cancer and chronic obstructive pulmonary disease (COPD) have similar etiologic factors, but the relationship between these diseases has not been investigated. This study aimed to investigate whether...
Lung-brain axis-generated inflammatory biomarkers in traumatic brain injury and acute respiratory distress syndrome: Role of mechanical ventilation/stress
2025
The unmet need for effective therapeutic strategies to address the bi-directional perturbation of the lung-brain axis following traumatic brain injury (TBI) or associated with Acute Lung Injury/Acute...
A comprehensive review on the interconnection of C-reactive protein, cardiac troponins, and cytokine storm in cardiovascular manifestations of COVID-19
2025
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with substantial cardiovascular morbidity and mortality, both during acute infection...
Identification of bipolar disorder related biomarkers, signaling pathways and potential therapeutic compounds based on bioinformatics methods and molecular docking technology
2025
Bipolar disorder (BD), also known as psychiatric disorder, affects millions of people all over the world. The aim of this investigation was to screen and verify hub genes involved in BD as well as to...
Review on zebra fish as an alternative animal model for neurological studies
2025
Zebrafish (Danio rerio) have emerged as a powerful alternative animal model in neurological research due to their unique combination of genetic, anatomical, and physiological characteristics. Their...
Machine learning and IoT in healthcare: Recent advancements, challenges & future direction
2025
The integration of Machine Learning and Deep Learning with IoT-enabled devices for real-time health monitoring has significantly revolutionized healthcare. These technologies facilitate the analysis...
Bridging traditional risk factors and genetic insights: A review on polygenic risk scores in cardiovascular diseases
2025
Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, with traditional risk models often falling short in predicting individual susceptibility-especially among diverse...
Time to embrace personalized medicine instead of only pursuing universaility of biomarkers
Available online 8 September 2025