Mechanistic insights on effective ratio of Linoelaidic and Docosapentaenoic acid by modulating adipogenic and inflammatory biomarkers in 3T3-L1 preadipocytes
November 2026
Obesity is a condition of energy balance in which nutrient intake consistently exceeds energy expenditure, increasing the risk of various potentially fatal disorders. Docosapentaenoic acid (DPA) is...
Amoxicillin and cotrimoxazole-driven dysbiosis disrupted blood cell levels, cytokine balance and induced oxido-nitrosative stress in young mice
November 2026
Amoxicillin and cotrimoxazole are among the most frequently prescribed antibiotics, yet their impact on gut microbiota and systemic physiology, particularly during early life, remains a critical concern....
An in-depth exploration of CNN-based deep learning models in cervical carcinoma analysis
November 2026
Cervical cancer has an extreme effect on women's health worldwide, recognized as the 4th most significant contributor to cancer fatalities among female. World Health Organization (WHO) states that there...
In silico screening of tripeptide inhibitors reveals potential lead compounds for targeting zika virus NS2B-NS3 protease
November 2026
ZIKV is a public health threat causing neurological complications such as microcephaly and Guillain-Barre syndrome, with the additional risk of sexual transmission. The absence of FDA-approved drugs...
Methanol extract of Smritisagara Rasa attenuates neurobehavior, neurochemical and stress indicators in rotenone-induced Drosophila model of Parkinson's disease
November 2026
Smritisagara Rasa (SSR), a traditional Ayurvedic herbo-mineral formulation, has long been prescribed for the treatment of Parkinson's disease (PD) since ancient times. Nevertheless, the underlying molecular...
Exploring the potential of IP-10 and sCD14 as inflammatory biomarkers in HIV–TB co-infection: a systematic review
November 2026
Human Immunodeficiency Virus (HIV) and tuberculosis (TB) are major global health challenges, especially in sub-Saharan Africa and Southeast Asia, where their co-infection greatly increases illness and...
Mapping autophagy-lncRNA co-expression networks in early ovarian carcinoma by stage-resolved transcriptomic modelling
November 2026
Early-stage ovarian carcinoma exhibits heterogeneous molecular programming that influences tumor progression and therapeutic vulnerability. Using RNA-seq data from 96 tumors (GSE101108), we developed...
Protective effects of nutritional and polyphenolic supplementation in polycystic ovarian syndromes
November 2026
Hormonal abnormalities, insulin resistance, and chronic inflammation are the hallmarks of Polycystic Ovary Syndrome (PCOS), a prevalent endocrine condition affecting women of reproductive age. Oxidative...
Multi-omics integration and machine learning reveal biomarker networks and therapeutic targets in Alzheimer's disease
November 2026
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited early diagnostic options and no curative therapy. This study presents a multi-region transcriptomic and systems biology...
Gut–kidney axis disruption by antibiotics: Dysbiosis, renal dysfunction and biomarker insights
November 2026
The integration of artificial intelligence and biotechnology in medicine: accelerating novelty in biomarker-targeted discovery and drug delivery systems
November 2026
Artificial intelligence (AI) and biotechnology are two transformative fields converging to benefit STEM because of their reliance on data and models. The tools from both fields have redefined and improved...
Bioscreening and phytochemical profiling of Phyllanthus niruri endophytic fungi with potential Anti-HCV applications
November 2026
This study proposes a novel strategy for antiviral drug discovery by exploring endophytic fungi associated with Phyllanthus niruri, a medicinal plant traditionally recognized for its therapeutic value...
Evaluation of withacoagulin from Withania coagulans for glycemic improvement and β-cell preservation in a type 2 diabetic model
November 2026
Type 2 diabetes mellitus remains a global health emergency, with existing therapies often failing to achieve durable glycemic control or preserve pancreatic β-cell function. In this study, we isolated...
Molecular biomarkers and nano-immunopharmacology in inflammatory carcinoma: Bridging mechanisms and therapeutic translation
November 2026
This section delineates the mechanistic framework linking chronic inflammation to carcinogenesis and critically explains how molecular biomarkers can be rationally exploited through nano-immunopharmacological...
Antioxidant and neuroprotective effects of Launaea taraxacifolia extract against aluminum-induced neurotoxicity
November 2026
This study evaluated the antioxidant and neuroprotective effects of ethanol leaf extract and fractions of Launaea taraxacifolia against aluminum chloride-induced neurotoxicity in rats. Sixty-six female...
In silico analysis of Coenzyme Q10 interaction with the heme-hemoglobin complex: Implications for oxidative stress and inflammation in severe malaria
November 2026
Plasmodium falciparum, the primary causative agent of severe malaria, catabolizes hemoglobin to obtain nutrients, resulting in the accumulation of toxic free heme. To mitigate this toxicity, the parasite...
Role of Akkermansia muciniphila in improving gut health for the prevention of type 2 diabetes
November 2026
Chronic inflammation, gut microbial dysbiosis, and metabolic dysregulation are closely interrelated and play a significant role in the pathogenesis of type 2 diabetes, a long-recognized global health...
Exploring trimethylamine N-oxide (TMAO) as a metabolic link between obstructive sleep apnea and cardiovascular risk: A cardiometabolic perspective
November 2026
Obstructive Sleep Apnea (OSA) is a condition that obstructs the upper airway during sleep, inducing intermittent hypoxia that affects the host metabolism, and is associated with gut microbiome dysbiosis....
FRF-HHO: Early ovarian cancer prediction using explainable fuzzy random forest optimized by Harris Hawks algorithm
November 2026
Ovarian cancer remains one of the most lethal gynecological malignancies, largely due to delayed diagnosis and the absence of reliable early screening tools. This study proposes an interpretable machine...
The Use of Machine Learning Algorithms in the Identification of Novel Biomarkers for Disorders of the Immune System
Available online 25 January 2026
Identifying biomarkers is critical for understanding the pathophysiology, diagnosis, and treatment of immune system disorders. Traditional biomarker discovery methods often face limitations in regard...
Molecular Imaging Biomarkers of the Tumour Microenvironment: Advances in Early Cancer Detection and Treatment Response Monitoring
Available online 22 January 2026
Molecular imaging of the tumor microenvironment (TME) is an excellent method for identifying cancer at an early stage and monitoring treatment progress. Emerging techniques, such as positron emission...
High-performance protease biosynthesis from Aspergillus niger through rice polish valorisation and RSM-based optimization
Available online 22 January 2026
Proteases are widely used industrial biocatalysts, but their economical and sustainable production remains challenging. This study investigates protease production by Aspergillus niger using rice polish...
In Vivo Multi-Omics Evaluation of Ellagic Acid–Gold Nanoparticles from Syzygium cumini for Glycemic Improvement and β-Cell Preservation in Type 2 Diabetic Mice
Available online 21 January 2026
Diabetes mellitus remains a major global health challenge, affecting over 537 million adults worldwide and this number is expected to rise 783 million by 2045, underscoring the need for improved therapeutic...
Evaluation of toxicity and antioxidant activities of various crude extracts of leaves and stems of Zygophyllumsimplex
2025
Zygophyllum simplex (Z. simplex) is a plant that has been used for a long time for the treatment of human diseases. Therefore, this present research study aims to prepare various plant extracts and...
Etiological connections between initial COVID-19 and two rare infectious diseases
2025
The origin of COVID-19 remains unclear despite extensive research. Theoretical models can simplify complex epigenetic landscapes by reducing vast methylation sites into manageable sets, revealing fundamental...