Investigation of the effects of polyherbal formulations against the combination of a high-fat cafeteria diet along with exercise modalities
2024
The aim of the present study was to make a polyherbal formulation of three herbs that would offset the negative effects of the high-fat cafeteria diet on rats and the beneficial effects of exercise....
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Isolation and characterization of cytotoxic and antioxidant biomarkers from the aerial parts of Suaedaaegyptica
2024
Chronic disease is an irregular change inside or outside of the tissues and organs that results in accumulation, local damage, and inflammation or irritation. Suaeda aegyptiaca (S. aegyptiaca) is a...
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Faecal microbial transplant
2024
Faecal Microbial Transplantation (FMT), have been shown to be successfully managed along with a variety of gastrointestinal disorders, including Clostridioides difficile infection (CDI), inflammatory...
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Paper based molecularly imprinted SERS substrate for early detection of lysophosphatidic acid in ovarian cancer
2024
The current study is related to fabrication of point-of-care molecularly imprinted paper-based analytical devices, specifically related to ovarian cancer early stage detection. The task involves creating...
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A brief history of urine examination - From ancient uroscopy to 21st century urinomics
2024
The art of uroscopy (Greek ouron-urine and skopeo-examination), the visual inspection of urine, is as old as the history of mankind. It had seen its ups and downs, was praised and derided, but was ultimately...
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Patient-derived primary culture-based prognostic model to predict tumor recurrence in patients with glioma
2024
The prognosis for glioma patients remains grim despite aggressive treatment approaches. Current molecular profiles have limitations in predicting glioma recurrence, highlighting the need for new and...
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Transforming early microbial detection: Investigating innovative biosensors for emerging infectious diseases
2024
The recent global pandemic has highlighted an increase in the prevalence of communicable diseases caused by pathogens. The swift transmission of these diseases within a short timeframe presents a substantial...
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Matrix metalloproteinase 7 as a diagnostic biomarker of biliary atresia: A systematic review
2024
Biliary atresia (BA) is a disease of the intrahepatic or extrahepatic bile ducts with an unknown etiology. It presents in neonates with jaundice, clay-colored stool, and often hepatomegaly. Early diagnosis...
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Inflammation-induced cellular changes: Genetic mutations, oncogene impact, and novel glycoprotein biomarkers
2024
Persistent inflammation can trigger the development of colorectal cancer, especially in patients with inflammatory bowel disease (IBD). The precise molecular mechanisms underlying this process are not...
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Nanomedicine in cancer therapy: Advancing precision treatments
2024
The progress made in the field of nanotechnology has resulted in the development of nanomedicine agents, which have demonstrated their efficacy as a promising clinical tool in the fight against different...
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A systematic study on key Epigenetic modulators in post-stroke conditions
2024
A stroke is a medical emergency characterized by the sudden interruption of blood flow to the brain, leading to cell death from oxygen deprivation. As a leading cause of mortality and long-term disability...
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Isovalerylglycine and α-Ketobutyrate are novel biomarkers that discriminate clear cell renal cell carcinoma in biopsy specimens using two-dimensional magnetic resonance spectroscopy
2023
Tumor heterogeneity and lack of pre-operative diagnostic biomarkers are key topics in the field of renal cell carcinoma (RCC) identification. Clear cell RCC (ccRCC) is an aggressive cancer subtype which...
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Probing biological network in concurrent carcinomas and Type-2 diabetes for potential biomarker screening: An advanced computational paradigm
2023
Type-2 diabetes mellitus (T2DM), the predominant form of diabetes in adults, is a co-morbid condition that exacerbates the severity of many other diseases, including cardiovascular disease, obesity,...
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Potential consequences of screening of occupational silica dust exposed workers for early detection of silicosis/silico-tuberculosis using a novel biomarker, club cell protein-16, with possible intervention by repurposing metformin
2023
Earlier, a study conducted by the Indian Council of Medical Research – National Institute of Occupational Health (ICMR-NIOH), India, evidenced that CC16 may be used as a proxy marker and screening tool...
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Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study
2023
The use of UCH-L1 detection with point-of-care (POC) assay alone has not been characterized for clinical use. This study compares the accuracies of POC UCH-L1 and Neuron-Specific Enolase (NSE) Elecsys®...
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Recombinant erythropoietin treatment improves serum podocyte marker levels in diabetic kidney disease
2023
Recombinant human erythropoietin (rHuEPO) is an effective treatment for renal anemia. Recently, there is evidence to suggest that rHuEPO may reduce podocyte injury in diabetic kidney disease (DKD)....
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Investigation of cystine as differential diagnostic biomarker between astrocytomas and oligodendrogliomas based on global- and targeted analysis using liquid chromatography/tandem mass spectrometric analysis
2023
Astrocytoma and oligodendroglioma are primary brain tumors classified as gliomas. Because there is difference in the prognostic significance of the extent of resection between IDH-mutant astrocytoma...
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Omicron’s intrinsic gene-gene interactions jumped away from earlier SARS-CoV-2 variants and gene homologs between humans and animals
2023
Omicron and its subvariants have become the predominant SARS-CoV-2 variants worldwide. The Omicron’s basic reproduction number (R0) has been close to 20 or higher. However, it is not known what caused...
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Taurine as a biomarker for aging: A new avenue for translational research
2023
The physiologic and irreversible process of ageing is accompanied by a wide range of structural and functional shifts at multiple different levels. It is also suggested that variations in the blood...
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Association of the circulating micro-RNAs with susceptible and newly diagnosed type 2 diabetes mellitus cases
2023
Diabetes mellitus (DM) is an array of metabolic diseases, which results from deregulation in insulin secretion or its action leading to abnormally high levels of blood sugar associated with long-term...
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Isolation and evaluation of significant antibacterial fraction of methanol and its derived fractions from the leaves extract of Zygophyllum simplex
2023
Food poisoning related to bacterial contamination is the most common disease and cause of death nowadays in developing countries. There are many plants that have made a revolution in the field of medicine....
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Therapeutic capability of selected medicinal plants' bioactive constituents against the mutant ovarian TP53 gene; a computational approach
2023
A mutant P53 protein plays such a crucial role in ovarian cancer, and natural compounds have been known to be effective in treating cancer. The current study was conducted to discover new mutant P53...
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Influence of deproteinization and demineralization process sequences on the physicochemical and structural characteristics of chitin isolated from Deep-sea mud shrimp (Solenocera hextii)
2022
Isolation of chitin from shrimp shell waste using chemical process is a well-adopted industrial practice due to its short process time and efficiency in removing both minerals and proteins from the...
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