Patient-derived primary culture-based prognostic model to predict tumor recurrence in patients with glioma
2024
The prognosis for glioma patients remains grim despite aggressive treatment approaches. Current molecular profiles have limitations in predicting glioma recurrence, highlighting the need for new and...
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Transforming early microbial detection: Investigating innovative biosensors for emerging infectious diseases
2024
The recent global pandemic has highlighted an increase in the prevalence of communicable diseases caused by pathogens. The swift transmission of these diseases within a short timeframe presents a substantial...
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Matrix metalloproteinase 7 as a diagnostic biomarker of biliary atresia: A systematic review
2024
Biliary atresia (BA) is a disease of the intrahepatic or extrahepatic bile ducts with an unknown etiology. It presents in neonates with jaundice, clay-colored stool, and often hepatomegaly. Early diagnosis...
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Inflammation-induced cellular changes: Genetic mutations, oncogene impact, and novel glycoprotein biomarkers
2024
Persistent inflammation can trigger the development of colorectal cancer, especially in patients with inflammatory bowel disease (IBD). The precise molecular mechanisms underlying this process are not...
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Nanomedicine in cancer therapy: Advancing precision treatments
2024
The progress made in the field of nanotechnology has resulted in the development of nanomedicine agents, which have demonstrated their efficacy as a promising clinical tool in the fight against different...
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A systematic study on key Epigenetic modulators in post-stroke conditions
2024
A stroke is a medical emergency characterized by the sudden interruption of blood flow to the brain, leading to cell death from oxygen deprivation. As a leading cause of mortality and long-term disability...
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Leveraging lean 4.0 technologies in healthcare: An exploration of its applications
2024
Lean 4.0, a fusion of lean manufacturing and digital technologies, is a powerful tool for implementing Industry 4.0. Its widespread use across sectors is driven by its ability to eliminate waste, reduce...
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Role of cognitive computing in enhancing innovative healthcare solutions
2024
Cognitive computing represents a groundbreaking development in healthcare, encompassing technological platforms that emulate the human brain's functionality. While cloud computing offers on-demand internet...
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Comparison of urinary proteome in the first two days after mating in male rats
2024
To explore whether differences between male rats on the next day of mating and on the day of mating can be reflected by the urine proteome....
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The effects of machine learning algorithms in magnetic resonance imaging (MRI), and biomarkers on early detection of Alzheimer's disease
2024
Alzheimer's Disease (AD) is a disorder that worsens over time causing loss of memory and decline of cognitive functions. Current methods for diagnosis consist of neuroimaging scans, magnetic resonance...
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Exploring fucosylation in lung cancer: Mechanisms, diagnosis, and therapeutic strategies
2024
Lung cancer remains a global health crisis, responsible for significant morbidity and mortality. Late-stage diagnosis often limits treatment options and patient survival. Therefore, identifying reliable...
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Association of vitamin B12 and vitamin D in T2DM patients in north Indian population
2024
Diabetes mellitus, highly prevalent endocrine disorder and metformin is the most frequently recommended oral hypoglycemic agent (OHA)....
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Therapeutic potential of black seed oil in treating rheumatoid arthritis: Insights on biochemical and genetic analyses of inflammatory signaling transducer
2024
Nigella sativa (Black seed) has been a longstanding component of traditional medicine. Rheumatoid arthritis, an autoimmune disorder targeting bone, cartilage, and synovial cells, leads to enduring joint...
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Gene-environment interactions and colorectal cancer risk: A case-control study on xenobiotic metabolizing enzyme polymorphisms in the Jammu& Kashmir, India population
2024
Cancer remains a significant global health concern, with colorectal cancer (CRC) showing a rising incidence, particularly among younger populations. Most CRC cases are linked to a complex interplay...
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World urine project
2024
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miRNA99a as a Potential target in P13K/Akt1/mTOR signaling pathway in progression of OSCC
2024
Oral cancer presents a significant global health challenge, driving ongoing research to enhance diagnostics and treatments. MicroRNAs, particularly miRNA99a, have emerged as key players in oral cancer's...
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Exploring the role of miR-361-3p in gastric cancer therapeutics and tumor progression
2024
Gastric cancer (GC) remains a leading cause of cancer-related deaths globally. Even with advancements in treatment, it is not known precisely which molecular pathways cause GC to proceed. MicroRNAs,...
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Development and applications of different types of green biosorbents for eliminations of hardness from water: A review on treatment, kinetics mechanism and future scope
2024
The presence of toxic materials in water solutions, mainly harmful metals and metalloids, is a significant ecological and community issue. In village areas, hardness is major groundwater toxicity. Hardness,...
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Isovalerylglycine and α-Ketobutyrate are novel biomarkers that discriminate clear cell renal cell carcinoma in biopsy specimens using two-dimensional magnetic resonance spectroscopy
2023
Tumor heterogeneity and lack of pre-operative diagnostic biomarkers are key topics in the field of renal cell carcinoma (RCC) identification. Clear cell RCC (ccRCC) is an aggressive cancer subtype which...
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Probing biological network in concurrent carcinomas and Type-2 diabetes for potential biomarker screening: An advanced computational paradigm
2023
Type-2 diabetes mellitus (T2DM), the predominant form of diabetes in adults, is a co-morbid condition that exacerbates the severity of many other diseases, including cardiovascular disease, obesity,...
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Potential consequences of screening of occupational silica dust exposed workers for early detection of silicosis/silico-tuberculosis using a novel biomarker, club cell protein-16, with possible intervention by repurposing metformin
2023
Earlier, a study conducted by the Indian Council of Medical Research – National Institute of Occupational Health (ICMR-NIOH), India, evidenced that CC16 may be used as a proxy marker and screening tool...
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Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study
2023
The use of UCH-L1 detection with point-of-care (POC) assay alone has not been characterized for clinical use. This study compares the accuracies of POC UCH-L1 and Neuron-Specific Enolase (NSE) Elecsys®...
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Recombinant erythropoietin treatment improves serum podocyte marker levels in diabetic kidney disease
2023
Recombinant human erythropoietin (rHuEPO) is an effective treatment for renal anemia. Recently, there is evidence to suggest that rHuEPO may reduce podocyte injury in diabetic kidney disease (DKD)....
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Investigation of cystine as differential diagnostic biomarker between astrocytomas and oligodendrogliomas based on global- and targeted analysis using liquid chromatography/tandem mass spectrometric analysis
2023
Astrocytoma and oligodendroglioma are primary brain tumors classified as gliomas. Because there is difference in the prognostic significance of the extent of resection between IDH-mutant astrocytoma...
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