FRF-HHO: Early ovarian cancer prediction using explainable fuzzy random forest optimized by Harris Hawks algorithm
2026
Ovarian cancer remains one of the most lethal gynecological malignancies, largely due to delayed diagnosis and the absence of reliable early screening tools. This study proposes an interpretable machine...
In vivo multi-omics evaluation of ellagic Acid–Gold nanoparticles from Syzygium cumini for glycemic improvement and β-cell preservation in type 2 diabetic mice
2026
Diabetes mellitus remains a major global health challenge, affecting over 537 million adults worldwide and this number is expected to rise 783 million by 2045, underscoring the need for improved therapeutic...
Molecular imaging biomarkers of the tumour microenvironment: Advances in early cancer detection and treatment response monitoring
2026
Molecular imaging of the tumor microenvironment (TME) is an excellent method for identifying cancer at an early stage and monitoring treatment progress. Emerging techniques, such as positron emission...
High-performance protease biosynthesis from Aspergillus niger through rice polish valorization and RSM-based optimization
2026
Proteases are widely used industrial biocatalysts, but their economical and sustainable production remains challenging. This study investigates protease production by Aspergillus niger using rice polish...
The use of machine learning algorithms in the identification of novel biomarkers for disorders of the immune system
2026
Identifying biomarkers is critical for understanding the pathophysiology, diagnosis, and treatment of immune system disorders. Traditional biomarker discovery methods often face limitations in regard...
Biomarker-guided precision immunotherapy in head and neck cancer: Harnessing toripalimab-tpzi as a PD-1 checkpoint inhibitor
2026
The recent humanized anti-programmed death-1 (PD-1) monoclonal antibody, toripalimab-tpzi, has now become a promising immunotherapeutic agent in the control of head and neck cancer (HNC), especially...
Evaluation of solvent-dependent yield and toxicity of selected spices using brine shrimp and zebrafish bioassays: Implications for aquaculture applications
2026
Spices are widely used culinary ingredients with notable antioxidant and antibacterial properties. In aquaculture, they function as immunostimulants and natural therapies, enhancing fish health and...
Multicenter evaluation of M2BPGi as a biomarker for liver fibrosis and hepatocellular carcinoma in chronic hepatitis B and C patients in Malaysia
2026
Chronic hepatitis B (HBV) and C (HCV) cause major global morbidity, especially in settings with limited diagnostic access. Liver biopsy is not routinely used for fibrosis assessment because of its invasive...
Pharmacological evaluation of betulinic acid in sodium valproate-induced autism spectrum disorder in rat pups
2026
Betulinic acid (BA), a natural compound isolated from many medicinal plants known for neuroprotective properties, was assessed for its potential to mitigate autism-like symptoms in rat pups following...
Intermittent fasting and circadian alignment: an immunometabolic synergy for HIV/TB management
2026
HIV and tuberculosis (TB) remain major global health challenges, compounded by chronic inflammation, immune dysregulation, and metabolic disturbance. Emerging evidence suggests that circadian alignment...
Towards a healthier world: Interdisciplinary approaches in cardiometabolic research
2026
The global burden of cardiometabolic diseases-including obesity, type 2 diabetes, metabolic syndrome, and their associated cardiovascular symptoms such as hypertension and dyslipidemia continues to...
Proteomic and metabolomic alterations in response to systemic stress in vivo
2026
Using liquid chromatography-tandem mass spectrometry, this study investigated the proteomic and metabolomic alterations associated with systemic stress in vivo. C57BL/6 mice were divided into two groups:...
Evaluation of Marsilea minuta Linn. for wound healing activity through the excision wound model
2026
The present study investigates the wound healing activity of Marsilea minuta Linn. extract on Wistar rats by using the excision wound model. After authentication at the Central Regional Botanical Survey...
Experimental evaluation of anxiolytic and anti-amnestic activities of aqueous and hydroalcoholic extracts of Sphaeranthus indicus L. (Mundi) in Swiss albino mice
2026
Sphaeranthus indicus L. (Mundi), a medicinal herb from the Asteraceae family, is traditionally cited in Ayurvedic texts for its Medhya (neurocognitive) properties. However, scientific evidence especially...
Systems-level transcriptomic investigation unveils essential molecular networks driving temozolomide resistance in lower-grade gliomas
2026
Low-grade gliomas (LGG) constitute a heterogeneous group of neoplasms arising from the supporting glial cells of the central nervous system (CNS). Patients typically undergo radiotherapy, chemotherapy,...
Biomarker-guided analysis of metabolic and inflammatory pathway modulation by Nigella sativa bioactive constituents
2026
Nigella sativa is a medicinal plant rich in bioactive constituents, particularly thymoquinone, with reported metabolic and anti-inflammatory activities. However, mechanistic evidence linking its phytochemical...
Nanorobotics in cancer treatment: Innovations, challenges, and future prospects
2026
Cancer is still a major worldwide health concern that calls for further precision medicine breakthroughs. With a focus on their revolutionary potential in targeted drug delivery and less invasive therapeutic...
Dietary supplementation of Bryophyllum pinnatum modulates C-reactive proteins, inflammatory cytokines, myeloperoxidase, and antioxidant enzyme activities in acetic acid-induced ulcerative colitis rats
2026
Anti-inflammatory effects of Bryophyllum pinnatum (Bp) in ulcerative colitis rats were investigated. Diet was formulated at (10% and 15%) supplementation levels using freeze-dried leaves. The protective...
Biological evaluation of Hoodia gordonii cactus against obesity on experimental animals
2026
The objective of the study was to determined antiobesity activity of Cactus, Hoodia gordonii on animals and to evaluate antihyperlipidemic property. The dried extract was supplied by Pharmacognosy and...
Pentraxin 3 (PTX3) as a cardiovascular biomarker: Differential expression and in silico mutagenesis of C1q binding sites
2026
Pentraxin 3 (PTX3) is an acute-phase glycoprotein implicated in cardiovascular inflammation and complement regulation. Its interaction with complement component C1q is critical for innate immune recognition,...
Assessment of glycemic biomarkers and lower urinary tract symptoms (LUTS) among adults with and without diabetes in South India: A pilot study
2026
Lower urinary tract symptoms (LUTS) are common among adults and substantially affect quality of life. Diabetes mellitus (DM) is known to influence LUTS through metabolic and neuropathic mechanisms,...
Hybrid molecular-image fusion network for enhanced lung cancer diagnosis using CT images
2026
Lung cancer is among the major causes of cancer-related deaths in the world, and the problem requires proper and timely diagnostic measures. The proposed study is HyMoIF-Net, a new radiogenomic deep...
Multi-omics biomarkers as emerging determinants in precision disease diagnosis and therapeutic monitoring
2026
Biomarkers objectively measurable biological characteristics indicating normal physiology, pathological states, or pharmacological responses are indispensable to precision medicine. The convergence...
Improving early detection of Alzheimer's and Parkinson's diseases through novel Ant colony optimization-based feature selection
2026
Neurological disorders such as Alzheimer's Disease (AD) and Parkinson's Disease (PD) pose significant global health challenges, affecting millions worldwide with projected doubling of cases by 2040....
Association of multiple biomarkers, CRP, uric acid, urea, ferritin with metabolic syndrome among young adults in Bhubaneswar
2026
MetS is a conglomeration of several disorders namely unusual weight gain, insulin resistance, hypertension and dyslipidemia that are likely to increase the risk of cardiovascular disease (CVD) and type...