Bridging traditional risk factors and genetic insights: A review on polygenic risk scores in cardiovascular diseases
2025
Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, with traditional risk models often falling short in predicting individual susceptibility-especially among diverse...
Network-based discovery of autophagy-regulating miRNA signatures in ovarian carcinoma
2025
Ovarian cancer (OC) remains a leading cause of gynaecologic mortality due to lack of reliable early detection biomarkers. Given the emerging role of autophagy in tumor progression, this study explored...
Ayurveda constructs as functional biomarkers: A narrative review of translational perspective on Generalized anxiety disorder
2025
Anxiety disorders are among the most prevalent psychiatric conditions worldwide, yet the search for reliable biomarkers remains inconclusive. While modern biomedicine emphasizes measurable parameters...
The diagnostic value of miRNAs combination for Kurdish NAFLD patients
2025
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver disorders ranging from simple steatosis to steatohepatitis. The development of non-invasive diagnostic tools is crucial for...
Mapping autophagy-lncRNA co-expression networks in early ovarian carcinoma by stage-resolved transcriptomic modelling
Available online 3 December 2025
Early-stage ovarian carcinoma exhibits heterogeneous molecular programming that influences tumor progression and therapeutic vulnerability. Using RNA-seq data from 96 tumors (GSE101108), we developed...
Exploring the potential of IP-10 and sCD14 as inflammatory biomarkers in HIV–TB co-infection: a systematic review
Available online 2 December 2025
Human Immunodeficiency Virus (HIV) and tuberculosis (TB) are major global health challenges, especially in sub-Saharan Africa and Southeast Asia, where their co-infection greatly increases illness and...
Methanol Extract of Smritisagara Rasa Attenuates Neurobehavior, Neurochemical and Stress Indicators in Rotenone-induced Drosophila Model of Parkinson’s Disease
Available online 28 November 2025
Smritisagara Rasa (SSR), a traditional Ayurvedic herbo-mineral formulation, has long been prescribed for the treatment of Parkinson’s disease (PD) since ancient times. Nevertheless, the underlying molecular...
In Silico Screening of Tripeptide Inhibitors Reveals Potential Lead Compounds for Targeting Zika Virus NS2B-NS3 Protease
Available online 19 November 2025
ZIKV is a public health threat causing neurological complications such as microcephaly and Guillain-Barre syndrome, with the additional risk of sexual transmission. The absence of FDA-approved drugs...
Mechanistic insights on effective ratio of Linoelaidic and Docosapentaenoic acid by modulating adipogenic and inflammatory biomarkers in 3T3-L1 preadipocytes
Available online 14 November 2025
Obesity is a condition of energy balance in which nutrient intake consistently exceeds energy expenditure, increasing the risk of various potentially fatal disorders. Docosapentaenoic acid (DPA) is...
Investigation of the effects of polyherbal formulations against the combination of a high-fat cafeteria diet along with exercise modalities
2024
The aim of the present study was to make a polyherbal formulation of three herbs that would offset the negative effects of the high-fat cafeteria diet on rats and the beneficial effects of exercise....
Isolation and characterization of cytotoxic and antioxidant biomarkers from the aerial parts of Suaedaaegyptica
2024
Chronic disease is an irregular change inside or outside of the tissues and organs that results in accumulation, local damage, and inflammation or irritation. Suaeda aegyptiaca (S. aegyptiaca) is a...
Faecal microbial transplant
2024
Faecal Microbial Transplantation (FMT), have been shown to be successfully managed along with a variety of gastrointestinal disorders, including Clostridioides difficile infection (CDI), inflammatory...
Paper based molecularly imprinted SERS substrate for early detection of lysophosphatidic acid in ovarian cancer
2024
The current study is related to fabrication of point-of-care molecularly imprinted paper-based analytical devices, specifically related to ovarian cancer early stage detection. The task involves creating...
A brief history of urine examination - From ancient uroscopy to 21st century urinomics
2024
The art of uroscopy (Greek ouron-urine and skopeo-examination), the visual inspection of urine, is as old as the history of mankind. It had seen its ups and downs, was praised and derided, but was ultimately...
Leveraging lean 4.0 technologies in healthcare: An exploration of its applications
2024
Lean 4.0, a fusion of lean manufacturing and digital technologies, is a powerful tool for implementing Industry 4.0. Its widespread use across sectors is driven by its ability to eliminate waste, reduce...
Comparison of urinary proteome in the first two days after mating in male rats
2024
To explore whether differences between male rats on the next day of mating and on the day of mating can be reflected by the urine proteome....
The effects of machine learning algorithms in magnetic resonance imaging (MRI), and biomarkers on early detection of Alzheimer's disease
2024
Alzheimer's Disease (AD) is a disorder that worsens over time causing loss of memory and decline of cognitive functions. Current methods for diagnosis consist of neuroimaging scans, magnetic resonance...
Association of vitamin B12 and vitamin D in T2DM patients in north Indian population
2024
Diabetes mellitus, highly prevalent endocrine disorder and metformin is the most frequently recommended oral hypoglycemic agent (OHA)....
Gene-environment interactions and colorectal cancer risk: A case-control study on xenobiotic metabolizing enzyme polymorphisms in the Jammu& Kashmir, India population
2024
Cancer remains a significant global health concern, with colorectal cancer (CRC) showing a rising incidence, particularly among younger populations. Most CRC cases are linked to a complex interplay...
World urine project
2024
miRNA99a as a Potential target in P13K/Akt1/mTOR signaling pathway in progression of OSCC
2024
Oral cancer presents a significant global health challenge, driving ongoing research to enhance diagnostics and treatments. MicroRNAs, particularly miRNA99a, have emerged as key players in oral cancer's...
Exploring the role of miR-361-3p in gastric cancer therapeutics and tumor progression
2024
Gastric cancer (GC) remains a leading cause of cancer-related deaths globally. Even with advancements in treatment, it is not known precisely which molecular pathways cause GC to proceed. MicroRNAs,...