Pharmacological evaluation of betulinic acid in sodium valproate-induced autism spectrum disorder in rat pups
2026
Betulinic acid (BA), a natural compound isolated from many medicinal plants known for neuroprotective properties, was assessed for its potential to mitigate autism-like symptoms in rat pups following...
Intermittent fasting and circadian alignment: an immunometabolic synergy for HIV/TB management
2026
HIV and tuberculosis (TB) remain major global health challenges, compounded by chronic inflammation, immune dysregulation, and metabolic disturbance. Emerging evidence suggests that circadian alignment...
Towards a healthier world: Interdisciplinary approaches in cardiometabolic research
2026
The global burden of cardiometabolic diseases-including obesity, type 2 diabetes, metabolic syndrome, and their associated cardiovascular symptoms such as hypertension and dyslipidemia continues to...
Proteomic and metabolomic alterations in response to systemic stress in vivo
2026
Using liquid chromatography-tandem mass spectrometry, this study investigated the proteomic and metabolomic alterations associated with systemic stress in vivo. C57BL/6 mice were divided into two groups:...
Evaluation of Marsilea minuta Linn. for wound healing activity through the excision wound model
2026
The present study investigates the wound healing activity of Marsilea minuta Linn. extract on Wistar rats by using the excision wound model. After authentication at the Central Regional Botanical Survey...
Experimental evaluation of anxiolytic and anti-amnestic activities of aqueous and hydroalcoholic extracts of Sphaeranthus indicus L. (Mundi) in Swiss albino mice
2026
Sphaeranthus indicus L. (Mundi), a medicinal herb from the Asteraceae family, is traditionally cited in Ayurvedic texts for its Medhya (neurocognitive) properties. However, scientific evidence especially...
Systems-level transcriptomic investigation unveils essential molecular networks driving temozolomide resistance in lower-grade gliomas
2026
Low-grade gliomas (LGG) constitute a heterogeneous group of neoplasms arising from the supporting glial cells of the central nervous system (CNS). Patients typically undergo radiotherapy, chemotherapy,...
Association of multiple biomarkers, CRP, uric acid, urea, ferritin with metabolic syndrome among young adults in Bhubaneswar
2026
MetS is a conglomeration of several disorders namely unusual weight gain, insulin resistance, hypertension and dyslipidemia that are likely to increase the risk of cardiovascular disease (CVD) and type...
In silico evaluation of itaconic acid as a potential inhibitor of KRAS and PPARG proteins in lung cancer
2026
Itaconic acid has emerged as a promising metabolite in cancer biology as a naturally occurring dicarboxylic acid synthesized by the immune response gene (IRG1). The molecular relationship between itaconic...
Dietary Supplementation of Bryophyllum pinnatum Modulates C-Reactive Proteins, Inflammatory Cytokines, Myeloperoxidase, and Antioxidant Enzyme Activities in Acetic Acid-Induced Ulcerative Colitis Rats.
Available online 15 April 2026
Anti-inflammatory effects of Bryophyllum pinnatum (Bp) in ulcerative colitis rats were investigated. Diet was formulated at (10% and 15%) supplementation levels using freeze-dried leaves. The protective...
Nanorobotics in Cancer Treatment: Innovations, Challenges, and Future Prospects
Available online 9 April 2026
Cancer is still a major worldwide health concern that calls for further precision medicine breakthroughs. With a focus on their revolutionary potential in targeted drug delivery and less invasive therapeutic...
Biomarker-guided analysis of metabolic and inflammatory pathway modulation by Nigella sativa bioactive constituents
Available online 1 April 2026
Nigella sativa is a medicinal plant rich in bioactive constituents, particularly thymoquinone, with reported metabolic and anti-inflammatory activities. However, mechanistic evidence linking its phytochemical...
Deep Learning-Based Automated Detection, Genetic Signature Identification and Classification of Oral Lesions for Early Diagnosis of Oral Cancer
Available online 28 March 2026
Oral cancer, particularly oral squamous cell carcinoma (OSCC), remains a major global health burden where early detection is critical for improving patient outcomes. Conventional diagnostic approaches,...
The Use of Machine Learning Algorithms in the Identification of Novel Biomarkers for Disorders of the Immune System
Available online 25 January 2026
Identifying biomarkers is critical for understanding the pathophysiology, diagnosis, and treatment of immune system disorders. Traditional biomarker discovery methods often face limitations in regard...
Evaluation of toxicity and antioxidant activities of various crude extracts of leaves and stems of Zygophyllumsimplex
2025
Zygophyllum simplex (Z. simplex) is a plant that has been used for a long time for the treatment of human diseases. Therefore, this present research study aims to prepare various plant extracts and...
Bringing lab to the field: Exploring innovations in point-of-care diagnostics for the rapid detection and management of tropical diseases in resource-limited settings
2025
Tropical diseases present major health challenges in regions with limited resources, where access to advanced laboratory facilities is often scarce. This study explores the innovative techniques emerging...
miRNA based target identification of TNFα gene in nephrotic syndrome
2025
Nephrotic syndrome (NS) can be caused by various underlying kidney conditions. In most cases, the exact cause of NS is unknown, although it may be related to the body's immune system malfunctioning....
CAR-T and nanotechnology: A comparative Perspective on autoimmune disease and cancer
2025
Nanotechnology has emerged as a key transformative force in upgrading Chimeric Antigen Receptor T-cell (CAR-T) from generation to generation in cancer and autoimmune treatment. Nanotechnology-aided...
The role of TGF-β in the development of lung cancer in patients with chronic obstructive pulmonary disease
2025
Lung cancer and chronic obstructive pulmonary disease (COPD) have similar etiologic factors, but the relationship between these diseases has not been investigated. This study aimed to investigate whether...
Machine learning and IoT in healthcare: Recent advancements, challenges & future direction
2025
The integration of Machine Learning and Deep Learning with IoT-enabled devices for real-time health monitoring has significantly revolutionized healthcare. These technologies facilitate the analysis...
Bridging traditional risk factors and genetic insights: A review on polygenic risk scores in cardiovascular diseases
2025
Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, with traditional risk models often falling short in predicting individual susceptibility-especially among diverse...
Network-based discovery of autophagy-regulating miRNA signatures in ovarian carcinoma
2025
Ovarian cancer (OC) remains a leading cause of gynaecologic mortality due to lack of reliable early detection biomarkers. Given the emerging role of autophagy in tumor progression, this study explored...
The diagnostic value of miRNAs combination for Kurdish NAFLD patients
2025
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver disorders ranging from simple steatosis to steatohepatitis. The development of non-invasive diagnostic tools is crucial for...