A family of multi-stable mechanisms based on the threefold-symmetric Bricard linkage
Available online 5 August 2025
Multi-stable structures capable of switching among stable states play an important role in various engineering applications. By extending the discrete stable state into a finite range of mechanism motion...
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Train Operational State Estimation: Technologies, Challenges, and Future Directions
Available online 5 August 2025
As the demand for intelligent transportation systems grows, train operations are becoming increasingly complex, making state estimation critical for improving railway safety and operational efficiency....
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Status quo, challenges and future directions of hydrogen medicine
Available online 5 August 2025
The hydrogen molecule (H2) has distinctive characteristics and advantages in broad-spectrum anti-inflammation, high biosafety and strong tissue permeability, exhibiting therapeutic potential in numerous...
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Toward Pan-Age Sepsis Detection: Leveraging Pediatric Transcriptome Data to Enhance Diagnostic Model Generalizability in Heterogeneous Populations
Available online 5 August 2025
Sepsis poses a threat to individuals across all age groups, from infants to geriatrics, due to its non-specific predisposition. Patients across different age groups demonstrate marked differences in...
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A special machine for solving NP-complete problems
July 2025
A specialized computer named as the Electronic Probe Computer (EPC) has been developed to address large-scale NP-complete problems. The EPC employs a hybrid serial/parallel computational model, structured...
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A metal-drug self-delivery nanomedicine alleviates tumor immunosuppression to potentiate synergistic chemo/chemodynamic therapy against hepatocellular carcinoma
July 2025
Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis. Chemotherapy is one of the first-line clinical therapeutic strategies for HCC. Still, the effectiveness...
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Symbiopersonal intelligence towards symbiotic and personalized digital medicine
July 2025
In this perspective, we introduce the concept of Symbiopersonal Intelligence (SymAI)—a specialized form of artificial intelligence designed to facilitate and optimize symbiotic interactions between...
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A multiscale perspective on cluster-based layered materials: Design and function optimization toward catalytic and energy storage applications
July 2025
•The design and assembly of cluster-based layered materials from a multiscale perspective is logically reviewed.•The properties and applications of cluster-based layered materials are demonstrated.•Current...
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Carrier-free delivery of nucleic acid and photosensitizer nanoparticles for enhanced photodynamic and gene antitumour therapy
July 2025
Activated anti-oxidation reactions in cells partially diminish the anticancer effect of photodynamic therapy (PDT), significantly hindering efforts to increase the efficacy of PDT. The expression of...
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Functions, mechanisms, and therapeutic implications of noncoding RNA in acute myeloid leukemia
July 2025
Acute myeloid leukaemia (AML) is a malignant disease of myeloid hematopoietic stem/progenitor cells. Despite improved understanding of the pathogenesis of AML since the 1980s, the standard treatment...
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Corporate sustainable operations management for carbon emissions reduction: An evolutionary perspective
July 2025
Carbon emissions reduction is a global goal for climate change mitigation. Manufacturing is a key carbon emission emitter, with commensurate pressures on manufacturing enterprises to implement sustainable...
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Direct monitoring of reaction intermediates through in situ characterization to promote the selectivity of N-integrated electrocatalytic CO2 reduction
July 2025
Energy-intensive chemical manufacturing is one of the largest contributors to global CO2 emissions. With the vigorous development of renewable energy, the electrocatalytic CO2 reduction reaction (CO2RR)...
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Multinuclear metal-organic coordination structures containing metal-cluster nodes studied by scanning tunneling microscopy
July 2025
Embedding metal clusters in surface-supported metal-organic frameworks gives rise to multinuclear metal-organic coordination structures (MMOCs). The controllable configurations, exposed clusters, and...
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PIAS4 regulates pluripotency exit and cell fate commitment in porcine embryonic stem cells
July 2025
Post-translational modifications (PTMs) are dynamic processes that regulate cell states by enhancing proteome diversity. However, the overall impact of PTMs on pluripotency exit in porcine embryonic...
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CRISPR/Cas system-guided plasmid mutagenesis without sequence restriction
July 2025
Plasmid mutagenesis is an essential step to engineer protein variants with desired properties. Direct generation of mutations on plasmids is a promising method compared to PCR-based methods and subcloning,...
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Obox1 deficiency impairs fertility in female mice
July 2025
•Obox1 deficiency result in reduced litter size and impaired oocyte ovulation.•Female mice lacking Obox1 exhibit decreased levels of gonadotropins and sex hormones.•Superovulated Obox1 knockout mice...
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Fauna-microbe diversity coupling lost in agricultural soils: Implications from the bacteria hidden in earthworm gut
July 2025
Earthworms are critical for supporting soil health and microbial diversity and simultaneously maintaining a highly diverse gut microbiome. The earthworm is predominantly vulnerable to physical disturbance,...
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A new pathway for pyrite formation in low-sulfate sediments driven by mineralization of reduced organic sulfur
July 2025
Although pyrite is the main sedimentary form of sulfur, an ample mechanistic comprehension of its formation in low-sulfate environments is lacking. Applying high depth-resolution multigeochemical and...
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Intelligent nanozymes: Biomimetic design, mechanisms and biomedical applications
July 2025
Nanozymes are a unique class of nanomaterials that possess intrinsic enzymatic properties, exhibiting similar reaction kinetics to natural enzymes. As enzyme substitutes in various biomedical applications,...
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Programmable DNA-based biomaterials for bone tissue engineering
July 2025
Bone defects are a common pathology in bone tissue diseases, and existing therapeutic interventions have significant limitations, highlighting the need for innovative strategies and advanced biomaterials....
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Targeted delivery and controlled release of polymeric nanomedicines for tumor therapy
July 2025
Drug therapy, including chemotherapy and immunotherapy, remains a cornerstone of cancer treatment; however, significant toxic side effects are often unavoidable, inhibiting tumor growth while causing...
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Improving small object detection via cross-layer attention
July 2025
Small object detection is a fundamental and challenging topic in the computer vision community. To detect small objects in images, several methods rely on feature pyramid networks (FPN), which can alleviate...
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Over-the-air federated learning: Status quo, open challenges, and future directions
July 2025
The development of applications based on artificial intelligence and implemented over wireless networks is increasingly rapidly and is expected to grow dramatically in the future. The resulting demand...
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Seahorse‐exoskeleton‐inspired structure with linear‐to‐torsion transition property for low-frequency vibration isolation
July 2025
•A seahorse-exoskeleton-inspired (SES) isolator for low-frequency vibration isolation is proposed.•The linear-to-torsion mechanism generates torsional inertia, reducing the natural frequency.•The nonlinear...
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