H4K20me3 erasure facilitates reprogramming to totipotent-like state by promoting DUX4 mediated transcription
Available online 27 August 2025
Epigenetic remodeling following fertilization is essential for the acquisition of embryonic totipotency. The role of H4K20me3, a key epigenetic modification, remains largely unexplored in the context...
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A Survey on Acoustic Sensing in the Metasurface Era: Challenges, Advances, and Applications
Available online 26 August 2025
Unlike RF sensing, which relies on dedicated sensors, acoustic sensing in ubiquitous environment takes advantage of affordable microphones and speakers in Commercial-off-the-Shelf (COTS) devices—originally...
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Research progress of omics technologies in forage breeding
Available online 26 August 2025
Forages are essential to global agriculture and ecosystems, with the development of high-yield, high-quality varieties as a cornerstone of efficient agricultural practices. However, traditional genetic...
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Endosomes: An underappreciated player in cell signal transduction
Available online 25 August 2025
Cellular signal transduction and endocytosis represent two critical biological mechanisms that facilitate the exchange of substances and information between cells and their external environment. Conventionally,...
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Graphene in photonic sensing: From fundamentals to cutting-edge applications
Available online 21 August 2025
Graphene-based photonic sensors have drawn considerable attention for their exceptional optical, electrical, and mechanical properties, enabling the development of highly sensitive, fast, and energy-efficient...
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Intraoperative Temporal Interference (TI)-Noninvasive Brain Stimulation Prevents Postoperative Delirium in Mice
Available online 16 August 2025
Postoperative delirium (POD), a common neurocognitive complication in the early postoperative period associated with high morbidity in elderly and high-risk surgical patients, faces fundamental research...
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Mechanism-Directed Design and Synthesis of a Dinuclear Copper Porphyrin for Efficient Electrocatalytic Hydrogen Evolution Reaction
Available online 16 August 2025
•Present mechanism-directed design and synthesis of a dinuclear Cu porphyrin for catalytic hydrogen evolution reaction.•Reveal the critical role of intramolecular electron transfer between the two Cu...
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A family of multi-stable mechanisms based on the threefold-symmetric Bricard linkage
Available online 5 August 2025
Multi-stable structures capable of switching among stable states play an important role in various engineering applications. By extending the discrete stable state into a finite range of mechanism motion...
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Train operational state estimation: Technologies, challenges, and future directions
Available online 5 August 2025
As the demand for intelligent transportation systems grows, train operations are becoming increasingly complex, making state estimation critical for improving railway safety and operational efficiency....
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Status quo, challenges and future directions of hydrogen medicine
Available online 5 August 2025
The hydrogen molecule (H2) has distinctive characteristics and advantages in broad-spectrum anti-inflammation, high biosafety and strong tissue permeability, exhibiting therapeutic potential in numerous...
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Toward Pan-Age Sepsis Detection: Leveraging Pediatric Transcriptome Data to Enhance Diagnostic Model Generalizability in Heterogeneous Populations
Available online 5 August 2025
Sepsis poses a threat to individuals across all age groups, from infants to geriatrics, due to its non-specific predisposition. Patients across different age groups demonstrate marked differences in...
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A special machine for solving NP-complete problems
July 2025
A specialized computer named as the Electronic Probe Computer (EPC) has been developed to address large-scale NP-complete problems. The EPC employs a hybrid serial/parallel computational model, structured...
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A metal-drug self-delivery nanomedicine alleviates tumor immunosuppression to potentiate synergistic chemo/chemodynamic therapy against hepatocellular carcinoma
July 2025
Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis. Chemotherapy is one of the first-line clinical therapeutic strategies for HCC. Still, the effectiveness...
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Symbiopersonal intelligence towards symbiotic and personalized digital medicine
July 2025
In this perspective, we introduce the concept of Symbiopersonal Intelligence (SymAI)—a specialized form of artificial intelligence designed to facilitate and optimize symbiotic interactions between...
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A multiscale perspective on cluster-based layered materials: Design and function optimization toward catalytic and energy storage applications
July 2025
•The design and assembly of cluster-based layered materials from a multiscale perspective is logically reviewed.•The properties and applications of cluster-based layered materials are demonstrated.•Current...
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Carrier-free delivery of nucleic acid and photosensitizer nanoparticles for enhanced photodynamic and gene antitumour therapy
July 2025
Activated anti-oxidation reactions in cells partially diminish the anticancer effect of photodynamic therapy (PDT), significantly hindering efforts to increase the efficacy of PDT. The expression of...
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Functions, mechanisms, and therapeutic implications of noncoding RNA in acute myeloid leukemia
July 2025
Acute myeloid leukaemia (AML) is a malignant disease of myeloid hematopoietic stem/progenitor cells. Despite improved understanding of the pathogenesis of AML since the 1980s, the standard treatment...
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Corporate sustainable operations management for carbon emissions reduction: An evolutionary perspective
July 2025
Carbon emissions reduction is a global goal for climate change mitigation. Manufacturing is a key carbon emission emitter, with commensurate pressures on manufacturing enterprises to implement sustainable...
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Direct monitoring of reaction intermediates through in situ characterization to promote the selectivity of N-integrated electrocatalytic CO2 reduction
July 2025
Energy-intensive chemical manufacturing is one of the largest contributors to global CO2 emissions. With the vigorous development of renewable energy, the electrocatalytic CO2 reduction reaction (CO2RR)...
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Multinuclear metal-organic coordination structures containing metal-cluster nodes studied by scanning tunneling microscopy
July 2025
Embedding metal clusters in surface-supported metal-organic frameworks gives rise to multinuclear metal-organic coordination structures (MMOCs). The controllable configurations, exposed clusters, and...
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PIAS4 regulates pluripotency exit and cell fate commitment in porcine embryonic stem cells
July 2025
Post-translational modifications (PTMs) are dynamic processes that regulate cell states by enhancing proteome diversity. However, the overall impact of PTMs on pluripotency exit in porcine embryonic...
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CRISPR/Cas system-guided plasmid mutagenesis without sequence restriction
July 2025
Plasmid mutagenesis is an essential step to engineer protein variants with desired properties. Direct generation of mutations on plasmids is a promising method compared to PCR-based methods and subcloning,...
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Obox1 deficiency impairs fertility in female mice
July 2025
•Obox1 deficiency result in reduced litter size and impaired oocyte ovulation.•Female mice lacking Obox1 exhibit decreased levels of gonadotropins and sex hormones.•Superovulated Obox1 knockout mice...
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Fauna-microbe diversity coupling lost in agricultural soils: Implications from the bacteria hidden in earthworm gut
July 2025
Earthworms are critical for supporting soil health and microbial diversity and simultaneously maintaining a highly diverse gut microbiome. The earthworm is predominantly vulnerable to physical disturbance,...
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