Activation of dimerized BRS3-EP3 suppresses melanoma cell migration through coupling Gαs protein
Available online 25 April 2024
•BRS3 and EP3 form dimers on HEK-293T cell membranes upon their co-expression•BRS3 and EP3 crosstalk switches to couple Gαs protein and induce P38 phosphorylation•BRS3 suppresses PGE2/EP3-mediated F-actin...
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Generating barcodes for nanopore sequencing data with PRO
Available online 25 April 2024
DNA barcodes, short and unique DNA sequences, play a crucial role in sample identification when processing many samples simultaneously, which helps reduce experimental costs. Nevertheless, the low quality...
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Review and Challenge: High Definition Map Technology for Intelligent Connected Vehicle
Available online 22 April 2024
•A comprehensive survey of high definition map for the intelligent connected vehicle.•A forward look from the history, standardization, building, and maintenance to its application.•Comparison between...
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Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy
Available online 21 April 2024
Dementia is characterized by synaptic and neuronal dysfunction in disease-specific brain regions. Repeated failure of dementia clinical trials with therapeutic drugs targeting abnormal protein aggregates...
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Cannabichromene from full-spectrum hemp extract exerts acute anti-seizure effects through allosteric activation of GABAA receptors
Available online 20 April 2024
The approval of Epidiolex, an anti-epileptic drug containing cannabidiol (CBD) as its active component, has brought hope to patients with refractory epilepsy. However, the anti-seizure effect of full-spectrum...
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A novel integrated ESID strategy of Critical Property-Flavor Quality Attributes of Huangqi Shengmai Yin
Available online 20 April 2024
There is still a gap between traditional Chinese medicine (TCM) and Western medicine, and it is crucial to build a bridge between them. In this study, taking Huangqi Shengmai Yin as a demonstration,...
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Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Available online 19 April 2024
The Lon proteases are evolutionarily conserved oligomeric hydrolases characterized by a built-in ATPase module. Here, we report the structures of LonC from Meiothermus taiwanensis (MtaLonC), a unique...
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Coordination of genome stability: Novel communication pathways between chloroplasts and other compartments in plant cells
Available online 18 April 2024
Chloroplasts have their own genomes, as do the nucleus and mitochondria. Coordination between these genomic compartments in plant cells is crucial for plant development and adaptation to the environment....
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The Application of Multi-scale Simulation in Advanced Electronic Packaging
Available online 16 April 2024
•This review systematically summarized the multiphysics simulation technology for electronic packaging.•This review highlighted the challenges and potential methods for modeling and solving coupled...
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Exploration of ultrafast dynamic processes in photocatalysis: advances and challenges
Available online 16 April 2024
Photocatalysis plays a crucial role in harnessing renewable energy by efficiently converting solar energy into chemical energy. Adequate cognition of photogenerated charge carrier dynamics in photocatalysis...
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Signal acquisition of brain-computer interfaces: A medical-engineering crossover perspective review
Available online 16 April 2024
Brain-computer interface (BCI) technology represents a burgeoning interdisciplinary domain that facilitates direct communication between individuals and external devices. The efficacy of BCI systems...
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The application of antibody-based agents in cancer therapy based on their mechanisms of action
Available online 15 April 2024
Monoclonal antibodies and antibody-based agents are undergoing remarkable development in cancer immunotherapy. Based on their structural components, these antibodies mediate the crosslinking of tumor...
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Tumoral IL-10-activated SHP2 in macrophages promotes mammary carcinoma progression
Available online 15 April 2024
The Src homology 2 domain-containing tyrosine phosphatase 2 (SHP2) is a non-receptor tyrosine phosphatase and acts as a convergent node for oncogenic cell-signaling cascades. SHP2 has been recognized...
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Engineering Exosomes and Exosome-like Nanovesicles for Improving Tissue Targeting and Retention
Available online 12 April 2024
Exosomes are natural nano-size particles secreted by human cells, containing numerous bioactive cargos. Serving as crucial mediators of intercellular communication, exosomes are involved in many physiological...
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Mechanical communication and function regulation of immune cells
Available online 12 April 2024
As the pivotal components of the immune system, immune cells can migrate rapidly and with flexibility to fulfill their critical functions. The cytoskeleton and mechano-sensitive proteins anchored within...
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Revealing the intricate mechanism governing the pH-dependent activity of a quintessential representative of flavoproteins, glucose oxidase
Available online 12 April 2024
Glucose oxidase (Gox), a prototypical flavoprotein, exhibits diverse industrial applications in glucose sensing and gluconic acid production. Its enzymatic activity is pH-dependent, with maximum activity...
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Neuromodulation with chemicals: Opportunities and challenges
Available online 12 April 2024
Chemicals play a crucial role in neurophysiological and neuropathological processes. By regulating the concentration of specific chemicals, receptors on the neuron cell membrane can be modulated to...
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Fine-Tune the Electronic Structure of Copper Nanowire Networks by Heteroatom Doping Toward Enhanced Fenton-like Reaction
Available online 11 April 2024
To fine-tune the configuration of electrons around metal centers is critical to enhancing the activation of peroxymonosulfate (PMS) for organic decontamination in a manner similar to the Fenton-like...
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Selective Oxidation by TS-1 coupled with in-situ Synthesised H2O2
Available online 10 April 2024
Feedstock valorisation with preformed H2O2 in conjunction with titanosilicate zeotypes is particularly attractive due to the increased selectivity, lower operating temperatures and improved process...
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New horizon of in-situ Raman spectroelectrochemistry on single-crystal surfaces
Available online 10 April 2024
Single crystal electrodes possess highly ordered and well-defined surface structures, making them ideal model systems for studying the mechanism of electrocatalytic reactions. The latest advancements...
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Characteristic and mechanism of pollution by laser cleaning high-value vehicle parts with a complex structure in remanufacturing industry
Available online 10 April 2024
Remanufacturing high-value vehicle parts is of substantial significance for the circular economy because it provides a second service life and reduces solid waste generation. Laser cleaning is a promising...
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DNA-based Hydrogels: Ideal Biomaterials for Cartilage Organoids
Available online 10 April 2024
•Using cartilage organoids is expected to be an effective treatment of osteoarthritis.•We first proposed to construct cartilage organoids by using DNA hydrogel.•DNA hydrogel can replace Matrigel to...
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A commentary of “Novel approaches in precise genome manipulations from single nucleotides to large DNA segments”: Top 10 Scientific Advances of 2023, China
Available online 10 April 2024
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A commentary of “Discovery of a new charge storage and collective reaction mechanism in lithium sulfur batteries”: Top 10 Scientific Advances of 2023, China
Available online 10 April 2024
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Integrating multi-omics data of childhood asthma using a deep association model
Available online 2 April 2024
Childhood asthma is one of the most common respiratory diseases with rising mortality and morbidity. The multi-omics data is providing a new chance to explore collaborative biomarkers and corresponding...
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