Targeting Non-classical Antigen Presentation Pathways: New Frontiers and Clinical Translation in Cancer Immunotherapy
Available online 15 October 2026
The efficacy of cancer immunotherapy largely depends on antigen presentation mediated by classical MHC molecules. However, tumor cells can achieve immune escape by downregulating MHC-I expression and...
Action-Perception-Driven Dual Closed-Loop Stroke Neurorehabilitation with Immersive Intervention and Pharmacotherapy Awareness
Available online 15 October 2026
Stroke remains a leading cause of death and long-term disability worldwide, with a high incidence in East Asia. Rehabilitation is often challenged by substantial inter-individual variability, weak coordination...
RePCV: Reducing Spatio-Temporal Redundancy for Efficient 3D Vision Analysis
Available online 15 October 2026
The key to unlocking space computing power networks: Tradeoff computing capability and energy consumption
Available online 14 October 2026
The second climax of satellite communication development dominated by low Earth orbit (LEO) constellations, has attracted broader attention and reached an unprecedented height compared with the first....
In vivo Modular Platform for Hepatocyte-specific Somatic Gene Perturbation to Study Postnatal Hepatocyte Maturation
Available online 14 October 2026
Hepatocyte maturation is a critical developmental process during which immature hepatocytes acquire full functionality. Cell type–restricted and temporally controllable gene perturbation in hepatocytes...
Unifying Perspectives on Linear Hidden Causal Representation Learning: from Graphical Models to Statistical and Algebraic Foundations
Available online 13 October 2026
Recent advances in integrated biophysical and biochemical microfluidic methods for circulating tumor cells isolation and analysis
September 2026
Cancer is a worldwide public health problem. Circulating tumor cells (CTCs) are one of the most significant tumor biomarkers, reflecting critical information of disease transcriptome, genome, and proteome....
Hydrogen peroxide on Mars and icy moons: Implications for the search for extraterrestrial signatures of prebiotic chemistry
September 2026
Hydrogen peroxide (H2O2) is increasingly recognized as an important molecule in prebiotic chemistry that potentially had a large impact on life’s early evolution. We highlight recent examples of H2O2...
In situ 3D bioprinting: The future of regenerative medicine
September 2026
3D bioprinting is utilized to design and construct scaffolds with scalable forms and physicochemical properties. Recently, this technology has been extensively studied in the field of biology and has...
Brain-wide atlas of outputs and inputs of mouse auditory cortex revealed by modified viral labeling strategies
September 2026
Understanding brain-wide connectivity is necessary to understand the principles of neural functions. While traditional neuron labeling methods have contributed to structural mapping, they often fall...
Radiotherapy followed by metformin neoadjuvant therapy drives superior pancreatic cancer ferroptosis and augments anti-tumor immunity
September 2026
Although neoadjuvant therapy has achieved higher levels of resectability and improved the survival outcomes of pancreatic carcinoma patients, cancer cells' resistance to conventional cell death has...
Harnessing the central dogma: Enzyme-driven gene diversification strategies for in cellulo continuous directed evolution
September 2026
In cellulo continuous directed evolution offers a powerful route to optimize biomolecules with enhanced or novel functions by enabling rapid, iterative exploration of vast fitness landscapes. At the...
Transcranial direct current stimulation and lesions hierarchically reorganize brain network dynamics with biological annotations
September 2026
Mapping human brain function based on neuromodulation and lesions could reorganize brain network dynamics and uncover causal relationships with behaviors or symptoms. However, the principles of reorganization,...
Modulation of nociceptive nerve activity as a novel therapeutic strategy in acute myeloid leukemia
September 2026
•AML remodels the neural microenvironment early in disease progression.•Leukemic cells preferentially accumulate in neural-sparse regions in bone marrow.•Pharmacological ablation of nociceptive nerves...
Systemic delivery of stealth adenoviral vector to reinvigorate antitumor immunity by PD-L1 genome editing and TIGIT/CD155 blocking
September 2026
Treatment with combined immune checkpoint blockade (CICB) has been considered as an effective approach to increase the objective response rate for cancer immunotherapy, but at the cost of significantly...
Intraoperative temporal interference (TI)-noninvasive brain stimulation prevents postoperative delirium in mice
September 2026
Postoperative delirium (POD), a common neurocognitive complication in the early postoperative period associated with high morbidity in elderly and high-risk surgical patients, faces fundamental research...
Accurate pathologic classification of aggressive myocarditis improves insights into patient precise medicine
September 2026
Because the disease's heterogeneity is ignored, the current diagnosis of myocarditis with advanced heart failure is imprecise, and there are no established criteria for subtyping this type of myocarditis....
Comparison of the biological effects of various radiation therapies for keloids by single-cell RNA sequencing reveals IRF1 as a novel target in keloid therapy
September 2026
Keloids are benign dermal tumors that arise from abnormal wound healing processes following skin lesions. Keloids are present in all human populations but occur most frequently in Africans. A significantly...
Effects of early-life tactile experience enrichment on autistic-like behaviors and synaptic alterations in Shank3 mutant mice
September 2026
Autism spectrum disorder (ASD) presents a significant therapeutic challenge due to limited treatment options. While non-pharmacological approaches based on sensory stimulation have shown promise in...
The multifaceted roles of tumor-infiltrating plasma cells in cancer immunology
September 2026
Activated B cells differentiate into plasma cells that can produce a vast repertoire of antibodies. The discovery of tumor-infiltrating plasma cells (TIPCs) has highlighted the importance of their interactions...
The dividend period of climate change–related mortality in China is coming to an end
September 2026
•It's unclear whether a descent phase exists in the net effect of temperature.•We propose a conception of the dividend period of climate change-related mortality.•The dividend period denotes the time...
Architecture and evolution of the lithosphere beneath the northern South China sea: Implications for plate-edge lithospheric thinning and rifting
September 2026
Passive margins formed by continental rifting and oceanic spreading exhibit a wide range of characteristics, many of which remain poorly understood. In this study, we investigate the continent-ocean...
ENSO-induced precipitation seasonality in the Chinese loess plateau during 1767–2050 CE
September 2026
Climate change has not only altered the total amount of rainfall but also significantly impacted its seasonal distribution. This alteration is particularly critical in monsoonal regions, where the availability...
Healthy lifestyle attenuates the clonal hematopoiesis-associated coronary artery disease risk
September 2026
Lifestyle factors and clonal hematopoiesis of indeterminate potential (CHIP) both contribute to the risk of developing coronary artery disease (CAD), but whether a healthy lifestyle could attenuate...
