Beyond Place Cells: Specific and Cooperative Roles of Hippocampal Interneuron Families in Spatial Coding
Available online 16 April 2026
The hippocampus constructs a cognitive map for spatial and mental navigation, whose fundamental units are the place fields of pyramidal cells. Prevailing models attribute place field generation and...
High-resolution mapping of soil total phosphorus in China: Revealing spatiotemporal patterns and driving mechanisms
Available online 16 April 2026
•Developed a 1 km resolution, layered spatiotemporal dataset of STP in China (2000-2020).•Revealed a macro-scale “central high, northern-southern low” pattern of STP, with a vertical decrease of 25.8%...
Metagenomic and metatranscriptomic insights into divergent mercury detoxification in the Mariana Trench sediments
Available online 15 April 2026
Mercury compounds accumulate in the Mariana Trench through sinking particles or carrion, yet the mercury cycling process and how hadal trench microbes cope with mercury toxicity remain largely unexplored....
Small-Molecule Autophagy Modulators: Mechanisms, Therapeutic Potential, and Development Challenges in Pathological Settings
Available online 15 April 2026
Autophagy is an evolutionarily conserved process in eukaryotic cells that delivers intracellular components to lysosomes for degradation and recycling. Increasing evidence has elucidated the regulation...
Geological records reveal chaotic diffusion during the Late Paleozoic Ice Age
Available online 15 April 2026
Chaotic diffusion arising from the long-term gravitational interactions between Earth and Mars has increasingly been recognized as a fundamental part of the chaotic behavior of the Solar system, yet...
Global change influences the prevalence and diversity of gut bacterial pathogens in soil invertebrates
Available online 13 April 2026
●Soil faunal gut harbors diverse potential pathogenic bacteria●High host biodiversity help reduce the proportion of gut pathogens●Global changes increase the proportion of gut potential pathogens●The...
Photochemistry and haze in chemically reducing terrestrial atmospheres
Available online 13 April 2026
Properties and processes within planetary atmospheres are critical for surface habitability. Evidence from the Earth suggests that our only known form of life has likely originated in a chemically reducing...
Targeted restoration of mitochondrial function mediates autophagy and glycolysis to promote irradiation-induced bone injury repair
Available online 13 April 2026
Radiotherapy remains a critical modality for tumor eradication in clinical practice. However, the bone tissue surrounding the tumor is highly susceptible to irradiation-induced damage due to its high...
Label-free proteomics and single-cell mass cytometry analysis of 5 immune tissues from mice with artesunate administration reveal immunosuppression of artesunate via BST2 and MDSCs
Available online 12 April 2026
Artesunate is a worldwide prevalent antimalarial medicine, which has also been demonstrated for anti-tumor, anti-virus and anti-autoimmune diseases. Yet the underlying molecular and cellular mechanisms...
Label-free digital protein sensing by integral plasmonic imaging
Available online 12 April 2026
The capability to detect trace-level protein in complex biofluids is critical in various fields, from fundamental biological research to clinical disease diagnosis. Digital protein sensing by counting...
Gut microbiota mediates tissue injury by promoting proteolysis and heme bioavailability in the small intestine
Available online 10 April 2026
•Extensive hydrolysis is essential for heme release from dietary myoglobin.•Intestinal microbiota mediates extensive hydrolysis of dietary myoglobin.•Short peptides facilitate PEPT1- and F-actin-dependent...
Magnetic Catheter Robot with Dynamic Force Feedback for Stiffness Identification and Abnormality Detection
Available online 7 April 2026
Ultra-intense laser pulses: From petawatt to exawatt, from multi-cycle to single-cycle
Available online 7 April 2026
Since the laser’s invention in 1960, the pursuit of higher peak power and stronger focused intensity has never stopped. Breakthroughs in chirped pulse amplification and optical parametric chirped pulse...
Inverse thermal design method for heat exchangers via digital twin model integrating deep learning surrogates with local thermal resistance evaluation
Available online 7 April 2026
This paper introduces an inverse design method for plate-fin heat exchangers (PFHEs) integrating digital twin, deep learning and inversion algorithm, which significantly differs from the conventional...
Genetic and linguistic landscapes of Gansu-Qinghai populations
Available online 7 April 2026
The Gansu-Qinghai (GQ) region is a critical Eurasian contact zone with exceptional linguistic and genetic diversity. However, genomic studies integrating genetic and linguistic evidence in areas with...
Chromatin regulator expression patterns predict prognosis and guide neoadjuvant therapy in esophageal squamous cell carcinoma
Available online 6 April 2026
Chromatin regulators (CRs), as key components of the epigenetic machinery, participate in tumor progression and therapeutic resistance by modulating chromatin structure and gene expression. Nonetheless,...
Dietary supplementation with fish oil, genetic risk, and glycemic control in patients with type 2 diabetes
Available online 5 April 2026
The effect of marine n-3 polyunsaturated fatty acids (PUFA) on glucose control among patients with type 2 diabetes (T2D) remains contentious. Whether the genetic risk modifies the effect remains unknown....
Dynamic roles of reactive iron in organic carbon preservation in marine sediments
Available online 4 April 2026
Iron oxides play a crucial role in carbon sequestration in marine sediments by forming associations with organic carbon (OC). However, iron oxides actively participate in the sedimentary biogeochemical...
Optimizing the enterprise inclusion threshold setting of China's national carbon market
March 2026
In July 2021, China launched its national carbon emission trading system (ETS), initially targeting thermal power plants with annual emissions exceeding 26,000 tons of carbon dioxide (CO2). Optimizing...
Building a global early-warning system for environmental risks with remote sensing
March 2026
Amid intensifying environmental risks, including climate change, biodiversity loss, and pollution, global ecosystems are under unprecedented pressure. Environmental monitoring forms the cornerstone...
Capture and identification of the electrogenerated picosecond intermediates by mass spectrometry
March 2026
•In-situ generation of electrochemical intermediates during electrospray ionization.•The first mass spectrometric identification of picosecond nitrenium/oxenium ions.•The first direct observation of...
Selective oxidation by TS-1 coupled with in-situ synthesised H2O2
March 2026
Feedstock valorisation with preformed H2O2 in conjunction with titanosilicate zeotypes is particularly attractive due to the increased selectivity, lower operating temperatures and improved process...
Designing precision measurement of the gravitational Aharonov-Bohm effect in microgravity
March 2026
Refinement of selective hydrogenation catalysts guided by the concept of ‘group recognition’
March 2026
Selective hydrogenation is crucial in the production of high-value chemicals, yet its efficient implementation remains challenging due to the absence of clear catalyst regulation strategies and in-depth...
