Enantiodivergent synthesis of axially chiral alkylidene cyclohexylamines by imine reductases-catalyzed desymmetrization
Available online 20 August 2025
Axially chiral alkylidene cycloalkanes are important scaffolds in various bioactive molecules, yet their synthesis remains challenging. In this study, we describe the imine reductases (IREDs)-catalyzed...
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Aminoalkylation of alkynyl bromides for accessing propargylamines via visible-light-driven multicomponent reaction
Available online 20 August 2025
Propargylamines are an important class of organic motifs that exist in a myriad of biologically active molecules. In this paper, we present a new approach for synthesising propargylamines, which utilises...
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Asymmetric synthesis of structurally diverse (S)-β-amino alcohols from simple aldehydes and formaldehyde
Available online 12 August 2025
Chiral β-amino alcohols represent a significant structural motif in many biologically active molecules. Developing an efficient biocatalytic method for synthesizing chiral β-amino alcohols with structural...
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CO2-promoted photoredox-catalyzed cascade cyclization of N-propargylindoles with sulfinates
Available online 12 August 2025
Simultaneous incorporation of a sulfonyl group and a tricyclic indole framework within a single molecular might yield structural motifs commonly found in bioactive compounds. Herein, we present a CO2-promoted...
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Skeletal recasting of benzo[c][1,2]dithiol-3-ones for the construction of 3-hydroxybenzo[b]thiophenes
Available online 11 August 2025
An unprecedented carbene-induced skeletal recasting of benzo[c][1,2]dithiol-3-ones is demonstrated herein. This Pd-catalyzed molecular editing of benzo[c][1,2]dithiol-3-ones serves as a powerful platform...
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Recent advances in the photocatalytic applications of ethyl bromodifluoroacetate: A review
Available online 7 August 2025
Organic compounds bearing fluorine atoms have received widespread attention in recent years owing to their specific bioactivity and good biocompatibility compared to their nonfluorinated counterparts....
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Aminoquinoline-directed electro/Ni dual-catalyzed C(sp2)-H alkylation with alkyl bromides
Available online 5 August 2025
Paired electrolysis offers an attractive platform for organic synthesis of avoiding the sacrificial anode. In this work, we developed a methodology of N,N′-bidentate aminoquinoline assistant-directed...
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Azide-based difunctionalization of alkenes
Available online 5 August 2025
As an important class of nitrogen-containing functional molecules, azides have attracted considerable attention in synthetic chemistry and functional materials due to their reaction diversity and derivatization...
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Carbon dioxide radical anion mediated regioselective carboxy-cyclization of alkenes
Available online 29 July 2025
Cyclopropyl fatty acid linkers and their derivatives serve as high-value pharmacophores in pharmaceutical and biotechnological research. Despite significant advancements in the hydrocarboxylation and...
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Direct C(sp2)-H thiolation of aldehydes via proton-coupled electron transfer
Available online 28 July 2025
As an unconventional redox mechanism, reductive proton-coupled electron transfer (PCET) of C = X bond has become an effective tool for C-C bond formation via a radical process. However, there were...
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Bromination and cyclization of 1,7-enynes: Easily access dibromo-3,4-dihydroquinolin-2(1H)-ones
Available online 23 July 2025
Oxidative cascade bromination/cyclization of 1,7-enynes with tetrabutylammonium tribromide (TBATB) through a radical process has been developed, providing a straightforward method to introduce two bromine...
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Robust, catalyst-free electroreduction of unactivated alkenes
Available online 19 July 2025
A robust, catalyst-free electroreduction protocol of unactivated alkenes without sacrificial anode was developed. This approach demonstrates a wide range of substrates, high chemo- and regioselectivity,...
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TsOH-assisted photocatalytic aerobic upcycling of polystyrene waste
Available online 9 July 2025
The persistent environmental challenge posed by polystyrene (PS) waste calls for efficient and sustainable recycling strategies. Herein, we report a TsOH-assisted, metal-free photocatalytic system for...
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Recent advances in electrochemical transformations of p-substituted phenols
Available online 9 July 2025
At present, the electrochemical transformations of p-substituted phenols have achieved plentiful applications in organic synthesis. The efficient functionalization of two key anodically generated intermediates—p-quinone...
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Oxocarbenium Lewis acid complex: A neutral thiol-specific bioconjugation reagent
Available online 4 July 2025
Oxocarbenium ions are pivotal intermediates in organic synthesis, driving key transformations like glycosylation, rearrangement and cyclization. However, their generation typically requires Lewis or...
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Pd@POPs-catalyzed carbonylative transformations of aryl bromides: Efficient synthesis of esters, amides, and topramezone
Available online 4 July 2025
In this study, we thoroughly investigated the performance of Pd@POPs in the heterogeneous catalytic carbonylation of aryl bromides. A variety of phenols and amines could be efficiently converted into...
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Palladium/copper-catalyzed 1,2-arylboration of styrenes with b2pin2 and indoles
Available online 4 July 2025
Boryldifunctionalization of alkenes has emerged as a valuable synthetic tool for constructing complex organoboron compounds. While significant advances have been achieved in carboboration reactions...
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A greener approach to Buchwald-Hartwig coupling. A sustainable Pd/C-catalyzed Csp2–N bond formation under microwave irradiation and bio-based solvent
Available online 27 June 2025
The Buchwald-Hartwig coupling enables the grafting of nitrogen-containing functionalities onto molecules, facilitating the synthesis of a wide variety of molecular structures. However, several challenges...
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Modular synthetic platform for diverse substituted benzylamines through selective amide-aldehyde-aldehyde cross-cyclization reaction
Available online 18 June 2025
Substituted benzylamines constitute an important structural motif in numerous natural products and pharmaceutical intermediates. Consequently, developing a straightforward and step-economical strategy...
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Solvent-polarity-controlled stereoselective synthesis of cis-acyclic indoline via photocatalytic dearomatization of indole
Available online 14 June 2025
Indolines, a privileged scaffold in natural products and bioactive molecules, hold immense potential in drug discovery and organic synthesis. Herein, we report a photocatalytic dearomatization strategy...
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Recent advances in the electrochemical synthesis of oligosaccharides and glycosides
Available online 13 June 2025
Sugars are fundamental building blocks in biological molecules such as oligosaccharides, glycoproteins, and glycosylated natural products. The construction of glycosidic bonds in a diastereoselective...
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One-pot asymmetric synthesis of chiral vicinal diols utilizing novel benzaldehyde lyases and carbonyl reductases
Available online 11 June 2025
Chiral vicinal diols and their derivatives play pivotal roles in pharmaceutical chemistry and organic synthesis. However, their synthesis remains challenging due to the presence of adjacent chiral centers....
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Pd/Ag dual-catalyzed asymmetric synthesis of sulfur-stereogenic sulfoximines via enantioselective intramolecular C−H arylation
Available online 10 June 2025
Sulfoximines, which often show significant bioactivity, are important motifs in pharmaceutical and agricultural chemicals. However, asymmetric synthesis of sulfoximines bearing S(VI) stereogenic centers...
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Electrochemical oxidation enabled HAT approach for the synthesis of quinolinones
Available online 9 June 2025
Quinolinones have been prepared by an intramolecular radical annulation of α-EWG (electron-withdrawing group) substituted amides and alkynes involving an electrochemical oxidation enabled hydrogen atom...
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Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review
Available online 7 June 2025
Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments,...
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