Four-component modular synthesis of sulfonylated indolo[2,1-a]isoquinolines via SO2 insertion/Smiles rearrangement radical relay strategy
Available online 20 May 2025
A multicomponent reaction of 1,8-enynes, aromatic amines, DABCO·(SO2)2 and tBuONO is achieved, affording diverse sulfonylated indolo[2,1-a]isoquinolines in moderate to good yields via SO2 insertion/Smiles...
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Biotechnological synthesis of nucleoside analogs: recent progress and perspectives
Available online 16 May 2025
Nucleoside analogs play an indispensable role in antiviral and anticancer therapies, and improving their synthesis methods has become a focal area of research. In recent years, technological breakthroughs...
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Copper camphorate based MOFs: efficient and recyclable catalysts for synthesis of propargylamines, oxazolidinones and cyclic carbonates
Available online 14 May 2025
We report the first application of copper camphorate based MOFs ([Cu2camph2dabco] – Cu-MOF-1 and [Cu2camph2bipy] - Cu-MOF-2) as catalysts in three-component A3-coupling of alkynes, aldehydes and amines....
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Rh(III)-catalyzed C2-arylation/lactonization of cyclic 1,3-dicarbonyls and ortho-borylbenzoic acid esters to access 3,4-fused isocoumarins
Available online 13 May 2025
A Rh-catalyzed C2-arylation/lactonization cascade of cyclic 1,3-dicarbonyls and ortho-borylbenzoic acid esters is described. Key to success is that nucleophilic cyclic 1,3-dicarbonyls can be converted...
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The cascade annulation approach to quinoxalines by radical NHC catalysis
Available online 7 May 2025
A wide range of functionalized quinoxalines were rapidly constructed by novel NHC-catalyzed cascade annulation of acyl oximes and isonitriles. The developed protocol characterized good functional group...
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Efficient bioproduction of 3-(4-thiazolyl)-l-alanine, an unnatural amino acid of pharmaceutical importance, by an enzymatic relay process
Available online 6 May 2025
As an l-histidine analog, 3-(4-thiazolyl)-l-alanine (TAla) has been attracting increasing biotechnological interest because it can serve as a key building block in the development of many novel therapeutic...
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Accelerating rational organoborazine discovery: predicted by machine learning, synthesized under continuous flow
Available online 24 April 2025
Substituting a benzene ring with a borazine ring in π-conjugated systems has garnered significant interest in recent years, particularly for its potential in enhancing optoelectronic device performance....
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Contamination and biotransformation of deoxynivalenol (DON) in common commercial foods: Current status, challenges and future perspectives
Available online 22 April 2025
Deoxynivalenol (DON) has received considerable attention due to its toxicity and widespread presence in food and feed. This review summarizes the DON contamination in commonly consumed commercially...
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Radical dehydroxylative C-glycosylation of 1-hydroxycarbohydrates enabled by photoredox catalysis
Available online 17 April 2025
C-Glycosides, known for their superior in vivo stability compared to their O- and N-glycoside counterparts, have been widely explored as drug candidates and utilized in biological research. Traditional...
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Green and sustainable site- and cross-selective C-H reductive coupling of para-quinone methides with quinoxaline-2(1H)-ones
Available online 15 April 2025
We herein disclose a novel activation mode for quinoxaline-2(1H)-ones via selective hydrogen atom transfer (HAT) of the N=Csp2-H bonds by synergistic photoredox catalysis and bromine radical catalysis,...
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Recent progress in selective liquid-phase hydrogenation of furfural on heterogeneous Ni-containing catalysts
Available online 9 April 2025
Lignocellulose biomass, without any doubts, is one of the most promising, and, therefore, one of the most studied sources for the production of biofuels, valuable chemicals and “green” solvents. Furfural...
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Mechanochemical syntheses of N-acyl sulfinamidines via iron-nitrenoids and their conversions to sulfur(VI) derivatives
Available online 7 April 2025
Herein, we present an iron-catalyzed mechanochemical synthesis of N-acyl sulfinamidines via nitrenoids generated from dioxazolones. Various substituents on both sulfenamides and thiols are well tolerated,...
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CO2 hydrogenation to methanol on the incapsulated Cu-Zn catalyst: Effect of the MCM-41 and SBA-15 supports and the method of preparation on catalytic activity
Available online 7 April 2025
The catalytic conversion of carbon dioxide toward methanol is of great practical and scientific importance in the concept of reducing CO2 emissions. Moreover, it can partially solve the problem of human...
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Asymmetric hydrogenation of α-pyrrolyl terminal alkenes: An easy access to enantioenriched pyrroles bearing a C2 Me-substituted stereogenic center
Available online 7 April 2025
Herein we report a Rh-catalyzed asymmetric hydrogenation of α-pyrrolyl terminal alkenes to afford a series of enantioenriched pyrroles bearing a C2 Me-substituted stereogenic center. The reaction features...
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N-Heterocyclic nitrenium-catalyzed triple domino reaction of organic iodides for the synthesis of phthalides and δ-lactones
Available online 7 April 2025
A triple domino reaction catalyzed by an N-heterocyclic nitrenium salt has been developed for the synthesis of phthalides and δ-lactones. This method offers operational simplicity, mild reaction conditions,...
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Novel biocatalyst derived from Araujia sericifera latex: Synthesis and applications
Available online 5 April 2025
Biocatalysts with lipase activity are increasingly required in different industrial sectors since they promote a large number of reactions with high selectivity and yield under mild conditions, promoting...
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Mn(III) Catalyzed Cascade Cross-coupling / Annulation / C(O)-C Bond Insertion / Rearrangement: Access to Multi-substituted Indolenines in Water
Available online 2 April 2025
This study presents an Mn-catalyzed method for the synthesis of multi-substituted indolenines via a cascade process in one-pot reaction which is conducted in water. The catalyst's efficiency, as low...
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N-aryl/-alkenyl difluoroketenimines: Transient intermediates for the general synthesis of difluoroalkylated heterocycles
Available online 2 April 2025
Fluorinated ketenimines not only have unique reactivities but also can be used as fluorinated building blocks, however, the research on their synthesis and application remains in its infancy. We herein...
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Environmentally friendly strategy for the direct conversion of sodium hypophosphite into organophosphorus compounds
Available online 28 March 2025
Sodium hypophosphite (NaH2PO2) stands out as a green, safe, stable, and cost-effective phosphorus source, presenting itself as one of the promising substitutes for traditional phosphorus trichloride...
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A ternary luminescent supramolecular assembly system for efficient photocatalysis and tunable white light emission
Available online 28 March 2025
A ternary host-guest complex composed of two pillar[5]arene derivatives (WP5 and m-TPEP5) and an Eosin Y derivative guest (WESY) has been demonstrated to form supramolecular nanoparticles in aqueous...
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A photocatalytic acylation of alkenes enabled by three-component oxidative difunctionalization and its applications in nature product synthesis
Available online 27 March 2025
A versatile platform for the construction of β-N/O-carbonyl subunit containing compounds and their analogues has been established through photocatalytic hydrogen transfer radical addition (HTRA) and...
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Annulation-induced hidden reactivity of N-(2-ethynylaryl)-1,2,3-triazoles to cinnolines under microwave irradiation
Available online 25 March 2025
An unprecedented microwave-assisted annulation-induced ring-opening of N-(2-ethynylaryl)-1,2,3-triazoles involving cleavage of C-N, C=C, and N=N bonds has been developed. This unique reaction allowed...
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Controllable stepwise fluorine elimination strategy for the chemodivergent synthesis of pyrido[2,1-a]isoquinolines
Available online 19 March 2025
A controllable stepwise fluorine elimination strategy has been reported, and used to selectively produce fluoro-substituted pyrido[2,1-a]isoquinolines and fluorine-free pyrido[2,1-a]isoquinolines through...
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Engineering glucose dehydrogenase from Sulfolobus sulfataricus toward utilizing diverse nicotinamide cofactor biomimetics
Available online 15 March 2025
Oxidoreductases are crucial for the production of widely utilized chiral building blocks, giving rise to a demand for costly NAD(P)/H. As potential substitutes for natural cofactors, nicotinamide cofactor...
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Chemoenzymatic two-step synthesis of tartaric acid employing glucose oxidase in combination with bimetallic AuPt/TiO2 catalyst
Available online 12 March 2025
Tartaric acid (TA) is a crucial hydroxy-carboxylic acid chelating agent extensively employed in the pharmaceutical, food, dye, and energy industries. The utilization of glucose oxidation for TA synthesis...
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