Visible-light-driven photocatalyst-free multicomponent reaction for synthesis of C3-alkylated isoindolinones
Available online 23 December 2025
A photocatalyst- and transition-metal-free three-component reaction of readily available 2-carboxybenzaldehydes, primary amines and 4-alkyl-1,4-dihydropyridines (alkyl-DHPs) for the synthesis of C3-alkylated...
Activation of diterpene hydrocarbon skeletons by microbial natural P450 oxidases
Available online 15 December 2025
Diterpenoids represent invaluable resources for novel drug discovery and development. The highly inertness of diterpene hydrocarbon skeletons, coupled with their multiple chiral centers, makes oxidative...
A small molecule EnT photocatalyst for rapid [2+2] cycloaddition
Available online 15 December 2025
Identifying novel catalysts for light-induced energy transfer (EnT) processes is crucial for advancing EnT-based chemical reactions. This work demonstrates that the readily available acylsilane, 1-(tert-butyldimethylsilyl)ethan-1-one,...
A membrane-mediated modulation for chemoenzymatic redox deracemization of secondary alcohols and applications
Available online 11 December 2025
The exploration of a chemoenzymatic dual catalysis system can bridge the methodological gap between chemical and biological catalysis under mild reaction conditions for the preparation of chiral molecules....
Continuous-flow harnesses the synergy of nitrogen dioxide and ozone for safe, catalyst-free and ultrafast arene nitration
Available online 10 December 2025
Green and scalable nitration of aromatic compounds remains a challenge in chemical synthesis. While acid-free nitration using simple nitrogen oxides is highly attractive, it is often plagued by poor...
Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis
Available online 9 December 2025
Enzyme engineering has emerged as a pivotal technology driving advances in biocatalysis, environmental remediation, and green chemistry. It is undergoing a transformative shift, propelled by the synergistic...
Visible-light-induced cascade radical sulfonation/annulation/isomerization reactions of propargyl chalcones with sodium sulfinates: Regioselective synthesis of sulfonyl 2H-chromene and 2H-quinoline derivatives
Available online 9 December 2025
A cascade approach has been developed for the one-pot three-step synthesis of sulfonyl-containing 2H-chromenes and 2H-quinoline derivatives from propargyl chalcones and sodium sulfinates. This protocol...
Advances in benzaldehyde lyase-catalyzed biotransformations: From enzyme engineering to industrial applications
Available online 9 December 2025
Benzaldehyde lyase (BAL), a thiamine diphosphate (ThDP)-dependent enzyme requiring divalent cations (e.g., Mg2+), mediates enantioselective C-C bond formation and cleavage to exclusively produce (R)-configured...
Transformation of ambient CO2 in air into cyclic carbonates mediated by a phosphorus-nitrogen PN3-pincer iron complex
November 2025
The atom-economical reaction of carbon dioxide (CO2) with epoxides possesses the potential to utilize captured CO₂ for synthesizing useful chemicals. Among a wide range of metal complexes employed for...
Selective cleavage of Csp3–N bonds in aliphatic tertiary amines enabled by difluorocarbene to access esters and thioethers
November 2025
Presented herein is a series of C–X (X = O, S) couplings for the synthesis of esters and thioethers via difluorocarbene-promoted selective Csp3–N bond cleavage between tertiary amines and carboxylic...
A water-soluble supermolecular cage for artificial light-harvesting nanoreactors
November 2025
Two discrete octahedral metallo-supramolecular cages were designed and constructed by using truxene-based pyridine L with enPd(NO3)2 or enPt(NO3)2, followed by detailed NMR, MS, UV absorption, and fluorescence...
Chiral bis(imidazoline) NCN pincer iridium(III)-catalyzed enantioselective alkynylation of trifluoropyruvates with terminal alkynes
November 2025
Readily prepared chiral bis(imidazoline) NCN pincer iridium(III) complexes have been developed as the new and highly stereoselective catalysts for the direct asymmetric addition of terminal alkynes...
Iron-catalyzed carbonylative synthesis of tert-alkyl thioesters
November 2025
In the context of transition metal-catalyzed carbonylation reactions, iron-catalyzed carbonylative transformation retains considerable value due to its high abundance, affordability, and diverse catalytic...
Palladium-catalyzed halosulfonylation of alkynes with ionic liquid as the green solvent and halide sources
November 2025
The first palladium-catalyzed halosulfonylation of alkynes with arylsulfonic acid under aerobic conditions was accomplished. This catalytic protocol provides a straightforward and effective synthetic...
Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review
November 2025
Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments,...
Direct C(sp3)-H functionalization with thiosulfonates via photoredox catalysis
November 2025
While C(sp3)-S bonds exist in many biologically active compounds, the direct catalytic C(sp3)-H thiolation remains elusive. Herein, we report a convenient and green C(sp3)-H thiolation approach mediated...
Chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes enabled by an Fe(III) photocatalyst
November 2025
We have developed a chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes. It offers several advantages, including the use of an environmentally friendly catalyst (5 mol%...
Radical dehydroxylative C-glycosylation of 1-hydroxycarbohydrates enabled by photoredox catalysis
November 2025
C-Glycosides, known for their superior in vivo stability compared to their O- and N-glycoside counterparts, have been widely explored as drug candidates and utilized in biological research. Traditional...
Synthesis of bridged bicyclic thiazine-2-thione and thiazole-2-thiones through DBU-promoted regioselective annulation of quinone monoacetals under mild conditions
November 2025
The first regioselective [4 + 2] annulation reactions of quinone monoacetals with isothiocyanates and Na2S have been accomplished. This convenient and novel protocol involves the synthesis of valuable...
Recent progress in selective liquid-phase hydrogenation of furfural on heterogeneous Ni-containing catalysts
November 2025
Lignocellulose biomass, without any doubts, is one of the most promising, and, therefore, one of the most studied sources for the production of biofuels, valuable chemicals and “green” solvents. Furfural...
Electrochemical selective deuterium labelling of N-heteroarenes
November 2025
Hydrogen-deuterium exchange (HIE) reaction is the most direct way to achieve the deuterium labeling as there is no need for extra pre-functionalization. Herein, we report an electrochemical selective...
Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
November 2025
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
Synthesis of naphtho[1,2-b]furan-2-carbaldehydes and naphtho[2,1-b]furan-2-carbaldehydes via electrocatalytic 3,3-rearrangement/cyclization of propargylic aryl ethers under mild conditions
November 2025
An electrocatalytic 3,3-rearrangement/cyclization approach has been developed for the transformation of aryl-substituted propargylic aryl ethers to naphtho[1,2-b]furan-2-carbaldehyde and naphtho[2,1-b]furan-2-carbaldehyde...
Visible-light-driven multicomponent reactions: Concurrent pyridylation and alkylation of styrenes
Available online 28 November 2025
Given the prevalence of pyridines in pharmaceuticals, methods for regioselectively introducing functional groups to the pyridine ring offer a categorical yet sustainable challenge strategy for expanding...
Electrochemical amino- or methoxymethylation of weak nucleophiles with methoxamine hydrochloride
Available online 28 November 2025
The in-situ generation of iminium ions from amines and aldehyde compounds, followed by nucleophilic attack (Mannich reaction), represents a powerful strategy for the formation of Mannich bases. However,...