Electrophilic aryl spiroannulation induced by diaryliodonium salts: efficient synthesis of [5,5]-spiro lactone-lactam scaffolds from α-cyanocarboxylates
June 2026
Spirocyclic architectures represent one of the privileged three-dimensional scaffolds in pharmaceutical chemistry and drug discovery, while the new-skeletal synthesis of spiromolecules from simple starting...
Electrochemical C-H thiocyanation of BODIPYs: Two birds with one stone of KSCN
June 2026
An efficient electrochemical C–H thiocyanation of BODIPYs was developed by using potassium thiocyanide as the source of thiocyanation. The straightforward C–H thiocyanation protocol possesses many advantages:...
Efficient templating synthesis of [12]cyclo-meta-phenylenes: A novel strategy for capturing fullerene
June 2026
The resorcin[4]arene-templated synthesis of the structure with [12]cyclo-meta-phenylene ([12]CMP), achieves a remarkable 53% overall yield in its key steps, overcoming the thermodynamic instability...
Contamination and biotransformation of deoxynivalenol (DON) in common commercial foods: Current status, challenges, and future perspectives
June 2026
Deoxynivalenol (DON) has received considerable attention due to its toxicity and widespread presence in food and feed. This review summarizes the DON contamination in commonly consumed commercially...
Synthesis of 1,4-oxathiins via [3+3] annulation of pyridinium 1,4-zwitterionic thiolates with iodonium ylides
June 2026
A straightforward and valuable approach for the synthesis of 1,4-oxathiins has been developed via [3+3] annulation of pyridinium 1,4-zwitterionic thiolates with iodonium ylides. C–S and C–O bonds were...
Accelerating rational organoborazine discovery: Predicted by machine learning, synthesized under continuous flow
June 2026
Substituting a benzene ring with a borazine ring in π-conjugated systems has garnered significant interest in recent years, particularly for its potential in enhancing optoelectronic device performance....
CO2 hydrogenation to methanol on the incapsulated Cu-Zn catalyst: Effect of the MCM-41 and SBA-15 supports and the method of preparation on catalytic activity
June 2026
The catalytic conversion of carbon dioxide to methanol is of great practical and scientific importance in the concept of reducing CO2 emissions. Moreover, it can partially solve the problem of human...
Light-driven enzymatic conversion of mevastatin into pravastatin by coupling P450sca-2 with the cyanobacterial photosynthetic system
June 2026
Cytochrome P450 enzymes (P450s) are highly attractive green biocatalysts with application potential in the fields of synthetic chemistry and synthetic biology. However, most P450 enzymatic reactions...
Accelerated flow synthesis of aripiprazole and brexpiprazole in environmentally benign solvents
June 2026
Aripiprazole and brexpiprazole are both second-generation atypical antipsychotic medications to treat a wide range of psychiatric disorders, the retail sales of which reached $1.35 billion and $2.07...
Recent advances in the electrochemical synthesis of oligosaccharides and glycosides
June 2026
Sugars are fundamental building blocks in biological molecules such as oligosaccharides, glycoproteins, and glycosylated natural products. The construction of glycosidic bonds in a diastereoselective...
One-pot asymmetric synthesis of chiral vicinal diols utilizing novel benzaldehyde lyases and carbonyl reductases
June 2026
Chiral vicinal diols and their derivatives play pivotal roles in pharmaceutical chemistry and organic synthesis. However, their synthesis remains challenging due to the presence of adjacent chiral centers....
A spirosilane ligand induced highly enantioselective Rh-catalyzed cycloisomerization of 1,6-enynes
June 2026
Transition metal-catalyzed cycloisomerization of 1,6-enynes is a highly effective approach to generating five-membered rings. Among the various catalytic systems developed, the use of chiral ligands...
Ir-catalyzed photoredox cascade radical annulation reactions toward phosphinimides bearing quaternary carbon center at room temperature
June 2026
Organophosphorus aza-heterocycles are widely found in the framework of numerous bioactive molecules, functional materials, and commercially available drugs. We report herein a photoredox-catalyzed radical...
Photocatalytic selective 1,4-oxyimination/diamination across C=C and N=N bonds to access structurally diverse N-N-N triazane derivatives
June 2026
A highly selective and atom-economical multi-component remote difunctionalization strategy has been successfully developed. This strategy utilizes precise control over the radical properties of bifunctional...
Recent advances in electrochemical transformations of p-substituted phenols
June 2026
At present, the electrochemical transformations of p-substituted phenols have achieved numerous applications in organic synthesis. The efficient functionalization of two key anodically generated intermediates—p-quinone...
Copper-catalyzed aerobic photodecarboxylation of carboxylic acids to aldehydes and ketones
June 2026
Base-metal-catalyzed decarboxylative transformations provide an economic pathway to the efficient functionalization of carboxylic acids. Herein, a copper-catalyzed aerobic photodecarboxylation of carboxylic...
Selective mono-methylation of primary alcohols and amines with methanol catalyzed by two-dimensional NHC-Ir coordination assemblies
Available online 29 May 2026
Methanol, as a low-cost, abundant, and sustainable C1 feedstock, has garnered considerable attention for methylation reactions via the borrowing hydrogen (BH) process. Herein, we designed and synthesized...
Biocatalytic synthesis of multiple stereogenic elements nonbiaryl atropisomers via simultaneous multichirality control
Available online 27 May 2026
The synthesis of complex nonbiaryl atropisomers with multiple stereogenic elements remains a significant challenge due to their flexible conformations and rotational freedom. Here, we report an ene-reductase-catalyzed...
Identification of acyl-CoA thioesterases in Mycolicibacterium neoaurum for the sustainable production of C22-steroids
Available online 20 May 2026
Mycolicibacterium phytosterol degradation is a cornerstone industrial strategy for the production of steroidal pharmaceuticals; however, the metabolic pathways governing C17 side-chain cleavage remain...
Leveraging B(C6F5)3-catalyzed hydroxyl protection for unlocking O-glycosylation
Available online 20 May 2026
Here, we report a mild, metal-free, and highly efficient catalytic strategy using B(C6F5)3 for both hydroxyl protection and direct O-glycosylation. This method enables the facile installation of tetrahydropyranyl...
Vitamin B1-catalyzed intramolecular ring-opening cyclization of cyclopropanes to access benzannulated seven-membered O-heterocycles
Available online 5 May 2026
Benzannulated seven-membered O-heterocycles, an important class of pharmaceutical scaffolds, currently lack efficient and mild synthetic methods. In this study, we utilized vitamin B1 as a green catalyst...
Photo-free electron donor-acceptor complexes driven divergent synthesis of thioethers and thioimidate esters with aryldiazonium salts and thiols/thiophenols
Available online 1 May 2026
A catalyst- and photo-free strategy for the divergent synthesis of thioethers and thioimidate esters from thiophenols/thiols and aryldiazonium salts has been developed. The reaction pathway is precisely...
Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis
April 2026
Enzyme engineering has emerged as a pivotal technology driving advances in biocatalysis, environmental remediation, and green chemistry. It is undergoing a transformative shift, propelled by the synergistic...
Regioselectively electrochemical Csp3-H alkoxylation for functionalized indanone
April 2026
An electrochemical regioselective Csp3-H alkoxylation has been developed to synthesize functionalized 1-indanone. In this process, electricity serves as the formal terminal oxidant, while the molecular...
Electrocatalytic regio- and stereoselective carboxylation of terminal alkynes with CO2
April 2026
Carboxylation with CO2 is a practical and streamlined way to construct a variety of sophisticated carboxylic acids and their derivatives. However, a series of elegant methods focus mainly on C(sp3)–...