Current status of dengue fever epidemics and vaccine development
February 2026
Dengue fever, an acute mosquito-borne infectious disease caused by dengue virus (DENV), is primarily endemic in tropical and subtropical regions. In recent years, the global incidence of dengue has...
Crimean-Congo hemorrhagic fever: An emerging threat in Europe
June 2026
Crimean-Congo hemorrhagic fever (CCHF), caused by Crimean-Congo hemorrhagic fever virus (CCHFV), is endemic in Africa, Asia, and Europe. However, CCHF epidemiology and epizootiology have been poorly...
Stabilization of prefusion hMPV F improves manufacturability and protective immunity across hMPV lineages
August 2026
Human metapneumovirus (hMPV) is a major cause of pediatric acute lower respiratory tract infections (ALRTIs), yet vaccine development has been hindered by the intrinsic metastability of the prefusion...
The antiviral role of TRIM25 in mammalian embryonic stem cells
August 2026
Mammalian embryonic stem cells (ESCs), despite lacking functional interferon (IFN) signaling, are remarkably resistant to viral infection. However, the mechanistic basis of their antiviral defenses...
SARS-CoV-2 3CLpro inhibits the replication of influenza viruses through the cleavage of NP and PA
August 2026
The co-circulation of multiple viruses can lead to distinct pathological outcomes, yet how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection influences other viral infections remains...
Identification and characterization of anti-chikungunya virus compounds using a biosafe toolkit
August 2026
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus for which no specific antiviral therapy is currently available. During the large outbreak in Foshan, Guangdong Province, China, in...
Antiviral agents for dengue virus
December 2025
Dengue virus (DENV) is a mosquito-borne pathogen responsible for a spectrum of illnesses, including dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Nearly half of the global population...
Recent progress in anti-Chikungunya virus drug discovery: Focus on the viral life cycle and direct-acting antivirals
August 2026
Chikungunya virus (CHIKV) belongs to the genus Alphavirus of the family Togaviridae. CHIKV infection generally causes severe clinical symptoms, including debilitating arthralgia, fever, hemorrhage and...
Pre-existing hemagglutinin-specific antibody levels are associated with B-cell repertoire maturation and antibody breadth after influenza vaccination
August 2026
Repeated influenza exposures generate complex antibody landscapes, yet how pre-existing antibodies are associated with subsequent vaccine responses remains unclear. We longitudinally tracked 21 adults...
HBV and host metabolic crosstalk: Reprogramming pathways for viral replication and pathogenesis
October 2025
Hepatitis B virus (HBV) establishes chronic infection through strategic manipulation of host metabolic networks, driving a spectrum of hepatic pathologies ranging from hepatitis to cirrhosis and hepatocellular...
The epidemiology and disease burden of enterovirus infections among hospitalized children in China: An 8-year national cross-sectional study
June 2026
Enterovirus (EV) infections represent a significant global and national health concern in children, leading to various complications. Although most children with EV infections generally have a favorable...
Engineering HSV-1 for Gene Therapy, Oncolytic Immunotherapy, and Neuroscience
Available online 26 August 2026
Herpes simplex virus type 1 (HSV-1) has emerged as a versatile platform for gene delivery, oncolytic immunotherapy, and neural circuit mapping. Its large genome, broad tropism, and engineering flexibility...
Blood and gut virome remodeling in gastric cancer: Anellovirus expansion and novel virus discovery
August 2026
Gastric cancer (GC) is a prevalent malignancy worldwide, yet effective early diagnostic tools remain lacking, and the role of the virome, a key component of the tumor microenvironment, in GC progression...
Current antiviral therapies and promising drug candidates against respiratory syncytial virus infection
April 2025
Respiratory syncytial virus (RSV) is one of the most common viruses leading to lower respiratory tract infections (LRTIs) in children and elderly individuals worldwide. Although significant progress...
RNA-centered regulation in SFTSV infection: Mechanisms, host interactions, and translational implications
Available online 22 August 2026
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen that causes substantial morbidity and high case fatality in severe cases, representing a major public health...
A HiBiT-Tagged influenza A virus reporter system reveals cytokine-inhibitory micropeptide 53 as a modulator of viral infection and immunopathology
October 2026
Influenza A virus (IAV) remains a major threat to human and animal health, highlighting the need for efficient approaches to identify host factors and antivirals. Reporter viruses are critical tools...
Genetic heterogeneity and pathogenic potential of historical Crimean-Congo hemorrhagic fever virus isolates in China
August 2026
The Crimean-Congo hemorrhagic fever virus (CCHFV) poses a significant public health threat. In China, CCHFV has been circulating for decades, yet the genomic diversity and pathogenic potential of the...
EHD4 facilitates Zika virus infection by regulating extracellular vesicle-associated viral release and cell attachment
October 2026
Extracellular vesicles (EVs) and other extracellular membrane-associated particles can contribute to viral dissemination; however, the host factors that regulate the composition and infectivity of EV-associated...
The role of T cells in influenza infection and vaccination
February 2026
Influenza virus infections cause significant illness or death every year, becoming a serious health risk. Currently, influenza vaccines mainly induce responses to antibodies against specific strains,...
A replication-defective tick-borne encephalitis virus generated by NS1 trans-complementation confers robust protective efficacy
August 2026
Tick-borne encephalitis virus (TBEV) poses a severe threat to public health, causing neurological disorders with high morbidity and mortality in endemic regions. Therefore, developing safe and effective...
Subcutaneous immunization with replication-competent live influenza virus confers durable protective immunity without respiratory pathology in mice
October 2026
Current influenza vaccination strategies are constrained by the trade-off between the safety of inactivated platforms and the immunogenic potency of live attenuated vaccines. Here, we provide a comprehensive...
Retinoic acid is a translation inhibitor against chikungunya virus both in vitro and invivo
August 2026
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes debilitating febrile and arthritic disease and remains a persistent public health threat in tropical and subtropical regions, with no clinically...
Ferritin nanoparticle-based vaccine enhances mucosal immunity by promoting antigen uptake and activation of alveolar macrophages
October 2026
•Ferritin nanoparticle-displayed mosaic tandem-RBD enhances respiratory mucosal immunity.•Intranasal immunization induces broad neutralizing antibodies and tissue-resident immune populations.•Nanoparticles...
Viral manipulation of DNA damage response signaling: Molecular mechanisms and therapeutic implications
October 2026
The DNA damage response (DDR) network maintains genomic integrity, functions as a signaling hub that viruses exploit to drive pathogenesis, and constitutes a central interface between viral infection...
Hybridoma-derived neutralizing monoclonal antibodies against Beta and Delta variants of SARS-CoV-2 in vivo
April 2023
Neutralizing monoclonal antibodies (mAb) are a major therapeutic strategy for the treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The continuous emergence of new...
