METTL3-activated CCNE2 promotes hepatocellular carcinoma cell growth, metastasis, stemness and radioresistance
March 2026
Methyltransferase-like 3 (METTL3) has been confirmed to participate in regulating hepatocellular carcinoma (HCC) progression. However, more roles and mechanisms of METTL3 in HCC progression still need...
Anatomy as a guide: Using learned priors for precise organ segmentation
March 2026
Accurate segmentation of abdominal organs from CT is essential for clinical tasks such as radiotherapy planning but is hindered by ambiguity at organ boundaries. Standard deep learning models fail to...
Integration of conventional MRI and diffusion-weighted imaging for differential diagnosis of high-grade gliomas and metastatic brain tumors
March 2026
Brain tumors, particularly high-grade gliomas (HGG) and solitary brain metastases (SBM), often present with overlapping clinical and imaging features, complicating accurate diagnosis and management....
Critical perspectives on nanoparticle-enabled radiopharmaceuticals: Integrating molecular imaging, targeted therapy, and theranostic translation
March 2026
Radiopharmaceuticals based on nanoparticles are transforming the landscape of molecular imaging, targeted therapy and theranostics. Nevertheless, despite the accelerating innovation, translation is...
Dosimetric comparison and clinical evaluation of hybrid three-dimensional conformal radiotherapy and intensity modulated radiotherapy in simultaneous integrated boost radiotherapy for breast cancer
March 2026
Hybrid radiotherapy plans combining three-dimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) aims to optimize dose distribution in simultaneous integrated...
Preclinical evaluation of [68Ga]Ga-DFO for molecular imaging of Vibrio cholerae infection
March 2026
In this study, a novel diagnostic radiopharmaceutical, [68Ga]Ga-DFO, was developed for positron emission tomography (PET) imaging of the pandemic infection of Vibrio cholerae....
The correlation between bone alteration and intestinal fibrosis of Crohn's disease: A preclinical μCT-based study on the bone-gut axis
March 2026
The relationship between osteoporosis and intestinal fibrosis, a prominent manifestation of Crohn's disease (CD), has not been fully investigated. Focusing on this correlation may offer new insights...
Association of mean cardiac dose with model-predicted risk of radiation-induced pericarditis in breast cancer patients
January 2026
This study aimed to investigate the association between mean cardiac dose (MCD) and the model-predicted risk of radiation-induced pericarditis in breast cancer patients undergoing radiotherapy....
Open problems for the preparation and quality control of Ac-225 radiopharmaceuticals
January 2026
The aim of this brief review is to analyze the persistent chemical and radiochemical hurdles that still hinder the development of clinically useful actinium-225 (225Ac) radiopharmaceuticals for alpha-targeted...
Stereotactic body radiation therapy enhances therapeutic efficacy of immune checkpoint inhibitors by promoting the releasing of interferon-γ and interleukin-2
January 2026
To explore whether stereotactic body radiation therapy (SBRT) could promote the release of serum interferon-γ (IFN-γ) and interleukin-2 (IL-2), as well as the prognostic value of IFN-γ in patients receiving...
Analysis of set-up errors in daily kilovolt fan beam CT for rectal cancer treated with volumetric modulated arc therapy
January 2026
To analyze inter-fractional set-up errors in rectal cancer patients undergoing volumetric modulated arc therapy (VMAT) guided by daily kilovolt fan beam CT (kV-FBCT)....
Accuracy study of deep learning-based synthetic CT images for adaptive radiotherapy of pelvic tumors
January 2026
To evaluate the accuracy of deep learning conversion of cone-beam computed tomography (CBCT) into synthetic CT (sCT) for adaptive pelvic radiotherapy and to inform clinical application....
Dosimetric evaluation of the PASSAG polymer gel dosimeter improved with sucrose using MRI
January 2026
One of the main constraints of polymer gel dosimeters for use in clinical settings is the high toxicity of their compounds. PASSAG gel dosimeter provides excellent dosimetric properties and very low...
The role of 131I in the treatment and management of thyroid cancer
January 2026
For individuals with thyroid cancer, the most common cause of mortality worldwide is recurrent, metastatic disease. Radioactive iodine (RAI) remains the cornerstone of treatment for these patients....
Comparative dosimetric analysis of hippocampal-sparing vs conventional craniospinal irradiation in central nervous system leukemia: A single-center study
January 2026
To evaluate dosimetric differences between hippocampal-sparing (HS) and conventional craniospinal irradiation (CSI) in central nervous system leukemia (CNSL) patients....
Myrtus communis ameliorates ionizing radiation-induced cardiopulmonary injury in rats: TROD-GROG-003 study
January 2026
Ionizing radiation (IR), widely used in diagnostic and therapeutic procedures, can damage vital organs such as the heart and lungs through oxidative stress. This study aims to assess the potential radioprotective...
Relationship between coronary CTA morphological parameters, serum ApoA1, ApoB/ApoA1, and prognosis of patients with coronary heart disease
January 2026
To explore the relationship between coronary computed tomography angiography (CTA) morphological parameters, serum apolipoprotein A1 (ApoA1), the ratio of apolipoprotein B (ApoB) to ApoA1 (ApoB/ApoA1),...
Radiation dosimetry of [124I]-metaiodobenzylguanidine (mIBG) dynamic PET/CT in pediatric neuroblastoma through animal-to-human extrapolation with MCNPX code and OLINDA/EXM software
January 2026
Iodine-124 metaiodobenzylguanidine (mIBG) positron emission tomography (PET)/computed tomography (CT) is well-established for imaging and pre-therapeutic dosimetry in pediatric neuroblastoma. However,...
Radiopharmaceuticals for microbiome imaging: A narrative review of emerging approaches to mapping host–microbe interactions
January 2026
The human microbiome has immense effects on immunity, metabolism, and therapeutic response, but non-invasive in vivo visualization is underdeveloped. Radiopharmaceuticals, traditionally applied in oncology...
Real-time motion compensation in cyberknife radiosurgery: Advances in fiducial marker tracking and clinical outcomes
January 2026
CyberKnife, a stereotactic radiosurgery (SRS) technique, delivers highly precise radiation beams to tumors. However, the patient motion, such as respiration and positional changes, can lead to tumor...
Exploring radiation pneumonitis associated with immune checkpoint inhibitors: Insights from the FAERS pharmacovigilance database
January 2026
The combination of immunotherapy and radiotherapy has become an important strategy for treating thoracic tumors. However, both treatment modalities can cause adverse effects to lung tissue. Research...