Association of mean cardiac dose with model-predicted risk of radiation-induced pericarditis in breast cancer patients
January 2026
This study aimed to investigate the association between mean cardiac dose (MCD) and the model-predicted risk of radiation-induced pericarditis in breast cancer patients undergoing radiotherapy....
Open problems for the preparation and quality control of Ac-225 radiopharmaceuticals
January 2026
The aim of this brief review is to analyze the persistent chemical and radiochemical hurdles that still hinder the development of clinically useful actinium-225 (225Ac) radiopharmaceuticals for alpha-targeted...
Stereotactic body radiation therapy enhances therapeutic efficacy of immune checkpoint inhibitors by promoting the releasing of interferon-γ and interleukin-2
January 2026
To explore whether stereotactic body radiation therapy (SBRT) could promote the release of serum interferon-γ (IFN-γ) and interleukin-2 (IL-2), as well as the prognostic value of IFN-γ in patients receiving...
An 18F-MD-PSMA (Multi-dentate PMSA Imaging Agent) PET/CT in Prostate Cancer Relapse: Results of a Retrospective Trial
2024
This study aimed to evaluate the performance of 18F-MD-PSMA PET/CT in patients previously treated for prostate cancer by either surgery or therapy, but later relapsed biochemically....
CT-guided Percutaneous Microwave Ablation Combined with Local Radiotherapy or Chemotherapy of Malignant Pulmonary Tumors
1 June 2024
The study aimed to investigate the clinical efficacy of CT-guided microwave ablation (MWA) combined with 125I seed implantation or bronchial arterial infusion (BAI) chemotherapy in the treatment of...
The Radioprotective Effect of LBP on Neurogenesis and Cognition after Acute Radiation Exposure
28 February 2024
Radiation exposure has been linked to the development of brain damage and cognitive impairment, but the protective effect and mechanism of Lycium barbarum pills (LBP) on radiation-induced neurological...
“One Method to Label Them All”: A Single Fully Automated Protocol for GMP-Compliant 68Ga Radiolabeling of PSMA-11, Transposable to PSMA-I&T and PSMA-617
28 February 2024
Prostate-specific membrane antigen (PSMA) is an ideal target for molecular imaging and targeted radionuclide therapy in prostate cancer. Consequently, various PSMA ligands were developed. Some of these...
Synthesis and Ready to Use Kit Formulation of EDTMP for the Preparation of 177Lu-EDTMP as a Bone Palliation Radiopharmaceutical
1 January 2023
With its suitable nuclear decay characteristics and large-scale production feasibility with adequate specific activity, 177Lu is regarded as an excellent radionuclide for developing bone pain palliation...
Toxicity and Tolerability of 177Lu-DOTA-TATE PRRT with a Modified Administered Activity Protocol in NETs of Variable Origin – A Phase 2 Registry Study
10 August 2022
Background : Peptide receptor radionuclide therapy (PRRT) has been recently approved for advanced, metastatic, or progressive neuroendocrine tumors (NETs)....
Calcium Carbonate Microparticles as Carriers of 224Ra: Impact of Specific Activity in Mice with Intraperitoneal Ovarian Cancer
2021
Background : Patients with advanced-stage ovarian cancer face a poor prognosis because of recurrent peritoneal cavity metastases following surgery and chemotherapy. Alpha-emitters may enable the efficient...
Extremity Exposure with 99mTc - Labelled Radiopharmaceuticals in Diagnostic Nuclear Medicine
2021
Background : Extremity exposures may raise the risk of cancer induction among radiographers involved in the preparation and administration of technetium-99m labelled radiopharmaceuticals....
Administered Pediatric Radiopharmaceutical Doses at a Tertiary Hospital in South Africa: A Comparison with Corresponding Activities Based on North American Consensus Guidelines and Administration of Radioactive Substances Advisory Committee Guidelines
2021
Background: Diagnostic nuclear medicine reveals physiological processes in vivo, facilitating early detection of disease prior to anatomical changes. However, in pediatric studies, the selection of...
Pre-feasibility Study for Establishing Radioisotope and Radiopharmaceutical Production Facilities in Developing Countries
2019
Background: A significant number of developing countries have no facilities to produce medical radioisotopes and radiopharmaceuticals....
Dosimetry and Toxicity Studies of the Novel Sulfonamide Derivative of Sulforhodamine 101([18F]SRF101) at a Preclinical Level
2019
Background: The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a Sulforhodamine 101 derivative that was previously synthesised by our group. The fluorescent dye SR101 has been reported as...