Harnessing Cis-regulatory elements for intelligent crop breeding
Available online 13 November 2026
The growing demand for climate-resilient and high-yielding crops has exposed a critical bottleneck in crop breeding. The predominant breeding paradigm anchored in protein-coding genes is increasingly...
Leaf-deposited nanoplastics reshape plant–herbivore interactions via species-specific metabolic defense elicitation and trans-trophic feedback
Available online 13 November 2026
•Isotopic tracing quantified foliar uptake and trophic transfer of DPS.•Cherry radish accumulates more DPS than water spinach under identical exposure.•DPS acts as an abiotic elicitor reprogramming...
Restoration of Noise-induced Hearing Loss through a Single Injection of a Thermosensitive Hydrogel with Clinically Available Components Encapsulating Dexamethasone
Available online 13 November 2026
•A thermosensitive hydrogel (P407/PCB) exhibits rapid sol-gel transition and sustained-release capabilities.•A single transtympanic Dexp@PLGA⊂Gel injection restores hearing thresholds in NIHL mice in...
Microenvironment-Activated Imaging and Labeling Chemistries to Light up Biological Dark Matter
Available online 13 November 2026
Microenvironment-activated imaging and labeling chemistries and related technologies serve as robust tools for decoding underexplored “biological dark matter”, capturing transient, weak, and spatiotemporally...
A sleep-active brainstem circuit selectively shapes stress-induced anxiety-like behavior
Available online 12 November 2026
Molecular Ferroelectric Acoustic Sensors Unlock Geological Hazards Infrasound
Available online 12 November 2026
Geological disasters are characterized by destructiveness, suddenness, and cascading effects. Accurate prediction remains challenging due to the difficulty in distinguishing disaster signals from those...
Thermally Robust Wide-Temperature Thermocells via Hofmeister-Driven Hierarchical Engineering
Available online 11 November 2026
Entropy-driven redox reactions in quasi-solid-state thermocells (QSTs) offer a promising route for ubiquitous low-grade heat recovery. However, their full potential is constrained by a fundamental trade-off:...
Similarity-aware dynamic ensemble approach for data asset pricing
Available online 11 November 2026
Pricing heterogeneous data assets is challenging because pricing relationships vary across the feature space and model competence is not uniform across assets. This study proposes a similarity-aware...
Precision tissue repair and regeneration: Anatomical guidance, mitochondrial targeting, and Neuro-Immune reprogramming
Available online 7 November 2026
The mechanism of peripheral neuropathic pain caused by chemotherapy: the role of nerve injury and inflammatory microenvironment
Available online 7 November 2026
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity of anticancer therapy, with the pain-predominant phenotype, chemotherapy-induced neuropathic pain (CINP), severely...
Host chemodiversity-driven microbiome engineering for smart crops
Available online 4 November 2026
Breeding crops with multiple excellent traits represents a promising solution to food crises under changing climatic conditions. Chemodiversity mediates plant-microbiome interactions, and engineering...
Extreme disasters of ice-rock avalanche–debris flow–flood chains in the Himalayan Region
Available online 4 November 2026
The Himalayan Region is one of the regions on Earth with the most complex geological structures, the most intense tectonic activity and the strongest glaciation, and it is also where giant basin-scale...
Characterization of a novel C-type lectin domain-containing protein (CLDC1) as the receptor to mediate β-glucan-induced trained immunity in zebrafish
Available online 3 November 2026
Trained immunity has been revealed as a de-facto innate immune memory, which confers elevated host response to subsequent pathogenic challenges. Although β-glucan is a well-known inducer of trained...
Intelligent 3D reconstruction and generation
Available online 2 November 2026
An Accurate and Robust Frequency Shift Method for Optically Challenging Surface 3D Measurement
Available online 31 October 2026
CryoSeek: A structure-first research paradigm for biological discovery
Available online 22 October 2026
Breakthroughs in structure determination and prediction have transformed structural biology. CryoSeek, a "structure-first" research strategy that employs cryo-electron microscopy (cryo-EM) as the primary...
Charting the future of RNA codon engineering via “dark” chemical modifications
Available online 21 October 2026
The central dogma of molecular biology has long conceptualized RNA as a passive messenger. However, emerging as a paradigm shift, the transition from descriptive epitranscriptomics to RNA codon engineering...
AI for composite disturbances/uncertainties: Dynamic modelling, estimation, and regulation
Available online 19 October 2026
The handling of uncertainty/disturbance has always been a fundamental problem in the realms of control science and artificial intelligence (AI). The well-known Bayesian statistical theory has provided...
JittorInfer: An Efficient LLM Inference Framework with Ascend NPUs
Available online 19 October 2026
Mechanical Forces as Regulators of Tumor Immunity: Mechanotransduction, Immune Escape, and Therapeutic Opportunities
Available online 17 October 2026
Cancer progression is increasingly recognized as a process shaped not only by genetic alterations but also by biophysical cues within the tumor microenvironment. Beyond soluble signaling networks, mechanical...
Targeting Non-classical Antigen Presentation Pathways: New Frontiers and Clinical Translation in Cancer Immunotherapy
Available online 15 October 2026
The efficacy of cancer immunotherapy largely depends on antigen presentation mediated by classical MHC molecules. However, tumor cells can achieve immune escape by downregulating MHC-I expression and...
Action-Perception-Driven Dual Closed-Loop Stroke Neurorehabilitation with Immersive Intervention and Pharmacotherapy Awareness
Available online 15 October 2026
Stroke remains a leading cause of death and long-term disability worldwide, with a high incidence in East Asia. Rehabilitation is often challenged by substantial inter-individual variability, weak coordination...
RePCV: Reducing Spatio-Temporal Redundancy for Efficient 3D Vision Analysis
Available online 15 October 2026
The key to unlocking space computing power networks: Tradeoff computing capability and energy consumption
Available online 14 October 2026
The second climax of satellite communication development dominated by low Earth orbit (LEO) constellations, has attracted broader attention and reached an unprecedented height compared with the first....
In vivo Modular Platform for Hepatocyte-specific Somatic Gene Perturbation to Study Postnatal Hepatocyte Maturation
Available online 14 October 2026
Hepatocyte maturation is a critical developmental process during which immature hepatocytes acquire full functionality. Cell type–restricted and temporally controllable gene perturbation in hepatocytes...
