Global change influences the prevalence and diversity of gut bacterial pathogens in soil invertebrates
Available online 13 April 2026
●Soil faunal gut harbors diverse potential pathogenic bacteria●High host biodiversity help reduce the proportion of gut pathogens●Global changes increase the proportion of gut potential pathogens●The...
Photochemistry and haze in chemically reducing terrestrial atmospheres
Available online 13 April 2026
Properties and processes within planetary atmospheres are critical for surface habitability. Evidence from the Earth suggests that our only known form of life has likely originated in a chemically reducing...
Targeted restoration of mitochondrial function mediates autophagy and glycolysis to promote irradiation-induced bone injury repair
Available online 13 April 2026
Radiotherapy remains a critical modality for tumor eradication in clinical practice. However, the bone tissue surrounding the tumor is highly susceptible to irradiation-induced damage due to its high...
Label-free proteomics and single-cell mass cytometry analysis of 5 immune tissues from mice with artesunate administration reveal immunosuppression of artesunate via BST2 and MDSCs
Available online 12 April 2026
Artesunate is a worldwide prevalent antimalarial medicine, which has also been demonstrated for anti-tumor, anti-virus and anti-autoimmune diseases. Yet the underlying molecular and cellular mechanisms...
Label-free digital protein sensing by integral plasmonic imaging
Available online 12 April 2026
The capability to detect trace-level protein in complex biofluids is critical in various fields, from fundamental biological research to clinical disease diagnosis. Digital protein sensing by counting...
Gut microbiota mediates tissue injury by promoting proteolysis and heme bioavailability in the small intestine
Available online 10 April 2026
•Extensive hydrolysis is essential for heme release from dietary myoglobin.•Intestinal microbiota mediates extensive hydrolysis of dietary myoglobin.•Short peptides facilitate PEPT1- and F-actin-dependent...
Magnetic Catheter Robot with Dynamic Force Feedback for Stiffness Identification and Abnormality Detection
Available online 7 April 2026
Ultra-intense laser pulses: from petawatt to exawatt, from multi-cycle to single-cycle
Available online 7 April 2026
Since the laser’s invention in 1960, the pursuit of higher peak power and stronger focused intensity has never stopped. Breakthroughs in chirped pulse amplification and optical parametric chirped pulse...
Inverse thermal design method for heat exchangers via digital twin model integrating deep learning surrogates with local thermal resistance evaluation
Available online 7 April 2026
This paper introduces an inverse design method for plate-fin heat exchangers (PFHEs) integrating digital twin, deep learning and inversion algorithm, which significantly differs from the conventional...
Genetic and linguistic landscapes of Gansu-Qinghai populations
Available online 7 April 2026
The Gansu-Qinghai (GQ) region is a critical Eurasian contact zone with exceptional linguistic and genetic diversity. However, genomic studies integrating genetic and linguistic evidence in areas with...
Chromatin regulator expression patterns predict prognosis and guide neoadjuvant therapy in esophageal squamous cell carcinoma
Available online 6 April 2026
Chromatin regulators (CRs), as key components of the epigenetic machinery, participate in tumor progression and therapeutic resistance by modulating chromatin structure and gene expression. Nonetheless,...
Dietary supplementation with fish oil, genetic risk, and glycemic control in patients with type 2 diabetes
Available online 5 April 2026
The effect of marine n-3 polyunsaturated fatty acids (PUFA) on glucose control among patients with type 2 diabetes (T2D) remains contentious. Whether the genetic risk modifies the effect remains unknown....
Dynamic roles of reactive iron in organic carbon preservation in marine sediments
Available online 4 April 2026
Iron oxides play a crucial role in carbon sequestration in marine sediments by forming associations with organic carbon (OC). However, iron oxides actively participate in the sedimentary biogeochemical...
Optimizing the enterprise inclusion threshold setting of China's national carbon market
March 2026
In July 2021, China launched its national carbon emission trading system (ETS), initially targeting thermal power plants with annual emissions exceeding 26,000 tons of carbon dioxide (CO2). Optimizing...
Building a global early-warning system for environmental risks with remote sensing
March 2026
Amid intensifying environmental risks, including climate change, biodiversity loss, and pollution, global ecosystems are under unprecedented pressure. Environmental monitoring forms the cornerstone...
Capture and identification of the electrogenerated picosecond intermediates by mass spectrometry
March 2026
•In-situ generation of electrochemical intermediates during electrospray ionization.•The first mass spectrometric identification of picosecond nitrenium/oxenium ions.•The first direct observation of...
Selective oxidation by TS-1 coupled with in-situ synthesised H2O2
March 2026
Feedstock valorisation with preformed H2O2 in conjunction with titanosilicate zeotypes is particularly attractive due to the increased selectivity, lower operating temperatures and improved process...
Designing precision measurement of the gravitational Aharonov-Bohm effect in microgravity
March 2026
Refinement of selective hydrogenation catalysts guided by the concept of ‘group recognition’
March 2026
Selective hydrogenation is crucial in the production of high-value chemicals, yet its efficient implementation remains challenging due to the absence of clear catalyst regulation strategies and in-depth...
Multiple Brillouin zone folding based broadband topological slow light in valley photonic crystals
March 2026
Seasonal variations of primary biological and biomass burning aerosols in the central Himalayas
March 2026
Organic aerosols from biomass burning and primary biological sources are ubiquitous in the Earth’s atmosphere. These aerosols have a significant impact on the absorption and scattering of solar radiation,...
Targeting fatty acid metabolism for cancer therapy
March 2026
As the main component of lipids, fatty acids are essential in supporting life activities regarding energy supply, cell composition, and signaling molecules. Enhancement of fatty acid (FA) synthesis,...
Joint effects of sleep behaviors and physical activity on brain structure and cognitive function
March 2026
Sleep behaviors and physical activity (PA) are widely used to predict the risk of neurodegenerative disease. However, how sleep and PA interact to influence brain and cognitive health remains unknown....
A key heavy metal-binding protein orchestrates plant resistance against a geminivirus
March 2026
Heavy metal-binding proteins (HMPs) are crucial for heavy metal ion transportation in plants, which is involved in plant nutrient absorption, morphogenesis, and immune responses. However, the molecular...
The separation and compactness on fuzzy partial metric spaces
March 2026
In this paper, we primarily examine various topological properties within fuzzy partial metric spaces (FPMS). First, we investigate the separation axioms of FPMS and demonstrate that the T2, T3, and...
