Photocatalyzed site-selective aryl C–H sulfinamidation via thianthracene salts
Available online 7 January 2026
Benzenesulfinamides are a critical class of S(IV) compounds that serve as important entry points to an array of emerging pharmaceutical molecules and bioactive substances. However, the widespread application...
Accessing tetrasubstituted CF2H 1-pyrrolines via electrochemical hydrodefluorination and [3+2] cascade cyclization
Available online 30 December 2025
Tetrasubstituted difluoromethyl 1-pyrrolines are scarcely reported compared to trifluoromethyl 1-pyrrolines. Herein, we present a novel access to difluoromethyl 1-pyrrolines through electrochemical...
Recent advances in ligand-accelerated nickel-catalyzed carbonylation under CO gas
Available online 29 December 2025
Carbonyl groups are fundamental structural motifs in organic chemistry, prominently featured in drug molecules, functional materials, and as versatile synthetic intermediates. Transition metal-catalyzed...
Harnessing N-nitroamines for direct deaminative coupling
Available online 29 December 2025
A novel deaminative strategy for aryl amines via N-nitroamines intermediates has been successfully developed, which substitutes the traditional diazo chemistry and directly converts the aryl C-N bond...
Time-dependent chemoselectivity in a single glycosyltransferase drives O- to C-glycosylation
Available online 26 December 2025
The inherent chemoselectivity of glycosyltransferases (GTs) toward specific acceptors is well established, yet the capacity of a single GT to achieve time-dependent chemoselective glycosylation has...
Phenoxazinone synthase-like activity of rationally designed heme enzymes based on cytochrome P450BM3
Available online 26 December 2025
The development of functional metalloenzymes provides a promising strategy for the sustainable synthesis of heterocyclic compounds such as phenazines and phenoxazinones. Here, we establish an H2O2-driven...
Visible-light-driven photocatalyst-free multicomponent reaction for synthesis of C3-alkylated isoindolinones
Available online 23 December 2025
A photocatalyst- and transition-metal-free three-component reaction of readily available 2-carboxybenzaldehydes, primary amines and 4-alkyl-1,4-dihydropyridines (alkyl-DHPs) for the synthesis of C3-alkylated...
Activation of diterpene hydrocarbon skeletons by microbial natural P450 oxidases
Available online 15 December 2025
Diterpenoids represent invaluable resources for novel drug discovery and development. The high inertness of diterpene hydrocarbon skeletons, coupled with their multiple chiral centers, makes oxidative...
A small molecule EnT photocatalyst for rapid [2+2] cycloaddition
Available online 15 December 2025
Identifying novel catalysts for light-induced energy transfer (EnT) processes is crucial for advancing EnT-based chemical reactions. This work demonstrates that the readily available acylsilane, 1-(tert-butyldimethylsilyl)ethan-1-one,...
A membrane-mediated modulation for chemoenzymatic redox deracemization of secondary alcohols and applications
Available online 11 December 2025
The exploration of a chemoenzymatic dual catalysis system can bridge the methodological gap between chemical and biological catalysis under mild reaction conditions for the preparation of chiral molecules....
Continuous-flow harnesses the synergy of nitrogen dioxide and ozone for safe, catalyst-free and ultrafast arene nitration
Available online 10 December 2025
Green and scalable nitration of aromatic compounds remains a challenge in chemical synthesis. While acid-free nitration using simple nitrogen oxides is highly attractive, it is often plagued by poor...
Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis
Available online 9 December 2025
Enzyme engineering has emerged as a pivotal technology driving advances in biocatalysis, environmental remediation, and green chemistry. It is undergoing a transformative shift, propelled by the synergistic...
Visible-light-induced cascade radical sulfonation/annulation/isomerization reactions of propargyl chalcones with sodium sulfinates: Regioselective synthesis of sulfonyl 2H-chromene and 2H-quinoline derivatives
Available online 9 December 2025
A cascade approach has been developed for the one-pot three-step synthesis of sulfonyl-containing 2H-chromenes and 2H-quinoline derivatives from propargyl chalcones and sodium sulfinates. This protocol...
Advances in benzaldehyde lyase-catalyzed biotransformations: From enzyme engineering to industrial applications
Available online 9 December 2025
Benzaldehyde lyase (BAL), a thiamine diphosphate (ThDP)-dependent enzyme requiring divalent cations (e.g., Mg2+), mediates enantioselective C-C bond formation and cleavage to exclusively produce (R)-configured...
Transformation of ambient CO2 in air into cyclic carbonates mediated by a phosphorus-nitrogen PN3-pincer iron complex
November 2025
The atom-economical reaction of carbon dioxide (CO2) with epoxides possesses the potential to utilize captured CO₂ for synthesizing useful chemicals. Among a wide range of metal complexes employed for...
Selective cleavage of Csp3–N bonds in aliphatic tertiary amines enabled by difluorocarbene to access esters and thioethers
November 2025
Presented herein is a series of C–X (X = O, S) couplings for the synthesis of esters and thioethers via difluorocarbene-promoted selective Csp3–N bond cleavage between tertiary amines and carboxylic...
A water-soluble supermolecular cage for artificial light-harvesting nanoreactors
November 2025
Two discrete octahedral metallo-supramolecular cages were designed and constructed by using truxene-based pyridine L with enPd(NO3)2 or enPt(NO3)2, followed by detailed NMR, MS, UV absorption, and fluorescence...
Chiral bis(imidazoline) NCN pincer iridium(III)-catalyzed enantioselective alkynylation of trifluoropyruvates with terminal alkynes
November 2025
Readily prepared chiral bis(imidazoline) NCN pincer iridium(III) complexes have been developed as the new and highly stereoselective catalysts for the direct asymmetric addition of terminal alkynes...
Iron-catalyzed carbonylative synthesis of tert-alkyl thioesters
November 2025
In the context of transition metal-catalyzed carbonylation reactions, iron-catalyzed carbonylative transformation retains considerable value due to its high abundance, affordability, and diverse catalytic...
Palladium-catalyzed halosulfonylation of alkynes with ionic liquid as the green solvent and halide sources
November 2025
The first palladium-catalyzed halosulfonylation of alkynes with arylsulfonic acid under aerobic conditions was accomplished. This catalytic protocol provides a straightforward and effective synthetic...
Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review
November 2025
Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments,...
Direct C(sp3)-H functionalization with thiosulfonates via photoredox catalysis
November 2025
While C(sp3)-S bonds exist in many biologically active compounds, the direct catalytic C(sp3)-H thiolation remains elusive. Herein, we report a convenient and green C(sp3)-H thiolation approach mediated...
Chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes enabled by an Fe(III) photocatalyst
November 2025
We have developed a chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes. It offers several advantages, including the use of an environmentally friendly catalyst (5 mol%...
Radical dehydroxylative C-glycosylation of 1-hydroxycarbohydrates enabled by photoredox catalysis
November 2025
C-Glycosides, known for their superior in vivo stability compared to their O- and N-glycoside counterparts, have been widely explored as drug candidates and utilized in biological research. Traditional...
Synthesis of bridged bicyclic thiazine-2-thione and thiazole-2-thiones through DBU-promoted regioselective annulation of quinone monoacetals under mild conditions
November 2025
The first regioselective [4 + 2] annulation reactions of quinone monoacetals with isothiocyanates and Na2S have been accomplished. This convenient and novel protocol involves the synthesis of valuable...