One-pot asymmetric synthesis of chiral vicinal diols utilizing novel benzaldehyde lyases and carbonyl reductases
Available online 11 June 2025
Chiral vicinal diols and their derivatives play pivotal roles in pharmaceutical chemistry and organic synthesis. However, their synthesis remains challenging due to the presence of adjacent chiral centers....
Share article
Pd/Ag dual-catalyzed asymmetric synthesis of sulfur-stereogenic sulfoximines via enantioselective intramolecular C−H arylation
Available online 10 June 2025
Sulfoximines, which often show significant bioactivity, are important motifs in pharmaceutical and agricultural chemicals. However, asymmetric synthesis of sulfoximines bearing S(VI) stereogenic centers...
Share article
Electrochemical oxidation enabled HAT approach for the synthesis of quinolinones
Available online 9 June 2025
Quinolinones have been prepared by an intramolecular radical annulation of α-EWG (electron-withdrawing group) substituted amides and alkynes involving an electrochemical oxidation enabled hydrogen atom...
Share article
Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review
Available online 7 June 2025
Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments,...
Share article
New avenues for asymmetric synthesis: N–H (+)-sparteine and analogues
Available online 7 June 2025
Sparteine, a naturally occurring chiral N-centered diamine, has been employed as a useful chiral ligand in numerous synthetic transformations, but due to a shortage of accessible intermediates, its...
Share article
Distance-driving host-guest recognition with boron-based molecular tweezers and its applications in catalysis
Available online 7 June 2025
Understanding the influence of structural variations on host-guest interactions is crucial for developing selective molecular recognition systems and efficient catalysts for chemical transformations....
Share article
Recent advances in the asymmetric catalytic synthesis of spirocyclic tetrahydroquinolines, tetrahydroisoquinolines and their derivatives
Available online 6 June 2025
This review summarizes the progress achieved in the asymmetric catalytic synthesis of spirocyclic tetrahydroquinolines, tetrahydroisoquinolines and their oxidized forms. To aid understanding, mechanistic...
Share article
Heterogeneous difunctional organic polymers with 2,2,6,6-tetramethylpiperidinyloxy and N-methylimidazole for selective oxidation of alcohols
Available online 5 June 2025
Highly selective transformation of biomass-derived platform chemicals into value-added chemicals is of great significance. Herein, a heterogeneous polymer catalyst was developed for the selective oxidation...
Share article
CO2-Promoted hydrosulfonylation of electron-deficient alkenes with sulfinates
Available online 3 June 2025
Herein, we report a method for direct C–sulfonyl bond formation, which represents a significant advancement in sustainable catalysis and green chemistry. By using carbon dioxide (CO2) as a renewable...
Share article
Engineering galactose oxidase for biocatalytic synthesis of 2-(furan-2-yl)-2-oxoacetic acid, a critical precursor of cefuroxime
Available online 2 June 2025
2-(Furan-2-yl)-2-oxoacetic acid (2-FOA) is a critical building block for the C7 side chain of cefuroxime, a second-generation antibiotic. Traditional chemical synthesis of 2-FOA involves harsh conditions...
Share article
Iron-catalyzed formation of six-membered rings from alkyne
Available online 29 May 2025
Iron compounds, exhibiting high catalytic behavior and excellent compatibility, have been considered as low-toxic, cheap, efficient and green catalysts for many important organic transformations. Organic...
Share article
Photoinduced α-addition and hydrogenation of carbazole-based alkenes
Available online 27 May 2025
The conjugate addition of nucleophiles to electron-deficient alkenes is the fundamental reaction in organic synthesis. However, the regio-inversed α-addition reaction remains largely underexplored at...
Share article
Applications of cytochrome P450 monooxygenases in the biosynthesis of active pharmaceutical ingredients
Available online 27 May 2025
The synthesis of active pharmaceutical ingredients (APIs) constitutes a pivotal juncture within the pharmaceutical industry, prompting researchers to relentlessly pursue novel methodologies that enhance...
Share article
Visible-light-induced cascade radical cyclization of aryl alkynoates with fluoroalkyl carboxylic anhydrides to construct fluoroalkylated coumarins
Available online 27 May 2025
We herein described an efficient and practical protocol for radical cyclization of aryl alkynoates to access 3-fluoroalkyl-substituted coumarins using readily available, easy-to-handle and low-cost...
Share article
Hydrogenation of organic carbonates and formate derivatives to formaldehyde under one atmosphere of H2 by an unsymmetrical phosphorus-nitrogen PN3P-pincer Mn complex
Available online 23 May 2025
A well-defined unsymmetrical phosphorus-nitrogen PN3P-Mn(I) complex catalyzed hydrogenation of organic carbonates and formate derivatives with 1 atm of H2 was developed, which could be applied in the...
Share article
Four-component modular synthesis of sulfonylated indolo[2,1-a]isoquinolines via SO2 insertion/Smiles rearrangement radical relay strategy
Available online 20 May 2025
A multicomponent reaction of 1,8-enynes, aromatic amines, DABCO·(SO2)2 and tBuONO is achieved, affording diverse sulfonylated indolo[2,1-a]isoquinolines in moderate to good yields via SO2 insertion/Smiles...
Share article
Biotechnological synthesis of nucleoside analogs: Recent progress and perspectives
Available online 16 May 2025
Nucleoside analogs play an indispensable role in antiviral and anticancer therapies, and improving their synthesis methods has become a focal area of research. In recent years, technological breakthroughs...
Share article
Copper camphorate based MOFs: Efficient and recyclable catalysts for synthesis of propargylamines, oxazolidinones and cyclic carbonates
Available online 14 May 2025
We report the first application of copper camphorate based MOFs ([Cu2camph2dabco] – Cu-MOF-1 and [Cu2camph2bipy] - Cu-MOF-2) as catalysts in three-component A3-coupling of alkynes, aldehydes and amines....
Share article
Rh(III)-catalyzed C2-arylation/lactonization of cyclic 1,3-dicarbonyls and ortho-borylbenzoic acid esters to access 3,4-fused isocoumarins
Available online 13 May 2025
A Rh-catalyzed C2-arylation/lactonization cascade of cyclic 1,3-dicarbonyls and ortho-borylbenzoic acid esters is described. Key to success is that nucleophilic cyclic 1,3-dicarbonyls can be converted...
Share article
The cascade annulation approach to quinoxalines by radical NHC catalysis
Available online 7 May 2025
A wide range of functionalized quinoxalines were rapidly constructed by novel NHC-catalyzed cascade annulation of acyl oximes and isonitriles. The developed protocol characterized good functional group...
Share article
Efficient bioproduction of 3-(4-thiazolyl)-l-alanine, an unnatural amino acid of pharmaceutical importance, by an enzymatic relay process
Available online 6 May 2025
As an l-histidine analog, 3-(4-thiazolyl)-l-alanine (TAla) has been attracting increasing biotechnological interest because it can serve as a key building block in the development of many novel therapeutic...
Share article
Accelerating rational organoborazine discovery: Predicted by machine learning, synthesized under continuous flow
Available online 24 April 2025
Substituting a benzene ring with a borazine ring in π-conjugated systems has garnered significant interest in recent years, particularly for its potential in enhancing optoelectronic device performance....
Share article
Contamination and biotransformation of deoxynivalenol (DON) in common commercial foods: Current status, challenges and future perspectives
Available online 22 April 2025
Deoxynivalenol (DON) has received considerable attention due to its toxicity and widespread presence in food and feed. This review summarizes the DON contamination in commonly consumed commercially...
Share article
Radical dehydroxylative C-glycosylation of 1-hydroxycarbohydrates enabled by photoredox catalysis
Available online 17 April 2025
C-Glycosides, known for their superior in vivo stability compared to their O- and N-glycoside counterparts, have been widely explored as drug candidates and utilized in biological research. Traditional...
Share article
Green and sustainable site- and cross-selective C-H reductive coupling of para-quinone methides with quinoxaline-2(1H)-ones
Available online 15 April 2025
We herein disclose a novel activation mode for quinoxaline-2(1H)-ones via selective hydrogen atom transfer (HAT) of the N=Csp2-H bonds by synergistic photoredox catalysis and bromine radical catalysis,...
Share article
