Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis
April 2026
Enzyme engineering has emerged as a pivotal technology driving advances in biocatalysis, environmental remediation, and green chemistry. It is undergoing a transformative shift, propelled by the synergistic...
Regioselectively electrochemical Csp3-H alkoxylation for functionalized indanone
April 2026
An electrochemical regioselective Csp3-H alkoxylation has been developed to synthesize functionalized 1-indanone. In this process, electricity serves as the formal terminal oxidant, while the molecular...
Electrocatalytic regio- and stereoselective carboxylation of terminal alkynes with CO2
April 2026
Carboxylation with CO2 is a practical and streamlined way to construct a variety of sophisticated carboxylic acids and their derivatives. However, a series of elegant methods focus mainly on C(sp3)–...
N-heterocyclic nitrenium-catalyzed photoreductive radical-polar crossover for alkene dicarbofunctionalization
April 2026
The photoredox radical-polar crossover paradigm is a valuable tool for 1,2-difunctionalization of alkenes. However, the use of unactivated alkyl halides as radical precursors remains far less developed....
Visible light induced synthesis of the Benzoyl bioisosteres: bicyclo[1.1.1]pentane-ketone group
April 2026
Benzoyl groups are commonly found in the structures of various pharmaceuticals, including non-steroidal anti-inflammatory drugs (NSAIDs), central nervous system stimulants, antihyperlipidemic agents,...
Mn2(CO)10-catalyzed direct protic hydrogen transfer with unactivated alkenes
April 2026
Transition-metal-catalyzed hydrogen-atom-transfer (HAT) reactions have proven to be effective strategies for obtaining important heterocycle scaffolds found in natural products. However, the electronic...
Biotechnological synthesis of nucleoside analogs: Recent progress and perspectives
April 2026
Nucleoside analogs play an indispensable role in antiviral and anticancer therapies, and improving their synthesis methods has become a focal area of research. In recent years, technological breakthroughs...
Modular trifluoromethylselenolation and fluoroalkylselenolation via Ag(I)-mediated selenium nitrogen exchange reaction of benzothiaselenazole-1-oxides
April 2026
By virtue of benzothiaselenazole-1-oxides as versatile building blocks and masked sulfoximines, we present a novel and practical trifluoromethylselenolation/fluoroalkylselenolation strategy via Ag(I)-mediated...
Photochemical nitrene transfer reactions of iminoiodinanes with sulfoxides
April 2026
Nitrene, as an important and intriguing versatile synthon, is widely utilized for the formation of diverse nitrogenous skeletons under thermal or photochemical conditions. Typically, the N-sulfonyl...
Modulating regioselectivity of CYP107J3-catalyzed isophorone hydroxylation by disrupting the hydrophobic balance of the substrate binding pocket
April 2026
4-Hydroxyisophorone (4HIP) is an oxygenated intermediate derived from isophorone, serving as an important flavor and fragrance and chiral synthon of pharmaceutical drugs. In this study, a newly identified...
Novel biocatalyst derived from Araujia sericifera latex: Synthesis and applications
April 2026
Biocatalysts with lipase activity are increasingly required in different industrial sectors since they promote a large number of reactions with high selectivity and yield under mild conditions, promoting...
The synthesis of multi-substituted benzazepine derivatives via Mn(III)-promoted oxidative annulation of isocyanides with boronic acids
April 2026
Seven-membered nitrogen-containing heterocyclic rings are important cores of anti-cancer, anti-antimicrobial, anti-malaria and other drugs. Therefore, efficient and expedient strategies for the synthesis...
Stereoselective oxidative C3–N bond dehydrogenation and aromatization of 1-carboxyl substituted tetrahydroisoquinolines employing pipecolate oxidase
April 2026
The dehydrogenation of C–N bond in 1,2,3,4-tetrahydroisoquinolines (THIQs), especially 1-substituted THIQs, is a type of fascinating transformation owing to its utility in synthetic organic chemistry....
Advances in benzaldehyde lyase-catalyzed biotransformations: From enzyme engineering to industrial applications
April 2026
Benzaldehyde lyase (BAL), a thiamine diphosphate (ThDP)-dependent enzyme requiring divalent cations (e.g., Mg2+), mediates enantioselective C-C bond formation and cleavage to exclusively produce (R)-configured...
Lewis Acid-Catalyzed [4π+2σ] Cycloaddition of Bicyclo[2.1.0]pentanes with Nitrones: Access to 2-Oxa-3-azabicyclo[3.2.1]octanes
Available online 1 April 2026
The hetero-bicyclo[3.2.1]octane scaffold is a prevalent structural motif in bioactive natural products and pharmaceuticals, yet general synthetic methods for its construction remain limited. Herein,...
Ferrioxalate photocatalysis as a versatile system for reductive iron catalysis
Available online 25 March 2026
A novel photochemical strategy based on the ligand-to-metal charge transfer (LMCT) process of ferrioxalate complexes has been developed. This method represents the first application of ferrioxalate...
Research progress on electrochemical reduction for ammonia synthesis using cobalt-based catalysts
Available online 21 March 2026
Electrocatalytic nitrate reduction to ammonia (NRA) offers a sustainable solution for simultaneously remediating wastewater and producing valuable ammonia; however, its practical application hinges...
Visible-light-catalyzed cascade carboxylation/cyclization of o-cyano(bi)arylacrylamides with formate for the synthesis of carboxylated quinolinones and ester-containing phenanthridines
Available online 19 March 2026
Described here is a visible-light-catalyzed cascade carboxylation/cyclization of o-cyano(bi)arylacrylamides with formate to access various carboxylated quinolinones and ester-containing phenanthridines....
One-dimensional covalent organic framework as a robust carrier for enhanced lipase immobilization and catalytic performance
Available online 17 March 2026
Enzymes catalyze stereoselective transformations under mild conditions, yet their industrial deployment remains constrained by intrinsic fragility, poor recyclability, and prohibitive cost. While immobilization...
Simultaneous construction of C-N axially chiral diarylamines and planar chiral ferrocenes via Pd-catalyzed asymmetric tandem reaction
Available online 12 March 2026
This work pioneers a palladium-catalyzed asymmetric tandem process merging intramolecular C–H arylation with intermolecular Buchwald–Hartwig amination. It establishes the first metal-catalyzed asymmetric...
Photocatalytic 1,2-difluoromethylation/aminosulfonylation of unactivated alkenes: Access to β-difluoromethylated sulfonamides
Available online 12 March 2026
While radical addition to SO2 serves as a fundamental strategy for constructing sulfone frameworks, its application in building sulfonamide skeletons, particularly for the modular installation of an...
Organocatalytic [4+4] annulation of indole-4-boronic acid with o-hydroxybenzyl alcohols for constructing indole-fused oxaborocanes
Available online 11 March 2026
An organocatalytic [4 + 4] annulation between indole-4-boronic acids and o-hydroxybenzyl alcohols has been developed. This method enables the synthesis of a diverse range of indole-fused oxaborocanes...
Visible-light-driven Na2CO3-enabled photocatalyst- and metal-free selective thio- and selenosulfonylation of unactivated alkenes
Available online 11 March 2026
Atom transfer radical addition (ATRA) of alkenes with thiosulfonates is a powerful strategy to construct valuable thioalkylsulfones. However, these methods employ complex catalytic systems, a high loading...
Stereodivergent protein engineering of alcohol dehydrogenase for the asymmetric synthesis of 2-arylidenequinuclidin-3-ols
Available online 11 March 2026
The enzymatic synthesis of chiral 2-arylidenequinuclidin-3-ols remains unexplored, despite their importance as pharmaceutical intermediates. In this study, an alcohol dehydrogenase from Lactobacillus...
Microfluidic-enabled solid-phase biosynthesis of carbohydrates
Available online 9 March 2026
Carbohydrates serve as essential energy sources, structural components, and bioactive substances in living organisms, making the study of their synthesis methods a significant focus in chemistry and...