Visible-light-catalyzed cascade carboxylation/cyclization of o-cyano(bi)arylacrylamides with formate for the synthesis of carboxylated quinolinones and ester-containing phenanthridines
Available online 19 March 2026
Described here is a visible-light-catalyzed cascade carboxylation/cyclization of o-cyano(bi)arylacrylamides with formate to access various carboxylated quinolinones and ester-containing phenanthridines....
One-dimensional covalent organic framework as a robust carrier for enhanced lipase immobilization and catalytic performance
Available online 17 March 2026
Enzymes catalyze stereoselective transformations under mild conditions, yet their industrial deployment remains constrained by intrinsic fragility, poor recyclability, and prohibitive cost. While immobilization...
Simultaneous construction of C-N axially chiral diarylamines and planar chiral ferrocenes via Pd-catalyzed asymmetric tandem reaction
Available online 12 March 2026
This work pioneers a palladium-catalyzed asymmetric tandem process merging intramolecular C–H arylation with intermolecular Buchwald–Hartwig amination. It establishes the first metal-catalyzed asymmetric...
Photocatalytic 1,2-difluoromethylation/aminosulfonylation of unactivated alkenes: Access to β-difluoromethylated sulfonamides
Available online 12 March 2026
While radical addition to SO2 serves as a fundamental strategy for constructing sulfone frameworks, its application in building sulfonamide skeletons, particularly for the modular installation of an...
Organocatalytic [4+4] annulation of indole-4-boronic acid with o-hydroxybenzyl alcohols for constructing indole-fused oxaborocanes
Available online 11 March 2026
An organocatalytic [4 + 4] annulation between indole-4-boronic acids and o-hydroxybenzyl alcohols has been developed. This method enables the synthesis of a diverse range of indole-fused oxaborocanes...
Visible-light-driven Na2CO3-enabled photocatalyst- and metal-free selective thio- and selenosulfonylation of unactivated alkenes
Available online 11 March 2026
Atom transfer radical addition (ATRA) of alkenes with thiosulfonates is a powerful strategy to construct valuable thioalkylsulfones. However, these methods employ complex catalytic systems, a high loading...
Stereodivergent protein engineering of alcohol dehydrogenase for the asymmetric synthesis of 2-arylidenequinuclidin-3-ols
Available online 11 March 2026
The enzymatic synthesis of chiral 2-arylidenequinuclidin-3-ols remains unexplored, despite their importance as pharmaceutical intermediates. In this study, an alcohol dehydrogenase from Lactobacillus...
Microfluidic-enabled solid-phase biosynthesis of carbohydrates
Available online 9 March 2026
Carbohydrates serve as essential energy sources, structural components, and bioactive substances in living organisms, making the study of their synthesis methods a significant focus in chemistry and...
Synthesis of chiral β-arylamines via diastereoselective addition of aryl hydrazones to imines
Available online 9 March 2026
Chiral β-arylamines could serve as key building blocks for the pharmaceutical industry and synthetic chemistry. Herein, we have developed methods for their synthesis via diastereoselective addition...
Photocatalytic radical amination/cyclization of N-allyl and N-homoallyl aldehyde hydrazones: Access to sulfonaminated pyrazoles and tetrahydropyridazines
Available online 6 March 2026
A photocatalytic strategy for the sulfonamidation/cyclization of N-allyl and N-homoallyl aldehyde hydrazones has been developed with N-aminopyridinium salts as sulfonylamino radical precursors. This...
Transition metal-free thiophene construction in pure water by multiplied C-H functionalization with enaminones and elemental sulfur
February 2026
A novel method for the synthesis of 2,4-disubstituted thiophenes via the reactions of N,N-disubstituted enaminones and elemental sulfur is developed. By simply heating the substrates in pure water in...
Electrochemical difunctionalization of isocyanides by a three-component reaction cascade Mumm rearrangement: Rapid access to sulfur-containing imides
February 2026
An efficient and practical electrochemical method for the three-component reaction cascade Mumm rearrangement of imides has been developed using a simple undivided cell with carbon electrodes at room...
A greener approach to Buchwald-Hartwig coupling. A sustainable Pd/C-catalyzed Csp2–N bond formation under microwave irradiation and bio-based solvent
February 2026
The Buchwald-Hartwig coupling enables the grafting of nitrogen-containing functionalities onto molecules, facilitating the synthesis of a wide variety of molecular structures. However, several challenges...
Photocatalyzed chemodivergent aerobic oxidation of naturally occurring Viridicatin and derivatives
February 2026
A chemodivergent reaction is an appealing way to construct molecules with enriched structure diversity in a controlled manner. A plethora of methodologies were developed based on this concept, and transition...
Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones
February 2026
Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical, pharmaceutical, and chemical industries as well as in material science. During the...
Iron-catalyzed non-directed arene C-H difluoromethylation
February 2026
Practical, undirected and selective catalytic functionalization of unactivated arenes remains a challenging problem in organic synthesis. We herein report a bioinspired L-cystine-derived ligand BCPOM/Fe-enabled...
Advances in the synthesis of C19-hydroxylated steroids
February 2026
The significant medicinal values associated with C19-hydroxylated steroids dictate a growing demand for new synthetic strategies that would provide facile access to these challenging targets. This review...
Electrochemical oxidation enabled HAT approach for the synthesis of quinolinones
February 2026
Quinolinones have been prepared by an intramolecular radical annulation of α-EWG (electron-withdrawing group) substituted amides and alkynes involving an electrochemical oxidation enabled hydrogen atom...
Mild and green thioacylation with dithiocarboxylates via photoredox catalysis
February 2026
A photocatalysis process-enabled thioacylation of amines has been developed with eco-friendly feedstock potassium dithiocarboxylates as green thioacyl sources and water as the reaction solvent. The...
Enantioselective epimerizations of meso-diols via asymmetric hydrogen atom abstraction catalysis
February 2026
A new type of asymmetric hydrogen atom abstraction catalysts, originated from the cinchona alkaloid family of natural products, has been successfully developed to access enantioselective epimerizations...
Brønsted acid catalyzed green and efficient construction of α-amino peroxides from 3-hydroxyisoindolinones and hydroperoxides
February 2026
A Brønsted acid-catalyzed peroxidation of 3-hydroxyisoindolinones with hydroperoxides has been established for the first time, which constructs α-amino peroxides bearing a tetrasubstituted stereocenter...
Efficient one-pot synthesis of ruthenium catalysts and their role in optimizing sugar alcohol production: Investigating structural sensitivity
February 2026
The study explores the feasibility of producing ruthenium catalysts supported on char through a one-pot synthesis, an original approach for the preparation of noble metal-based catalysts in this field....
Directed evolution of stereoselective enzymes meets click reactions: Asymmetric synthesis of chiral triazoles using a Cu(I)-compatible halohydrin dehalogenase
February 2026
We report for the first time the combination of directed evolution focused on enhancing and reversing the stereoselectivity of an enzyme with Cu(I)-mediated click chemistry (CuAAC), providing an asymmetric...
Recent advances in photocatalytic C-H amination to nitrogenous structures
February 2026
Nitrogen-containing structures represent a significant branch exhibiting remarkable biological activity, surpassing non-nitrogen architectures. Given the vast array of nitrogen-containing compounds...
Palladium-catalyzed chemoselective synthesis of arylamines from cyclohexanones with ammonium salts
February 2026
The primary objective of organic synthesis is the utilization of inexpensive and readily available industrial chemicals in large quantities to produce valuable organic compounds. This study introduces...