Enantio- and diastereoselective cyclopropanation of CF3-imidoyl sulfoxonium ylides by chiral-at-metal Rh(III) complex
Available online 6 September 2025
An enantio- and diastereoselective cyclopropanation of CF3-imidoyl sulfoxonium ylides with α,β-unsaturated 2-acyl imidazoles catalyzed by chiral-at-metal Rh(III) complex has been demonstrated for the...
Visible-light-induced cascade radical cyclization of aryl alkynoates with fluoroalkyl carboxylic anhydrides to construct fluoroalkylated coumarins
August 2025
We herein described an efficient and practical protocol for radical cyclization of aryl alkynoates to access 3-fluoroalkyl-substituted coumarins using readily available, easy-to-handle and low-cost...
Unraveling chemical glycosylation: DFT insights into factors imparting stereoselectivity
August 2025
Stereoselective chemical glycosylation reactions are pivotal for preparing manifold biologically and medically important compounds, while mechanisms of chemical glycosylation reactions remain obscure...
Synthesis of dydrogesterone by aromatization-dearomatization strategy
August 2025
Dydrogesterone as an agonist of the progesterone receptor is an important and selective synthetic progesterone used for the treatment of a variety of conditions associated with progesterone deficiency...
Green polyurethanes from bio-based building blocks: Recent advances and applications
August 2025
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers due to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable,...
Palladium-catalyzed tandem aza-Heck reaction of alkene-tethered oxime esters with cyclopropanols
August 2025
Aza-Heck cyclization of alkene-tethered oxime esters has received considerable attention as an effective strategy for synthesizing 1-pyrroline derivatives. However, the achievement of tandem aza-Heck...
α-Chloroketones enabled Rh(III)-catalyzed enantioselective C–H [4+2] annulation of sulfoximines under mild and redox-neutral conditions
August 2025
Taking advantage of facilely available α-chloroketones as C(sp3)-based electrophilic partners and oxidized alkyne equivalents, we here present a novel CpxRh(III)-catalyzed enantioselective C–H [4 +...
Harnessing redox-inactive rare-earth metals for photocatalytic reductive coupling of benzyl bromides
August 2025
Compared with rare and expensive late-transition metals, rare-earth photocatalysts are much less investigated in synthetic chemistry, particularly concerning redox-inactive rare-earth metals. Herein,...
1,5-Pentanediol production from 3,4-dihydro-2H-pyran and acetic acid via successive reactions of esterification and hydrogenation
August 2025
1,5-Pentanediol as an important chemical intermediate is commonly used for the manufacture of polyesters and polyurethanes. A novel process was developed for the production of bio-based 1,5-pentanediol...
Graphene oxide in palladium nanoparticle (GrafeoPlad): A new class of functional materials
August 2025
Water-soluble graphene oxide was encapsulated within the lattice of Pd nanoparticles using Zn as reducing agent affording a completely new class of functional materials dubbed herein “GrafeoPlad” for...
Recent advances in transition-metal-free conversion of aldehydes to ketones
August 2025
The preparation of functionalized ketones occupies an important position in synthetic organic chemistry because ketones are ubiquitous structural motifs in a broad range of compounds with various applications....
Photo- and electro-induced perfluoroalkylation/cyclization of o-hydroxyaryl enaminones: Synthesis of perfluoroalkyl chromones
August 2025
A practical, metal-, and additive-free strategy for photo- and electro-induced perfluoroalkylation/cyclization of o-hydroxyaryl enaminones with sodium perfluoroalkanesulfinates under mild conditions...
Enantioselective domino alkyl arylation of vinyl phosphonates by combining photoredox and nickel catalysis
August 2025
A nickel/photoredox mediated asymmetric domino alkyl arylation of vinyl phosphonates to generate a diverse array of enantioenriched α-aryl phosphonates is disclosed. This asymmetric three-component...
Controlled generation of ortho-quinone methides and (4+3) cyclization with 2-indolylalcohols by dual photoredox/Brønsted acid relay catalysis
August 2025
Given the significance of oxacyclic frameworks in molecular scaffolds and drug discovery, it is intriguing to precisely construct and manipulate such ring systems in chemical research. In this area,...
Metal-free and visible-light-mediated method enables the synthesis of olefins from ketones
August 2025
Direct synthesis of olefins continues to attract stellar attention due to the high importance of olefins. In this context, due to the wide availability of ketones, the synthesis of olefins directly...
Advances of Ugi reaction in natural product synthesis
August 2025
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...
Enantiodivergent synthesis of axially chiral alkylidene cyclohexylamines by imine reductases-catalyzed desymmetrization
Available online 20 August 2025
Axially chiral alkylidene cycloalkanes are important scaffolds in various bioactive molecules, yet their synthesis remains challenging. In this study, we describe the imine reductases (IREDs)-catalyzed...
Aminoalkylation of alkynyl bromides for accessing propargylamines via visible-light-driven multicomponent reaction
Available online 20 August 2025
Propargylamines are an important class of organic motifs that exist in a myriad of biologically active molecules. In this paper, we present a new approach for synthesising propargylamines, which utilises...
Asymmetric synthesis of structurally diverse (S)-β-amino alcohols from simple aldehydes and formaldehyde
Available online 12 August 2025
Chiral β-amino alcohols represent a significant structural motif in many biologically active molecules. Developing an efficient biocatalytic method for synthesizing chiral β-amino alcohols with structural...
CO2-promoted photoredox-catalyzed cascade cyclization of N-propargylindoles with sulfinates
Available online 12 August 2025
Simultaneous incorporation of a sulfonyl group and a tricyclic indole framework within a single molecular might yield structural motifs commonly found in bioactive compounds. Herein, we present a CO2-promoted...
Skeletal recasting of benzo[c][1,2]dithiol-3-ones for the construction of 3-hydroxybenzo[b]thiophenes
Available online 11 August 2025
An unprecedented carbene-induced skeletal recasting of benzo[c][1,2]dithiol-3-ones is demonstrated herein. This Pd-catalyzed molecular editing of benzo[c][1,2]dithiol-3-ones serves as a powerful platform...
Recent advances in the photocatalytic applications of ethyl bromodifluoroacetate: A review
Available online 7 August 2025
Organic compounds bearing fluorine atoms have received widespread attention in recent years owing to their specific bioactivity and good biocompatibility compared to their nonfluorinated counterparts....
Aminoquinoline-directed electro/Ni dual-catalyzed C(sp2)-H alkylation with alkyl bromides
Available online 5 August 2025
Paired electrolysis offers an attractive platform for organic synthesis of avoiding the sacrificial anode. In this work, we developed a methodology of N,N′-bidentate aminoquinoline assistant-directed...
Azide-based difunctionalization of alkenes
Available online 5 August 2025
As an important class of nitrogen-containing functional molecules, azides have attracted considerable attention in synthetic chemistry and functional materials due to their reaction diversity and derivatization...
Carbon dioxide radical anion mediated regioselective carboxy-cyclization of alkenes
Available online 29 July 2025
Cyclopropyl fatty acid linkers and their derivatives serve as high-value pharmacophores in pharmaceutical and biotechnological research. Despite significant advancements in the hydrocarboxylation and...