Advancing sustainable quinolines synthesis via ZnIn2S4 heterogeneous photocatalysis
August 2026
In this study, we report a sustainable, visible-light-driven heterogeneous photocatalytic system to address these issues, using the ternary sulfide ZnIn2S4 (ZIS) as a photoredox catalyst. Our protocol...
Recent advances in the photocatalytic applications of ethyl bromodifluoroacetate: A review
August 2026
Organic compounds bearing fluorine atoms have received widespread attention in recent years owing to their specific bioactivity and good biocompatibility compared to their nonfluorinated counterparts....
Iron-catalyzed formation of six-membered rings from alkyne
August 2026
Iron compounds, exhibiting high catalytic behavior and excellent compatibility, have been considered as low-toxic, cheap, efficient, and green catalysts for many important organic transformations. Organic...
Biocompatible C–S bond construction for diarylmethyl thioethers
August 2026
We have developed a sustainable method for the construction of C–S bonds, in line with green chemistry principles, and modifiable for thiol-specific conjugation. Selecting p-quinone methides (p-QMs)...
Divergent asymmetric reactions of α-alkenyl ketones with β,γ-alkynyl-α-imino esters enabled by chiral phosphoric acids
August 2026
Divergent asymmetric synthesis provides access to a wide range of isomers from the same starting material by modifying the reaction conditions, which plays an important role in the efficient construction...
Photoredox decarboxylative acylation of carboxylic acid by 4-acyl-1,2,3-triazoliums
August 2026
Recent advancements in NHC-based radical coupling reactions have introduced NHC-derived ketyl radicals as innovative persistent radicals. However, current work involves NHC-based radical-radical coupling...
Environmentally friendly strategy for the direct conversion of sodium hypophosphite into organophosphorus compounds
August 2026
Sodium hypophosphite (NaH2PO2) stands out as a green, safe, stable, and cost-effective phosphorus source, making it one of the promising substitutes for traditional phosphorus trichloride (PCl3). Its...
Transition-metal-free defluorinative cyclization of perfluoroalkyl alkenyl iodides with C,N-dinucleophiles: Synthesis of (E)-perfluoroalkenyl pyrroles
August 2026
Functionalization of the C-F bond in perfluoroalkyl substances represents an emerging focus in organic chemistry. We report here a transition-metal-free intermolecular defluorinative cyclization of...
Organocatalytic asymmetric cyclization of aminochalcones and azlactones: Synthesis of 3,4-dihydroquinolinones
August 2026
A novel and efficient reaction of aminochalcones and azlactones has been developed under the catalysis of bifunctional organocatalysts. The corresponding enantioenriched 3,4-dihydroquinolinones were...
Electrochemical late-stage modification of hydralazine an antihypertensive drug. A green strategy for the synthesis of nano-structured new sulfonylhydrazine derivatives
August 2026
This work is focused on the electrochemical late-stage modification of hydralazine (1-hydrazinylphthalazine) (HYD), a common antihypertensive drug, and the synthesis of its new sulfonylhydrazine derivatives....
Copper(I)-catalyzed asymmetric hydrophosphination of alkenyl azaarenes
August 2026
Hydrophosphination of α,β-unsaturated carbonyl compounds is one of the most common methods to prepare chiral phosphines. Herein, a copper(I)-catalyzed asymmetric hydrophosphination of alkenyl azaarenes...
Engineering Clostridium ljungdahlii for efficient 3-hydroxybutyrate production from one-carbon gases
August 2026
3-Hydroxybutyrate (3-HB) has attracted great attention due to its importance as a building block in the production of high-value chemicals and polymers. Autotrophic Clostridium species have the potential...
Oxidative halogenation enabled by 2-haloethanol and aqueous H2O2 under metal-free conditions
August 2026
Electrophilic halogenation reactions have been recognized as robust approaches to accessing synthetically useful organohalides. Herein, we disclose an exclusive oxidative halogenation pathway, which...
Photo-catalyzed dearomative coupling of benzylmalonates and alkynes with CO2, leading to spiro-1,4-cyclohexadiene carboxylic acids
August 2026
A dearomative coupling reaction of benzylmalonates and alkynes with CO2via visible-light catalysis is developed, leading to a series of spiro-1,4-cyclohexadiene carboxylic acids. This three-component...
Recent advances in the catalytic asymmetric synthesis of spirocyclic tetrahydroquinolines, tetrahydroisoquinolines, and their derivatives
August 2026
Spirocyclic tetrahydroquinolines (spiro-THQs) and tetrahydroisoquinolines (spiro-iTHQs), along with their derivatives, constitute a prominent class of natural products that exhibit a broad spectrum...
Catalytic conversion of furfural to 2-methylfuran: Regulating the synergy between hydrogenation and C–O bond cleavage
Available online 2 August 2026
The selective hydrogenolysis of furfural (FUR) to 2-methylfuran (2-MF) has attracted substantial attention as a representative biomass-upgrading approach. Despite the development of numerous catalytic...
“Control from root design”: A proactive strategy for green and sustainable API process research and development
Available online 21 July 2026
We detail the concept, implementation, and illustrative applications of the “control from root design” (CRD) strategy for developing safe, environmentally benign, simple, health-protective, quality-assured,...
Recent advances in para-selective C–H bond functionalization of aniline derivatives
Available online 17 July 2026
Positional selectivity control in the C–H bond functionalization of aniline derivatives remains a formidable challenge in synthetic organic chemistry. Owing to the broad utility of these compounds across...
Visible-light induced site-selective C(sp3) –H epoxidation of amides
Available online 11 July 2026
Oxiranes are among the most valuable reagents in the chemical sciences, with applications that span pharmaceuticals, agrochemicals, and functional materials. Although remarkable progress has been achieved...
Electrophilic aryl spiroannulation induced by diaryliodonium salts: efficient synthesis of [5,5]-spiro lactone-lactam scaffolds from α-cyanocarboxylates
June 2026
Spirocyclic architectures represent one of the privileged three-dimensional scaffolds in pharmaceutical chemistry and drug discovery, while the new-skeletal synthesis of spiromolecules from simple starting...
Electrochemical C-H thiocyanation of BODIPYs: Two birds with one stone of KSCN
June 2026
An efficient electrochemical C–H thiocyanation of BODIPYs was developed by using potassium thiocyanide as the source of thiocyanation. The straightforward C–H thiocyanation protocol possesses many advantages:...
Efficient templating synthesis of [12]cyclo-meta-phenylenes: A novel strategy for capturing fullerene
June 2026
The resorcin[4]arene-templated synthesis of the structure with [12]cyclo-meta-phenylene ([12]CMP), achieves a remarkable 53% overall yield in its key steps, overcoming the thermodynamic instability...
Contamination and biotransformation of deoxynivalenol (DON) in common commercial foods: Current status, challenges, and future perspectives
June 2026
Deoxynivalenol (DON) has received considerable attention due to its toxicity and widespread presence in food and feed. This review summarizes the DON contamination in commonly consumed commercially...
Synthesis of 1,4-oxathiins via [3+3] annulation of pyridinium 1,4-zwitterionic thiolates with iodonium ylides
June 2026
A straightforward and valuable approach for the synthesis of 1,4-oxathiins has been developed via [3+3] annulation of pyridinium 1,4-zwitterionic thiolates with iodonium ylides. C–S and C–O bonds were...
Accelerating rational organoborazine discovery: Predicted by machine learning, synthesized under continuous flow
June 2026
Substituting a benzene ring with a borazine ring in π-conjugated systems has garnered significant interest in recent years, particularly for its potential in enhancing optoelectronic device performance....