Transition metal-free thiophene construction in pure water by multiplied C-H functionalization with enaminones and elemental sulfur
February 2026
A novel method for the synthesis of 2,4-disubstituted thiophenes via the reactions of N,N-disubstituted enaminones and elemental sulfur is developed. By simply heating the substrates in pure water in...
Electrochemical difunctionalization of isocyanides by a three-component reaction cascade Mumm rearrangement: Rapid access to sulfur-containing imides
February 2026
An efficient and practical electrochemical method for the three-component reaction cascade Mumm rearrangement of imides has been developed using a simple undivided cell with carbon electrodes at room...
A greener approach to Buchwald-Hartwig coupling. A sustainable Pd/C-catalyzed Csp2–N bond formation under microwave irradiation and bio-based solvent
February 2026
The Buchwald-Hartwig coupling enables the grafting of nitrogen-containing functionalities onto molecules, facilitating the synthesis of a wide variety of molecular structures. However, several challenges...
Photocatalyzed chemodivergent aerobic oxidation of naturally occurring Viridicatin and derivatives
February 2026
A chemodivergent reaction is an appealing way to construct molecules with enriched structure diversity in a controlled manner. A plethora of methodologies were developed based on this concept, and transition...
Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones
February 2026
Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical, pharmaceutical, and chemical industries as well as in material science. During the...
Iron-catalyzed non-directed arene C-H difluoromethylation
February 2026
Practical, undirected and selective catalytic functionalization of unactivated arenes remains a challenging problem in organic synthesis. We herein report a bioinspired L-cystine-derived ligand BCPOM/Fe-enabled...
Advances in the synthesis of C19-hydroxylated steroids
February 2026
The significant medicinal values associated with C19-hydroxylated steroids dictate a growing demand for new synthetic strategies that would provide facile access to these challenging targets. This review...
Electrochemical oxidation enabled HAT approach for the synthesis of quinolinones
February 2026
Quinolinones have been prepared by an intramolecular radical annulation of α-EWG (electron-withdrawing group) substituted amides and alkynes involving an electrochemical oxidation enabled hydrogen atom...
Mild and green thioacylation with dithiocarboxylates via photoredox catalysis
February 2026
A photocatalysis process-enabled thioacylation of amines has been developed with eco-friendly feedstock potassium dithiocarboxylates as green thioacyl sources and water as the reaction solvent. The...
Enantioselective epimerizations of meso-diols via asymmetric hydrogen atom abstraction catalysis
February 2026
A new type of asymmetric hydrogen atom abstraction catalysts, originated from the cinchona alkaloid family of natural products, has been successfully developed to access enantioselective epimerizations...
Brønsted acid catalyzed green and efficient construction of α-amino peroxides from 3-hydroxyisoindolinones and hydroperoxides
February 2026
A Brønsted acid-catalyzed peroxidation of 3-hydroxyisoindolinones with hydroperoxides has been established for the first time, which constructs α-amino peroxides bearing a tetrasubstituted stereocenter...
Efficient one-pot synthesis of ruthenium catalysts and their role in optimizing sugar alcohol production: Investigating structural sensitivity
February 2026
The study explores the feasibility of producing ruthenium catalysts supported on char through a one-pot synthesis, an original approach for the preparation of noble metal-based catalysts in this field....
Directed evolution of stereoselective enzymes meets click reactions: Asymmetric synthesis of chiral triazoles using a Cu(I)-compatible halohydrin dehalogenase
February 2026
We report for the first time the combination of directed evolution focused on enhancing and reversing the stereoselectivity of an enzyme with Cu(I)-mediated click chemistry (CuAAC), providing an asymmetric...
Recent advances in photocatalytic C-H amination to nitrogenous structures
February 2026
Nitrogen-containing structures represent a significant branch exhibiting remarkable biological activity, surpassing non-nitrogen architectures. Given the vast array of nitrogen-containing compounds...
Palladium-catalyzed chemoselective synthesis of arylamines from cyclohexanones with ammonium salts
February 2026
The primary objective of organic synthesis is the utilization of inexpensive and readily available industrial chemicals in large quantities to produce valuable organic compounds. This study introduces...
Unsaturated C2 synthons in photocatalysis: Taming and directing acetylene and ethylene in radical reactions
Available online 28 January 2026
The conversion of the simplest unsaturated C2 molecular building units (C2H2 and C2H4) to high-value-added fine chemicals has been a pivotal domain in modern synthetic chemistry. Because of the inherent...
Chemoenzymatic synthesis of ADP-d-glycero-β-d-manno-heptose using a bifunctional kinase/nucleotidyltransferase
Available online 21 January 2026
Adenosine-diphosphate-d-glycero-β-d-manno-heptose (ADP-d,d-heptose) and adenosine-diphosphate-l-glycero-β-d-manno-heptose (ADP-l,d-heptose) are potent agonists of innate immunity. They also serve as...
Cobalt-catalyzed enantioselective hydroalkylation of oxanorbornene for the construction of chiral bridged oxabicyclic structures
Available online 19 January 2026
Available online Oxanorbornene is a versatile building block in natural product and pharmaceutical synthesis, yet its enantioselective hydroalkylation with bridged ring retention remains underdeveloped....
Radical-mediated selective cascade addition/annulation of ((2-isocyanophenyl)methylene)dibenzenes for the divergent synthesis of 3H-indoles and indolines
Available online 17 January 2026
A radical-mediated selective cascade addition/annulation of ((2-isocyanophenyl)methylene)dibenzenes for the divergent synthesis of 3,3-diaryl-3H-indoles and 2-alkyl-3,3-diarylindolines under transition...
Porous materials for photo-enzyme-coupled catalysis: Bridging the gap between light-driven and enzymatic process
Available online 14 January 2026
Porous materials bridge the gap between light-driven and enzymatic process in photo-enzyme-coupled catalytic systems (PECS), which integrate the energy conversion of photocatalysis with the high selectivity...
Photocatalyzed site-selective aryl C–H sulfinamidation via thianthracene salts
Available online 7 January 2026
Benzenesulfinamides are a critical class of S(IV) compounds that serve as important entry points to an array of emerging pharmaceutical molecules and bioactive substances. However, the widespread application...
Accessing tetrasubstituted CF2H 1-pyrrolines via electrochemical hydrodefluorination and [3+2] cascade cyclization
Available online 30 December 2025
Tetrasubstituted difluoromethyl 1-pyrrolines are scarcely reported compared to trifluoromethyl 1-pyrrolines. Herein, we present a novel access to difluoromethyl 1-pyrrolines through electrochemical...
Recent advances in ligand-accelerated nickel-catalyzed carbonylation under CO gas
Available online 29 December 2025
Carbonyl groups are fundamental structural motifs in organic chemistry, prominently featured in drug molecules, functional materials, and as versatile synthetic intermediates. Transition metal-catalyzed...
Harnessing N-nitroamines for direct deaminative coupling
Available online 29 December 2025
A novel deaminative strategy for aryl amines via N-nitroamines intermediates has been successfully developed, which substitutes the traditional diazo chemistry and directly converts the aryl C-N bond...
Time-dependent chemoselectivity in a single glycosyltransferase drives O- to C-glycosylation
Available online 26 December 2025
The inherent chemoselectivity of glycosyltransferases (GTs) toward specific acceptors is well established, yet the capacity of a single GT to achieve time-dependent chemoselective glycosylation has...