Controllable stepwise fluorine elimination strategy for the chemodivergent synthesis of pyrido[2,1-a]isoquinolines
October 2026
A controllable stepwise fluorine elimination strategy has been reported, and used to selectively produce fluoro-substituted pyrido[2,1-a]isoquinolines and fluorine-free pyrido[2,1-a]isoquinolines through...
Enantioselective synthesis of chiral N-arylpyrroles through photoinduced desymmetrization
October 2026
The C–N axial chirality is widely present in natural products, bioactive molecules, and chiral ligands. Catalytic asymmetric construction of C–N axially chiral compounds is a challenging task due to...
Enhancing the catalytic efficiency of nitrilase for sterically hindered substrates by distal sites engineering
October 2026
Nitrilases are enzymes capable of converting nitriles into carboxylic acids under mild conditions. However, wild type nitrilases typically exhibit poor catalytic efficiency towards sterically hindered...
Applications of cytochrome P450 monooxygenases in the biosynthesis of active pharmaceutical ingredients
October 2026
The synthesis of active pharmaceutical ingredients (APIs) constitutes a pivotal juncture within the pharmaceutical industry, prompting researchers to relentlessly pursue novel methodologies that enhance...
Green solvent-controlled switchable synthesis of six-membered N-heterocycles and seven-membered O-heterocycles
October 2026
The BF3·OEt2 promoted switchable synthesis of six-membered N-heterocycles and seven-membered O-heterocycles from readily available feedstocks was developed by the adjustment of green solvents EA and...
A direct Ni-catalyzed deoxygenative Suzuki-Miyaura cross-coupling reaction of phenols via the formation of active O-phenyluronium
October 2026
Herein, we demonstrate that activation of phenols by tetramethylfluoroformamidinium hexafluorophosphate (TFFH) enables the establishment of the general Ni-catalyzed method for deoxygenative Suzuki-Miyaura...
TFA-catalyzed cascade annulation of thioamides with aromatic hydrazides/amines: An internal oxidant-triggered protocol to diverse N-heterocycles
October 2026
An internal oxidant-triggered highly efficient protocol for the synthesis of diverse N-heterocycles (benzothiazoles, benzoxazoles, quinazolines, and 1,3,4-oxadiazoles) by TFA-catalyzed cascade annulation...
Activation of diterpene hydrocarbon skeletons by microbial natural P450 oxidases
October 2026
Diterpenoids represent invaluable resources for novel drug discovery and development. The high inertness of diterpene hydrocarbon skeletons, coupled with their multiple chiral centers, makes oxidative...
Palladium/copper-catalyzed 1,2-arylboration of styrenes with b2pin2 and indoles
October 2026
Boryldifunctionalization of alkenes has emerged as a valuable synthetic tool for constructing complex organoboron compounds. While significant advances have been achieved in carboboration reactions...
Palladium-catalyzed allylic amination of vinyl bicyclo[1.1.0]butanes: A strain release approach toward alkylidenecyclobutanes
October 2026
A palladium-catalyzed allylic amination of vinyl bicyclo[1.1.0]butanes with amines is described. This protocol is featured with its novel activation model, broad substrate scope and mild reaction conditions,...
Palladium-catalyzed ionic liquids-mediated cascade carbonylative alkynylation of diaryl ethers with alkynes
October 2026
An NHC-palladium-catalyzed ionic liquid-mediated cascade carbonylative alkynylation of diaryl ethers with alkynes in basic “task-specific” ionic liquid for the assembly of structurally diverse alkynones...
Copper-catalyzed deuterodehalogenation of aryl halides
October 2026
There is growing potential and interest in the development of precise and practical deuterium labelling methodologies using an easy-handling deuterated source for alkylarenes and methylarenes. Here...
The cascade annulation approach to quinoxalines by radical NHC catalysis
October 2026
A wide range of functionalized quinoxalines were rapidly constructed by novel NHC-catalyzed cascade annulation of acyl oximes and isonitriles. The developed protocol characterized good functional group...
Recent advances in ligand-accelerated nickel-catalyzed carbonylation under CO gas
October 2026
Carbonyl groups are fundamental structural motifs in organic chemistry, prominently featured in drug molecules, functional materials, and as versatile synthetic intermediates. Transition metal-catalyzed...
Microwave-assisted pyrolysis synthesis: Atomic-scale regulation for green and efficient catalyst preparation
October 2026
This perspective article systematically elaborates on the research progress of microwave-assisted pyrolysis synthesis (MAPS) for atomic-scale, precise regulation of catalysts, a green, energy-efficient...
Process development and kilogram-scale synthesis of eslicarbazepine acetate via highly efficient iridium-catalyzed asymmetric hydrogenation
Available online 29 September 2026
A practical and scalable process for the synthesis of the antiepileptic API eslicarbazepine acetate has been developed. The process features a highly efficient iridium-catalyzed asymmetric hydrogenation...
Recent advances in copper nitride for the electrochemical reduction of carbon dioxide
Available online 9 September 2026
The electrochemical carbon dioxide reduction reaction (CO2RR) offers a promising pathway for converting CO2 into valuable fuels and chemicals via renewable electricity, representing an essential approach...
Supramolecular docking: Taming flexible alkyl chains for crystallography via active molecular recognition
Available online 4 September 2026
A supramolecular docking strategy has been developed for the SCXRD determination of flexible alkyl-chain-containing molecules. By incorporating pillar[5]arene-based recognition units into MOFs, EtP5-MOF-2...
Advancing sustainable quinolines synthesis via ZnIn2S4 heterogeneous photocatalysis
August 2026
In this study, we report a sustainable, visible-light-driven heterogeneous photocatalytic system to address these issues, using the ternary sulfide ZnIn2S4 (ZIS) as a photoredox catalyst. Our protocol...
Recent advances in the photocatalytic applications of ethyl bromodifluoroacetate: A review
August 2026
Organic compounds bearing fluorine atoms have received widespread attention in recent years owing to their specific bioactivity and good biocompatibility compared to their nonfluorinated counterparts....
Iron-catalyzed formation of six-membered rings from alkyne
August 2026
Iron compounds, exhibiting high catalytic behavior and excellent compatibility, have been considered as low-toxic, cheap, efficient, and green catalysts for many important organic transformations. Organic...
Biocompatible C–S bond construction for diarylmethyl thioethers
August 2026
We have developed a sustainable method for the construction of C–S bonds, in line with green chemistry principles, and modifiable for thiol-specific conjugation. Selecting p-quinone methides (p-QMs)...
Divergent asymmetric reactions of α-alkenyl ketones with β,γ-alkynyl-α-imino esters enabled by chiral phosphoric acids
August 2026
Divergent asymmetric synthesis provides access to a wide range of isomers from the same starting material by modifying the reaction conditions, which plays an important role in the efficient construction...
Photoredox decarboxylative acylation of carboxylic acid by 4-acyl-1,2,3-triazoliums
August 2026
Recent advancements in NHC-based radical coupling reactions have introduced NHC-derived ketyl radicals as innovative persistent radicals. However, current work involves NHC-based radical-radical coupling...
Environmentally friendly strategy for the direct conversion of sodium hypophosphite into organophosphorus compounds
August 2026
Sodium hypophosphite (NaH2PO2) stands out as a green, safe, stable, and cost-effective phosphorus source, making it one of the promising substitutes for traditional phosphorus trichloride (PCl3). Its...