Analysis of MIR155HG gene polymorphisms and ulcerative colitis susceptibility in the Chinese Han Population
June 2026
Aberrant expression of miR-155 has been implicated in the pathogenesis of inflammatory bowel disease (IBD), where its dysregulation may contribute to impaired intestinal barrier integrity and sustained...
DICER1 dysregulation triggers reprogramming of a specific miRNA subset, promotes mesenchymal cell fates and slows TNBC tumorigenic phenotypes
June 2026
DICER1 is a key processing enzyme required for the generation of mature and active miRNAs. Mutations that diminish DICER1 function result in widespread changes in miRNA levels, resulting in changes...
The paradox of nuclear miRNAs: Mechanisms, therapeutic potential, and future directions
June 2026
Nuclear microRNAs represent a novel class of non-canonical miRNAs localized within the nucleus, distinguished from classical cytoplasmic miRNAs by their unique ability to activate gene transcription....
Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability
June 2026
Vulnerable carotid atherosclerotic plaques are prone to cap rupture and thrombosis, yet definitive assessment still relies on postoperative histology. We investigated whether circulating circular RNAs...
Investigation of cervical cell image segmentation technology based on deep learning and non-coding RNAs
April 2026
Cervical cancer remains a significant health concern worldwide, necessitating effective diagnostic methods such as cervical cell image segmentation. This review outlines the challenges and importance...
The progress of m6A methylation-regulated non-coding RNAs in osteogenic differentiation and osteoporosis
April 2026
N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic RNA, and has increasingly been recognized as a critical regulator of gene expression at both the transcriptional and...
Circular RNA MALAT1 as a potential target for antimetastatic therapy
April 2026
Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) located in the nucleus that is involved in the regulation of gene expression and alternative splicing...
The regulatory role of circGDI2 in hepatocellular carcinoma proliferation and glycolysis with the involvement of m6A modification
April 2026
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy, and metabolic reprogramming, particularly glycolysis, plays a crucial role in its progression. Circular RNAs (circRNAs) and N6-methyladenosine...
TPR is required for circRNA, lncRNA and mRNA nuclear export
April 2026
Efficient RNA nuclear export is essential for proper cellular function and normal physiology, with defects in this process leading to pathological consequences. Our study aimed to investigate the role...
LncRNA ZFAS1 in hepatocellular carcinoma: A systematic review of molecular mechanisms and clinical translation
April 2026
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality globally, with its high recurrence rate and therapeutic resistance underscoring the urgent need for breakthrough molecular...
circ_0103896/miR-432–5p/FTO feedback loop suppresses the formation and progression of intracranial aneurysm
April 2026
Circular RNAs (circRNAs) and m6A RNA methylation play crucial roles in the pathogenesis of intracranial aneurysm (IA); however, their regulatory interplay remains unclear. Through circRNA profiling...
Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression
April 2026
Intervertebral disc (IVD) degeneration (IVDD) is the pathological foundation and principal cause for degenerative spine related diseases. Currently, its molecular pathogenesis and reliable biomarkers...
The crosstalk network of non-coding RNAs: Emerging opportunities for the clinical application of osteoporosis
April 2026
Current methods for testing bone density lack the capability to detect patients with early bone loss, and existing osteoporosis therapies have limitations in their efficacy and safety. Therefore, the...
Epigenetic H3K4me3 activation of miR-155-5p promotes intervertebral disc degeneration via autophagy and ageing in nucleus pulposus cells
April 2026
Nucleus pulposus (NP) cell ageing and impaired autophagy - lysosome biogenesis (ALB) are key drivers of intervertebral disc degeneration (IVDD). The upstream epigenetic regulation of transcription factor...
SNHG5 enhances colorectal cancer metastasis through RNA–protein interaction with GNB2 and activation of canonical Wnt signaling
April 2026
Colorectal cancer (CRC) is one of the most prevalent and lethal malignancies worldwide, with distant metastasis—particularly to the liver—representing the primary cause of poor prognosis. Long non-coding...
Mechanistic roles of long non-coding RNAs in gastric cancer therapy resistance
April 2026
Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide. While gastrointestinal tumor screening has reduced incidence and mortality, its treatment faces is hindered by challenges...
Non-coding RNAs in congenital heart disease and placental development: Bridging molecular mechanisms to clinical biomarkers and therapies
February 2026
Non-coding RNAs (ncRNAs) have emerged as pivotal regulators of gene expression, orchestrating embryonic development and disease pathogenesis. This review synthesizes current knowledge on the origin,...
Long non-coding RNAs in B-cell acute lymphoblastic leukemia: Disease implication, challenges and therapeutic opportunities
February 2026
B-cell acute lymphoblastic leukemia (B-ALL) manifests as an abnormal proliferation of neoplastic B-cell lymphocytes, adversely affecting both children and adults. Despite the advancements in cancer...
LncRNA-EME1 enhances BRCA1 recruitment and alters repair of DNA damage in cervical cancer radioresistance
February 2026
Cervical cancer is a significant cause of mortality in women globally, and radioresistance limits the effectiveness of standard radiotherapy treatment. Exploring the molecular mechanisms that contribute...
ncFN: a comprehensive non-coding RNA function annotation framework based on a global and heterogeneous biomolecular network
February 2026
Increasing evidence indicates that non-coding RNAs (ncRNAs) have emerged as essential factors in most biological processes through diverse mechanisms. However, the biological functions of most ncRNAs...
MiR-21 modulates P.g-LPS induced apoptosis and inflammatory response in HUVECs via NF-κB/iNOS/NO pathway by targeting PDCD4
February 2026
Porphyromonas gingivalis lipopolysaccharide (P.g-LPS), a key virulence factor in periodontitis, contributes to systemic vascular diseases, notably atherosclerosis. MicroRNA-21 (miR-21), a critical post-transcriptional...
Integrative analysis of tissue and circulating miRNAs as biomarkers for progression and survival in hepatocellular carcinoma
February 2026
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with limited biomarkers available for early diagnosis and risk stratification. In this study, we performed an integrative...
List of reviewers in 2025
February 2026