Biophysical and NMR analysis reveals binding affinity between HAX1 and CLPB proteins
February 2025
HCLS1-associated protein X-1 (HAX1) is a multifunctional mitochondrial protein involved in the regulation of apoptosis, a crucial process of programmed cell death, and mRNA processing. Despite its significance,...
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In-cell dehydration of sodium manganese hexacyanoferrate cathode revealed by solid-state NMR
February 2025
The hard-to-remove lattice water has been regarded as a significant obstacle impeding the practical use of Prussian blue analogue cathodes for sodium-ion batteries. This work monitored the electrochemical...
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Spontaneous increasing of sensitivity and resolution in parahydrogen-induced hyperpolarization by RASER
February 2025
Enhancing the sensitivity of nuclear magnetic resonance (NMR) technology has been the focus of NMR research for decades, which offers the potential to significantly expand its applications in chemistry,...
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RF power design optimization in MRI system
August 2021
Magnetic resonance image quality and patient safety have been the focus of engineering and research ever since the invention of equipment in the early 1970s. In high field (or ultrahigh field) MRI systems,...
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Distinct association of HRAS and KRAS with Mn2+ ion illustrated by paramagnetic NMR
February 2025
Rat sarcoma virus oncogene (RAS) proteins are of crucial oncogenic proteins and are involved in several essential intracellular processes. The RAS protein has an intrinsic metal binding site for Mg2+,...
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Progress in magnetic resonance imaging of the glymphatic system
November 2024
The glymphatic system (GS) is a newly discovered brain anatomy. Its discovery improves our understanding of brain fluid flow and waste removal paths and provides an anatomical basis for the flow of...
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Magnetic resonance imaging techniques for lithium-ion batteries: Principles and applications
May 2024
Operando monitoring of internal and local electrochemical processes within lithium-ion batteries (LIBs) is crucial, necessitating a range of non-invasive, real-time imaging characterization techniques...
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Cloud-magnetic resonance imaging system: In the era of 6G and artificial intelligence
February 2025
Magnetic resonance imaging (MRI) plays an important role in medical diagnosis, generating petabytes of image data annually in large hospitals. This voluminous data stream requires a significant amount...
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Dynamic nuclear polarization and chemically induced hyperpolarization: Progress, mechanisms, and opportunities
Available online 29 January 2025
Nuclear magnetic resonance (NMR) spectroscopy is a powerful and broadly used spectroscopic technique for characterizing molecular structures and dynamics. Yet the power of NMR is restricted by its inherently...
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Numerical design of transverse gradient coil with transformed magnetic gradient field over an effective imaging area
February 2025
Gradient coil is an essential component of a magnetic resonance imaging (MRI) scanner. To achieve high spatial resolution and imaging speed, a high-efficiency gradient coil with high slew rate is required....
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Probing electronic structures of transition metal complexes using electron paramagnetic resonance spectroscopy
February 2023
Electron paramagnetic resonance (EPR) or electron spin resonance (ESR) has been widely employed to characterize transition metal complexes. However, because of the high degree of complexity of transition...
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Overview and progress of X-nuclei magnetic resonance imaging in biomedical studies
November 2023
Proton nuclear (1H) is the observed nucleus on which most magnetic resonance imaging (MRI) applications depend. Most traditional 1H MRI can provide structural and functional information about organisms,...
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Rigid and stable nitroxide spin label for high-resolution distance measurements on proteins by DEER experiments
Available online 28 February 2025
The distance distributions between two site-specifically anchored spin labels in a protein, measured by pulsed electron-electron double resonance (PELDOR or DEER), provide rich sources of structural...
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23Na relaxometry: An overview of theory and applications
May 2023
23Na is a nuclear magnetic resonance (NMR)-active isotope with a nuclear spin quantum number of 3/2. 23Na relaxation phenomenon is at the core of 23Na NMR measurement and analysis. Due to the dominance...
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19F NMR study of proteins with parallel incorporation of multiple fluorinated aromatic amino acids
Available online 22 February 2025
Although the parallel incorporation of fluorinated aromatic amino acids (FAAAs) into proteins has been explored since 2010, the corresponding 19F NMR investigation has been lacking to date. To assess...
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Facile identification of fluorosurfactant category in aqueous film-forming foam concentrates via optimized 19F NMR
August 2024
Aqueous film-forming foams (AFFFs) are the primary source of toxic perfluoroalkyl and polyfluoroalkyl substances (PFAS) in wastewater. Thus, it is urgent to develop a facile and fast method for identifying...
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Analysis of the electron transfer pathway in small laccase by EPR and UV–vis spectroscopy coupled with redox titration
August 2024
Bacterial small laccases (SLAC) are promising industrial biocatalysts due to their ability to oxidize a broad range of substrates with exceptional thermostability and tolerance for alkaline pH. Electron...
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A review of functional MRI application for brain research of Chinese language processing
February 2023
As one of the most widely used languages in the world, Chinese language is distinct from most western languages in many properties, thus providing a unique opportunity for understanding the brain basis...
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Specific protein-urea interactions
August 2022
The mechanism of urea's action in protein denaturation remains largely unknown. To provide an experimental basis for molecular dynamics (MD) simulations on urea-protein interactions, we investigated...
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Solid-state NMR of vulcanized natural rubber/butadiene rubber blends: Local organization and cross-linking heterogeneities
November 2024
Elastomer blends, among which natural rubber (NR) and butadiene rubber (BR), are involved in many components of the automotive/tire industry. A comprehensive understanding of their mechanical behavior...
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NMR methods for investigating functionally relevant biomolecular dynamics
Available online 19 March 2025
The dynamics of biomolecules span across a wide range of timescales, reflecting the complexity of free energy landscapes of biomolecules. Among these, the microsecond-to-millisecond (μs–ms) timescale...
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Progress in in-situ electrochemical nuclear magnetic resonance for battery research
May 2024
A thorough understanding of the fundamental electrochemical and chemical processes in batteries is crucial to advancing energy density and power density. However, the characterizations of such processes...
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Rheo-NMR: A versatile hyphenated technique for capturing molecular dynamics and structure under flow
February 2024
The general development of Rheo-NMR during the last four decades as well as selective hyphenated apparatuses is presented. Based on different magnet types, the current review is divided into two categories,...
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Using NMR-detected hydrogen-deuterium exchange to quantify protein stability in cosolutes, under crowded conditions in vitro and in cells
November 2023
We review the use of nuclear magnetic resonance (NMR) spectroscopy to assess the exchange of amide protons for deuterons (HDX) in efforts to understand how high concentration of cosolutes, especially...
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The rise of NMR-integrated fragment-based drug discovery in China
Available online 29 January 2025
Nuclear magnetic resonance (NMR) spectroscopy is an indispensable tool to probe weak protein-ligand interactions, which are key to the hit identification and hit-to-lead evolution in fragment-based...
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