Development of a low-cost microfluidic chip for hyaluronidase-free oocyte denudation in mammals
2025
Infertility in mammals is one of the most intricate medical issues requiring non-traditional interventions. In Vitro Fertilization (IVF) is one of the modern medical technologies currently used to treat...
Modeling and simulation of soft bio-mimetic fingers with a novel soft thumb design for bionic hand applications using ANN
2025
The paper presents a novel design for a soft bio-mimetic finger and soft thumb structure for bionic hand applications. It introduces an anthropomorphic pneumatic flexible finger system using a PneuNets...
Microbial electrosynthesis meets synthetic biology: Bioproduction from waste feedstocks
2025
Integrating electrochemistry and biology, microbial electrosynthesis (MES) enhances feedstock-to-product conversion by utilizing electroactive microorganisms to harness electrical energy for driving...
Supercritical CO2 extraction of artemisinin from Artemisia annua plant and the biotechnological production of artemisinin precursors: A dual-focus review
2025
Artemisinin, a vital compound renowned for its potent antimalarial properties, has garnered significant attention due to its therapeutic importance and critical role in combating malaria. The extraction...
Emergence of β-lactamase-producing Proteus mirabilis in clinical settings: A genotypic investigation of resistance mechanisms and carbapenemase genes blaNDM-1 and blaKPC-2
2025
Proteus mirabilis, an opportunistic pathogen frequently implicated in urinary and wound infections, has shown increasing multidrug resistance, posing significant therapeutic challenges. The study aims...
Tackling carbapenem-resistant Acinetobacter baumannii (CRAB) and their virulence factors using biosynthesized silver nanoparticles combined with imipenem
2025
Carbapenem-resistant Acinetobacter baumannii is an extremely hazardous microorganism due to its high level of resistance to a wide array of antibiotics, making it a significant public health concern....
Biogenic synthesis of silver nanoparticles using Sida cuneifolia leaf extract for enhanced antibacterial, cytotoxic, and anti-biofilm activities
2025
Antimicrobial resistance (AMR) is one of the global threats that needs to be addressed. Nanotechnology represents a promising way to address this issue due to its multifaceted mode of action. This study...
Cell bank system, establishment, and application in the virus research, diagnosis, and biopharmaceutical industries
2025
The use of cells in research and diagnostic studies is important. This is of paramount importance in the biopharmaceutical product industry because cells are one of the most important platforms in the...
Circular economy through integrated industrial ecology: Innovations in resource recovery and process re-design
2025
Industrial ecology provides systems-thinking for re-designing industrial processes with greater resource efficiency, waste reduction, and circularity. This review discusses future directions in process...
Development of doubled haploid lines in spring wheat (Triticum aestivum L.) through wheat × maize hybridization and colchicine application
2025
Bangladesh faces a significant deficit in wheat grain production relative to its national demand, largely due to the prolonged duration-typically 10 to 12 years-required to release a new variety through...
MicroRNA alterations in sperm of infertile men: Insights into oligozoospermia, asthenozoospermia, and teratozoospermia
2025
Male infertility makes up almost 50 % of infertility cases in couples. Contributing factors include urogenital abnormalities, hormone imbalances, and genetic mutations. Current research highlights the...
CFD study and experimental verification of droplet formation characteristics in a flow-focusing microfluidic device
2025
This study numerically investigates droplet formation in a three-dimensional flow-focusing microchannel and validates the results with a lithographically fabricated device (error <4%). The effects of...
Organ-on-chip technology: Opportunities and challenges
2024
Organ-on-chip (OOC) technology is an innovative approach that reproduces human organ structures and functions on microfluidic platforms, offering detailed insights into intricate physiological processes....
Therapeutic advancements in nanomedicine: The multifaceted roles of silver nanoparticles
2024
Nanotechnology has the advantages of enhanced bioactivity, reduced toxicity, target specificity, and sustained release and NPs can penetrate cell membranes. The small size of silver nanoparticles, AgNPs,...
Understanding virus retention mechanisms on protein a chromatography based on using different wash buffers – Evaluating the possibility for a generic wash buffer toolbox to improve virus clearance capacity
2024
During manufacturing of mammalian-cell derived monoclonal antibodies (mAbs) virus clearance capacity of the downstream process has to be demonstrated. The protein A chromatography step typically achieves...
Antibiotic susceptibility and virulence factors of bacterial species among cancer patients
2024
Antibiotic resistance is one of the most significant challenges of the 20-s century, and the misuse of antibiotics is a driver of antimicrobial resistance. This study aimed to assess the prevalence...
The potential of copper oxide nanoparticles in nanomedicine: A comprehensive review
2024
Nanotechnology is a modern scientific discipline that uses nanoparticles of metals like copper, silver, gold, platinum, and zinc for various applications. Copper oxide nanoparticles (CuONPs) are effective...
Unraveling current breakthroughs in Scorodocarpus borneensis phytochemical therapeutics: A systematic review
2024
Scorodocarpus borneensis, also known as the Kulim tree or Garlic tree, has been consumed by the local communities in Southeast Asia as traditional spice using its old leaves, stem bark, and seeds. The...
CRISPR/Cas9 improves targeted knock-in efficiency in Aspergillusoryzae
2024
Aspergillus oryzae is an important fungus in food and industrial enzyme production. In A. oryzae, targeted knock-in transformation is primarily limited to homologous recombination (HR)-based systems,...
aXonica: A support package for MRI based Neuroimaging
2024
Magnetic Resonance Imaging (MRI) assists in studying the nervous system. MRI scans undergo significant processing before presenting the final images to medical practitioners. These processes are executed...
The future of cell-free synthetic biology
2024
Cell-free synthetic biology aims at the targeted replication, design, and modification of life processes in open systems by breaking free of constraints such as cell membrane barriers and living cell...
Screening, characterization, and production of Bacillus cereus (S55) bioflocculant isolated from soil for application in wastewater treatment
2024
This research evaluated a bacterial strain, Bacillus cereus (S55), isolated from the soil for its bioflocculant production capabilities. The strain was identified through morphological and 16s rRNA...
A comparative exploration of mRNA capping enzymes
2024
With the wide application of messenger RNA (mRNA) technology in medicine and vaccine fields, higher requirements are put forward for mRNA expression efficiency in vivo. Since the 5′ cap structure can...