Current therapies and advances in the development pipeline of pre-erythrocytic preventive drugs
2025
Malaria prevention remains a cornerstone strategy for reducing global mortality and morbidity. Although the two World Health Organization (WHO)-recommended pre-erythrocytic malaria vaccines, RTS,S/AS01...
Recent malaria outbreak in the USA: Risk of and response to malaria reintroduction in non-endemic regions
2024
The emergence of locally transmitted Plasmodium vivax malaria in Florida from May to July 2023 underscores the persistent threat of malaria reintroduction in non-endemic regions. The increasing instances...
S–6P exhibits better immunogenicity than S–2P at lower doses of COVID-19 mRNA vaccines
2024
The objective of this study was to determine whether a new combination of immunogens could be more effective than the S–2P design in terms of eliciting an immune response. The study aimed to use a unified...
In vitro culture and genetic modification of Babesia gibsoni
2024
Babesia gibsoni, a unicellular eukaryotic parasite causing babesiosis in dog, is primarily transmitted through tick feeding. The intraerythrocytic stage, during which the parasite reproduce within the...
Progress of exosomes in diagnosis of tuberculosis
2024
Tuberculosis (TB) is a globally prevalent infectious disease caused by Mycobacterium tuberculosis. A majority of TB patients develop a latent infection, making disease diagnosis more challenging. However,...
Global, regional, and national burden of dengue, 1990–2021: Findings from the global burden of disease study 2021
2024
Dengue is an acute viral infectious disease caused by the dengue virus and transmitted through mosquitoes. Although numerous studies have examined the global burden of dengue, comprehensive and systematic...
Machine learning models for predicting residual malaria infections using environmental factors: A case study of the Jazan region, Kingdom of Saudi Arabia
2024
Malaria is a global public health problem affecting more than 100 countries. Meteorological factors on the other hand represent a major driving force behind malaria transmission and other vector-borne...
Chromosome-level genome assembly, reannotation and decoding of a Trichomonas vaginalis clinical isolate from Shiyan, Central China
2024
Trichomonas vaginalis trophozoite is a pathogen that causes trichomoniasis, the most common neglected sexually transmitted disease. The reference genome of T. vaginalis is derived from the G3 strain....
A review of epidemiological characteristics, risk factors, and prevention strategies of human anthrax in China
2024
Anthrax is a severe infectious illness triggered by the bacterium Bacillus anthracis. This bacterium is naturally found in soil and mainly impacts domestic and wild animals. Human anthrax infection...
Characterizations of Prototheca wickerhamii clinical isolates and their interactions with macrophages
2024
As global climate change exacerbates, the emergence of rare pathogens causing outbreaks is on the rise, with Prototheca species becoming notable threats. Within the protothecosis science popularization...
Harnessing bioinformatics for the development of a promising multi-epitope vaccine against tuberculosis: The ZL9810L vaccine
2024
Tuberculosis (TB) is a global infectious disease posing a serious threat to human health, caused by Mycobacterium tuberculosis (MTB) infection. Although vaccination is the most effective way to prevent...
Efforts of rabies elimination with a One Health approach and SARE tools in Ethiopia
2024
Rabies is a viral zoonosis which affects nearly every region of the world. Once symptoms appear, the disease is 100 % fatal, although it is 100 % preventable through vaccination. Human rabies is typically...
Public health significance, seroprevalence and associated risk factors of bovine brucellosis in selected dairy farms of North Shewa zone, Amhara region, Ethiopia
2024
Bovine brucellosis is a zoonotic disease that causes economic crises in dairy cattle production and poses public health impact. A cross sectional study was conducted between November 2021 to April 2022...
Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective
2024
Neuropsychiatric disorders (NDDs) have been associated with maternal immune activation (MIA) in epidemiologic studies, such as prospective birth cohort studies. There is evidence linking maternal infectious...
Global, regional, and national burden of malaria, 1990–2021: Findings from the global burden of disease study 2021
2024
Malaria is an infectious disease transmitted by mosquitoes and caused by Plasmodium parasites. This study analyzes data from the Global Burden of Disease (GBD) Study 2021 to systematically assess global...
A mathematical model for understanding and controlling monkeypox transmission dynamics in the USA and its implications for future epidemic management
2024
Although outbreaks of human monkeypox (mpox) caused by the monkeypox virus (MPXV) have decreased globally, little is known about the short-term dynamics of this disease, thus highlighting a critical...
Emergencies of zoonotic diseases, drivers, and the role of artificial intelligence in tracking the epidemic and pandemics
2024
Zoonotic illnesses are defined as diseases that can be transmitted from animals to humans through various channels. More than sixty percent of disease-causing organisms capable of affecting humans are...
Influences of vaginal microbiota on human papillomavirus infection and host immune regulation: What we have learned?
2023
The alteration of microbiota in different host niches has been associated with numerous adverse health outcomes that affect millions of human patients annually. In last few years the interest has been...
A new scoring system to predict tuberculosis among South-Tunisian patients with lymphocytic meningitis
2023
Death and poor outcome due to Tuberculous meningitis (TBM) is greatly influenced by the delayed treatment initiation, which often occurs in lymphocytic meningitis (LM). This study aimed to propose an...
Decoding Infection and Transmission: Deciphering the mystery of infectious diseases from data-based research
2023
Infectious diseases, also known as communicable diseases, are a continuous threat to humans. Infectious disease itself is results of multifactorial effects, and a multidisciplinary research field. How...
Efficacy and safety of directly acting antiviral drugs in HCV patients with HIV in liver transplantation: A meta-analysis
2023
HCV/HIV co-infections were initially a contentious consideration for liver transplantation, primarily due to their suboptimal response to interferon-based treatments and unfavorable post-transplantation...
The prevalence, diagnosis, and dissemination of mcr-1 in colistin resistance: Progress and challenge
2023
Considered as the last defense line against Gram-negative bacteria, colistin is particularly effective against multiple drug-resistant bacteria such as multi-drug resistance (MDR) and carbapenem-resistant...
Observation of intestinal flora diversity with the parasites infection process in a nonlethal malaria model of BALB/c mice induced by Plasmodium yoelii 17XNL strain
2023
Gut flora plays an important role in infectious diseases such as malaria, but few studies are conducted in the associated filed of murine malaria infected with Plasmodium yoelii 17XNL (Py 17XNL). In...
The impact of environmental and host factors on wolbachia density and efficacy as a biological tool
2023
Wolbachia, a bacterium found naturally in some species of Aedes and Culex mosquitoes, has gained significant attention for it's potential in controlling mosquito-borne diseases and suppressing mosquito...