A novel approach to disease modeling: The SEIVR model with a vulnerable compartment
2025
The SEIR model is a cornerstone in epidemiology and offers insights into the spread of infectious diseases. It extends the basic SIR model to include an Exposed (E) compartment, to account for the incubation...
Trends in the minimum inhibitory concentrations for four agents against methicillin-resistant Staphylococcus aureus in bloodstream infections in China: a 6-year multi-center study from 2017 to 2022
2025
Staphylococcus aureus bacteremia is a critical and pernicious infection, and in particular methicillin-resistant Staphylococcus aureus (MRSA) is increasing in treatment failure. This study analyzed...
Genomic insights into disease vectors: Divergent evolution of mosquitoes, tsetse flies, sand flies and kissing bugs
2025
Vector-borne diseases pose major global health challenges, with mosquitoes, tsetse flies, and sand flies serving as key insect vectors. This review explores the genomic basis of hematophagy, reproduction,...
Decoding the Bite: Sensory cues, host heterogeneity, and pathogen manipulation in mosquito host-seeking behavior
2025
Mosquitoes, primarily females, require blood meals for reproduction, making them prolific biters and major vectors of diseases such as malaria, dengue, Zika, and West Nile. This review synthesizes the...
Sexual development in apicomplexan parasites: past and future
2025
Sexual development is an important process in eukaryotic organisms that involves the fusion of gametes to produce genetically diverse offspring. In apicomplexan parasites, sexual development is crucial...
Genome-wide identification of characteristic nucleotide fragments for surveillance and subtype typing of influenza A viruses
2025
Influenza A viruses, members of the Orthomyxoviridae family, are major causative agents of past flu pandemics and can infect a wide range of hosts depending on their hemagglutinin (HA) and neuraminidase...
Recurring diphtheria outbreaks in Nigeria: A holistic review of challenges, knowledge and strategic recommendations for control
2025
Diphtheria is a vaccine-preventable bacterial disease that has contributed to the large number of deaths in Nigeria. There have been numerous outbreaks after the COVID-19 pandemic. However, the challenges...
Response to Chikungunya fever in China: are we ready?
2025
Chikungunya fever (CHIK) is caused by the Chikungunya virus (CHIKV), a mosquito-borne RNA virus of the Alphavirus genus (family Togaviridae). CHIK has been imported and caused several local epidemic...
Mosquitoes as pesticide disseminators: Advancing pyriproxyfen-based technologies for next-generation vector control
2025
Mosquito-borne diseases, including dengue, Zika, chikungunya, and malaria, pose significant global health challenges, exacerbated by rising insecticide resistance in key vectors like Aedes and Anopheles....
NMCR-6, a novel nonmobile colistin resistance gene in Vibrio bacteria: full characterization and global perspective
2025
Amid rising bacterial resistance, polymyxins are a critical last resort against multidrug-resistant Gram-negative infections. Understanding and predicting the emergence of novel, nonmobile colistin...
Revolutionizing infectious disease surveillance: Multi-omics technologies and AI-driven integration
2025
The integration of advanced technologies, including next-generation sequencing, multiomics approaches, and artificial intelligence (AI), has revolutionized pathogen surveillance and preparedness. Multiomics...
Decoding the host-pathogen-environment interaction: Integrated insights into Helicobacter pylori virulence and epidemiological transmission
2025
A primary cause of peptic ulcer, gastric carcinoma, and chronic gastritis is the Gram-negative pathogenic bacteria Helicobacter pylori (H. pylori). Grasping its mechanisms of pathogenesis and transmission...
Establishment and characterization of a novel cell line from Culex tritaeniorhynchus for arbovirus and arthropod-specific virus research
2025
To establish and systematically characterize a contemporary cell line derived from Culex. tritaeniorhynchus collected in Hubei Province, China, with the goal of providing a standardized in vitro tool...
Current therapies and advances in the development pipeline of pre-erythrocytic preventive drugs
2025
Malaria prevention remains a cornerstone strategy for reducing global mortality and morbidity. Although the two World Health Organization (WHO)-recommended pre-erythrocytic malaria vaccines, RTS,S/AS01...
Recent malaria outbreak in the USA: Risk of and response to malaria reintroduction in non-endemic regions
2024
The emergence of locally transmitted Plasmodium vivax malaria in Florida from May to July 2023 underscores the persistent threat of malaria reintroduction in non-endemic regions. The increasing instances...
S–6P exhibits better immunogenicity than S–2P at lower doses of COVID-19 mRNA vaccines
2024
The objective of this study was to determine whether a new combination of immunogens could be more effective than the S–2P design in terms of eliciting an immune response. The study aimed to use a unified...
Progress of exosomes in diagnosis of tuberculosis
2024
Tuberculosis (TB) is a globally prevalent infectious disease caused by Mycobacterium tuberculosis. A majority of TB patients develop a latent infection, making disease diagnosis more challenging. However,...
Global, regional, and national burden of dengue, 1990–2021: Findings from the global burden of disease study 2021
2024
Dengue is an acute viral infectious disease caused by the dengue virus and transmitted through mosquitoes. Although numerous studies have examined the global burden of dengue, comprehensive and systematic...
Machine learning models for predicting residual malaria infections using environmental factors: A case study of the Jazan region, Kingdom of Saudi Arabia
2024
Malaria is a global public health problem affecting more than 100 countries. Meteorological factors on the other hand represent a major driving force behind malaria transmission and other vector-borne...
Characterizations of Prototheca wickerhamii clinical isolates and their interactions with macrophages
2024
As global climate change exacerbates, the emergence of rare pathogens causing outbreaks is on the rise, with Prototheca species becoming notable threats. Within the protothecosis science popularization...
Efforts of rabies elimination with a One Health approach and SARE tools in Ethiopia
2024
Rabies is a viral zoonosis which affects nearly every region of the world. Once symptoms appear, the disease is 100 % fatal, although it is 100 % preventable through vaccination. Human rabies is typically...
Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective
2024
Neuropsychiatric disorders (NDDs) have been associated with maternal immune activation (MIA) in epidemiologic studies, such as prospective birth cohort studies. There is evidence linking maternal infectious...
Global, regional, and national burden of malaria, 1990–2021: Findings from the global burden of disease study 2021
2024
Malaria is an infectious disease transmitted by mosquitoes and caused by Plasmodium parasites. This study analyzes data from the Global Burden of Disease (GBD) Study 2021 to systematically assess global...
A mathematical model for understanding and controlling monkeypox transmission dynamics in the USA and its implications for future epidemic management
2024
Although outbreaks of human monkeypox (mpox) caused by the monkeypox virus (MPXV) have decreased globally, little is known about the short-term dynamics of this disease, thus highlighting a critical...
Emergencies of zoonotic diseases, drivers, and the role of artificial intelligence in tracking the epidemic and pandemics
2024
Zoonotic illnesses are defined as diseases that can be transmitted from animals to humans through various channels. More than sixty percent of disease-causing organisms capable of affecting humans are...