Gut dysbiosis-induced cerebral clock suppression mediates deltamethrin immunotoxicity via the brain-thyroid-immune Axis
2027
The paradigm for understanding how environmental pollutants affect aquatic organisms is shifting from direct tissue damage to remote regulation via complex inter-system communication. However, the exact...
The ecotoxicity of environmental 6PPD exposure to Onychostoma macrolepis: A correlative water–gut microbial framework
2027
The tire antioxidant 6PPD is increasingly detected in traffic-impacted aquatic environments, yet its potential effects on native freshwater fish and associated microbial communities in inland river...
Benzothiazoles and benzotriazoles in the dust and human urine samples from the e-waste recycling industry: occurrence, distribution, and occupational exposure assessment
2027
Benzothiazoles (BTHs) and benzotriazoles (BTRs) are high production volume chemicals widely incorporated into electronic products, yet their environmental occurrence and potential occupational exposure...
Insights into the immunotoxicity of typical PPD and PPDQ compounds through integrating network toxicology and experimental validation
2027
The rapid expansion of the automotive industry has led to increasing environmental release of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6PPDQ). Notably, N-isopropyl-N′-phenyl-1,4-phenylenediamine...
Differential physiological and biochemical responses to herbicide stress: Why Trachemys scripta elegans outperforms native turtles?
2027
Herbicide pollution poses a growing threat to freshwater ecosystems, yet their sublethal effects on freshwater turtles remain largely understudied. Invasive turtle species are considered to be more...
Associations between environmental endocrine-disrupting chemicals exposure and cardiometabolic markers: integrated epidemiological and in silico analyses
2027
Environmental endocrine-disrupting chemicals (EDCs) are increasingly implicated in cardiometabolic disorders. Conventional studies have focused on specific types of pollutants or individual cardiometabolic...
Heavy metal sources and associated ecological and human health risks in coastal islands of the Ganges–Brahmaputra–Meghna delta, Bangladesh
2026
The coastal islands of the Ganges–Brahmaputra–Meghna delta are ecologically vital but increasingly threatened by rising heavy metal contamination from natural and anthropogenic sources. This study assessed...
Ecotoxicity of emerging pollutants: Interactive impact of polystyrene nanoplastics and Metanil yellow on Artemia salina
2026
Increasing concern surrounds the impact of pollutants on marine ecosystems, particularly the combined effects of nanoplastics and synthetic dyes. This present study evaluated the toxicity of 100 nm...
Impacts of drilling on soil and groundwater heavy metal pollution: A comprehensive review
2026
This review focuses on the environmental consequences of drilling activities, specifically concerning soil and groundwater contamination, biodiversity loss, and air and water pollution. Drilling operations...
Metabolomic signature and prediction of incident lung cancer from air pollution exposure in a national cohort: Unraveling the link and underlying role
2026
Air pollution exposure has been identified as a pathogenic factor of lung cancer, whereas the metabolic profile disturbance involved and its underlying role remain unclear while attract much attent...
Urinary nitrogen flame retardants and renal dysfunction: Population evidence with ferroptosis-related mediation
2026
Nitrogen flame retardants (NFRs) are a class of emerging environmental pollutants with nephrotoxic effects, yet their mechanistic contributions to kidney stone formation remain unclear. In this case-control...
Role of Gal-3 mediated lysophagy in arsenic-induced chicken hepatocyte injury
2026
Arsenic is one of the important pollutants in the environment. As the main target organ of arsenic exposure, the liver contains a large number of lysosomes, which play an important role in liver injury...
Chlorine release induced by contact electrification between polyvinyl chloride microplastics and moist air
2026
Polyvinyl chloride (PVC) microplastics (MPs) are prevalent in the atmosphere and, as they migrate, inevitably interact with flowing moist air. Despite this, our understanding of the surface chemistry...
Generation mechanisms, environmental behaviors, and treatment technologies of conventional and emerging contaminants in landfill leachate: A review
2026
Landfill leachate, derived from municipal solid waste landfills, is generated by external factors (e.g., rainfall erosion, solar radiation) and internal processes (e.g., physical sedimentation, chemical...
Time-dependent toxicity and key toxic components of five neonicotinoid mixtures under environmental concentrations in the Yangtze River Basin
2026
Neonicotinoids (NEOs), as widely used insecticides, have raised increasing concerns regarding their ecological impacts. Current knowledge on the mixture toxicity of NEOs, particularly under environmental...
First in situ application of a non-invasive sampling approach to assess pesticide effects on amphibian enzymatic activities
2026
Amphibians are particularly vulnerable to pesticide exposures, according to numerous laboratory and field studies. Enzymatic activities in biological tissues and body condition are usually proposed...
Digestive enzyme-driven desorption of phenanthrene from microplastics in a simulated human gut
2026
Microplastics (MPs) are ubiquitous in aquatic environments and readily adsorb surrounding pollutants during transport. Upon ingestion, these pollutant-laden MPs may release their adsorbed contaminants...
Vanadium in agroecosystems: Toxicity across the soil-microbe-plant-human continuum
2026
Vanadium (V) is a key element for multiple industrial applications due to its exceptional physicochemical properties. Nevertheless, the extensive utilization of V has raised significant environmental...
Dispersed black carbon mediates intergenerational BDE-47 toxicity in zebrafish by regulating steroidogenesis: Attenuated parental toxicity with exacerbated offspring impairment
2026
Persistent organic pollutants (POPs) are a class of long-lasting, high-risk contaminants in aquatic environments, and their toxicity is modulated by fluctuations in environmental factors. Dispersed...
A semi-enclosed bay as a pharmaceutical hotspot and an open strait as a regional reservoir: Contrasting pharmaceuticals and antibiotic resistance
2026
Pharmaceuticals and antibiotic resistance genes (ARGs) are increasingly recognized as emerging pollutants in coastal ecosystems, yet their contrasting behaviors in open straits versus semi-enclosed...
The differential cardiotoxicity effects and molecular mechanisms induced by two emerging organophosphorus flame retardants (EHDPP and DPHP) with similar parent structures in zebrafish
2026
Herein, we systematically compared the cardiotoxicity effects of two structurally similar organophosphate flame retardants (OPFRs; EHDPP and its major metabolite DPHP) using zebrafishi as a model organism....
Early-pregnancy exposure to persistent organic pollutants and bile acid alterations in relation to gestational glucose–lipid homeostasis
2026
Persistent Organic Pollutants (POPs) are globally distributed, bioaccumulative chemicals that are increasingly implicated as environmental contributors to metabolic toxicity; however, the mechanistic...
Multimedia distribution and ecological risks of bisphenol a in the Arctic Ocean: Insights from the east Siberian and Chukchi seas
2026
Bisphenol A (BPA), a widely used chemical and known endocrine-disrupting chemical (EDC), has estrogen activity and the ability to migrate over long distances, which could pose a potential threat to...
Life cycle benzophenone 1 exposure induces anxiety- and depression-like behaviors in zebrafish via endoplasmic reticulum stress-mediated dopaminergic system dysfunction
2026
Environmental exposure to benzophenones (BPs) has emerged as a potential risk factor for the comorbidity of anxiety and depression. Among them, BP1 has attracted increasing attention due to its potential...
From molecules to outcome: A network toxicology analysis and adverse outcome pathway for 6-PPDQ-induced metabolic dysfunction-associated fatty liver disease
2026
6-PPDQ readily accumulates in the liver, disrupting hepatic glucose and lipid homeostasis and precipitating liver injury. Whether it can also trigger the chronic metabolic disease metabolic dysfunction-associated...