Tissue-specific bioaccumulation and hepatotoxicity of 6PPD and 6PPD-Quinone in zebrafish
2026
Tire additive 6PPD and its transformation product 6PPD-Quinone have garnered substantial attention due to their association with mass salmon mortality events. This study investigated the bioaccumulation...
HFPO-DA and PFOA exert differential combined toxicity with Cd in Paramecium: growth, behavior and molecular insights
2026
Hexafluoropropylene oxide dimer acid (HFPO-DA) has come into use as an alternative to perfluorooctanoic acid (PFOA), but it remains elusive whether their comparative toxicities in aquatic organisms...
Assessing the health risks of environmentally relevant concentrations of fluoride and phenanthrene: Neurobehavioral toxicity induced in zebrafish through disruption of the microbiome-gut-brain axis and suppression of Wnt/β-catenin signalling
2026
Chronic exposure to fluoride and phenanthrene is recognized as a significant risk factor for neurobehavioral toxicity, and the gut-brain axis has been identified as a key mechanism in the development...
Time-dependent toxicity and key toxic components of five neonicotinoid mixtures under environmental concentrations in the Yangtze River Basin
2026
Neonicotinoids (NEOs), as widely used insecticides, have raised increasing concerns regarding their ecological impacts. Current knowledge on the mixture toxicity of NEOs, particularly under environmental...
New Approach Methodologies (NAMs) reveal triphenyl phosphate (TPP) disrupts lipid metabolism in estuarine fish via PPARγ activation: A concentration-dependent transcriptomic and molecular docking study
2026
There is an urgent need for a more efficient and ethical approach to chemical toxicity assessment. The emergence of New Approach Methodologies (NAMs) based on fish embryos transcriptomics provides a...
First in situ application of a non-invasive sampling approach to assess pesticide effects on amphibian enzymatic activities
2026
Amphibians are particularly vulnerable to pesticide exposures, according to numerous laboratory and field studies. Enzymatic activities in biological tissues and body condition are usually proposed...
Source analysis of heavy metals in groundwater of centralized drinking water sources and seasonal variations of health risks in Wuzhou City, Pearl River Delta, China
2026
Groundwater serves as a critical source for centralized drinking water, particularly in rapidly urbanizing regions, yet its quality is increasingly threatened by heavy metals (HMs) pollution. Systematic...
Distinct bacterial community structure, assembly and functions between aged and multiple petroleum-contaminated sites
2026
Petroleum contamination threatens soil ecosystems, but microbial responses in multi-contaminated area (MCA) and aged-contaminated area (ACA) remain unclear. This study compared bacterial communities...
The hidden mediator between polycyclic aromatic hydrocarbon exposure and cognitive function of elder adults: FT3/FT4 ratio
2026
Polycyclic aromatic hydrocarbons (PAHs) are neurotoxicants that may induce cognitive deficits via thyroid dysfunction. Older adults, due to physiological decline, are more susceptible to such toxicants....
Neurotoxicity of typical liquid crystal monomers in zebrafish: Disruption of neurotransmitter pathways and underlying mechanisms
2026
The neurotoxicological risks associated with liquid crystal monomers (LCMs), widely used in display technologies, have raised significant ecological and health concerns, yet they remain insufficiently...
Chlorpyrifos cardiotoxic responses may be mediated by phagocytic activation in larval zebrafish
2026
Chlorpyrifos, an organophosphate insecticide, is used throughout the world, with frequent detections being reported in both surface and ground water. The neurotoxic effects of chlorpyrifos have been...
Influencing mechanisms of multiple factors on seasonal variation of atmospheric polybrominated diphenyl ethers and their internal exposure risk in cold region
2026
Atmospheric pollutants exhibit seasonal variations in their concentrations and associated exposure risk due to seasonal alternations. The influencing mechanisms of multiple factors on the seasonal variation...
Deciphering the TLR-mediated immunotoxic adverse outcome pathway of pentachlorophenol in marine medaka (Oryzias melastigma)
2026
Pentachlorophenol (PCP) is a persistent organic pollutant commonly detected in marine environments, and recent studies have confirmed its adverse effects on the immune systems of aquatic organisms....
Microplastic-mediated enrichment of polycyclic aromatic hydrocarbons (PAHs) and their toxic effects on coral symbionts: Evidence from oxidative stress and energy metabolic disturbance
2026
Microplastics (MPs) and polycyclic aromatic hydrocarbons (PAHs) are persistent organic pollutants prevalent in coral reef ecosystems. MPs may exacerbate PAH bioaccumulation and toxicity via a “Trojan...
Childhood exposure to per- and polyfluoroalkyl substances in educational environments: Arising from stationery and implications for health
2026
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous in consumer manufacturing, but their occurrence in stationery products and the associated exposure risk to children in educational environments...
Polymer-specific toxicity of microplastics to Microcystis aeruginosa: Growth inhibition, physiological responses, and molecular mechanisms
2026
Microplastics (MPs), as emerging contaminants, are increasingly prevalent in the environment, posing significant threats to ecosystems and human health. However, the ecological risks associated with...
Polystyrene microplastics disrupt osteogenic differentiation via lysosome-mediated mitochondrial dysfunction: Protective role of mTOR signaling
2026
Polystyrene microplastics (PS-MPs), increasingly detected in aquatic environments, raise health concerns for humans and animals. However, their specific cellular effects remain incompletely characterized....
Bridging interspecific sensitivity gaps in Cladocera: A review of computational frameworks for ecological risk assessment
2026
Aquatic environment protection faces escalating challenges from emerging contaminants, which present complex ecological risks. Cladocera, ecologically pivotal crustacean zooplankton in lentic freshwater...
Digestive enzyme-driven desorption of phenanthrene from microplastics in a simulated human gut
2026
Microplastics (MPs) are ubiquitous in aquatic environments and readily adsorb surrounding pollutants during transport. Upon ingestion, these pollutant-laden MPs may release their adsorbed contaminants...
Comparative algal toxicity assessment of a novel hydrophobic ionic liquid used in metal extraction processes
2026
The task-specific ionic liquid di-[trioctyl-(8-phenyloctyl)-phosphonium] pamoate, [TOPP]2[PAM], was designed as a highly hydrophobic substance for “greener” metal extraction. During metal extraction,...
Pollution by polar pesticides and pharmaceuticals and risk assessment in surface water bodies along the French Mediterranean coast: Complementarity of target and non-target screenings
2025
Anthropogenic activities are the source of a wide range of organic micropollutants (OMPs) found in all water bodies. Among them, pharmaceuticals and pesticides are the most found in watercourses and...
Synergistic mechanism of modified nZVI and Citrobacter reshaping sludge microbiome drives co-removal of HBCD and nutrients in municipal wastewater
2025
Hexabromocyclododecane (HBCD), a persistent and toxic brominated flame retardant, poses severe ecological and health risks due to its bioaccumulation and endocrine-disrupting effects. Effective removal...
BiOI-embedded molecularly imprinted polymer-functionalized BiOIO3 photocatalyst with spatially coupled dual-active sites for efficient selective citalopram removal
2025
Achieving high-selectivity priority identification and degradation of target pollutants in complex water environments using photocatalytic technology remain challenging. Herein, we proposed a novel...
Flexible Au tape-based SERS sensor for atmospheric microplastic detection
2025
The analysis of microplastics is important due to their widespread presence and potential health impacts. While most research has focused on investigating microplastics in aqueous environments, real-time...
Mechanisms of three typical endocrine-disrupting chemicals causing myocardial infarction: Gene-level computational modeling
2025
Endocrine disruptors chemicals (EDCs), as environmental pollutants, have been recognized as potential risk factors for myocardial infarction (MI), but the specific mechanism of action is still unclear....