Integration-recognition triggered RPA-PfAgo fluorescence biosensor for one-pot detection assemblage A and B of Giardia duodenalis
March 2026
Giardia duodenalis is a common intestinal protozoan that causes diarrhea, vomiting in humans and mammals. Consequently, early diagnosis plays a crucial role in the control giardiasis. Here we combined...
CARS2 modulates cell malignant transformation induced by IFN-γ through manipulation of arginine metabolism in bovine mammary epithelial cells
March 2026
Malignant transformation induced by IFN-γ in bovine mammary epithelial cells (BMECs) is a pathological process that affects multiple cellular functions, including impaired milk fat synthesis. But the...
Confronting bacterial mastitis: From pathogen diversity to sustainable control in the post-antibiotic era
March 2026
Bacterial mastitis (BM) is a purulent inflammatory disease caused by a variety of pathogenic microorganisms, which is common in dairy cows, posing a major threat to animal husbandry. This article reviews...
Flagellin: A crucial virulence factor coordinating bacterial pathogenesis and host immune responses
March 2026
Flagella serve as the motility organs of bacteria, possessing not only the capability to facilitate movement through mechanisms such as rotation and swinging but also playing a crucial role in the establishment...
Structural and functional characterization of reovirus S1 gene-encoded proteins: Implications for viral pathogenesis and rational vaccine design
March 2026
Avian reovirus (ARV) represents a significant avian pathogen that imposes substantial economic burdens on the global poultry industry. Although it is primarily associated with arthritis and tenosynovitis,...
Recent progress on rapid diagnostic methods for viral diseases
March 2026
Viral diseases pose a persistent and evolving threat to global public health, with far-reaching impacts on clinical practice, epidemiology, and socioeconomic stability. Over the past decade, frequent...
Zoonotic diseases in low and middle-income countries (LMICs): Economic burden, challenges, strategies, and future directions
March 2026
More than 200 zoonotic diseases are known to affect humans, representing a significant share of both emerging and existing infectious diseases worldwide. These diseases pose a major global public health...
Viola yedoensis Makiho alleviates LPS-induced oxidative stress and inflammatory injury by regulating Nrf2 and NF-κB/NLRP3 signaling pathways in broilers
March 2026
Viola yedoensis Makiho (VYM), a traditional Chinese herbal medicine with anti-inflammatory and antioxidative properties, was investigated for its effects on lipopolysaccharide (LPS)-induced liver damage...
Will avian influenza virus (H10N3) cause a major public health threat?
March 2026
Avian influenza viruses (AIVs) cause significant economic losses to the poultry industry and pose a persistent threat to public health due to their capacity for cross-species infection of mammals and...
Zoonotic diseases (zoonoses): Definitions, classifications, hazards, and prevention strategies
March 2026
Zoonotic diseases, also known as zoonoses, are infectious diseases that can be transmitted between humans and animals, including livestock, wildlife, and companion animals. These diseases have become...
Trichomonas vaginalis inhibits autophagy in VK2/E6E7 cells via the AMPK-ULK1 pathway
March 2026
Trichomonas vaginalis (T. vaginalis) is an infectious protozoan parasite responsible for trichomoniasis, which is one of the world's most pervasive non-viral sexually transmitted infections globally....
Toxic Effects and Detoxification Strategies of Aflatoxin B1
Available online 16 February 2026
Aflatoxin B1 (AFB1), a highly carcinogenic mycotoxin produced primarily by Aspergillus flavus and A. parasiticus, is classified as a Group 1 carcinogen by the International Agency for Research on Cancer...
Orf Virus Remodels Tumor Immune Microenvironment in Melanoma Mouse Models Revealed by Single-Cell RNA Sequencing
Available online 13 February 2026
Oncolytic viruses (OVs) display tumor-suppressing capacity through direct oncolysis and induction of anti-tumor immunity. Orf virus (ORFV) has shown considerable properties in inducing tumor cell pyroptosis...
Synergistic effects of arsenic and dibutyl phthalate on renal autophagy inhibition and fibrosis based on transcriptomic and computational toxicology
Available online 10 February 2026
As an endocrine-disrupting chemical, dibutyl phthalate (DBP) is extensively utilized in industry, and it poses substantial hazards to both ecological and human health. Arsenic (As) is prevalent in everyday...
Bacillus subtilis and Bacillus megaterium alleviate colitis induced by DSS and depression-like behavior through the modulation of intestinal flora
Available online 5 February 2026
Inflammatory bowel disease (IBD) induces chronic intestinal inflammation and, in severe cases, may promote the development of colon cancer. IBD is frequently accompanied by psychiatric comorbidities...
A replication-deficient live vaccine candidate against the rabies virus infection in mice
Available online 5 February 2026
Generating recombinant viruses lacking an essential gene for producing infective viral particles represents a promising approach to developing safer live viral vaccines. The envelope-spikes glycoprotein...
Orf virus impairs tumor-promoting capacity of tumor-derived extracellular vesicles
Available online 5 February 2026
Oncolytic viruses (OVs) can selectively replicate in tumor cells and trigger anti-tumor immunity. However, it remains unclear whether OVs can target the process of "information transmission" between...
A narrative review for antibacterials design and modification targeting outer membrane against Gram-negative bacteria
Available online 1 February 2026
With the increasing prevalence of refractory multidrug-resistant Gram-negative bacterial infections, the development of novel antibacterials targeting Gram-negative pathogens has become an urgent priority....
Centennial African swine fever: A comprehensive overview
Available online 18 January 2026
African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious and often fatal disease that affects domestic pigs and wild boars. Since its initial identification in Kenya...
Microbiota and metabolic perturbations in bull semen: Links to heat stress-induced quality decline
Available online 15 January 2026
Heat stress (HS) poses a major environmental issue that negatively impacts the reproductive efficiency of bulls. However, the complex interactions among HS-induced declines in semen quality, sperm metabolism,...
A multidimensional analysis of the pathogenesis of endometritis in dairy cows: A review
Available online 13 January 2026
Bovine endometritis is a major reproductive disease in postpartum dairy cows that significantly undermines herd productivity and the long-term economic sustainability of dairy operations globally. This...
Evaluation of the immune protective efficacy afforded by a telomerase interacting protein OTU in Eimeria tenella
Available online 12 January 2026
Chicken coccidiosis threatens the development of the poultry industry. The protective antigen genes applied to genetically engineered vaccines against Eimeria tenella (E. tenella) include TA4, SO7,...
Mogroside V inhibits the tunicamycin-induced endoplasmic reticulum stress in Caco-2 cells
Available online 12 January 2026
Endoplasmic reticulum stress (ERS) is a key driver of intestinal epithelial barrier dysfunction and inflammation, pathological features implicated in gastrointestinal disorders. Mogroside V (MV), a...
Intestinal microbiota dysbiosis in bovine mastitis: Its role and strategies for prevention and control targeting intestinal microbiota
Available online 3 January 2026
Mastitis in dairy cattle persists as a significant global challenge, imposing substantial economic losses and compromising animal welfare. Conventional antibiotic-based protocols remain clinically effective...
The effects of serotonin (5-hydroxytryptamine) on histone acetylation in early porcine embryos
December 2025
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter with emerging roles in mammalian embryonic development. However, its epigenetic effects on early porcine embryos remain poorly understood....