CARS2 modulates cell malignant transformation induced by IFN-γ through manipulation of arginine metabolism in bovine mammary epithelial cells
Available online 21 July 2025
Malignant transformation induced by IFN-γ in bovine mammary epithelial cells (BMECs) is a pathological process that affect multiple cellular functions including impaired milk fat synthesis. But the...
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Integration-recognition triggered RPA-PfAgo fluorescence biosensor for one-pot detection assemblage A and B of Giardia duodenalis
Available online 16 July 2025
Giardia duodenalis is a common intestinal protozoan that causes diarrhea, vomiting in humans and mammals. Consequently, a early diagnoses plays a crucial role in the control giardiasis. Here we combined...
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Emerging challenges and advances in porcine viral pathogenesis: A decade in review
Available online 4 July 2025
The past decade has witnessed unprecedented challenges posed by porcine viruses, driven by globalization and intensive livestock practices. This review consolidates critical findings from recent literature,...
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Omega-3 polyunsaturated fatty acids, especially DHA and EPA, remold gut microbiota to suppress inflammation in rabbits with atherosclerosis
June 2025
Atherosclerosis (AS) caused by a high-fat diet becomes a critical cause of cardiovascular diseases, which has been regarded as an urgent public health problem. Omega-3 polyunsaturated fatty acids (omega-3...
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Uncovering the profile of ubiquitination motif in catalytic proteins using sequence contextual features
June 2025
Ubiquitin molecules modify their target protein by conjugating the amino group of lysine side chain, thereby regulating the activity and function of most intracellular proteins. However, within multiple...
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Pathogens infected or carried by exotic pets pose emerging threat to human health
June 2025
Exotic pets refer to a variety of uncommon pets that are different from traditional pets such as cats, dogs, birds and fish. Due to the convenience of international travel, the diversity and globalization...
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Virulence factors in biofilm formation and therapeutic strategies for Staphylococcus aureus: A review
June 2025
Staphylococcus aureus (S. aureus) is a significant human pathogen known for its ability to form biofilms, which increase its resistance to antibiotics and immune defenses. This review delves into the...
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CRISPR/Cas13a-based RNA analysis for non-enrichment Listeria monocytogenes in food
June 2025
Listeria monocytogenes (LM) is an opportunistic and invasive Gram-positive bacterium. They can grow in foods that are closely related to humans. However, the development of rapid and sensitive methods...
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Prevalence of zoonotic diseases in the Northeastern region, one health perspective
June 2025
Zoonotic diseases are long known for their disease transmission from animals to human beings or from human beings to animals. These illnesses are primarily spread by the ingestion of contaminated food...
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Progress in the molecular epidemiology of chikungunya virus
June 2025
In recent years, with the global climate warming up, Aedes albopictus and Aedes aegypti have gradually expanded their range of activities from the tropics to subtropical and temperate regions, which...
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Host immune response to Cryptosporidium spp.: Insights and perspectives for vaccine development
June 2025
Cryptosporidium, a zoonotic protozoan parasite, poses a significant threat to both public health and the livestock sectors globally, leading to lethal diarrheal disease and associated economic losses....
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Human papillomavirus 115 infects Yili horses
June 2025
The E6 gene of human papillomavirus 115 (HPV-115) has been amplified in samples from Yili horses. This study aims to investigate the unexpected presence of HPV-115 in horses, considering whether it...
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The cellular host factors for severe fever with thrombocytopenia syndrome virus infection
June 2025
Severe fever with thrombocytopenia syndrome (SFTS) is a newly discovered life-threatening disease caused by SFTS virus (SFTSV), an emerging tick-borne bunyavirus. The severity of SFTSV infection can...
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Berberine hydrochloride attenuates avian pathogenic Escherichia coli-induced macrophage inflammation via NAD⁺/NADH-SIRT1-NF-κB regulatory axis
Available online 12 June 2025
Avian pathogenic Escherichia coli (APEC) poses a significant threat to the poultry industry, primarily causing multisystemic infections through respiratory tract invasion, which can lead to acute mortality....
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Host protein eEF1A1 affected the infection of Cryptosporidium parvum through interacting with CpHSP90
Available online 31 May 2025
Cryptosporidium parvum (C. parvum) is a common protozoan pathogen that causes severe diarrhea in humans and animals. HSP90 plays a key role in eukaryotic growth and development. Previous studies have...
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A comprehensive review of tick-borne disease epidemiology, clinical manifestations, pathogenesis, and prevention
Available online 21 May 2025
Ticks are arthropod vectors that transmit pathogens by biting and bloodsucking, and they have been found to carry or transmit over one hundred types of pathogens. The majority of these pathogens are...
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Advances in endometrial receptivity and embryo implantation by multi-omics techniques
Available online 19 May 2025
Endometrial receptivity is a critical determinant of successful embryo implantation, yet current clinical assessments (e.g., ultrasound, hysteroscopy) primarily focus on morphological evaluation and...
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Current review for biological control of six common environmental mycotoxins
Available online 15 May 2025
Aflatoxin B1 (AFB1), zearalenone (ZEN), deoxynivalenol (DON), T-2 toxin (T-2), fumonisin B1 (FB1) and ochratoxin A (OTA) are the 6 most common environmental mycotoxins that are widely present in food...
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First report of a pure growth of Providencia stuartii infection in the United Kingdom isolated from a dog with suppurative otitis
Available online 13 May 2025
The authors report a seven-year-old dog imported from Romania with otitis caused by a pure growth of Providencia stuartii. This has rarely been isolated in the UK but never been described as the single...
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Epidemiological survey of cat infectious diseases in China from 2022 to 2023
Available online 10 April 2025
The study investigates and analyzes the positive rates of 11 cat pathogens in 14 provinces across China from 2022 to 2023. The aim is to enhance understanding of the epidemiological characteristics...
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Trichomonas vaginalis inhibits autophagy in VK2/E6E7 cells via the AMPK-ULK1 pathway
Available online 7 April 2025
Trichomonas vaginalis (T. vaginalis) is an infectious protozoan parasite responsible for trichomoniasis, which is one of the world's most pervasive non-viral sexually transmitted infections globally....
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The effects of serotonin (5-hydroxytryptamine) on histone acetylation in early porcine embryos
Available online 4 April 2025
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter with emerging roles in mammalian embryonic development. However, its epigenetic effects on early porcine embryos remain poorly understood....
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Combining herbal fermentation with Lactobacillus expressing recombinant PEDV-S1 protein offers protection against PEDV infection
Available online 2 April 2025
The porcine epidemic diarrhea virus (PEDV) causes porcine epidemic diarrhea, an acute, highly contagious infectious disease that has caused significant economic losses in the global pig industry. Due...
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Oral administration of antimicrobial peptide MPX ameliorates orchitis and inflammatory damage in other organs
March 2025
Bacterial orchitis has a very high percentage of reproductive diseases in males. Therefore, specific medicines are urgently needed to prevent and treat orchitis. Antimicrobial peptides (AMPs) are widely...
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Emerging role of ruminal microbiota in the development of perinatal bovine diseases
March 2025
As the largest and most important digestive organ of ruminant, rumen was a natural fermentation tank of dairy cows, in which there were many kinds of microorganisms. These microorganisms constituted...
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