Recent Articles

Clinically relevant variants detected in Chinese children with global developmental delay/intellectual disability: An exome-wide sequencing study

July 2025

Yimeng Qiao | Nan Lv | Tongchuan Li | Ye Cheng | Yunqian Li | Jiqiang Dong | Meimei Han | Yang Gu | Qing Shang | Qinghe Xing

GATA2 up-regulation restores androgen receptor chromatin association and advances darolutamide resistance in prostate cancer

July 2025

Tianyi Zhou | Chengtai Yu | Yali Han | Bin He | Qin Feng

Exploring the role of FTO in preeclampsia pathogenesis: Insights into m6A modification and decidualization

July 2025

Jing Tong | Liang Zhang | Jing Bai | Cong Zhang

CRISPR/Cas9 screening reveals Zfp607b as a novel transcription factor regulating myogenesis

July 2025

Siyuan Liu | Wei Wang | Zishuai Wang | Chao Yan | Guohao Han | Weiwei Liu | Yuxing Huang | Wangchang Li | Shengsong Xie | Zhonglin Tang

Systematic pan-cancer analysis identifies DNASE2 as a potential prognostic marker and immunotherapeutic target for glioblastoma multiforme

July 2025

Jun Cao | Si Chen | Ping An | Xingqiang Wang | Xinru Xiao | Shichao Li | Ye Cheng

PTEN and novel TEK germline variants associated with the phenotypes of PTEN hamartoma tumor syndrome

July 2025

Hongrui Chen | Bin Sun | Yanchun Zhou | Chen Hua | Xiaoxi Lin

Epigenetic modulation of thyroid cancer metastasis and glycolysis through circSSU72-mediated ubiquitination of gamma-catenin and beta-catenin signaling

July 2025

Zeyu Zhang | Duntao Su | Xiangyuan Qiu | Lei Yao | Fada Xia | Xinying Li

A novel mutation in KDR is associated with retinal venous beading and cerebral cavernous malformation

July 2025

Xiaonan Zhuang | Yuqiao Ju | Gezhi Xu | Xin Huang

Characterization of a novel HIV-1 second-generation circulating recombinant form (CRF144_07C) in Ganzhou, China

July 2025

Xiaoyi Zhang | Hongmin Cao | Yating Chen | Chaoxian Lian | Ting Zeng | Junjie Liu | Junzhi Su | Qian Gao | Fengxiu Zhu | Yuning Zhang | Dandan Huang | Yanheng Zhou | Xin Chen

ISG15 regulates auto-inflammation by modulating NF-κB signaling pathway

July 2025

Meiqi Hou | Chao Yuan | Xiaopei Zhou | Zhenxing Liu | Nianyi Sun | Jinze Li | Xianqin Zhang

Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β pro-inflammatory signaling

July 2025

Hang He | Yuchen Wen | Qingran Huo | Hanzhi Yu | Jingjing Liu | Wenyan Jin | Zhiqin Wang | Huaquan Wang | Zhigang Zhao | Zhigang Cai

Identification of a disease-associated germline mutation (A64T) of the ring finger protein 186 gene (RNF186) in Korean patients with ulcerative colitis

July 2025

Sang-Hun Park | Sae-Young Won | Yong-Chan Kim

Identification of the underlying molecular mechanisms of primary biliary cholangitis and ulcerative colitis comorbidity

July 2025

Weijia Han | Ting Song | Qi Wang | Chunyang Huang

A causal association between immune cells and hypertrophic cardiomyopathy: A bidirectional Mendelian randomization study

July 2025

Fang He | Qiangzhong Pi | Jun Yang | Mengning Wan | Jiang Yu | Ding Yang | Yongzheng Guo | Xiaorong Li

Arhgap29 deficiency causes EEC like syndrome in mice

July 2025

Dandan Chi | Yumeng Wang | Lili Yu | Wenyan Ruan | Beibei Zhang | Jian Ma | Xiaohong Duan | Yongqing Huang

Autoantigenic peptide landscape of rheumatoid arthritis-associated HLA class II

July 2025

Irina A. Ishina | Anton P. Zhiyanov | Inna N. Kurbatskaia | Azad E. Mamedov | Stepan A. Nersisyan | Rustam H. Ziganshin | Igor E. Eliseev | Yunna S. Petrusenko | Anastasia V. Nikonova | Elizaveta S. Zhbanova | Maria A. Salnikova | Leyla A. Ovchinnikova | Ilgar Z. Mamedov | Alexey N. Davydov | Kamila S. Nurbaeva | Tatiana A. Lisitsyna | Tatiana M. Reshetnyak | Alexander M. Lila | Evgeniy L. Nasonov | Yakov A. Lomakin | Alexey A. Belogurov | Hongkai Zhang | Alexander G. Tonevitskiy | Yury P. Rubtsov | Alexander G. Gabibov | Maria Y. Zakharova

The MTMR11 variants identified in a short stature cohort compromise the dephosphorylation ability of MTM1 on SMAD5 to up-regulate BMP signaling

July 2025

Kai Yang | Hongdou Li | Rui Peng | Bo Wu | Yiping Shen | Tongjin Zhao | Chentao Li | Weimin Wang | Hongyan Wang

Nrf2: A key regulator in chemoradiotherapy resistance of osteosarcoma

July 2025

Xianglin Peng | Jing Feng | Han Yang | Ping Xia | Feifei Pu

Osteosarcoma (OS), frequently observed in children and adolescents, is one of the most common primary malignant tumors of the bone known to be associated with a high capacity for invasion and metastasis....

The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases

July 2025

Hemanyun Bai | Fanji Meng | Kangling Ke | Lingyan Fang | Weize Xu | Haitao Huang | Xiao Liang | Weiyan Li | Fengya Zeng | Can Chen

With the advancement of high-throughput sequencing and bioinformatics, an increasing number of overlooked small noncoding RNAs (sncRNAs) have emerged. These sncRNAs predominantly comprise transfer RNA-derived...

GOT2: New therapeutic target in pancreatic cancer

July 2025

Jiarui Bu | Zeyu Miao | Qing Yang

In recent years, the incidence and mortality rates of pancreatic cancer have been steadily increasing, and conventional therapies have shown a high degree of tolerance. Therefore, the search for new...

Update on R-loops in genomic integrity: Formation, functions, and implications for human diseases

July 2025

Min Zhu | Xinyu Wang | Hongchang Zhao | Zhenjie Wang

R-loops, three-strand nucleic acid structures, have emerged as crucial players in various physiological processes, including the regulation of gene expression, DNA replication, and class switch recombination....

Advances in the mechanism and therapies of achondroplasia

July 2025

Hangang Chen | Ruobin Zhang | Min Jin | Jing Yang | Lin Chen | Yangli Xie

Achondroplasia (ACH), is the prevailing type of genetic dwarfism in humans, caused by mutations in fibroblast growth factor receptor 3 (FGFR3) that are inherited in an autosomal dominant manner. FGFR3...

The role of RNA binding proteins in cancer biology: A focus on FMRP

July 2025

Yunlu Jia | Ruyin Jia | Yongxia Chen | Xuanyi Lin | Nadire Aishan | Han li | Linbo Wang | Xiaochen Zhang | Jian Ruan

RNA-binding proteins (RBPs) act as crucial regulators of gene expression within cells, exerting precise control over processes such as RNA splicing, transport, localization, stability, and translation...