Recent Articles

Synergistic anti-tumor activity of ciclopirox olamine and metformin in triple-negative breast cancer

March 2026

Yakun Wu | Hui Lyu | Congcong Tan | Margaret E. Larsen | Shou-Ching Tang | Shile Huang | Bolin Liu

A comprehensive analysis of immune checkpoint receptor–ligand pairs in aortic diseases highlights the immunosuppressive roles of CD155 and CD274

March 2026

Ying Shao | Fatma Saaoud | Keman Xu | Yifan Lu | Sheng Wu | Laisel Martinez | Roberto Vazquez-Padron | Beata Kosmider | Hong Wang | Xiaofeng Yang

CTHRC1 promotes the progression of clear cell renal cell carcinoma via the PI3K/AKT/GSK3β signaling pathway

March 2026

Wei Xie | Zhouyong Fu | Thomas Skutella | Qing Jiang | Ronggui Zhang | Yuanfeng Zhang

Integrated genomic analysis of EDNRB common and rare variants in Hirschsprung disease

March 2026

Xiaoyu Zuo | Jinglu Zhao | Zipeng Liu | Yuxiao Yao | Dingyang Li | Xiaogang Xu | Huimin Xia | Lihua Huang | Jixiao Zeng | Yan Zhang

Molecular profiling unveils genetic complexity and identifies potential new driver mechanisms in head and neck paragangliomas

March 2026

Sara Mellid | Eduardo Caleiras | Ángel M. Martínez-Montes | Alicia Arenas | Scherezade Jiménez | María Monteagudo | Rocío Letón | Roberta Radu | Ruth Álvarez-Díaz | Ester Arroba | Alberto Diaz-Talavera | Natalia Martínez-Puente | Cristina Álvarez-Escolá | Marta Pineda | Milagros Balbín | Fátima Al-Shahrour | Cristina Rodriguez-Antona | Cristina Montero-Conde | Luis J. Leandro-García | Emiliano Honrado | Miguel Soria-Tristán | Mercedes Robledo | Alberto Cascón

TTC21B variants disrupt the left-right asymmetry and pronephric development in zebrafish

March 2026

Linxia Deng | Yuan Yang | Xiaoling Yin | Jing Yang | Yijie Duan | Kang Wang | Weicheng Duan | Yu Zhang | Bo Xiong | Jianhua Zhou

Surface glia for modeling ALS-FTD-associated mutant C9orf72 toxicity in the nervous system of Drosophila

March 2026

Yanan Wei | Brittany Anne Snow | Ciara Crowley Stevenson | Hongyu Miao | Jasdeep Kaur | Seung Gee Lee | Nam Chul Kim | Woo Jae Kim

SLC1A3 promotes survival and immune escape of pancreatic adenocarcinoma by regulating the JAK/STAT pathway

March 2026

Yihang Liu | Huimin Chang | Xiaobo Wang | Xue Zhao | Yongjun Dang | Ling Zhang | Shuai Wang

GRWD1 inhibits nucleolar stress and reduces the sensitivity of hepatocellular carcinoma to oxaliplatin

March 2026

Yuanyuan Li | Yumeng Wu | Shenghuan Zuo | Wenjing Zhao | Jibin Liu | Yilang Wang | Xiubing Zhang | Jian Xu | Feng Sun | Dianzheng Zhang | Shudong Zhu | Aiguo Shen

Hypoxia-mediated CRIP2 activation via NICD1 translocation regulates glycolysis and cell death

March 2026

Sunyoung Park | Sang-Ha Baik | Leon F. Palomera | Eunae Kim | Hark Kyun Kim | Jun-Sik Kim | Jong Ho Kim | Chanhee Kim | Thiruma V. Arumugam | Dong-Gyu Jo

Optimized Yamanaka factors combined with TERT gene therapy for enhanced anti-aging effects

March 2026

Mengmeng Jiang | Qianqian Xu | Zhengzhi Wu

Intense light mitigates hypoxia-induced right ventricular remodeling and dysfunction through reducing inflammation associated with PF4+ resident macrophages

March 2026

Dingyuan Tian | Yingzi Pan | Xiaoyue Lai | Xinyu Bao | Pan Zheng | Yan Tan | Chun Liu | Ziyang Wang | Qingyuan Yang | Yang Liu | Xiaoqin Wan | Zhihui Zhang | Fang Deng

Hypoxia-induced right ventricular (RV) remodeling and dysfunction present a significant health risk to populations experiencing prolonged hypoxic conditions. Intense light, a noninvasive and easily...

Fra2, a potential therapeutic target for silicosis

March 2026

Yuanmeng Qi | Jiarui Xia | Xuesong Zhang | Xiaoying Li | Qimeng Li | Zhenzhen Yang | Wu Yao | Changfu Hao | Youliang Zhao

Deficiency of TMEM16F in hair cells prevents diabetes-related and noise-induced hearing loss

March 2026

Liyuan Chen | Na Wang | Jiajia Li | Yan Li | Li Yi | Yupeng Ling | Qiuling Zhao | Yibing Fang | Guilan Chen | Bo Zeng

Drosophila phenylketonuria modeling helps reveal the disease etiology and the modulation role of iron

March 2026

Fan Du | Bing Zhou

Internal translation of truncated protein isoforms throughout the connexin gene family

March 2026

María José Muñoz | Alejandro Cabrera-Andrade | Ane Gutierrez-Aguirregabiria | Ipek Ilgin Gönenc | Santiago Ramón y Cajal | Trond Aasen

A new and more informative subtyping scheme for breast cancer based on co-expression of metabolic genes

March 2026

Chongren Pei | Yuzhe Zhang | Jun Xiao | Qing He | Wenyong Zhang | Ying Xu

Multi-omics analysis of lactylation as a prognostic signature: A pan-cancer study

March 2026

Xinning Liu | Yanping Wang | Yufeng Cao | Jinbao Zong

NAD+ supplementation augments the efficacy of the PARP1 inhibitor PJ34 in a 6-OHDA-induced model of Parkinson’s disease

March 2026

Mengling Hu | Xiaoqian Li | Dongsheng Fan | Lu Yu | Fan Ren | Jianming Wu | Jianing Mi | Yang Zheng | Xiaogang Zhou | Dalian Qin | Anguo Wu

Novel GNAO1 variant in α-helical domain reveals alternative mechanism of disease

March 2026

William Grant Ludlam | Jana Domínguez-Carral | Angeles Schteinschnaider | Kirill A. Martemyanov | Juan Darío Ortigoza-Escobar

METTL3 in Cr (VI)-induced carcinogenesis and CXCL6 expression associated with lung cancer development

March 2026

Jie Liu | Xiao Han | Fan-Li Sun | Xue Wang | Lin Wang | Yan-Qiu Zhao | Wen-Jing Liu | Bing-Hua Jiang

Mechanotransduction and musculoskeletal regeneration: Molecular mechanisms and interdisciplinary applications

March 2026

Xiajie Huang | Wenjun Hao | Yangzhou Mo | Xinyun Liang | Xiaomei Wu | Daofu Zeng | Yubin Mo | William Lu | Di Chen | Yan Chen

Distraction osteogenesis, or the Illizarov technique, induces bone regeneration using distractive mechanical forces. Nevertheless, Wolff's law holds that bone adapts to reverse compressive mechanical...

Non-clinical safety considerations on genome editing using the CRISPR/Cas system

March 2026

Parto Toofan | Mark Singh | Andrew Brooks | Keith McLuckie

Recent advances in gene editing using the CRISPR/Cas system have revolutionized genome editing, opening new horizons for human cellular and gene therapy products. Genome editing technologies are rapidly...