Isolation and phylogenetic analysis of swinepox virus from pigs in China
Available online 11 July 2025
•This study presents the first characterization and analysis of key host genes of SWPV from the Chinese lineage.•A SWPV strain (SWPV/AH/China/2024) was successfully isolated.•Genetic evolution analysis...
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Thermal tolerance and inactivation of Ebola virus
Available online 9 July 2025
•The investigation demonstrated a high level of tolerance of EBOV to thermal disinfection.•A water-bath is recommended and the tubes should be fully submerged during the process.•The established inactivation...
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SNX10 enhances HCoV-OC43 infection by facilitating viral entry and inhibiting virus-triggered autophagy
Available online 9 July 2025
The ongoing coronavirus epidemic, including the novel coronavirus (COVID-19), continues to pose a significant threat to global public health. Host targets address multiple stages of the viral life cycle...
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The Coronavirus 3CL protease: Unveiling Its Complex Host Interactions and Central Role in Viral Pathogenesis
Available online 7 July 2025
The 3CL protease, a highly conserved enzyme in the coronavirus, plays a crucial role in the viral life cycle by facilitating viral replication through precise cleavage of polyproteins. Beyond its proteolytic...
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Identification of a novel ectromelia virus from rodent: Implications for use as an in vivo infection model for vaccine and antiviral research
Available online 7 July 2025
Ectromelia virus (ECTV), a member of the Orthopoxvirus genus, serves as both a causative agent of mousepox and a pivotal surrogate model for studying highly pathogenic orthopoxviruses. While genomic...
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STAT5-c-Myc-axis regulates B cell metabolism in vaccinated individuals and COVID-19 recovered patients
Available online 7 July 2025
SARS-CoV-2 infection and vaccination both trigger immune responses. The former leads to naturally acquired immunity, while the latter induces active immunity through artificial means. However, the distinct...
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Single-cycle Rift Valley fever virus particles from stable replicon cells enable discovery of antiviral CNX-1351 for multiple RNA viruses
Available online 4 July 2025
Rift Valley fever virus (RVFV) is a high-containment pathogen that causes severe diseases in humans, with no approved therapeutics available. Its classification as a biosafety level 3 (BSL-3) agent...
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Clinical outcomes after HBsAg clearance in chronic hepatitis B patients treated with Peg-IFN α:A study with an 11- to 173-month follow-up
Available online 4 July 2025
To investigate the risk and influencing factors of long-term liver adverse events in chronic hepatitis B patients achieving hepatitis B surface antigen (HBsAg) clearance after pegylated interferon α...
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Rapid and accurate detection of infectious SARS-CoV-2 by viral receptor capture combined with loop-mediated isothermal amplification
Available online 1 July 2025
Rapid and accurate detection of infectious virus particles, not just viral nucleic acid, is essential to avoid unnecessary quarantine and effectively control the spread of viral diseases such as coronavirus...
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SARS-CoV-2-encoded miR-nsp3-3p promotes pulmonary fibrosis by inhibiting expression of ALCAM
Available online 1 July 2025
microRNAs (miRNAs) derived from viruses, have been detected in body fluids and are known to regulate the expression of host genes. Recent evidence indicates that SARS-CoV-2-encoded miRNAs could contribute...
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Isolation and identification of a newly discovered broad-spectrum Acinetobacter baumannii phage and therapeutic validation against pan-resistant Acinetobacter baumannii
Available online 27 June 2025
The treatment of Acinetobacter baumannii (A. baumannii) poses significant clinical challenges due to its multidrug/pan-drug resistance. In this study, we isolated a broad-spectrum lytic A. baumannii...
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First isolation and genomic characterization of a novel inter-genotype recombinant feline calicivirus from domestic cats: implications for viral evolution
Available online 27 June 2025
•Two strains of FCV with distinct genotypes were successfully isolated and identified.•First identification of recombination between GI and GII.•Significant antigenic cross-reactivity with traditional...
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Identification of PEDV inhibitors targeting 3CL protease
Available online 27 June 2025
Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV), is a highly contagious gastrointestinal disease characterized by vomiting, diarrhea, and dehydration, with mortality...
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Virome diversity in small mammals from south China: insights into virus evolution, transmission, and ecology
Available online 27 June 2025
Mammals are critical reservoirs of human infectious diseases and the spillover of viruses is related to climate conditions. We conducted meta-transcriptomic sequencing of 226 mammals (bats, rodents,...
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The slow progression of Japanese encephalitis in aged mice is likely associated to B cell recruitment in the brain
Available online 3 June 2025
The Japanese encephalitis virus (JEV) causes Japanese encephalitis (JE), a severe disease that primarily affects children and induces significant central nervous system complications. With the widespread...
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Decoding the virome reveals diverse novel viruses in tree shrews (Tupaia belangeri) in Yunnan Province
Available online 1 June 2025
Viruses circulating in small mammals possess the potential to infect humans. Tree shrews are a group of small mammals inhabiting widely in forests and plantations, but studies on viruses in tree shrews...
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Clofazimine targeting the spike protein and RdRp exhibits highly efficient antiviral activity against porcine epidemic diarrhea virus in vitro
Available online 1 June 2025
Porcine epidemic diarrhea virus (PEDV) infection causes acute watery diarrhea in neonatal piglets, leading to substantial economic losses within the pig farming industry. This study demonstrates that...
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Severe enterovirus A71 infection is associated with dysfunction of T cell immune response and alleviated by Astragaloside A
Available online 29 May 2025
Enterovirus A71 (EV-A71) is the major causative pathogen for severe hand-foot-mouth disease (HFMD), a predominantly childhood-associated communicable disease. The mechanisms that children manifest severe...
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Eltrombopag, an FDA-approved drug, inhibits dengue virus type 2 by targeting NS2B-NS3 protease
Available online 28 May 2025
Dengue viruses (DENV) have spread throughout the world and pose a huge threat to human life. The most widespread serotype is type 2 DENV (DENV 2), which has no specific treatment. NS2B-NS3 protease...
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Compromised efferocytosis during aging is related to COVID-19 severity in mice
Available online 24 May 2025
Aging is one of the greatest risk factors for morbidity caused by the coronavirus disease 2019 (COVID-19). In older individuals, a dysregulated immune response to severe acute respiratory syndrome coronavirus...
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Human endogenous retrovirus W family envelope protein (ERVWE1) regulates macroautophagy activation and micromitophagy inhibition via NOXA1 in schizophrenia
Available online 24 May 2025
The human endogenous retrovirus type W envelope glycoprotein (ERVWE1), located at chromosome 7q21–22, has been implicated in the pathophysiology of schizophrenia. Our previous studies have shown elevated...
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Host factor RBM25 promotes HBV replication through Yin Yang 1-mediated cccDNA transcription
Available online 22 May 2025
The persistence of covalently closed circular DNA (cccDNA) in hepatitis B virus (HBV)-infected hepatocytes remains a major obstacle to effective antiviral treatment. Understanding the molecular mechanisms...
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Elevated interferon-induced transmembrane protein 3 in platelets and megakaryocytes suppresses Crimean-Congo hemorrhagic fever viral infection by interacting with glycoprotein Gc
Available online 21 May 2025
Crimean-Congo hemorrhagic fever (CCHF) is a hemorrhagic fever caused by infection with the CCHF virus (CCHFV) and has a mortality rate of up to 30 %. Thrombocytopenia is a hallmark of CCHF; however,...
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Mutational landscapes of NITD008-resistant EV71 variants revealed through population sequencing
Available online 21 May 2025
•The mutation spectra between WT population and NITD008-resistant populations during replication are compared.•The 2C protein may be a new target of NITD008 as a nucleotide analogue against EV71 infection.•Antiviral...
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Characterization of a SARS-CoV-2 infection model in golden hamsters with diabetes mellitus
Available online 17 May 2025
Being widespread across the globe, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps evolving and generating new variants and continuously poses threat to public health, especially...
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