Wet-adhesive and antibacterial PAH-TPP coacervates with self-mineralizing capability for cranial flap fixation
October 2025
Repositioning and securing the cranial bone flap after craniotomy remain significant challenges in neurosurgery. Traditional fixation methods often suffer from weak mechanical strength, bioinertness,...
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Microalgae-based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effects
October 2025
Gouty arthritis (GA) is a type of inflammatory arthritis caused by the deposition of monosodium urate crystals. Current clinical therapies fail to simultaneously reduce uric acid (UA) levels and alleviate...
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Engineering microneedles for biosensing and drug delivery
October 2025
Microneedles (MNs) are small, minimally invasive devices that typically measure from tens to hundreds of micrometers in length and are usually less than a millimeter in diameter. Their purpose is to...
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Real-time magnetic resonance visualization of tumor acidosis as a precognition indicator of therapeutic efficacy
October 2025
Traditional antitumor strategies often require sufficient time to assess the effectiveness according to changes in tumor structure. Once ineffective, patients may miss the critical window for pursuing...
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Antiviral nanomedicine: Advantages, mechanisms and advanced therapies
October 2025
The emergence of novel viral pathogens and the limitations of conventional antiviral therapies necessitate innovative strategies to combat persistent and pandemic threats. This review details the role...
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A dual-targeting strategy to inhibit colorectal cancer liver metastasis via tumor cell ferroptosis and cancer-associated fibroblast reprogramming
October 2025
Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, with liver metastasis posing a significant therapeutic challenge. Within the “seed and soil” paradigm, disrupting both tumor...
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Charge balance transition enabled Janus hydrogel for robust wet-tissue adhesion and anti-postoperative adhesion
October 2025
Janus hydrogels have recently emerged as promising bioadhesives for efficient wet-tissue adhesion and anti-postoperative adhesion. However, existing Janus hydrogel adhesives normally need varied chemical...
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Trapzyme as multimodal Janus nanoplatform for apoptosis-based immunotherapy of periodontitis
October 2025
Accumulation of pro-inflammatory macrophages caused by apoptosis deficiency is a major contributing factor for periodontitis progression. Inducing apoptosis of these macrophages is thus a promising...
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Bioengineered platelet nanoplatform enables renal-targeted dexamethasone delivery for chronic nephritis therapy with dual anti-inflammatory/anti-fibrotic effects and minimized systemic toxicity
October 2025
Chronic nephritis management remains challenging due to the compromised therapeutic efficacy and severe systemic complications of conventional glucocorticoid therapy. Here, we developed a bioinspired...
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Near-field electrospun 3D anisotropic fiber-hydrogel scaffold integrated with photothermal effect for skin wound healing
October 2025
Wound healing remains a critical clinical challenge due to inflammatory responses, oxidative stress in the wound microenvironment, and impaired tissue remodeling. In this study, an anisotropic scaffold...
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Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration
October 2025
This comprehensive review elucidates the critical role of efferocytosis in tissue repair and regeneration processes, while systematically exploring innovative approaches through which tissue engineering...
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Biomimetic extracellular vesicles derived from chimeric antigen receptor monocytes to treat glioblastoma: An efficient and safe intranasal drug delivery nanoplatform
October 2025
Extracellular vesicles (EVs) have emerged as a promising pharmacotherapeutic modality for glioblastoma (GBM) drug delivery. However, the clinical translation of EVs remains restricted due to their low...
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From mechanism to applications: Advanced microneedles for clinical medicine
September 2025
Advanced microneedles (MNs) are a series of complex and multifunctional MNs designed for a variety of clinical applications that are not only efficacious but also cost-effective, acceptable, and safe....
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Application of bioactive materials primary cilia as a novel delivery vehicle
September 2025
Primary cilia are hair-like structured cell organelles functioning as cellular antennae with chemosensory and mechanosensory roles. Dysfunction of cilia results in ciliopathies, including renovascular...
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Engineered nerve guide conduit enhances peripheral nerve regeneration by modulating the microenvironment through macrophage-triggered cascade reactions
September 2025
Nerve regeneration after peripheral nerve injury (PNI) depends on exogenous and endogenous pro-healing signals in the microenvironment. Maintaining immune system homeostasis and remodeling the regenerative...
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Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap
September 2025
Biomedical and dental implants have enhanced healthcare but concurrently increased the risk of infections. Innovations in smart biomaterials, especially those responding to light stimuli through photocatalytic...
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Radiation cross-linked collagen scaffolds facilitate root coverage and keratinized gingival regeneration
September 2025
The study aimed to develop a radiation cross-linked collagen scaffold (RCS) and assess its potential for root coverage and keratinized gingival regeneration, addressing the prevalent issue of gingival...
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Antibacterial MXenes: An emerging non-antibiotic paradigm for surface engineering of orthopedic and dental implants
September 2025
The colonization of planktonic bacteria onto implant surfaces is a serious concern in the medical field due to increasing infection-related mortality and fiscal difficulties worldwide. Various static,...
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Dental follicle stem cell-derived small extracellular vesicles ameliorate pulpitis by reprogramming macrophage metabolism
September 2025
Vital pulp therapy (VPT) is considered a conservative means of preserving the vitality and function of the dental pulp after injury. However, current VPT has unfavorable effects on inflamed pulp. Mesenchymal...
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A sandwich-like nanofibrous scaffold with macrophage phenotype transformation and myogenic differentiation for skeletal muscle regeneration
September 2025
Skeletal muscle injuries caused by trauma, infections, or sports tear are common clinical diseases. Currently, the regeneration and repair of muscle tissue, which is highly heterogeneous, remains a...
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Dose-dependent osteoimmunomodulatory effects of amorphous calcium phosphate nanoparticles promote 3D-printed scaffold-mediated bone regeneration
September 2025
Regenerating critical-sized long bone defects poses substantial challenges due to limitations of autografts and processed allografts. Biomaterial scaffolds offer versatile alternatives, yet their effectiveness...
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3D-printed advanced scaffold armed with exosomes derived from human skeletal stem cell identified by single-cell RNA sequencing enhances osteochondral regeneration
September 2025
Osteochondral defects (OCDs) pose a significant clinical challenge due to their limited self-repair capacity. The complex structure and distinct biological properties of articular cartilage and subchondral...
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HydroWrap for T2DM-Related Fractures: A smart H2S-delivery controller modulating Macrophage senescence
September 2025
Impaired fracture healing in type 2 diabetes mellitus (T2DM) poses a significant clinical challenge, primarily due to a compromised bone microenvironment driven by senescent macrophages and their amplifying...
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Tryptophan-producing bacteria to mitigate osteoporosis and intestinal dysfunction
September 2025
The relationship between gut microbiota and host health and disease is intricate, with microbiota-derived metabolites playing a crucial role in the gut-organ axis. In this study, we observe significantly...
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Subaqueous acoustic pressure system based one day heterotypic pseudo-islet spheroid formation with adipose derived stem cells for graft survival-related function enhancement
September 2025
To overcome Type 1 diabetes mellitus (T1DM), which can cause hyperglycemia due to diminished insulin secretion of β-cell function, islet transplantation has been developed with various strategies including...
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