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ISSN: 2452-199X
CN: 10-1775/Q
p-ISSN: 2097-1192

Highly tough and conformal silk-based adhesive patches for sutureless repair of gastrointestinal and peripheral nerve defects

The use of tissue adhesive patches provides a promising therapeutic approach for sutureless repair of soft tissue injuries. However, existing tissue adhesive patches are confronted with serious challenges...

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Multifunctional hydrogel encapsulated with baicalin for full-layer regeneration of drug-resistant bacteria-infected wounds after radiotherapy

The post-radiotherapy wounds are common in patients. The irradiation-induced reactive oxygen species (ROS) accumulation, nucleic acid damage, and inflammation greatly hinder wound healing. The irradiation-induced...

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Oral microbiota-regulating and inflammation-targeted polymersome-hydrogels for RNAi therapy of ulcerative colitis

The treatment of ulcerative colitis is harassed by its intricate pathogenesis and the harsh gastrointestinal environment. Herein, oral microbiota-regulating and inflammation-targeted polymersome-hydrogels...

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Stromal-platelet membrane-inspired nanoparticles (SPIN) for targeted heart repair

Myocardial infarction (MI), commonly known as a heart attack, remains a leading cause of death worldwide. Standard treatments, such as coronary stent placement or coronary artery bypass graft surgery,...

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Dual-functional probiotic hydrogel with puerarin integration for microbiota-neuroimmune regulation in antibiotic-free periodontitis therapy

Periodontitis is an inflammatory disease caused by the imbalance of the periodontal microbial ecosystem. Traditional treatment methods not only kill pathogenic bacteria but also inhibit the growth of...

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Emerging biomedical engineering strategies for hair follicle regeneration

Hair follicle undergoes cyclical regeneration that relies on the spatiotemporal coordination of epithelial-mesenchymal interactions and multiple signaling pathways. However, hair follicle homeostasis...

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Delivering LINE1 antisense oligonucleotides via endothelial targeting extracellular vesicles to ameliorate myocardial infarction-induced cardiac senescence

Transposable elements (TEs) constitute a significant portion of the nuclear genome, but their influence on and ability to manage their activity during tissue regeneration remain largely unknown. Here,...

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Dual nanozymes-loaded core-shell microneedle patches with antibacterial and NETs-degradation bifunctional properties for periodontitis treatment

Periodontitis, a chronic inflammatory disease affecting over one billion people worldwide, is characterized by bacterial infections and hyperactive immune responses. Recent studies have revealed that...

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Anti-fatigue adhesive non-swelling hydrogel constructed by covalent topological structure and micro-nano gel for stretchable bioelectronics

Hydrogel adhesives are rapidly emerging as a promising candidate toward flexible bioelectronics due to their adhesive characteristics and tissue-like mechanical properties. However, current hydrogel...

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An injectable and dual-crosslinked hydrogel for controlled and permanent vascular embolization

Embolization that deliberately blocks target blood vessels through the delivery of embolic agents has emerged as a preferred therapy for various vascular-related diseases. Although various embolic materials...

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Strategies and applications of antibacterial surface-modified biomaterials

Bacterial infections and biofilm-associated antibiotic resistance continue to pose significant challenges in biomedical applications, often resulting in device-related complications and therapeutic...

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Nanostructured GelMA colloidal gels as bioinks for freeform multi-mode 3D printing: better replacement for the classical GelMA polymeric inks

Methacrylated gelatin (GelMA) hydrogels have been well-recognized as a widely-used natural polymer for biofabrications due to the adaptability for multiple crosslinking schemes, desirable biocompatibility...

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A novel organoid model retaining the glioma microenvironment for personalized drug screening and therapeutic evaluation

Glioma is an aggressive brain tumor with a poor prognosis. Establishing an in vitro culture model that closely replicates the cellular composition and microenvironment of the original tumor has been...

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Bioinspired micro-structured fibers for biomedical applications

Fibers, which are common in nature, have been playing an integral role in the life of mankind ranging from traditional textile industries to modern medical fields. Inspired by the spinning process of...

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Biomimetic gender-specific human skin model based on gonads/epidermis-on-a-chip

The development of bionic skin is crucial for progressing our understanding of skin physiology and pathologies, while the precise replication of human skin features in skin models remains a challenge....

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Engineering ROS-responsive double network hydrogel as bioactive barrier for postoperative abdominal adhesions prevention

Postoperative adhesions are common and severe complications, which affect up to 90 % of patients undergoing abdominal surgery. Despite the application of various strategies to minimize adhesions, the...

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Mesenchymal stem cell activity across a graded scaffold-hydrogel composite biomaterial for tendon-to-bone enthesis repair

The severity of rotator cuff injury outcomes and a lack of tendon-to-bone enthesis regeneration strategies have inspired advances in biomaterials science to develop methods for interfacial tissue engineering....

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A bio-inspired screwed small-diameter vascular graft for endotheliazation and arterial regeneration

The frequent failures of small-diameter vascular grafts (SDVGs) mainly result from thrombosis and insufficient endothelialization. Despite recent biochemical modification strategies aiming to enhance...

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Engineering NO delivery system renormalizes the excitability of inhibitory interneurons after spinal cord injury via chloride extrusion

Spinal cord injury (SCI)-induced severe neurological deficits arise from persistent ionic dysregulation and the dysfunction of inhibitory interneurons. Nitric oxide (NO) serves as a critical second...

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Shape memory bone screws loading L-arginine and Ca2+ propagate mechanical stimulation, energize bone cells and augment bone regeneration

Metallic bone screws are clinically used to fix the fractured bone fragments in bone defect treatment; yet they present compromised therapeutic efficacy due to poor osseointegration and tissue support....

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Advanced nanotherapies for precision treatment of inflammatory lung diseases

Inflammatory lung diseases, particularly those associated with acute pulmonary inflammation, represent a major clinical challenge due to their high global morbidity and mortality rates, as well as the...

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Single-atom Pt-doped ceria nanozymes mitigate myocardial ischemia reperfusion injury via cardiomyocyte-targeted uptake and suppression of reactive oxygen species

The primary treatment for myocardial infarction (MI) is restoring blood flow to the obstructed coronary artery. However, this approach can paradoxically generate reactive oxygen species (ROS), leading...

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Facile fabrication of antioxidative and antibacterial hydrogel films to accelerate infected diabetic wound healing

Diabetic wounds are accompanied with hemorrhage, excessive reactive oxygen species accumulation, microbial infection, and poor exudate management. Current dressings are insufficient to modulate the...

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Mechanosignaling and 3D morphological adaptation of MSCs in response to hydrogel rigidity underpin angiogenic and immunomodulatory efficacy for ischemic injury regeneration

Activating angiogenic and immunomodulatory potential of stem cells through optimized cultivation strategies presents significant opportunities for cell-based tissue therapeutics. Among others, hydrogels...

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Optimizing type H vessels formation via short fibers 3D scaffolds with maintaining redox homeostasis for osteoporotic bone remodeling

Precise regulation of intraosseous angiogenesis is essential for effectively repairing osteoporotic bone defects. However, the dual imbalance of redox homeostasis and the osteogenesis-angiogenesis coupling...

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