Dual nanozymes-loaded core-shell microneedle patches with antibacterial and NETs-degradation bifunctional properties for periodontitis treatment
November 2025
Periodontitis, a chronic inflammatory disease affecting over one billion people worldwide, is characterized by bacterial infections and hyperactive immune responses. Recent studies have revealed that...
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Nanostructured GelMA colloidal gels as bioinks for freeform multi-mode 3D printing: better replacement for the classical GelMA polymeric inks
November 2025
Methacrylated gelatin (GelMA) hydrogels have been well-recognized as a widely-used natural polymer for biofabrications due to the adaptability for multiple crosslinking schemes, desirable biocompatibility...
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A novel organoid model retaining the glioma microenvironment for personalized drug screening and therapeutic evaluation
November 2025
Glioma is an aggressive brain tumor with a poor prognosis. Establishing an in vitro culture model that closely replicates the cellular composition and microenvironment of the original tumor has been...
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Bioinspired micro-structured fibers for biomedical applications
November 2025
Fibers, which are common in nature, have been playing an integral role in the life of mankind ranging from traditional textile industries to modern medical fields. Inspired by the spinning process of...
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Biomimetic gender-specific human skin model based on gonads/epidermis-on-a-chip
November 2025
The development of bionic skin is crucial for progressing our understanding of skin physiology and pathologies, while the precise replication of human skin features in skin models remains a challenge....
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Engineering ROS-responsive double network hydrogel as bioactive barrier for postoperative abdominal adhesions prevention
November 2025
Postoperative adhesions are common and severe complications, which affect up to 90 % of patients undergoing abdominal surgery. Despite the application of various strategies to minimize adhesions, the...
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Mesenchymal stem cell activity across a graded scaffold-hydrogel composite biomaterial for tendon-to-bone enthesis repair
November 2025
The severity of rotator cuff injury outcomes and a lack of tendon-to-bone enthesis regeneration strategies have inspired advances in biomaterials science to develop methods for interfacial tissue engineering....
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Engineering NO delivery system renormalizes the excitability of inhibitory interneurons after spinal cord injury via chloride extrusion
November 2025
Spinal cord injury (SCI)-induced severe neurological deficits arise from persistent ionic dysregulation and the dysfunction of inhibitory interneurons. Nitric oxide (NO) serves as a critical second...
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Shape memory bone screws loading L-arginine and Ca2+ propagate mechanical stimulation, energize bone cells and augment bone regeneration
November 2025
Metallic bone screws are clinically used to fix the fractured bone fragments in bone defect treatment; yet they present compromised therapeutic efficacy due to poor osseointegration and tissue support....
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Facile fabrication of antioxidative and antibacterial hydrogel films to accelerate infected diabetic wound healing
November 2025
Diabetic wounds are accompanied with hemorrhage, excessive reactive oxygen species accumulation, microbial infection, and poor exudate management. Current dressings are insufficient to modulate the...
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Mechanosignaling and 3D morphological adaptation of MSCs in response to hydrogel rigidity underpin angiogenic and immunomodulatory efficacy for ischemic injury regeneration
November 2025
Activating angiogenic and immunomodulatory potential of stem cells through optimized cultivation strategies presents significant opportunities for cell-based tissue therapeutics. Among others, hydrogels...
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Advances in cold atmospheric plasma therapy for cancer
November 2025
Cold atmospheric plasma (CAP) has emerged as a promising, non-invasive therapeutic strategy for cancer treatment, leveraging reactive species to selectively induce cancer cell death while sparing healthy...
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Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery
November 2025
As an innovative physiotherapeutic approach, magnetic hyperthermia therapy (MHT) has unique advantages including minimal invasiveness, precise temperature control, and deep tissue penetration capabilities....
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Supramolecular drug-laden hydrogel based on structural tautomerization enhances drug delivery for rheumatoid arthritis treatment
November 2025
Rheumatoid arthritis (RA) is a major autoimmune disease characterized by significant joint inflammation and bone destruction. Many first-line RA treatment drugs such as methotrexate (MTX) have limited...
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Biomolecule-functionalized dental implant surfaces: Towards augmenting soft tissue integration
November 2025
Dental implants are the primary solution for tooth replacement, providing both aesthetic and functional restoration. Their long-term success depends not only on osseointegration but also on robust peri-implant...
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Transcutaneous electrotherapy of facial nerve injuries based on dissolvable conductive microneedles
November 2025
Local electrical stimulation (LES) is a widely used clinical method to treat peripheral nerve injury. However, existing plate electrodes (PE) usually suffer from low electronic transport efficiency,...
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Advancements in biomaterials and bioactive solutions for lumbar spine fusion cages: Current trends and future perspectives
November 2025
Spinal fusion is considered today as the last treatment option for different spinal conditions, such as degenerative and infectious illnesses. It consists of fusing two or more vertebrae to obtain reinforcement/fixation...
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Inhibition of ARH2 by pH/ROS-responsive nanosystem for improved lung adenocarcinoma immunochemotherapy
November 2025
Immunotherapy resistance remains a substantial barrier to improving treatment outcomes for patients with lung adenocarcinoma (LUAD). Identifying effective immunotherapy target is crucial for enhancing...
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Light-cured millineedle platform delivers “nano-pomegranate” for combinatorial electrodynamic therapy and cuproptosis against oral carcinoma
November 2025
Monomodal therapies often fail to eradicate tumors due to the complexity of tumorigenesis and microenvironmental resistance. Electrodynamic therapy (EDT) and cuproptosis as emerging antitumor therapies...
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Timed photothermal therapy combining fluorescence-on chemotherapy maximizes tumor treatment
November 2025
Photothermal therapy (PTT) combined with chemotherapy is a promising strategy for tumor treatment. However, its efficacy is often limited by the uncertainty of the irradiation timing of the photothermal...
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Advanced cell-adaptable hydrogels for bioprinting
November 2025
Bioprinting provides a promising tool to customize human tissues for medicine. Currently, it is expected to generate a tissue from the printed tissue construct that is consisted of biomaterials and...
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Self-assembling peptide inspired by insulin and type 1 insulin-like growth factor for the treatment of androgenetic alopecia
November 2025
Androgenetic alopecia (AGA), the most prevalent form of hair loss, urgently requires breakthroughs in existing therapies due to limitations such as medication side effects, recurrence risks, and treatment...
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Spore-inspired inhalation drug delivery system for asthma therapy
November 2025
The delivery efficiency of drugs in the lung is crucial for inhaled therapies targeting pulmonary diseases. However, current inhalation carriers face challenges overcoming pulmonary barriers, leading...
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Mechanism and regulatory strategy study on promoting vascularized bone regeneration via intracellular zinc ion transport
November 2025
Bone regeneration is a major clinical challenge. The main obstacles to bone injury repair are local blood flow disorders and hypoxic microenvironments. Mesenchymal stem cell (MSC) therapy has notable...
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Photocatalytic CO-releasing spray hydrogel for in situ postoperative cancer treatment
November 2025
The high invasiveness and metastatic potential of breast cancer increase the risk of postoperative recurrence. To address this issue, a composite hydrogel drug delivery system based on sodium alginate...
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