Extracellular vesicles derived from salivary gland stem cells cultured on microwell scaffolds loaded with WNT3A promote the recovery of salivary gland function damaged by radiation via the YWHAZ-PI3K-AKT pathway
October 2025
Salivary gland (SG) stem cell-derived extracellular vesicles (EVs) are promising agents for regenerative therapy, but efficient production and targeted delivery remain key challenges. We developed a...
Share article
Hypoxia preconditioned MSC exosomes attenuate high-altitude cerebral edema via the miR-125a-5p/RTEF-1 axis to protect vascular endothelial cells
October 2025
Vasogenic edema, caused by the disruption of the blood-brain barrier (BBB), is a significant pathological factor in high-altitude cerebral edema (HACE). Due to the rapid progression and high mortality...
Share article
Biosynthesis of a dual growth factors (GFs) functionalized silk sericin hydrogel to promote chronic wound healing in diabetic mice
October 2025
Chronic non-healing wounds, such as diabetic foot, pressure sores and bedsores have seriously affected the life quality of patients worldwide. GFs provide a potential solution to promote chronic wound...
Share article
Novel strategy for tumor immunotherapy using FITC-folate bispecific adapter bridged CAR immune cell cocktails
October 2025
Adoptive immune cell-based therapies have shown promise in cancer treatment, yet their efficacy against solid tumors is often limited by the immunosuppressive tumor microenvironment (TME). To overcome...
Share article
Mitigation of radiation-induced esophageal fibrosis by macrophage-targeted phosphatidylserine-containing liposomes with partial PEGylation
October 2025
Radiation-induced fibrosis (RIF) is a major complication following radiotherapy treatment. Macrophages are the key regulators of inflammatory responses and have emerged as critical targets for the prevention...
Share article
MⅡ-polyphosphate-based wax-like material with osteogenesis and blood occlusion
October 2025
There is a constant need for materials that combine hemostasis and osteogenesis in orthopedic surgery. Current hemostatic materials lack biodegradability, osteogenic properties, and hemostatic efficacy....
Share article
A strategy to prepare robust enzyme@covalent organic framework microcapsules: a new platform for biosensing
October 2025
Enzyme biosensors, despite their high specificity and sensitivity, are constrained by the inherent fragility of enzymes. Despite being considered ideal for enzyme protection by in-situ covalent organic...
Share article
Targeted co-delivery of IL-10 and catalase for cooperative therapeutic effect on acute kidney injury
October 2025
Kidney disease has emerged as a significant public health concern, affecting approximately 10 % of adults worldwide. Especially, acute kidney injury (AKI) increases in-hospital morbidity and mortality....
Share article
Bidirectional mechanisms and emerging strategies for implantable bioelectronic interfaces
October 2025
Neural network functionality depends on the signaling of excitable cells and intricate synaptic connections, which collectively promote advanced functions of the brain, such as perception, motor control,...
Share article
Comparison of 5 BMPs for their chondrogenic potentials and microfracture-mediated cartilage repair using heparin/PEAD coacervate sustained release polymer
October 2025
Cartilage defect repair and osteoarthritis treatments remain clinical challenges. Microfracture is a commonly used surgical procedure for the treatment of cartilage defects but often leads to fibrocartilage...
Share article
Functionally graded scaffold with M2 macrophage-derived LncRNA-Encoded peptide: Mechanistic and therapeutic evaluation for rotator cuff repair
October 2025
The rotator cuff is prone to tear under degenerative changes or mechanical injury, leading to excessive inflammation, extracellular matrix degradation, and unsatisfactory prognosis. Interleukin-4 (IL-4)...
Share article
Antibody-functionalized iron-based nanoplatform for ferroptosis-augmented targeted therapy of HER2-positive breast cancer
October 2025
Human epidermal growth factor receptor 2 positive (HER2+) breast cancer, as a subtype with high invasiveness and poor prognosis, faces issues of intertumoral heterogeneity and signaling pathway dysregulation...
Share article
Skin's 'nano-shield' hydrogel: Co-delivery of myricetin-laurate nanoagents eliminates fungus and promotes skin regeneration
October 2025
Cutaneous fungal infections, particularly those caused by Candida albicans, pose significant clinical challenges due to high recurrence rates and rising antifungal resistance. Conventional therapies,...
Share article
Strategic advances in Vat Photopolymerization for 3D printing of calcium phosphate-based bone scaffolds: A review
October 2025
3D-printing has emerged as a leading technology for fabricating personalized scaffolds for bone regeneration. Among the 3D-printing technologies, vat photopolymerization (VP) stands out for its high...
Share article
From mechanism to application: programmed cell death pathways in nanomedicine-driven cancer therapies
October 2025
Programmed cell death (PCD) plays a crucial role in preventing cancer initiation and progression. Among the diverse PCD pathways, cuproptosis, pyroptosis, and ferroptosis have garnered attention for...
Share article
Modular assembled biomimetic nanobubbles for synergistic therapy of ischemic stroke via cascade modulation thrombo-inflammatory network
October 2025
Dynamic pathology-adaptive nanodelivery systems represent a promising frontier in acute ischemic stroke (AIS) therapy. Here, we report a thrombo-inflammatory cascade-targeted biomimetic nanobubble engineered...
Share article
Three-stage sequential targeted nasal drops for correcting abnormal mitochondrial division in microglia
October 2025
Abnormal mitochondrial division in microglia significantly impacts central nervous system (CNS) diseases. However, treating CNS diseases through microglial mitochondria presents several challenges:...
Share article
Amorphous calcium zinc phosphate promotes macrophage-driven alveolar bone regeneration via modulation of energy metabolism and mitochondrial homeostasis
October 2025
The repair of alveolar bone defects continues to pose a significant challenge within the field of stomatology. As the primary implant material utilized in clinical treatment, the mechanisms by which...
Share article
Enhanced piezocatalytic therapy of MRSA-infected osteomyelitis using ultrasound-triggered copper nanocrystals-doped barium titanate
September 2025
Osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) biofilms poses a major therapeutic challenge due to persistent infection and bone loss. Optimizing anti-infection and promoting...
Share article
Amyloid-induced mineralization: From biological systems to biomimetic materials
September 2025
Amyloid deposits are widely presented in ectopic calcification associated with many degenerative diseases, such as calcific aortic valve disease and Alzheimer's disease. Recently, amyloid-like secondary...
Share article
Delivery of GAS5 by LNP promotes tendon-bone healing in rotator cuff injury
September 2025
It is observed in clinical practice that worse healing in rotator cuff tear (RCT) is closely associated with osteoporosis in patients. Herein, from the statistical analysis, we further confirmed that...
Share article
Lung cancer intravasation-on-a-chip: Visualization and machine learning-assisted automatic quantification
September 2025
During lung cancer metastasis, tumor cells undergo epithelial-to-mesenchymal transition (EMT), enabling them to intravasate through the vascular barrier and enter the circulation before colonizing secondary...
Share article
Oral oncolytic magnetotactic bacteria elicit anti-colorectal tumor immunity and reprogram microbiota metabolism
September 2025
Therapeutic outcomes of colorectal cancer (CRC) are influenced by intestinal microbiota and metabolites. To leverage the tumor-tropism and microbiota-regulating properties of bacteria, we developed...
Share article
Production and hosting by Elsevier on behalf of KeAi Communications Co. Ltd