Biomaterial-mediated Cell Atlas: an insight from single-cell and spatial transcriptomics
December 2025
Biomaterials serve as bridges between synthetic structures and biological systems, facilitating interactions with bodily tissues and regulating cellular responses. However, the intricate mechanisms...
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Engineering injectable bone/bioadhesive grafts delivery system with self-healing properties for bone regeneration
December 2025
The incidence of open bone defects caused by high kinetic and potential energy injuries has significantly increased. Bone grafting, typically in the form of granules, is widely recognized as the most...
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Bioenergetic-active hydrogel drives extracellular matrix synthesis for cartilage repair
December 2025
Bioenergy plays a fundamental role in cartilage anabolic processes such as extracellular matrix (ECM) synthesis. The design of bioenergetic-active materials for accelerating these processes provides...
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Tannic acid-loaded zinc- and copper-doped mesoporous bioactive glass nanoparticles: Potential antioxidant nanocarriers for wound healing
December 2025
Polyphenols such as tannic acid (TA) with antibacterial and antioxidant activities have recently attracted significant attention for wound healing applications. Mesoporous bioactive glass nanoparticles...
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Stable, bioactive hydrogel coating on silicone surfaces for non-invasive decontamination via photochemical treatment
December 2025
Polydimethylsiloxane (PDMS) is widely used in biomedical applications due to its biocompatibility, chemical stability, flexibility, and resistance to degradation in physiological environments. However,...
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Bioinspired porous core-shell microspheres with spatiotemporal delivery coordinate immunomodulatory-osteogenic coupling via NF-κB/P-STAT6 and Rho/MAPK signaling for enhanced calvarial regeneration
December 2025
Critical-sized calvarial defects remain a formidable clinical challenge due to dyssynchronous immunomodulation-osteogenesis coupling and unregulated growth factor release. Here, a bioinspired porous...
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CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer
December 2025
The five-year survival rate of patients with colorectal cancer (CRC) liver metastasis is less than 30 %, and chemotherapy resistance and metastatic microenvironment remodeling are the current treatment...
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Lactobacillus extracellular vesicle-driven oxygen-releasing photothermal hydrogel reprograms macrophages and promotes angiogenesis to accelerate diabetic wound healing
December 2025
Chronic wound healing remains clinically challenging due to insufficient angiogenesis coupled with persistent inflammatory microenvironments. Macrophage M2 polarization plays a pivotal role in resolving...
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Injectable sustained-release danshensu sodium-loaded nanoparticle hydrogel targets macrophages to improve myocardial microenvironment for myocardial infarction treatment
December 2025
Myocardial infarction (MI) induces cardiomyocyte necrosis, inflammation, fibrosis, and ventricular remodeling, leading to heart failure. To address this, we developed an intelligent cardiac patch, SMM@Gel,...
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Self-assembled hybrid hydrogel microspheres create a bone marrow-mimicking niche for bone regeneration
December 2025
Bone marrow (BM), a natural niche rich in growth factors and bone marrow mesenchymal stem cells (BMSCs), provides an optimal regenerative microenvironment and is widely used in clinical applications....
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Lithium fine-tunes biodegradation of Zn-based implant to promote osseointegration through immunomodulation
December 2025
The intricate degradation dynamics exhibited by biodegradable alloys significantly influence host responses during the implantation process, posing challenges in achieving stable osseointegration. It...
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Shape memory hydrogels in tissue engineering: Recent advances and challenges
December 2025
Shape memory hydrogels (SMHs) have emerged as transformative materials in tissue engineering, owing to their unique ability to recover their original shape after deformation. These hydrogels combine...
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Nano MgO loaded thermosensitive HPCH@HA hydrogel accelerates in situ bone repair through osteoimmunomodulation while enhancing angiogenesis and osteogenesis
December 2025
Bone defect repair is a complex physiological process, starting with early modulation by the inflammatory immune system, and involves multiple physiological events, including angiogenesis, osteogenic...
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Jahn-Teller distortion-engineered self-propelled nanorobots for mitochondrial targeting and bioenergetic disruption in tumor therapy
December 2025
Mitochondrial metabolism plays a pivotal role in tumor progression, yet effective therapeutic targeting remains constrained by limited tissue penetration and lack of spatiotemporal control. Herein,...
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Three-dimensional cell sheet model improves in vitro prediction accuracy of osteogenic potential for biodegradable magnesium-based metals
December 2025
Biodegradable metals have been increasingly utilized clinically due to their biosafety and pro-osteogenic properties. However, conventional monolayer cell-based preclinical safety evaluation methods...
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Autograft-matching wireless bioelectronic conduits: Magneto-electric coupling enabled taurine metabolism activation for peripheral nerve repair
December 2025
Peripheral nerve injuries remain a clinical challenge due to the limitations of autografts and unstable electrical signals in existing bioelectronic therapies. It is necessary to develop innovative...
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Spontaneous dynamic modulation of ionic/immune microenvironment on polyetheretherketone for sequential anti-infection and osseointegration
December 2025
Initial implant-related infection and subsequent poor osseointegration are the main causes of implant placement failure. The extracellular microenvironment is an important mediator of behaviors of cell...
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Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation
December 2025
The limited bone regeneration and suboptimal immune responses constitute the major challenges in repairing critical-sized bone defects. As an emerging therapeutic modality, mesenchymal stem cell-derived...
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Sprayable hydrogel sponge for neurovascular microenvironment reconstruction and inflammation modulation in diabetic wound healing
December 2025
Diabetic wounds are characterized by chronic inflammation, vascular insufficiency, and peripheral neuropathy, which collectively disrupt the neurovascular microenvironment essential for coordinated...
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Point-of-care treatment of acute skin wound by portable in-situ electrospinning nanofiber dressings with rapid hemostasis, anti-infection, and angiogenesis effects
December 2025
The increasing prevalence of acute traumatic injuries caused by traffic accidents, and natural disasters presents multifaceted challenges such as hemorrhages in irregular wounds and being susceptible...
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3D printing of chitosan hydrogel reinforced with tubular nanoclay for hemostasis and infected wound healing
December 2025
Developing hydrogel dressings capable of rapid hemostasis and accommodating irregular wounds is crucial for infected wound healing. Customizable 3D-printed hydrogels, highly sought after for wound management,...
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Nanotechnology strategies for endometrium health: Are we on the right track?
December 2025
The endometrium is a vital mucosal tissue which undergoes cyclical regeneration, differentiation, and remodeling upon hormonal, cellular, and molecular signaling networks. Dysregulation of these processes...
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Multifunctional hydrogel encapsulated with baicalin for full-layer regeneration of drug-resistant bacteria-infected wounds after radiotherapy
November 2025
The post-radiotherapy wounds are common in patients. The irradiation-induced reactive oxygen species (ROS) accumulation, nucleic acid damage, and inflammation greatly hinder wound healing. The irradiation-induced...
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Oral microbiota-regulating and inflammation-targeted polymersome-hydrogels for RNAi therapy of ulcerative colitis
November 2025
The treatment of ulcerative colitis is harassed by its intricate pathogenesis and the harsh gastrointestinal environment. Herein, oral microbiota-regulating and inflammation-targeted polymersome-hydrogels...
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Stromal-platelet membrane-inspired nanoparticles (SPIN) for targeted heart repair
November 2025
Myocardial infarction (MI), commonly known as a heart attack, remains a leading cause of death worldwide. Standard treatments, such as coronary stent placement or coronary artery bypass graft surgery,...
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