Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Trigonelline against diabetic nephropathy via targeting MMP9
Available online 19 August 2025
Diabetic nephropathy (DN) is a renal complication arising from diabetes and represents a leading contributor to end-stage renal disease. Current therapeutic strategies for DN are associated with significant...
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Network pharmacology and experimental verification reveals the anti-growth and anti-migration roles of allicin in non-small cell lung cancer
Available online 19 August 2025
Allicin is considered to have anti-tumor activity in lung cancer (LC), but the underlying molecular mechanism remains unclear. This study aimed to evaluate the pharmacological mechanism of allicin against...
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Identification of breast cancer biomarkers through bioinformatics approach
Available online 19 August 2025
Breast cancer (BC) remains a major global health burden, particularly among women, and early identification of molecular biomarkers is critical for improving diagnostic and therapeutic strategies. This...
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Andrographolide inhibits microglia inflammation and M1-like macrophage polarization after traumatic brain injury by regulating BRD4 expression
Available online 19 August 2025
Traumatic brain injury (TBI) is the leading cause of death and disability in young people. Andrographolide (Andro) has a wide range of therapeutic effects. In this study, we aimed to explore the effects...
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Based on Network Pharmacology and Molecular Docking Simulation: a Study of the Potential Targets and Mechanisms of Hesperetin action in ameliorating Henoch-Schönlein Purpura in Children
Available online 19 August 2025
IgA-mediated inflammation and reactive oxygen species production in Henoch-Schönlein purpura (HSP) account for important reasons in human microvascular endothelial cell (HDMVEC) damage. Hesperetin (HST)...
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Targeting calcineurin to combat fungal infections: Computational insights into phytochemicals as promising antifungal agents
Available online 19 August 2025
Although both fungi and bacteria are considered the primary causes of dermatological diseases, Aspergillus fumigatus, Candida albicans, and Cryptococcus neoformans are the predominant pathogens responsible...
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Uncovering the mechanism of ARRDC3 in non-small cell lung cancer cisplatin resistance and autophagy based on bioinformatics and experimental verification
Available online 19 August 2025
Cisplatin (DDP) is a commonly used first-line chemotherapy drug for non-small cell lung cancer (NSCLC), but the emergence of DDP resistance greatly reduces its therapeutic effect. Arrestin domain-containing...
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Matrine suppresses the malignant progression of esophageal cancer by inhibiting the expression of CTSB
Available online 18 August 2025
Esophageal cancer (EC), as one of the most common digestive cancers, significantly affects the quality of human life. The aim of this study was to investigate whether matrine-mediated Cathepsin B (CTSB)...
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Ginsenoside Rh3 suppresses cell proliferation, metastasis, and oxidative stress of colorectal cancer via targeting HSP90AA1
Available online 13 August 2025
Ginsenoside Rh3 has been identified as an anti-cancer agent in colorectal cancer (CRC), and heat shock protein 90 alpha family class A member 1 (HSP90AA1) exhibits oncogenic function in CRC. This study...
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TRPV receptors in pain research: Bridging molecular mechanisms to clinical treatments
Available online 24 July 2025
The cation channels known as transient receptor potential vanilloid (TRPV) are shown in various groups of tissues, such as the heart, lung, and brain, and in both excitable and non-excitable cells....
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Imperatorin remits malignant progression of endometrial cancer by silencing E2F1/SLC3A2
Available online 16 July 2025
Endometrial cancer (EC) remains the most common gynecologic malignancy. Imperatorin (IMP), a bioactive natural furanocoumarin derivative, has demonstrated diverse pharmacological properties with particular...
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Formulation, antimicrobial, and antioxidant effect of anti-acne serum containing extracts of striata scrophularia and rosemary plants
Available online 8 July 2025
Infectious diseases like acne, caused by bacteria and fungi, are prevalent worldwide. The rise of antibiotic-resistant bacteria has prompted the search for natural alternatives....
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Susceptibility testing of Escherichia coli and Salmonella enterica to plant essential oils and commercial antibiotics
Available online 8 July 2025
Antimicrobial resistance (AMR) is a global emergency linked to the indiscriminate use of drugs and can be transmitted through food, posing risks to human health. This study aimed to evaluate the antimicrobial...
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Network pharmacology, molecular docking, and experimental validation to explore dihydromyricetin attenuates LPS-induced acute lung injury by promoting FGFR1
Available online 7 July 2025
Acute lung injury (ALI) is a serious clinical condition characterized by severe lung inflammation, and its pathogenesis is complex. Dihydromyricetin (DHM), a bioactive flavonoid component isolated from...
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Fosinopril ameliorates renal injury in diabetic nephropathy by inactivating the SRC/NF-κB pathway
Available online 18 June 2025
Diabetic nephropathy (DN) is a serious complication of diabetes, characterized by renal tissue injury. Fosinopril, an ACE inhibitor, has been shown to have renoprotective effects in DN, but the underlying...
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Exploration of the potential molecular mechanism of magnolol in colorectal cancer treatment based on network pharmacology and molecular docking
Available online 18 June 2025
Colorectal cancer (CRC) has experienced a global rise in incidence, with chemotherapy resistance becoming a significant challenge during clinical treatment. Magnolol, a natural compound derived from...
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Study on the effect of molecular regulation on oxaliplatin resistance and macrophage polarization in esophageal squamous cell carcinoma based on the multiomics bioinformatic analysis and experimental verification
May 2025
Oxaliplatin (OHP) resistance remains a major therapeutic challenge in esophageal squamous cell carcinoma (ESCC). While Wnt1 inducible signaling pathway protein 1 (WISP1) has been implicated in tumor...
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Computational and biological perspective of phytoconstituents and their synthetic derivatives in antidiabetic therapy
May 2025
The global rise in diabetes has intensified the search for safer, multi-target therapeutic options. Plant-based phytoconstituents and their synthetic derivatives are drawing attention for their promising...
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Novel antimalarial 2-substituted quinoline thiosemicarbazone derivatives: Rational designing, molecular docking studies, ADME-tox properties, synthesis & in vitro activity
May 2025
Malaria remains a dangerous threat to nearly half of the world’s population, with the potential to be life-threatening. The most effective treatment currently available for uncomplicated and severe...
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In silico and in vitro investigation of anticancer effect of novel anthraquinone compound on MDA-MB-231 cells
May 2025
The serious adverse effects of chemotherapeutics forced to produce new bioactive substances such as anthraquinone derivatives....
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The inhibitory effects of Cucurbitacin B on hypopharyngeal cancer cell malignant behaviors were investigated based on network pharmacology and molecular docking
May 2025
Hypopharyngeal cancer is a metastatic squamous cell carcinoma of the head and neck (SCCHN), and the early symptoms are not obvious. Cucurbitacin B (Cu-B) is the most abundant member of the Cucurbitacin...
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Garcinol: An emerging epigenetic modifier with versatile anticancer properties
May 2025
Garcinol, a phenolic compound found in the fruit rind of Garcinia plants has gained significant attention for its diverse bioactivities viz. antibacterial, anti-inflammatory, anti-oxidant, and neuroprotective...
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Advancements in minimally invasive transdermal drug delivery systems
April 2025
Minimally invasive drug delivery systems (MIDDS) have revolutionized pharmacological therapies by offering substitute techniques that improve therapeutic accuracy and efficacy while reducing pain, discomfort,...
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The mechanisms of Mahuang decoction in treating COPD: Insights from network pharmacology and in vivo studies
April 2025
Chronic obstructive pulmonary disease (COPD) is a major cause of significant mortality worldwide. Mahuang decoction (MHD), a classic traditional Chinese medicine, has demonstrated encouraging therapeutic...
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Development and evaluation of optimized molecularly imprinted polymer (MIP) for targeted drug delivery of 5-Fluorouracil
April 2025
Our research described in this paper focuses on the development and evaluation of molecularly imprinted polymer (MIP) for targeted drug delivery of 5-Fluorouracil (5-FU)....
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