Investigating the neuroprotective effects and the potential mechanisms of β-amyrenone in cerebral ischemic/reperfusion injury based on pharmacology network, bioinformatics, and molecular docking simulation
Available online 9 October 2025
Cerebral ischemic/reperfusion injury (CIRI) can cause secondary injury to the neurons, which remains unresolved in the clinic. β-amyrenone harbors anti-inflammatory effects. The present study aims to...
Investigation into the mechanism of columbianadin’s inhibition of breast cancer development using network pharmacology and molecular dynamics simulation
Available online 7 October 2025
Breast cancer (BC) remains a significant global health challenge, necessitating the exploration of novel therapeutic agents. Columbianadin (CBN), a natural compound, has shown potential anti-cancer...
The application of immunoprotein inhibitor treatment regimens based on PD-L1: A retrospective analysis after the progression of advanced gastric cancer
Available online 3 October 2025
The aim of this study was to evaluate the therapeutic efficacy and safety of immunotherapy beyond progression in advanced gastric cancer (GC) after the failure of first-line immunotherapy in combination...
Efficacy and safety of PD-1/PD-L1 inhibitors for relapsed/metastatic nasopharyngeal carcinoma: A systematic review and meta-analysis
Available online 25 September 2025
A systematic evaluation was performed to investigate the efficacy and safety of programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors in relapsed/metastatic nasopharyngeal carcinoma...
Development and characterization of suppository formulation for rectal delivery of clarithromycin
Available online 20 September 2025
Clarithromycin (CLR), a broad-spectrum antibiotic, is widely used to treat genitourinary infections caused by Gram positive bacteria via conventional drug delivery approaches, such as tablets. However,...
Synthesis, characterization, and neuroprotective effect of taxifolin-conjugated gold nanoparticles against amyloid βeta induced Alzheimer’s disease
Available online 12 September 2025
Alzheimer's disease (AD) is characterized by amyloid beta peptide (Aβ) accumulation, oxidative stress, neuro inflammation, and progressive memory loss. Taxifolin, a flavonoid with neuroprotective effects,...
Fosinopril ameliorates renal injury in diabetic nephropathy by inactivating the SRC/NF-κB pathway
July 2025
Diabetic nephropathy (DN) is a serious complication of diabetes, characterized by renal tissue injury. Fosinopril, an ACE inhibitor, has been shown to have renoprotective effects in DN, but the underlying...
Exploration of the potential molecular mechanism of magnolol in colorectal cancer treatment based on network pharmacology and molecular docking
July 2025
Colorectal cancer (CRC) has experienced a global rise in incidence, with chemotherapy resistance becoming a significant challenge during clinical treatment. Magnolol, a natural compound derived from...
Matrine suppresses the malignant progression of esophageal cancer by inhibiting the expression of CTSB
July 2025
Esophageal cancer (EC), as one of the most common digestive cancers, significantly affects the quality of human life. The aim of this study was to investigate whether matrine-mediated regulation of...
Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Trigonelline against diabetic nephropathy via targeting MMP9
July 2025
Diabetic nephropathy (DN) is a renal complication arising from diabetes and represents a leading contributor to end-stage renal disease. Current therapeutic strategies for DN are associated with significant...
Network pharmacology and experimental verification reveals the anti-growth and anti-migration roles of allicin in non-small cell lung cancer
July 2025
Allicin is considered to have anti-tumor activity in lung cancer (LC), but the underlying molecular mechanism remains unclear. This study aimed to evaluate the pharmacological mechanism of allicin against...
Identification of breast cancer biomarkers through bioinformatics approach
July 2025
Breast cancer (BC) remains a major global health burden, particularly among women, and early identification of molecular biomarkers is critical for improving diagnostic and therapeutic strategies. This...
Andrographolide inhibits microglia inflammation and M1-like macrophage polarization after traumatic brain injury by regulating BRD4 expression
July 2025
Traumatic brain injury (TBI) is the leading cause of death and disability in young people. Andrographolide (Andro) has a wide range of therapeutic effects. This study aimed to explore the effects and...
Based on Network Pharmacology and Molecular Docking Simulation: A Study of the Potential Targets and Mechanisms of Hesperetin Action in Ameliorating Henoch-Schönlein Purpura in Children
July 2025
IgA-mediated inflammation and reactive oxygen species production in Henoch-Schönlein purpura (HSP) account for important reasons in human microvascular endothelial cell (HDMVEC) damage. Hesperetin (HST)...
Targeting calcineurin to combat fungal infections: Computational insights into phytochemicals as promising antifungal agents
July 2025
Although both fungi and bacteria are considered the primary causes of dermatological diseases, Aspergillus fumigatus, Candida albicans, and Cryptococcus neoformans are the predominant pathogens responsible...
Uncovering the mechanism of ARRDC3 in non-small cell lung cancer cisplatin resistance and autophagy based on bioinformatics and experimental verification
July 2025
Cisplatin (DDP) is a commonly used first-line chemotherapy drug for non-small cell lung cancer (NSCLC), but the emergence of DDP resistance greatly reduces its therapeutic effect. Arrestin domain-containing...
Exploring N-acetyl-1,3,4-oxadiazoline derivatives against Alzheimer's disease: ADMET, molecular docking, and DFT analysis
July 2025
Alzheimer's disease is a progressive neurodegenerative illness characterized by cognitive decline and memory loss. It is primarily caused by the buildup of neurofibrillary tangles made of hyperphosphorylated...
Targeting Ngt1-mediated GlcNAc transport in Candida albicans: An in silico approach for antifungal therapy
July 2025
The commensal yeast, Candida albicans, has the enormous metabolic flexibility to utilize alternative carbon sources such as N-acetylglucosamine (GlcNAc) at infection sites, thereby facilitating its...
Innovative approaches in insulin delivery: Exploring molecular techniques and system developments
July 2025
Diabetes is the most prevalent endocrine disease, divided into Type I and Type II, affecting a large number of people globally. The most effective and safest drug for reducing blood sugar levels is...
TRPV receptors in pain research: Bridging molecular mechanisms to clinical treatments
Available online 24 July 2025
The cation channels known as transient receptor potential vanilloid (TRPV) are shown in various groups of tissues, such as the heart, lung, and brain, and in both excitable and non-excitable cells....
Network pharmacology, molecular docking, and experimental validation of dihydromyricetin attenuating LPS-induced acute lung injury by promoting FGFR1
June 2025
Acute lung injury (ALI) is a serious clinical condition characterized by severe lung inflammation, and its pathogenesis is complex. Dihydromyricetin (DHM), a bioactive flavonoid component isolated from...
Formulation, antimicrobial, and antioxidant effect of anti-acne serum containing extracts of striata scrophularia and rosemary plants
June 2025
Infectious diseases like acne, caused by bacteria and fungi, are prevalent worldwide. The rise of antibiotic-resistant bacteria has prompted the search for natural alternatives....
Susceptibility testing of Escherichia coli and Salmonella enterica to plant essential oils and commercial antibiotics
June 2025
Antimicrobial resistance (AMR) is a global emergency linked to the indiscriminate use of drugs and can be transmitted through food, posing risks to human health. This study aimed to evaluate the antimicrobial...
Imperatorin remits malignant progression of endometrial cancer by silencing E2F1/SLC3A2
June 2025
Endometrial cancer (EC) remains the most common gynecologic malignancy. Imperatorin (IMP), a bioactive natural furanocoumarin derivative, has demonstrated diverse pharmacological properties with particular...
Ginsenoside Rh3 suppresses cell proliferation, metastasis, and oxidative stress of colorectal cancer via targeting HSP90AA1
June 2025
Ginsenoside Rh3 has been identified as an anti-cancer agent in colorectal cancer (CRC), and heat shock protein 90 alpha family class A member 1 (HSP90AA1) exhibits oncogenic function in CRC. This study...