Exploring the molecular mechanism of Qilian Fuzheng capsule for treatment of non-small cell lung cancer using network pharmacology, RNA-seq, molecular docking and experimental verification
Available online 22 October 2025
Qilian Fuzheng capsule (QL) has been used for the treatment of various malignant tumors, but the underlying mechanisms are largely unclear. In this study, we aimed to explore the effects and potential...
The effect of serotonergic receptors (5HT3) on seizure threshold and mitochondrial damage induced by amitriptyline in the mouse brain
Available online 22 October 2025
Epilepsy is a chronic nervous system disorder in humans, characterized by disturbed brain function and altered levels of consciousness....
From melanocyte loss to targeted therapy: A comprehensive review of vitiligo management
Available online 22 October 2025
Vitiligo is a chronic dermatological condition characterized by the loss of melanocytes, resulting in depigmented patches on the skin. The epidemiology, pathogenesis, existing and developing treatment...
Loxoprofen relieves osteoarthritis development via repressing PI3K-AKT/NF-κB signaling pathways
Available online 18 October 2025
Loxoprofen, a cyclooxygenase (COX) inhibitor, has been utilized in the management of osteoarthritis (OA). However, the underlying mechanisms of loxoprofen regulating OA process remain unknown....
Formulation and optimization of Kaempferol nanoemulsion-based gel for treating skin erythema using Box-Behnken statistical design
Available online 17 October 2025
The objective of this study is to develop and characterize Kaempferol (KMF)-loaded nanoemulsion-based gel formulations for the treatment of skin erythema. A Box-Behnken design was utilized to optimize...
Investigating the mechanism of curcumin against LUAD malignant progression and macrophage M2 polarization based on network pharmacology, bioinformatics, and molecular docking
Available online 16 October 2025
Lung adenocarcinoma (LUAD) is a subtype of non-small cell lung cancer (NSCLC) that poses significant mortality risks. Curcumin, a natural polyphenolic compound with documented anti-inflammatory and...
METTL14-induced N6-methyladenosine modification on TPX2 mRNA inhibits tumor progression in clear cell renal cell carcinoma
Available online 15 October 2025
Clear cell renal cell carcinoma (ccRCC) accounts for 70 % of all renal cell carcinoma (RCC) types, and 30 % of patients with ccRCC present with metastasis at the time of initial diagnosis. Given the...
Revealing the neuroprotective mechanism of irisin on stroke based on network pharmacology, molecular docking and experimental validation
Available online 15 October 2025
Irisin has been confirmed to play a neuroprotective effect in stroke. However, the mechanism of irisin in treating stroke remains unclear....
Mechanism exploration of baicalein in pediatric allergic rhinitis based on high-throughput database, network pharmacology and molecular docking
Available online 15 October 2025
Allergic rhinitis (AR) is a prevalent disease affecting the health of people of all ages, even pediatric populations. Baicalein is an important therapeutic drug for AR. This study was performed for...
Exploring DPP-IV inhibitors for diabetes treatment: A comprehensive study on molecular docking, molecular dynamics simulation, and in-vitro DPP-IV assay
Available online 13 October 2025
Dipeptidyl peptidase-4 (DPP-IV) inhibitors are established medications for type 2 diabetes, but there's a continuous search for even more potent and effective options....
Investigating the therapeutic potential of jiawei xuanbi decoction in rheumatoid arthritis via network pharmacology and cell experiments
Available online 11 October 2025
Rheumatoid arthritis (RA) is an autoimmune disease marked by symmetrical chronic polyarticular inflammation, which may increase the risk of disability in severe cases. Jiawei Xuanbi Decoction (JWXB),...
A high dose of 2-APB enhances neurotoxicity induced by 6-hydroxydopamine in rats
Available online 10 October 2025
Boron-containing compounds (BCCs), such as 2-aminodiphenyl borinate (2-APB), are studied as active agents on the central nervous system (CNS). At doses ≤ 10 mg/kg, 2-APB administration induces neuronal...
Identification of active compounds and therapeutic mechanisms of traditional Chinese medicine for periarthritis of shoulder for promoting blood circulation and removing stasis (PBRS): A network pharmacology and randomized controlled study
Available online 10 October 2025
Periarthritis of Shoulder (PS) is a prevalent condition characterized by shoulder pain and restricted movement, affecting 2–5 % of the global population. This study aims to elucidate the active compounds...
An appraisal on biomolecular imaging in diagnosis of neurological disorders and innovation in clinical research
Available online 10 October 2025
Biological indicators, or biomarkers, play an increasingly important role in the study and diagnosis of neurological diseases. Over the last several decades, the use of imaging biomarkers has increased...
Investigating the neuroprotective effects and the potential mechanisms of β-amyrenone in cerebral ischemic/reperfusion injury based on pharmacology network, bioinformatics, and molecular docking simulation
Available online 9 October 2025
Cerebral ischemic/reperfusion injury (CIRI) can cause secondary injury to the neurons, which remains unresolved in the clinic. β-amyrenone harbors anti-inflammatory effects. The present study aims to...
Investigation into the mechanism of columbianadin’s inhibition of breast cancer development using network pharmacology and molecular dynamics simulation
Available online 7 October 2025
Breast cancer (BC) remains a significant global health challenge, necessitating the exploration of novel therapeutic agents. Columbianadin (CBN), a natural compound, has shown potential anti-cancer...
The application of immunoprotein inhibitor treatment regimens based on PD-L1: A retrospective analysis after the progression of advanced gastric cancer
Available online 3 October 2025
The aim of this study was to evaluate the therapeutic efficacy and safety of immunotherapy beyond progression in advanced gastric cancer (GC) after the failure of first-line immunotherapy in combination...
Efficacy and safety of PD-1/PD-L1 inhibitors for relapsed/metastatic nasopharyngeal carcinoma: A systematic review and meta-analysis
Available online 25 September 2025
A systematic evaluation was performed to investigate the efficacy and safety of programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors in relapsed/metastatic nasopharyngeal carcinoma...
Development and characterization of suppository formulation for rectal delivery of clarithromycin
Available online 20 September 2025
Clarithromycin (CLR), a broad-spectrum antibiotic, is widely used to treat genitourinary infections caused by Gram positive bacteria via conventional drug delivery approaches, such as tablets. However,...
Synthesis, characterization, and neuroprotective effect of taxifolin-conjugated gold nanoparticles against amyloid βeta induced Alzheimer’s disease
Available online 12 September 2025
Alzheimer's disease (AD) is characterized by amyloid beta peptide (Aβ) accumulation, oxidative stress, neuro inflammation, and progressive memory loss. Taxifolin, a flavonoid with neuroprotective effects,...
Fosinopril ameliorates renal injury in diabetic nephropathy by inactivating the SRC/NF-κB pathway
July 2025
Diabetic nephropathy (DN) is a serious complication of diabetes, characterized by renal tissue injury. Fosinopril, an ACE inhibitor, has been shown to have renoprotective effects in DN, but the underlying...
Exploration of the potential molecular mechanism of magnolol in colorectal cancer treatment based on network pharmacology and molecular docking
July 2025
Colorectal cancer (CRC) has experienced a global rise in incidence, with chemotherapy resistance becoming a significant challenge during clinical treatment. Magnolol, a natural compound derived from...
Matrine suppresses the malignant progression of esophageal cancer by inhibiting the expression of CTSB
July 2025
Esophageal cancer (EC), as one of the most common digestive cancers, significantly affects the quality of human life. The aim of this study was to investigate whether matrine-mediated regulation of...
Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Trigonelline against diabetic nephropathy via targeting MMP9
July 2025
Diabetic nephropathy (DN) is a renal complication arising from diabetes and represents a leading contributor to end-stage renal disease. Current therapeutic strategies for DN are associated with significant...
Network pharmacology and experimental verification reveals the anti-growth and anti-migration roles of allicin in non-small cell lung cancer
July 2025
Allicin is considered to have anti-tumor activity in lung cancer (LC), but the underlying molecular mechanism remains unclear. This study aimed to evaluate the pharmacological mechanism of allicin against...