Parabacteroides distasonis-derived ursodeoxycholic acid alleviates macrophage foaming and atherosclerosis progression by targeting NLRP3
Available online 26 November 2025
Atherosclerosis (AS) is a persistent immune-mediated inflammatory condition characterized by high morbidity and mortality rates. Ursodeoxycholic acid (UDCA) exhibits anti-inflammatory properties and...
Luteolin exerts potential therapeutic effects on bladder cancer by modulating key pathways and target proteins
Available online 26 November 2025
Bladder cancer (BC) is a common urological malignancy characterized by high recurrence and metastasis rates, posing significant challenges for its treatment. Despite advances in diagnosis and treatment,...
Multi-modal investigation of doxorubicin-induced osteoporosis: Network toxicology, machine learning, and imaging techniques
Available online 26 November 2025
Osteoporosis (OP) is a systemic skeletal disorder characterized by reduced bone mass and increased fracture risk. Emerging evidence indicates that the chemotherapeutic agent doxorubicin (DOX) significantly...
Exploring the mechanisms of Ginkgo biloba extract in treating attention deficit hyperactivity disorder based on network pharmacology and molecular docking
Available online 25 November 2025
Ginkgo biloba extract (GBE) has been found to be effective in treating neurological diseases. However, whether GBE can be used to treat attention deficit hyperactivity disorder (ADHD) and its potential...
Peptide HDP15 protects against cognitive impairment after ischemia-reperfusion injury by regulating PRKN-mediated mitochondrial autophagy
Available online 25 November 2025
Post-stroke cognitive impairment (PSCI) involves complex pathophysiology and lacks specific therapeutic approaches. Synaptic plasticity and mitochondrial dysfunction are key pathological mechanisms...
In vitro and in silico analysis reveal the potential mechanisms of Liu-Wei-Di-Huang-Wan formula for tinnitus treatment
Available online 25 November 2025
Tinnitus remains a challenging auditory disorder with limited effective treatments. Liu-Wei-Di-Huang-Wan formula (LWDHW) has shown promising effects in alleviating tinnitus symptoms. This study aims...
Exploring the mechanism of piperlongumine in promoting ferroptosis in cervical cancer based on network pharmacology and molecular docking analysis
Available online 25 November 2025
Cervical cancer is the fourth most common cancer in women, characterized by a high incidence. Piperlongumine, a bioactive alkaloid derived from Piper longum, exhibits diverse biological activities....
Exploring the mechanistic basis of Jiang Dan Jian Ji decoction (JDJJ) for chronic kidney disease treatment through network pharmacology
Available online 25 November 2025
Chronic kidney disease (CKD) represents a significant global public health challenge. Jiang Dan Jian Ji Decoction (JDJJ), a clinically used Traditional Chinese Medicine (TCM) formulation, has demonstrated...
Triptolide and quercetin coordinately regulate the network pharmacology mechanism of renal cancer
Available online 19 November 2025
Renal cell carcinoma (RCC) is characterized by high metastatic potential, therapeutic resistance, and limited treatment options. Traditional Chinese Medicine (TCM)–derived compounds, such as triptolide...
Structure-guided target prioritization of heterocyclic carboxamides for hyperlipidemia and obesity via cheminformatics, network biology, and docking studies
Available online 19 November 2025
Target identification for hyperlipidemia and obesity remains challenging due to limitations in data quality, target validation, and clinical translation....
Uncovering celecoxib’s anti-breast cancer mechanisms through network pharmacology, molecular docking, and dynamics
Available online 19 November 2025
Celecoxib has gained attention as a potential anti-tumor agent in breast cancer. This study systematically elucidated the therapeutic mechanisms of celecoxib in this malignancy....
Bioinformatics analysis uncovers vital targets and potential small molecule drugs for neonatal necrotizing enterocolitis
Available online 19 November 2025
In neonates, necrotizing enterocolitis (NEC) remains highly destructive with serious impacts on life. Discovering useful biomarkers and potential drugs for treating neonatal NEC is of great importa...
Mitigation of cyclophosphamide-induced hepatoxicity by Allium ampeloprasum Subsp Iranicum: A potential protective agent in chemotherapy
Available online 17 November 2025
The liver is essential for drug metabolism and detoxification, and cyclophosphamide (CP) can induce hepatotoxicity via oxidative stress and inflammatory responses. Allium ampeloprasum subsp. Iranicum...
Based on network pharmacology and molecular docking to explore the mechanism that Papaverine alleviates Alzheimer disease
Available online 17 November 2025
Papaverine is a benzyl isoquinoline alkaloid extracted from poppy plant species. Unlike other poppy seed extracts, Papaverine is mainly used for smooth muscle relaxation and vascular dilation. The underlying...
Research on the mechanism by which quercetin affects ferroptosis in breast cancer cells through regulating USP9X/PIAS4
Available online 15 November 2025
Breast cancer stands as a formidable malignant tumor posing a severe threat to women’s health globally, characterized by alarmingly high rates of morbidity and mortality. Quercetin has demonstrated...
Scutellaria Baicalensis Georgi: A review on botany, phytoconstituents, and pharmacological activities
Available online 8 November 2025
Scutellaria baicalensis (Huang-Qin), prominently avowed as Chinese Skullcap, is a traditional herb that has been historically diversified and used culturally in Chinese medicine. The review focused...
Nanoemulgel-based delivery of 3-O-Acetyl-11-Keto-β-Boswellic Acid and basil oil for enhanced transdermal efficacy: In vitro anti-inflammatory and antioxidant assessment
September 2025
3-O-Acetyl-11-Keto-β-Boswellic Acid (AKBA) has potent anti-inflammatory, anti-oxidant, and anti-arthritic activities. Despite AKBA’s strong therapeutic potential, its clinical utility is hindered by...
Computational design and evaluation of hydrantoin derivatives as potential anti-tubercular agents: Insight from ADMET, molecular docking, DFT, and molecular dynamic simulations
September 2025
The global burden of tuberculosis and the rise of drug-resistant Mycobacterium tuberculosis strains continue to challenge effective disease control, underscoring the need for novel therapeutic agents...
From stem cells to therapeutics: Advancing islet function restoration through mesenchymal stem cell-based drug research
September 2025
Islet transplantation marks a new frontier in diabetes treatment, with considerable application potential in both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM). Recent advances...
Curcumin ameliorates the progression of osteoarthritis through the METTL3/OLFM4 pathway
September 2025
Previous studies have indicated that curcumin (Cur) exhibits excellent anti-inflammatory and anti-oxidant properties and possesses potential therapeutic value in Osteoarthritis (OA). However, the underlying...
Exploring the mechanism of Si Miao Yong An Tang in the treatment of diabetic foot ulcers based on network pharmacology and molecular docking
September 2025
Si Miao Yong An Tang (SMYA), a Chinese herbal formula with a long history of use, that has been found to be effective in Diabetic Foot Ulcers(DFU).An explanation of how the aforementioned formula is...
Design and screening of novel geniposide derivatives as xanthine oxidase inhibitors for hyperuricemia treatment using QSAR, Molecular docking, Molecular dynamics simulation, ADMET, and DFT Approaches
September 2025
Design of novel xanthine oxidase inhibitors via computational modeling of geniposide derivatives for treatment of hyperuricemia. Due to the excessive use of geniposide inhibitors and the detrimental...
Andrographolide reverses lung cancer cisplatin resistance by targeting CDK1: A network pharmacology and experimental study
September 2025
Cisplatin resistance represents a major therapeutic challenge in lung cancer treatment. Andrographolide (Andro), a bioactive diterpenoid lactone, has shown potential as a chemosensitizing agent. However,...
Virtual screening and molecular dynamics simulations reveal insights into drug repurposing strategies against New Delhi metallo-β-lactamase
September 2025
Antibiotic resistance continues to pose a serious threat to public health globally, drawing attention from health agencies and governments worldwide. Among the various resistance mechanisms, the emergence...
Targeting VP14-Arginine kinase interaction: An in-silico approach to combat white spot disease in black tiger shrimp (Penaeus monodon)
September 2025
Penaeid shrimp aquaculture serves as a vital contributor to economic growth and employment in many low- and middle-income countries. However, the industry continues to face major setbacks due to viral...