Characterization of a SARS-CoV-2 Infection Model in Golden Hamsters with Diabetes Mellitus
Available online 17 May 2025
Being widespread across the globe, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps evolving and generating new variants and continuously poses threat to public health, especially...
Share article
Nucleophosmin 1 inhibits the replication of influenza A virus by competitively binding viral RNA with viral proteins
Available online 8 May 2025
Influenza A viruses (IAVs) are single-stranded negative-sense RNA viruses that continually challenge animal and human health. In IAV-infected cells, host RNA-binding proteins play key roles in the life...
Share article
A Mouse Model of Crimean-Congo Hemorrhagic Fever Virus-induced Coagulopathy
Available online 30 April 2025
•A mouse model for CCHFV-induced coagulopathy was developed and characterized using STAT1 knockout mice.•High doses of CCHFV resulted in delayed tail bleeding time, shortened PT and APTT, and prolonged...
Share article
Characterization of novel highly pathogenic avian influenza A(H5N6) clade 2.3.4.4b virus in wild birds, East China, 2024
April 2025
•We reported a novel H5N6 HPAIV belonging to clade 2.3.4.4b in wild birds in eastern China.•The novel H5N6 HPAIV most likely descended from clade 2.3.4.4b H5N1 virus in Japan.•The novel H5N6 HPAIV evolved...
Share article
Evaluating the performance of the PREDAC method in flu vaccine recommendations over the past decade (2013–2023)
April 2025
•PREDAC is a semi-automated and user-friendly method for flu vaccine recommendations based on HA protein sequences.•PREDAC performed comparably to the WHO in recommending vaccines of influenza A(H3N2)...
Share article
Current antiviral therapies and promising drug candidates against respiratory syncytial virus infection
April 2025
Respiratory syncytial virus (RSV) is one of the most common viruses leading to lower respiratory tract infections (LRTIs) in children and elderly individuals worldwide. Although significant progress...
Share article
Zika virus transmission in Aedes aegypti: A systematic study on the ability of mosquitoes to transmit the virus horizontally and vertically
April 2025
Zika virus (ZIKV) is a mosquito-borne virus belonging to the genus Orthoflavivirus, and the family Flaviviridae. It commonly presents with febrile-like symptoms, neurological issues, and pregnancy complications...
Share article
Phylogenitc analysis and immunogenicity comparison of porcine genotype G9 rotavirus in China from 2020–2023
April 2025
As an emerging genotype, the G9 genotype rotaviruses (RVs) are widespread among humans and pigs, and have been reported in many countries and regions in the recent years. Moreover, porcine G9 strains...
Share article
Identification and genetic analysis of new ephemeroviruses in wild boars in China
April 2025
Ephemeroviruses (EVs) are arthropod-borne rhabdoviruses and were isolated exclusively from cattle and haematophagous arthropods until two new ephemeroviruses were first identified from domestic pigs...
Share article
Sphingomyelin phosphodiesterase 3 as a novel host factor inhibiting hepatitis B virus transcription
April 2025
•SMPD3 is identified as a novel host factor that inhibits Hepatitis B virus (HBV) replication at the transcriptional level.•SMPD3 knockdown enhances HBV replication in various cell models, increasing...
Share article
Artemisia annua L. leaf extracts suppress influenza virus infection by targeting the viral nucleoprotein and blocking mitochondria-mediated apoptosis
April 2025
Artemisia annua L. is a medicinal herb with multiple therapeutic applications, whereas its anti-influenza A virus (IAV) efficiency and mechanism of action are still unclear. Here, we investigated the...
Share article
Identification of an immunodominant neutralizing epitope of porcine astrovirus type 5 capsid protein
April 2025
•A neutralizing monoclonal antibody against the capsid protein of PAstV5 was prepared for the first time.•The B cell epitope of PAstV5 capsid protein was identified for the first time.•The monoclonal...
Share article
In vivo quantitative proteomic analysis of porcine alveolar macrophages in PRRSV-infected pigs
April 2025
Porcine reproductive and respiratory syndrome (PRRS), a highly infectious immunosuppressive disease caused by porcine reproductive and respiratory syndrome virus (PRRSV), has led to significant economic...
Share article
Virus profiling of bronchoalveolar lavage fluid in hospitalized non-COVID-19 adult patients with pulmonary infection from November 2020 to November 2021
April 2025
Identifying the cause of respiratory tract infections is important for reducing the burden of diagnosis and treatment. To assess viral etiologies of hospitalized patients with pulmonary infection, bronchoalveolar...
Share article
Epidemiological and molecular characteristics of human parainfluenza virus in southern China during 2016–2020
April 2025
Human parainfluenza viruses (HPIV) are common viral pathogens in acute respiratory infection (ARI). We aimed to describe the epidemiological and molecular characteristics of HPIV from ARI patients....
Share article
Qingqi Guxue Decoction induces S cell cycle arrest to inhibit replication of severe fever with thrombocytopenia syndrome virus
April 2025
Severe fever with thrombocytopenia syndrome (SFTS) is a novel emerging acute infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), characterized by high fever and thrombocytopenia....
Share article
Development of a reporter HBoV1 strain for antiviral drug screening and life cycle studies
April 2025
Human bocavirus 1 (HBoV1; family: Parvoviridae) causes a wide spectrum of respiratory diseases in children and gastroenteritis in adults. A lack of sensitive cell lines and efficient animal models hinders...
Share article
Host factor Naf1 restricts HIV-1 infection of myeloid cells and compromises the capacity of dendritic cell to prime CD4+ T cell
April 2025
Naf1 (Nef-associated factor 1) is a host protein that interacts with human immunodeficiency virus type 1 (HIV-1) Nef protein. We and others have previously demonstrated that Naf1 restricts HIV-1 infection...
Share article
The SARS-CoV-2 NSP4 T492I mutation promotes double-membrane vesicle formation to facilitate transmission
April 2025
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in mutations not only in the spike protein, aiding immune evasion, but also in the NSP3/4/6 proteins, crucial...
Share article
Structure-function insights into the dual role of African swine fever virus pB318L: A typical geranylgeranyl-diphosphate synthase and a nuclear import protein
April 2025
African swine fever virus (ASFV) pB318L is an important protein for viral replication that acts as a membrane-bound trans-geranylgeranyl-diphosphate synthase (GGPPS) catalyzing the condensation of isopentenyl...
Share article
Issue Cover
April 2025
Share article
A noninfectious pseudovirus system for an emerging orthoflavivirus
Available online 23 April 2025
•A trans-complementation system for Usutu virus (USUV) recapitulates authentic viral replication.•High yield of TMN-ΔNS1 virus was obtained with no recombination into replication competent viruses occurring...
Share article
Coadministration of ribavirin and arenaviral entry inhibitor LHF-535 enhances antiviral benefit against authentic lassa virus
Available online 12 April 2025
•A new strain of Lassa virus (LASV) was successfully isolated and characterized.•The combination of ribavirin and LHF-535 has been demonstrated to exhibit synergistic effects in inhibiting LASV.•The...
Share article
Scutellaria barbata D. Don extracts alleviate SARS-CoV-2 induced acute lung injury by inhibiting virus replication and bi-directional immune modulation
Available online 12 April 2025
The emergence of SARS-CoV-2 variants and drug-resistant mutants emphasizes the urgent need to develop novel antiviral agents. In the present study, we examined the therapeutic effect of the Chinese...
Share article
Viral pseudo-enzyme facilitates KSHV lytic replication via suppressing PFAS-mediated RTA deamidation
Available online 12 April 2025
Deamidation, a type of post-translational modification commonly considered a hallmark of protein “aging” and function decay, is increasingly recognized for its pivotal role in regulating biological...
Share article