Isolation and identification of a newly discovered broad-spectrum Acinetobacter baumannii phage and therapeutic validation against pan-resistant Acinetobacter baumannii
Available online 27 June 2025
The treatment of Acinetobacter baumannii (A. baumannii) poses significant clinical challenges due to its multidrug/pan-drug resistance. In this study, we isolated a broad-spectrum lytic A. baumannii...
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First isolation and genomic characterization of a novel inter-genotype recombinant feline calicivirus from domestic cats: implications for viral evolution
Available online 27 June 2025
•Two strains of FCV with distinct genotypes were successfully isolated and identified.•First identification of recombination between GI and GII.•Significant antigenic cross-reactivity with traditional...
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Identification of PEDV inhibitors targeting 3CL protease
Available online 27 June 2025
Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV), is a highly contagious gastrointestinal disease characterized by vomiting, diarrhea, and dehydration, with mortality...
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Virome diversity in small mammals from south China: insights into virus evolution, transmission, and ecology
Available online 27 June 2025
Mammals are critical reservoirs of human infectious diseases and the spillover of viruses is related to climate conditions. We conducted meta-transcriptomic sequencing of 226 mammals (bats, rodents,...
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The slow progression of Japanese encephalitis in aged mice is likely associated to B cell recruitment in the brain
Available online 3 June 2025
The Japanese encephalitis virus (JEV) causes Japanese encephalitis (JE), a severe disease that primarily affects children and induces significant central nervous system complications. With the widespread...
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Decoding the virome reveals diverse novel viruses in tree shrews (Tupaia belangeri) in Yunnan Province
Available online 1 June 2025
Viruses circulating in small mammals possess the potential to infect humans. Tree shrews are a group of small mammals inhabiting widely in forests and plantations, but studies on viruses in tree shrews...
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Clofazimine targeting the spike protein and RdRp exhibits highly efficient antiviral activity against porcine epidemic diarrhea virus in vitro
Available online 1 June 2025
Porcine epidemic diarrhea virus (PEDV) infection causes acute watery diarrhea in neonatal piglets, leading to substantial economic losses within the pig farming industry. This study demonstrates that...
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Severe enterovirus A71 infection is associated with dysfunction of T cell immune response and alleviated by Astragaloside A
Available online 29 May 2025
Enterovirus A71 (EV-A71) is the major causative pathogen for severe hand-foot-mouth disease (HFMD), a predominantly childhood-associated communicable disease. The mechanisms that children manifest severe...
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Eltrombopag, an FDA-approved drug, inhibits dengue virus type 2 by targeting NS2B-NS3 protease
Available online 28 May 2025
Dengue viruses (DENV) have spread throughout the world and pose a huge threat to human life. The most widespread serotype is type 2 DENV (DENV 2), which has no specific treatment. NS2B-NS3 protease...
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Compromised efferocytosis during aging is related to COVID-19 severity in mice
Available online 24 May 2025
Aging is one of the greatest risk factors for morbidity caused by the coronavirus disease 2019 (COVID-19). In older individuals, a dysregulated immune response to severe acute respiratory syndrome coronavirus...
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Human endogenous retrovirus W family envelope protein (ERVWE1) regulates macroautophagy activation and micromitophagy inhibition via NOXA1 in schizophrenia
Available online 24 May 2025
The human endogenous retrovirus type W envelope glycoprotein (ERVWE1), located at chromosome 7q21–22, has been implicated in the pathophysiology of schizophrenia. Our previous studies have shown elevated...
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Host factor RBM25 promotes HBV replication through Yin Yang 1-mediated cccDNA transcription
Available online 22 May 2025
The persistence of covalently closed circular DNA (cccDNA) in hepatitis B virus (HBV)-infected hepatocytes remains a major obstacle to effective antiviral treatment. Understanding the molecular mechanisms...
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Elevated interferon-induced transmembrane protein 3 in platelets and megakaryocytes suppresses Crimean-Congo hemorrhagic fever viral infection by interacting with glycoprotein Gc
Available online 21 May 2025
Crimean-Congo hemorrhagic fever (CCHF) is a hemorrhagic fever caused by infection with the CCHF virus (CCHFV) and has a mortality rate of up to 30 %. Thrombocytopenia is a hallmark of CCHF; however,...
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Mutational landscapes of NITD008-resistant EV71 variants revealed through population sequencing
Available online 21 May 2025
•The mutation spectra between WT population and NITD008-resistant populations during replication are compared.•The 2C protein may be a new target of NITD008 as a nucleotide analogue against EV71 infection.•Antiviral...
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Characterization of a SARS-CoV-2 infection model in golden hamsters with diabetes mellitus
Available online 17 May 2025
Being widespread across the globe, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps evolving and generating new variants and continuously poses threat to public health, especially...
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Nucleophosmin 1 inhibits the replication of influenza A virus by competitively binding viral RNA with viral proteins
Available online 8 May 2025
Influenza A viruses (IAVs) are single-stranded negative-sense RNA viruses that continually challenge animal and human health. In IAV-infected cells, host RNA-binding proteins play key roles in the life...
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A mouse model of Crimean-Congo hemorrhagic fever virus-induced coagulopathy
Available online 30 April 2025
•A mouse model for CCHFV-induced coagulopathy was developed and characterized using STAT1 knockout mice.•High doses of CCHFV resulted in delayed tail bleeding time, shortened PT and APTT, and prolonged...
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Characterization of novel highly pathogenic avian influenza A(H5N6) clade 2.3.4.4b virus in wild birds, East China, 2024
April 2025
•We reported a novel H5N6 HPAIV belonging to clade 2.3.4.4b in wild birds in eastern China.•The novel H5N6 HPAIV most likely descended from clade 2.3.4.4b H5N1 virus in Japan.•The novel H5N6 HPAIV evolved...
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Evaluating the performance of the PREDAC method in flu vaccine recommendations over the past decade (2013–2023)
April 2025
•PREDAC is a semi-automated and user-friendly method for flu vaccine recommendations based on HA protein sequences.•PREDAC performed comparably to the WHO in recommending vaccines of influenza A(H3N2)...
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Current antiviral therapies and promising drug candidates against respiratory syncytial virus infection
April 2025
Respiratory syncytial virus (RSV) is one of the most common viruses leading to lower respiratory tract infections (LRTIs) in children and elderly individuals worldwide. Although significant progress...
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Zika virus transmission in Aedes aegypti: A systematic study on the ability of mosquitoes to transmit the virus horizontally and vertically
April 2025
Zika virus (ZIKV) is a mosquito-borne virus belonging to the genus Orthoflavivirus, and the family Flaviviridae. It commonly presents with febrile-like symptoms, neurological issues, and pregnancy complications...
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Phylogenitc analysis and immunogenicity comparison of porcine genotype G9 rotavirus in China from 2020–2023
April 2025
As an emerging genotype, the G9 genotype rotaviruses (RVs) are widespread among humans and pigs, and have been reported in many countries and regions in the recent years. Moreover, porcine G9 strains...
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Identification and genetic analysis of new ephemeroviruses in wild boars in China
April 2025
Ephemeroviruses (EVs) are arthropod-borne rhabdoviruses and were isolated exclusively from cattle and haematophagous arthropods until two new ephemeroviruses were first identified from domestic pigs...
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Sphingomyelin phosphodiesterase 3 as a novel host factor inhibiting hepatitis B virus transcription
April 2025
•SMPD3 is identified as a novel host factor that inhibits Hepatitis B virus (HBV) replication at the transcriptional level.•SMPD3 knockdown enhances HBV replication in various cell models, increasing...
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Artemisia annua L. leaf extracts suppress influenza virus infection by targeting the viral nucleoprotein and blocking mitochondria-mediated apoptosis
April 2025
Artemisia annua L. is a medicinal herb with multiple therapeutic applications, whereas its anti-influenza A virus (IAV) efficiency and mechanism of action are still unclear. Here, we investigated the...
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