A HiBiT-Tagged Influenza A Virus Reporter System Reveals Cytokine-Inhibitory Micropeptide 53 as a Modulator of Viral Infection and Immunopathology
Available online 5 September 2026
Influenza A virus (IAV) remains a major threat to human and animal health, highlighting the need for efficient approaches to identify host factors and antivirals. Reporter viruses are critical tools...
ACSL3 at the UPR crossroads: Tactician of anti-influenza defense, target of influenza offense
Available online 4 September 2026
•A new dimension of the host-IAV arms race is revealed, centered on ACSL3 at the UPR crossroads.•Key questions remain regarding ACSL3-UPR sensor interfaces and ACSL3 induction/degradation mechanisms.•Addressing...
Identification and genome characterization of circovirus in Masked Palm Civets (Paguma larvata) from Guangdong Province, China
Available online 3 September 2026
•First identification of Pl-CV in mainland China, with a 34.0% detection rate in farmed civets.•Pl-CV DNA was detected in liver (31.4%) and intestine (25.7%) specimens from one Shaoguan farm.•Four complete...
RNF152 regulates prototype foamy virus replication by targeting Gag polyubiquitination and VLPs production
Available online 2 September 2026
Prototype foamy viruses (PFVs) are complex retroviruses that establish long-term latent infections in hosts without causing disease, positioning them as potential safe gene transfer vectors. Understanding...
Retinoic acid is a translation inhibitor against chikungunya virus both in vitro and invivo
August 2026
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes debilitating febrile and arthritic disease and remains a persistent public health threat in tropical and subtropical regions, with no clinically...
Recent progress in anti-Chikungunya virus drug discovery: Focus on the viral life cycle and direct-acting antivirals
August 2026
Chikungunya virus (CHIKV) belongs to the genus Alphavirus of the family Togaviridae. CHIKV infection generally causes severe clinical symptoms, including debilitating arthralgia, fever, hemorrhage and...
The C-terminal T234 residue of VP3 is required for KREMEN1 receptor-dependent infectivity and pathogenesis of coxsackieviruses A10 and A8
August 2026
Coxsackievirus A10 (CVA10) is a major causative agent of hand, foot and mouth disease and utilizes KREMEN1 (KRM1) as its cellular receptor. While our previous work identifies VP2 residue K140 as a universal...
Effectiveness of lignans against severe fever with thrombocytopenia syndrome virus infection
August 2026
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes a life-threatening infectious disease with high mortality. Currently, there are no approved...
Whole-genome evolutionary dynamics of human parainfluenza virus type 3 in Shanghai, China, 2016–2024
August 2026
•Fifty whole-genome sequencing revealed co-circulating HPIV-3 C3 sub-lineages C3f and C3a in Shanghai, China.•Whole-genome phylogeny dated the HPIV-3 tMRCA to ∼1925.6 and revealed two post-1990 demographic...
Hidden diversity of coronaviruses in high-altitude plateau mammals
August 2026
•Pikas and marmots from plateaus host divergent α- and β-CoVs, including the candidate subgenera Pibecovirus and Mabecovirus.•The plateau CoVs show distinctive genomic features (relocated HE gene, variable...
Pygenic acid A, a small-molecule PD-1/SHP-2 inhibitor, enhances efficacy of therapeutic melanoma vaccines and prophylactic influenza vaccines
August 2026
Overcoming immunosuppressive tumor microenvironments remains a critical challenge in advanced vaccine development. Here, we evaluated Pygenic acid A (PA), an intracellular small-molecule inhibitor targeting...
MMF inhibits poxvirus infection by disrupting IMPDH2 interaction with USP5 and inducing its rod-and-ring assemblies
August 2026
Monkeypox virus (MPXV), a pathogenic orthopoxvirus, has caused major outbreaks and emerged as a global public health threat. Although antivirals approved for smallpox are used therapeutically against...
Host OTUB2 and viral PLpro stabilize NSP8 to promote SARS-CoV-2 replication
August 2026
The ubiquitin-proteasome system (UPS) plays a central role in antiviral defense but is also frequently hijacked by viruses to facilitate their replication. Here, we demonstrate that the host deubiquitinase...
The antiviral role of TRIM25 in mammalian embryonic stem cells
August 2026
Mammalian embryonic stem cells (ESCs), despite lacking functional interferon (IFN) signaling, are remarkably resistant to viral infection. However, the mechanistic basis of their antiviral defenses...
A replication-defective tick-borne encephalitis virus generated by NS1 trans-complementation confers robust protective efficacy
August 2026
Tick-borne encephalitis virus (TBEV) poses a severe threat to public health, causing neurological disorders with high morbidity and mortality in endemic regions. Therefore, developing safe and effective...
Genetic heterogeneity and pathogenic potential of historical Crimean-Congo hemorrhagic fever virus isolates in China
August 2026
The Crimean-Congo hemorrhagic fever virus (CCHFV) poses a significant public health threat. In China, CCHFV has been circulating for decades, yet the genomic diversity and pathogenic potential of the...
Stabilization of prefusion hMPV F improves manufacturability and protective immunity across hMPV lineages
August 2026
Human metapneumovirus (hMPV) is a major cause of pediatric acute lower respiratory tract infections (ALRTIs), yet vaccine development has been hindered by the intrinsic metastability of the prefusion...
A modular APEX biosensor enables sensitive and visualized monitoring of viral protease activity
August 2026
Viral proteases are key targets for the development of broad-spectrum antiviral drugs development. However, screening platform capable of accurately assessing inhibitor activity within physiologically...
SARS-CoV-2 3CLpro inhibits the replication of influenza viruses through the cleavage of NP and PA
August 2026
The co-circulation of multiple viruses can lead to distinct pathological outcomes, yet how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection influences other viral infections remains...
Pre-existing hemagglutinin-specific antibody levels are associated with B-cell repertoire maturation and antibody breadth after influenza vaccination
August 2026
Repeated influenza exposures generate complex antibody landscapes, yet how pre-existing antibodies are associated with subsequent vaccine responses remains unclear. We longitudinally tracked 21 adults...
Identification and characterization of anti-chikungunya virus compounds using a biosafe toolkit
August 2026
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus for which no specific antiviral therapy is currently available. During the large outbreak in Foshan, Guangdong Province, China, in...
Enteroviruses antagonize the host restriction factor ABL2 via proteasomal degradation to facilitate viral replication
August 2026
Enteroviruses, including Coxsackievirus B3 (CVB3), are significant human pathogens that cause severe diseases, such as viral myocarditis, pancreatitis, and encephalitis. ABL proto-oncogene 2 (ABL2),...
Blood and gut virome remodeling in gastric cancer: Anellovirus expansion and novel virus discovery
August 2026
Gastric cancer (GC) is a prevalent malignancy worldwide, yet effective early diagnostic tools remain lacking, and the role of the virome, a key component of the tumor microenvironment, in GC progression...
Y-box-binding protein 1 stabilizes the capsid protein of porcine circovirus type 2 to promote viral replication
August 2026
Porcine circovirus type 2 (PCV2), a major causative agent of PCV2-associated diseases, poses a serious threat to the global swine industry. The stability of PCV2 capsid (Cap) protein is critical for...
Hijacking the host heparan sulfate-cell-surface ribonucleoproteins (RNPs) scaffold pathway for viral immune evasion
August 2026
•Viral nucleocapsid proteins may co-opt this host scaffold for cell-surface display.•Surface-displayed viral proteins can bind chemokines, suppressing immune cell recruitment....