Antisera and antivirals targeting the conserved domains in SARS-CoV-2 S2 subunit are effective against ACE2-using MERSr-CoVs with spillover potential
Available online 15 September 2025
•S2 subunit remains high conserved throughout coronavirus evolution.•BA.5/BF.7-infection induces weak cross-immune response against MERS-related coronaviruses (MERSr-CoVs) in humans.•HR1LS based on...
A Safe and Broad-spectrum SARS-CoV-2 mRNA Vaccine with a New Delivery System for In-situ Expression
Available online 4 September 2025
Since the outbreak of SARS-CoV-2 in late 2019, the cumulative number of confirmed cases worldwide has surpassed 778 million, and the number of deaths has exceeded 7 million, posing a significant threat...
Ubiquitously expressed transcript isoform 2 (UXT-V2) restricts HSV-2 replication by targeting glycoprotein B for degradation through ubiquitin-proteasome pathway
Available online 2 September 2025
Herpes simplex virus 2 (HSV-2) is a major pathogen causing neonatal herpes and increasing the risk of human immunodeficiency virus 1 (HIV-1) infection. However, the mechanisms underlying host restriction...
Antigenic and structural insights into a Henipavirus attachment glycoprotein
Available online 2 September 2025
The novel henipavirus, Langya henipavirus (LayV), was identified in China in 2022. The invasion of host cells by the henipavirus is facilitated through the interaction between viral attachment (G) and...
The slow progression of Japanese encephalitis in aged mice is likely associated to B cell recruitment in the brain
August 2025
The Japanese encephalitis virus (JEV) causes Japanese encephalitis (JE), a severe disease that primarily affects children and induces significant central nervous system complications. With the widespread...
Isolation and identification of a newly discovered broad-spectrum Acinetobacter baumannii phage and therapeutic validation against pan-resistant Acinetobacter baumannii
August 2025
The treatment of Acinetobacter baumannii (A. baumannii) poses significant clinical challenges due to its multidrug/pan-drug resistance. In this study, we isolated a broad-spectrum lytic A. baumannii...
First isolation and genomic characterization of a novel inter-genotype recombinant feline calicivirus from domestic cats: Implications for viral evolution
August 2025
•Two strains of FCV with distinct genotypes were successfully isolated and identified.•First identification of recombination between GI and GII.•Significant antigenic cross-reactivity with traditional...
Identification of PEDV inhibitors targeting 3CL protease
August 2025
Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV), is a highly contagious gastrointestinal disease characterized by vomiting, diarrhea, and dehydration, with mortality...
Virome diversity in small mammals from south China: Insights into virus evolution, transmission, and ecology
August 2025
Mammals are critical reservoirs of human infectious diseases and the spillover of viruses is related to climate conditions. We conducted meta-transcriptomic sequencing of 226 mammals (bats, rodents,...
Rapid and accurate detection of infectious SARS-CoV-2 by viral receptor capture combined with loop-mediated isothermal amplification
August 2025
Rapid and accurate detection of infectious virus particles, not just viral nucleic acid, is essential to avoid unnecessary quarantine and effectively control the spread of viral diseases such as coronavirus...
SARS-CoV-2-encoded miR-nsp3-3p promotes pulmonary fibrosis by inhibiting expression of ALCAM
August 2025
microRNAs (miRNAs) derived from viruses, have been detected in body fluids and are known to regulate the expression of host genes. Recent evidence indicates that SARS-CoV-2-encoded miRNAs could contribute...
Single-cycle Rift Valley fever virus particles from stable replicon cells enable discovery of antiviral CNX-1351 for multiple RNA viruses
August 2025
Rift Valley fever virus (RVFV) is a high-containment pathogen that causes severe diseases in humans, with no approved therapeutics available. Its classification as a biosafety level 3 (BSL-3) agent...
Clinical outcomes after HBsAg clearance in chronic hepatitis B patients treated with Peg-IFN α: A study with an 11- to 173-month follow-up
August 2025
To investigate the risk and influencing factors of long-term liver adverse events in chronic hepatitis B patients achieving hepatitis B surface antigen (HBsAg) clearance after pegylated interferon α...
The coronavirus 3CL protease: Unveiling its complex host interactions and central role in viral pathogenesis
August 2025
The 3CL protease, a highly conserved enzyme in the coronavirus, plays a crucial role in the viral life cycle by facilitating viral replication through precise cleavage of polyproteins. Beyond its proteolytic...
Identification of a novel ectromelia virus from rodent: Implications for use as an in vivo infection model for vaccine and antiviral research
August 2025
Ectromelia virus (ECTV), a member of the Orthopoxvirus genus, serves as both a causative agent of mousepox and a pivotal surrogate model for studying highly pathogenic orthopoxviruses. Although genomic...
STAT5-c-Myc-axis regulates B cell metabolism in vaccinated individuals and COVID-19 recovered patients
August 2025
SARS-CoV-2 infection and vaccination both trigger immune responses. The former leads to naturally acquired immunity, while the latter induces active immunity through artificial means. However, the distinct...
Thermal tolerance and inactivation of Ebola virus
August 2025
•The investigation demonstrated a high level of tolerance of EBOV to thermal disinfection.•A water-bath is recommended and the tubes should be fully submerged during the process.•The established inactivation...
Isolation and phylogenetic analysis of swinepox virus from pigs in China
August 2025
•This study presents the first characterization and analysis of key host genes of SWPV from the Chinese lineage.•A SWPV strain (SWPV/AH/China/2024) was successfully isolated.•Genetic analysis shows...
Quercetin inhibits herpes simplex virus 1 replication in corneal epithelium and suppresses keratitis progression
August 2025
Quercetin is a natural compound with potent antiviral effects; however, its role in the treatment of herpes simplex keratitis (HSK) remains underexplored. Here, we investigated the antiviral effects...
ARRDC3 promotes lysosome-mediated YAP degradation to inhibit enterovirus replication
August 2025
Enterovirus D68 (EV-D68) and enterovirus A71 (EV-A71) are two major types of enteroviruses that pose emerging challenges to public health and have the potential to cause outbreaks, yet their pathogenic...
Co-circulation of all four DENV serotypes during 2016 outbreak in Sinaloa, Mexico: First report of DENV-4 in patients
August 2025
•The serotype with the highest incidence during the 2016 dengue outbreak in Sinaloa was DENV-2, followed by DENV-4.•This study represents the first report of the DENV-4 serotype in Sinaloa, Mexico,...
Epidemiological and genomic surveillance of influenza A virus (pdm09 H1N1 and H3N2) strains from 2017 to 2025 in Tianjin, China
August 2025
Influenza A virus (IAV) remains a global public health concern, causing influenza-like illness and severe respiratory tract infections. Two major subtypes, A/pdm09 H1N1 and A/H3N2, circulate globally,...
Issue Cover
August 2025
The 2025 national symposium on virology concludes in Changchun: Fostering exchanges and driving innovations in China’s virology
Available online 29 August 2025
Bibliometric analysis of global research output on viral vaccines and antivirals in the 21st century
Available online 26 August 2025
•A total of over 190,000 SCIE-indexed research papers focusing on viral vaccines and antiviral drugs were systematically retrieved for the period 2000–2024.•Article counts show a steady annual growth...