Analysis of pathological changes and virus-susceptible cells in the testes following MPXV infection in a rhesus macaque model
Available online 3 November 2026
Monkeypox virus (MPXV) is an emerging public health threat, with increasing epidemiological and clinical evidence supporting sexual transmission, including detection of viral DNA in semen. However,...
First insight into the virome composition of the vulnerable Naemorhedus griseus
October 2026
The Chinese goral (Naemorhedus griseus) is identified as a vulnerable species on the Red List of China's Biodiversity and listed as a national second-class key protected wild animal in China. Despite...
A fatal human case of co-infection with severe fever with thrombocytopenia syndrome virus and Nairobi sheep disease virus
October 2026
•First fatal human co-infection with SFTSV and NSDV.•First confirmed natural human NSDV infection in China.•Haemaphysalis longicornis is a potential vector for SFTSV and NSDV....
Viral manipulation of DNA damage response signaling: Molecular mechanisms and therapeutic implications
October 2026
The DNA damage response (DDR) network maintains genomic integrity, functions as a signaling hub that viruses exploit to drive pathogenesis, and constitutes a central interface between viral infection...
Liver injury during Ebola virus infections: Characteristics and molecular mechanisms
October 2026
Ebola virus (EBOV) causes severe and often fatal Ebola virus disease (EVD) in humans, posing a major threat to global public health. Since EVD was first identified in the Democratic Republic of Congo...
RNF152 regulates prototype foamy virus replication by targeting Gag polyubiquitination and VLPs production
October 2026
Prototype foamy viruses (PFVs) are complex retroviruses that establish long-term latent infections in hosts without causing disease, positioning them as potential safe gene transfer vectors. Understanding...
Identification and genome characterization of circovirus in masked palm civets (Paguma larvata) from Guangdong Province, China
October 2026
•First identification of Pl-CV in Chinese mainland, with a 34.0% detection rate in farmed civets.•Pl-CV DNA was detected in liver (31.4%) and intestine (25.7%) specimens from one Shaoguan farm.•Four...
ACSL3 at the UPR crossroads: Tactician of anti-influenza defense, target of influenza offense
October 2026
•A new dimension of the host-IAV arms race is revealed, centered on ACSL3 at the UPR crossroads.•Key questions remain regarding ACSL3-UPR sensor interfaces and ACSL3 induction/degradation mechanisms.•Addressing...
A HiBiT-Tagged influenza A virus reporter system reveals cytokine-inhibitory micropeptide 53 as a modulator of viral infection and immunopathology
October 2026
Influenza A virus (IAV) remains a major threat to human and animal health, highlighting the need for efficient approaches to identify host factors and antivirals. Reporter viruses are critical tools...
Epidemiological characteristics and in-hospital burden of infectious mononucleosis among hospitalized children in China, 2021–2023
October 2026
This multicenter study described the epidemiological characteristics, recorded first-ranked secondary diagnoses, and in-hospital burden of pediatric infectious mononucleosis (IM) hospitalizations in...
Synergistic effect of combinational SHEN26 and PF07817883 in SARS-CoV-2 infection
October 2026
•ATV014 (SHEN26) and PF07817883 exhibited potent synergistic antiviral activity against SARS-CoV-2 in vitro.•In vivo, the combination showed synergistic antiviral and tissue-repair effects superior...
Flavivirus NS1 possesses NTPase and RNA helix unwinding activities
October 2026
Flaviviruses are a group of arthropod-borne positive-sense RNA viruses, including Zika virus (ZIKV), dengue virus 2 (DENV2) and Japanese encephalitis virus (JEV). For RNA viruses, RNA helicases play...
EHD4 facilitates Zika virus infection by regulating extracellular vesicle-associated viral release and cell attachment
October 2026
Extracellular vesicles (EVs) and other extracellular membrane-associated particles can contribute to viral dissemination; however, the host factors that regulate the composition and infectivity of EV-associated...
Subcutaneous immunization with replication-competent live influenza virus confers durable protective immunity without respiratory pathology in mice
October 2026
Current influenza vaccination strategies are constrained by the trade-off between the safety of inactivated platforms and the immunogenic potency of live attenuated vaccines. Here, we provide a comprehensive...
Human brain organoids and neural progenitor cells model oropouche virus infection and reveal varied responses to antiviral therapies
October 2026
•Human brain organoids and neural progenitor cells are susceptible to OROV infection.•NHC (the active form of molnupiravir) shows suboptimal antiviral efficacy against OROV in neural models.•IFN-α strongly...
SFTSV exploits PPM1K to inhibit apoptosis through the Bcl-2/BAX/Caspase-3 axis for efficient replication
October 2026
SFTSV (Severe fever with thrombocytopenia syndrome virus) causes severe febrile illness with high case fatality rates and poses a growing public health threat, while the molecular basis by which it...
Epidemiology-guided discovery of a K1-specific lytic phage with therapeutic potential against ST23-K1 multidrug-resistant hypervirulent Klebsiella pneumoniae
October 2026
Phage therapy has emerged as a promising alternative for combating multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) infections. Recent advances suggest that tailoring phage cocktails...
SwiVirScan, a high-throughput platform for profiling antibodies to swine-associated viruses, reveals extensive viral exposure histories in pigs
October 2026
Pigs are crucial as food sources, biomedical models, and reservoirs of some zoonotic viruses, yet their comprehensive viral exposure history remains poorly understood. Here, we developed SwiVirScan,...
Multiomics reveals alterations in the gut microbiome, host proteins, and host metabolites correlating with SADS-CoV pathogenicity and the immune response in piglets
October 2026
Swine acute diarrhea syndrome coronavirus (SADS-CoV) infection causes severe acute diarrhea, vomiting, and lethality in piglets. To explore the molecular mechanisms by which intestinal flora regulate...
Recurrent intrahost G-gene haplotype structures suggest potential co-transmission in RSV-A
October 2026
Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization worldwide. Its molecular epidemiology rests on consensus G-gene sequences, which capture only the dominant virus in each...
Monocyte-associated C1q upregulation and complement activation contribute to vascular endothelial and multi-organ injury in severe dengue
October 2026
Dengue virus (DENV) infection causes a broad spectrum of clinical manifestations, ranging from self-limiting dengue fever (DF) to life-threatening severe dengue (SD). Increased vascular permeability...
A dual-glycoprotein-targeting bispecific nanoantibody confers potent neutralization against Nipah virus
October 2026
Nipah virus (NiV) is a biosafety level 4 pathogen that has consistently posed a significant threat to public health. The two envelope proteins on the viral surface, the receptor-binding protein (RBP)...
Ferritin nanoparticle-based vaccine enhances mucosal immunity by promoting antigen uptake and activation of alveolar macrophages
October 2026
•Ferritin nanoparticle-displayed mosaic tandem-RBD enhances respiratory mucosal immunity.•Intranasal immunization induces broad neutralizing antibodies and tissue-resident immune populations.•Nanoparticles...
ZNF598 enhances FAT10-mediated non-covalent stabilization of Tat to promote HIV-1 transcription and replication
October 2026
Human immunodeficiency virus type 1 (HIV-1) Tat is essential for efficient viral transcription and replication, and its stability is tightly controlled by host factors. In our previous study, we showed...
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October 2026
