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ISSN: 1995-820X
CN: 42-1760/Q
p-ISSN: 1674-0769

A Mouse Model of Crimean-Congo Hemorrhagic Fever Virus-induced Coagulopathy

•A mouse model for CCHFV-induced coagulopathy was developed and characterized using STAT1 knockout mice.•High doses of CCHFV resulted in delayed tail bleeding time, shortened PT and APTT, and prolonged...

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A noninfectious pseudovirus system for an emerging orthoflavivirus

•A trans-complementation system for Usutu virus (USUV) recapitulates authentic viral replication.•High yield of TMN-ΔNS1 virus was obtained with no recombination into replication competent viruses occurring...

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Coadministration of ribavirin and arenaviral entry inhibitor LHF-535 enhances antiviral benefit against authentic Lassa virus

•A new strain of Lassa virus (LASV) was successfully isolated and characterized.•The combination of ribavirin and LHF-535 has been demonstrated to exhibit synergistic effects in inhibiting LASV.•The...

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Scutellaria barbata D. Don extracts alleviate SARS-CoV-2 induced acute lung injury by inhibiting virus replication and bi-directional immune modulation

The emergence of SARS-CoV-2 variants and drug-resistant mutants emphasizes the urgent need to develop novel antiviral agents. In the present study, we examined the therapeutic effect of the Chinese...

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Viral pseudo-enzyme facilitates KSHV lytic replication via suppressing PFAS-mediated RTA deamidation

Deamidation, a type of post-translational modification commonly considered a hallmark of protein “aging” and function decay, is increasingly recognized for its pivotal role in regulating biological...

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Differential susceptibility of immunodeficient mice to MPXV infection and the impact of various inoculation routes

Monkeypox virus (MPXV), a member of the Orthopoxvirus genus, caused a large-scale global outbreak in 2022. Developing mouse models for MPXV infection is crucial for advancing research on vaccines and...

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TEMPORARY REMOVAL: Comparative metatranscriptome analysis in gut reveals insignificant host or microbiota changes in SARS-related coronavirus naturally infected bats

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article...

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Structure-function insights into the dual role of African swine fever virus pB318L: A typical geranylgeranyl-diphosphate synthase and a nuclear import protein

African swine fever virus (ASFV) pB318L is an important protein for viral replication that acts as a membrane-bound trans-geranylgeranyl-diphosphate synthase (GGPPS) catalyzing the condensation of isopentenyl...

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The SARS-CoV-2 NSP4 T492I mutation promotes double-membrane vesicle formation to facilitate transmission

The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in mutations not only in the spike protein, aiding immune evasion, but also in the NSP3/4/6 proteins, crucial...

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Qingqi Guxue Decoction induces S cell cycle arrest to inhibit replication of severe fever with thrombocytopenia syndrome virus

Severe fever with thrombocytopenia syndrome (SFTS) is a novel emerging acute infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), characterized by high fever and thrombocytopenia....

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Insights into cross-species infection by coronavirus: Porcine epidemic diarrhea virus infections in the rodent

The cross-species infection of coronaviruses has resulted in several major epidemics since 2003. Therefore, it is of great importance to explore the host ranges of coronaviruses and their features among...

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Development of a reporter HBoV1 strain for antiviral drug screening and life cycle studies

Human bocavirus 1 (HBoV1; family: Parvoviridae) causes a wide spectrum of respiratory diseases in children and gastroenteritis in adults. A lack of sensitive cell lines and efficient animal models hinders...

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Development and immunoprotection assessment of novel vaccines for avian infectious bronchitis virus

Infectious bronchitis (IB), a highly contagious acute respiratory disease affecting avian species, poses significant challenges to poultry production. The causative agent, Infectious Bronchitis Virus...

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Host factor Naf1 restricts HIV-1 infection of myeloid cells and compromises the capacity of dendritic cell to prime CD4+ T cell

Naf1 (Nef-associated factor 1) is a host protein that interacts with human immunodeficiency virus type 1 (HIV-1) Nef protein. We and others have previously demonstrated that Naf1 restricts HIV-1 infection...

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Virus profiling of bronchoalveolar lavage fluid in hospitalized non-COVID-19 adult patients with pulmonary infection from November 2020 to November 2021

Identifying the cause of respiratory tract infections is important for reducing the burden of diagnosis and treatment. To assess viral etiologies of hospitalized patients with pulmonary infection, bronchoalveolar...

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The SARS-CoV-2 3CL protease inhibits pyroptosis through the cleavage of gasdermin D

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of novel coronavirus disease 2019, can cause acute respiratory symptoms and even death globally. However, the immune...

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Epidemiological and molecular characteristics of human parainfluenza virus in southern China during 2016–2020

Human parainfluenza viruses (HPIV) are common viral pathogens in acute respiratory infection (ARI). We aimed to describe the epidemiological and molecular characteristics of HPIV from ARI patients....

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Identification of an immunodominant neutralizing epitope of porcine astrovirus type 5 capsid protein

•A neutralizing monoclonal antibody against the capsid protein of PAstV5 was prepared for the first time.•The B cell epitope of PAstV5 capsid protein was identified for the first time.•The monoclonal...

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In vivo quantitative proteomic analysis of porcine alveolar macrophages in PRRSV-infected pigs

Porcine reproductive and respiratory syndrome (PRRS), a highly infectious immunosuppressive disease caused by porcine reproductive and respiratory syndrome virus (PRRSV), has led to significant economic...

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Artemisia annua L. leaf extracts suppress influenza virus infection by targeting the viral nucleoprotein and blocking mitochondria-mediated apoptosis

Artemisia annua L. is a medicinal herb with multiple therapeutic applications, whereas its anti-influenza A virus (IAV) efficiency and mechanism of action are still unclear. Here, we investigated the...

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Rapid preparation and characterization of pan-sarbecovirus mRNA vaccine candidates based on the receptor binding domain

•We developed a rapid approach for small-scale mRNA vaccine preparation against pan-sarbecovirus infection.•An mRNA vaccine developed on this platform effectively elicits the production of neutralizing...

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Discovery and characterization of a novel carlavirus in Ligularia jaluensis plants

Ligularia jaluensis is an important medicinal and ornamental plant in China. However, the viruses capable of infecting Ligularia jaluensis remains unknown. Here, we identified a novel carlavirus, tentatively...

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Insights into recent advancements in human and animal rotavirus vaccines: Exploring new frontiers

Rotavirus infections cause severe gastroenteritis and dehydration in young children and animals worldwide, leading to high rates of morbidity and mortality, predominantly in low- and middle-income countries....

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Gene flow and its sporadic spillover: H10 and N5 avian influenza viruses from wild birds and the H10N5 human cases in China

On January 30, 2024, China announced the first human case of H10N5 influenza infection. Prior to this, human cases of H10N7 and H10N8 had been reported. It is now appropriate to re-examine the evolution...

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PB2 627V and HA 217 sites synergistically affect the lethality of H9N2 in mice

The H9N2 subtype avian influenza virus (AIV) continues to propagate and undergo evolution within China, thereby posing a significant threat to the poultry industry. This study encompassed the collection...

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