Sun Yat-sen University Sun Yat-sen University, founded by Dr. Sun Yat-sen and with an educational tradition spanning over 100 years, is a preeminent research, academic and cultural center and the premier location for talent development in South China. Under the direct supervision of the Ministry of Education of the People?s Republic of China, and s...
Sun Yat-sen University, founded by Dr. Sun Yat-sen and with an educational tradition spanning over 100 years, is a preeminent research, academic and cultural center and the premier location for talent development in South China. Under the direct supervision of the Ministry of Education of the People?s Republic of China, and strongly supported by both the Ministry and Guangdong Province, Sun Yat-sen University has developed into a modern comprehensive university that enjoys a reputation as a top-tier university nationally and a renowned university internationally.
Under the direct supervision of the National Health and Family Planning Commission, the Third Affiliated Hospital of Sun Yat-sen University is a modern general academic hospital incorporating medical care, education, research, and community service. It has consistently been ranked highly in the national league table in many aspects such as development scale, research ability, personnel training, and technical and equipment capacity. Currently, the 2200-bed hospital has four campuses: Tianhe, Lingnan, Yuedong and Zhaoqing (however, the number of hospital beds does not include the Yuedong and Zhaoqing campuses).
The hospital contains a wide range of medical disciplines with clear features. It has five national key disciplines, namely internal medicine (nerve), surgery (general surgery), neurology, internal medicine (endocrinology), and otorhinolaryngology. The seven Clinical Key Specialty Development Projects of the Ministry of Health are also represented in the hospital; namely endocrinology, Chinese medicine for liver disease, general surgery, urology surgery, infectious diseases, rheumatology and immunology, and nursing. Hepatology is the leading hospital discipline and is the only domestic discipline developed by the integration of surgical hepatology & hepatology medicine with Chinese & Western hepatology medicine. It includes medicine, surgery, transplantation, intensive care, imaging, invasive therapy, laboratory, and biotherapy in hepatology, and is a strong multidisciplinary group that combines clinical research and treatments.
Furthermore, the hospital is very competitive in the aspect of research. It has nine departments that are qualified to perform national drug clinical trials, one national engineering research center of the Ministry of Education, three provincial key laboratories, four provincial clinical research centers, and two clinical and translational medicine research centers of the Guangzhou municipality. The hospital has cultivated an academic staff of high quality, which is especially highlighted by the number of middle-aged and young academic leaders, and academics with distinguished achievements. Aside from their academic attainments, academic staff members are also very innovative and competitive.
It is worth noting that the hospital initiated the "1+3+4" key construction project, which will establish one national key laboratory (for liver disease), three platforms (clinical and translational medicine in stem cell and regenerative medicine, clinical and translational medicine in immunology, and precision medicine based on molecular diagnosis technology), and four regional featured medical centers (for liver disease, autoimmune diseases, psychology and children's developmental behavior, and metabolic diseases). Along with the implementation of these projects, the hospital hopes to accelerate the development of its long-term goals: "To become a national first class hospital, to reach international standards, and to strengthen its featured clinical disciplines."
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Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes. Activation of oncogenes stimulates cell growth and survival, while loss-of-function mutations of tumor suppressor genes result in unrestrained cell growth. In this review, we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC...