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ISSN: 2542-5684
CN: 44-1725/R
p-ISSN: 2096-2878

Heterogeneous population of macrophages in the development of non-alcoholic fatty liver disease☆

Non-alcoholic fatty liver disease (NAFLD) is characterized by a spectrum of hepatic diseases, including fatty liver, non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. NAFLD is...

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Camrelizumab (SHR-1210) treatment for recurrent hepatocellular carcinoma after liver transplant: A report of two cases

Immune checkpoint inhibitors are generally contraindicated for post-transplant patients. However, we report two patients with metastatic hepatocellular carcinoma (HCC) treated with camrelizumab (SHR-1210),...

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Protective effects of Longhu Rendan on chronic liver injury and fibrosis in mice

Liver fibrosis resulting from persistent liver injury represents a major healthcare problem globally. Traditional Chinese medicine has played an essential role in the treatment of liver fibrosis in...

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Chinese expert consensus on evaluation of donor and donor liver for split liver transplantation

With the advent of the era of organ donation after citizen's death, split liver transplantation (SLT) can effectively increase the supply of donor livers and shorten the transplantation wait time for...

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Expert consensus on the role of hematological markers in the early clinical screening of hepatocellular carcinoma

The disease burden of hepatocellular carcinoma (HCC) in China is heavy, and the prognosis is still unfavourable. Therefore, early screening of high-risk groups of HCC through simple methods is the key...

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Effects of intestine-specific deletion of fibroblast growth factor 15 on alcoholic liver disease development in mice

Alcoholic liver disease (ALD) is an important and growing cause for the development of chronic liver diseases in the world. Bile acid (BA) levels are increased in patients with ALD and dysregulation...

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Non-alcoholic fatty liver disease development: A multifactorial pathogenic phenomena

Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of excessive intrahepatic fat, is a leading metabolic disorder also considered as the hepatic manifestation of metabolic...

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Diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria: A case report

Erythropoietic protoporphyria (EPP) is a rare inherited disease caused by partial deficiency activity of the enzyme ferrochelatase (FECH), resulting in excessive accumulation of protoporphyrin IX in...

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Quantification of liver fat deposition in obese and diabetic patients: A pilot study on the correlation with myocardium and periapical fat content

Non-alcoholic fatty liver disease (NAFLD) is a worldwide health problem, which associated with systemic health problems and causes a higher risk of all-cause mortality. The leading causes of death in...

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Impact of antibiotics on the efficacy of immune checkpoint inhibitors in the treatment of primary liver cancer

Immune checkpoint inhibitors (ICIs) are widely used in the treatment of liver cancer. However, the interaction with other drugs may change the efficacy of ICIs. Few studies investigated the effects...

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Clinical outcome of Yttrium-90 selective internal radiation therapy (Y-90 SIRT) in unresectable hepatocellular carcinoma: Experience from a tertiary care center

Whereas Yttrium-90 selective internal radiation therapy (Y-90 SIRT) was shown to improve local tumor control in non-Asian population, the efficacy of this therapy for Asian population in real-world...

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Immune cells in alcohol-related liver disease

Alcohol-related liver disease (ALD), which is caused by excessive alcohol consumption, is one of the most common types of liver disease and a primary cause of hepatic injury, with a disease spectrum...

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Recent insights into the pathogeneses and therapeutic targets of liver diseases: Summary of the 4th Chinese American liver Society/Society of Chinese Bioscientists in America Hepatology Division Symposium in 2021

The 4th Chinese American Liver Society (CALS)/Society of Chinese Bioscientists in America (SCBA) Hepatology Division Annual Symposium was held virtually on October 29–30, 2021. The goal of the CALS...

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Plasma angiopoietin 2 as a novel prognostic biomarker in alcohol-related cirrhosis and hepatitis

Severe alcoholic hepatitis (SAH), the most florid form of alcohol-related liver disease (ALD), has a mortality rate of 16% at 28 days. The angiopoietin-Tie 2 system regulates angiogenesis and inflammation,...

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Risk factors for very low-level viremia in patients with chronic hepatitis B virus infection: A single-center retrospective study

Several effective antiviral drugs are now available; however, the risk of liver-related complications is still present. Low-level viremia (LLV), defined as a hepatitis B virus (HBV) deoxyribonucleic...

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Portopulmonary hypertension: Current developments and future perspectives

Portopulmonary hypertension (POPH) is a severe pulmonary vascular disease secondary to portal hypertension and a subset of Group 1 pulmonary hypertension (PH). The pathological changes of POPH are indistinguishable...

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Marked elevation of serum alpha-fetoprotein following Clonorchis sinensis infection: A rare case report

Clonorchiasis, also known as the liver fluke disease, is caused by eating raw freshwater fish or shrimps that contain Clonorchis sinensis cyst larvae, which mainly involves the hepatobiliary system....

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The clinical implication of gamma-glutamyl transpeptidase in COVID-19

Coronavirus disease 2019 (COVID-19) is a life-threatening disease that predominantly causes respiratory failure. The impact of COVID-19 on other organs remains elusive. Herein, we aimed to investigate...

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Fructooligosaccharides enhance the therapeutic effect of xiao-zhi-fang on non-alcoholic fatty liver disease via regulating intestinal flora

Non-alcoholic fatty liver disease (NAFLD) is a frequently occurring clinical disease, which could be treated by traditional Chinese medicine. However, the effects and mechanisms of xiao-zhi-fang (XZF)...

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Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of...

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A clinically relevant combination treatment with doxorubicin and cyclophosphamide does not induce hepatotoxicity in C57BL/6J mice

Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity. A combination chemotherapy regimen of doxorubicin (DOX) and cyclophosphamide (CPS) is employed in treatment...

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Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis

Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics. We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography...

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Indocyanine green fluorescence imaging: A novel technique in liver transplantation

Indocyanine green (ICG) is a fluorescent dye that is widely used in hepatobiliary surgery for fluorescence contrast. ICG is selectively absorbed by the liver after intravenous injection and then secreted...

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Correlation of effective hepatic blood flow with liver pathology in patients with hepatitis B virus

Effective hepatic blood flow (EHBF) decreases with liver disease progression, and identifying liver pathology is critical for patients with liver disease. This study was designed to elucidate the correlation...

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Liver-specific microRNA-185 knockout promotes cholesterol dysregulation in mice

The liver plays a key role in regulating whole body cholesterol homeostasis. Hepatic cholesterol accumulation causes liver injury in fatty liver disease and hypercholesterolemia increases the risk of...

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