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ISSN: 2542-5684
CN: 44-1725/R
p-ISSN: 2096-2878

Indocyanine green fluorescence imaging: A novel technique in liver transplantation

Indocyanine green (ICG) is a fluorescent dye that is widely used in hepatobiliary surgery for fluorescence contrast. ICG is selectively absorbed by the liver after intravenous injection and then secreted...

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Correlation of effective hepatic blood flow with liver pathology in patients with hepatitis B virus

Effective hepatic blood flow (EHBF) decreases with liver disease progression, and identifying liver pathology is critical for patients with liver disease. This study was designed to elucidate the correlation...

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Liver-specific microRNA-185 knockout promotes cholesterol dysregulation in mice

The liver plays a key role in regulating whole body cholesterol homeostasis. Hepatic cholesterol accumulation causes liver injury in fatty liver disease and hypercholesterolemia increases the risk of...

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Wu Mengchao: A blade warrior against liver cancer☆

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Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease

Bile acids are a family of atypical steroids generated at the interface of liver-intestinal microbiota acting on a ubiquitously expressed family of membrane and nuclear receptors known as bile acid...

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Bile acid metabolism and bile acid receptor signaling in metabolic diseases and therapy

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Gut microbiome in liver pathophysiology and cholestatic liver disease

An increasing amount of evidence has shown critical roles of gut microbiome in host pathophysiology. The gut and the liver are anatomically and physiologically connected. Given the critical role of...

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Bile acid receptors and signaling crosstalk in the liver, gut and brain

Bile acids are physiological detergents derived from cholesterol that aid in digestion and nutrient absorption, and they play roles in glucose, lipid, and energy metabolism and in gut microbiome and...

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Bile acids and metabolic surgery

The epidemic of obesity and its co-mortalities has reached an alarming level worldwide. Currently, metabolic surgeries, especially the Roux-en-Y gastric bypass and vertical sleeve gastrectomy, are the...

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Farnesoid X receptor and fibroblast growth factor 15/19 as pharmacological targets

The farnesoid X receptor (FXR) is a nuclear receptor and transcriptional regulator activated by bile acids or synthetic FXR agonists. FXR is expressed highly in the liver and intestine where modulation...

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Metformin alleviates cholestasis-associated nephropathy through regulating oxidative stress and mitochondrial function

Cholestasis-associated renal injury or cholemic nephropathy (CN) is a serious clinical problem. Previous studies mentioned that oxidative stress and mitochondrial impairment play a role in CN. There...

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Mitigation of cholestasis-associated hepatic and renal injury by edaravone treatment: Evaluation of its effects on oxidative stress and mitochondrial function

The liver is the primary organ affected by cholestasis, and complications such as renal injury, renal failure, and the need for renal transplantation are associated with cholestatic liver disease. There...

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Expert consensus on perioperative management of liver transplantation in adults with acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) is a syndrome in which acute liver failure with extrahepatic organ failure occurs on chronic liver disease. Recently, liver transplantation is the only effective...

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Mesenchymal stem cells therapy for acute liver failure: Recent advances and future perspectives

Acute liver failure (ALF) is a life-threatening disease characterized by the rapid development of hepatocyte death and a systemic inflammatory response, which leads to high mortality. Despite the prevention...

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Clinical perspectives of isoniazid-induced liver injury

Isoniazid (INH) is a synthetic anti-mycobacterial agent used to treat active or latent tuberculosis (TB). INH has been in clinical use for nearly 70 years and remains broadly utilized at the front line...

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Novel organoid model in drug screening: Past, present, and future

Advances in the field of stem cells have led to the development of a technology called organoids. Organoids are cell cluster structures formed by the cultivation of stem cells in a three-dimensional...

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Vitamins and non-alcoholic fatty liver disease: A molecular insight

The incidence of non-alcoholic fatty liver disease (NAFLD) is rising rapidly across the globe. NAFLD pathogenesis is largely driven by an imbalance in hepatic energy metabolism, and at present, there...

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Hsa-miR-637 inhibits human hepatocyte proliferation by targeting Med1-interacting proteins

Recent studies have shown that mediator complex subunit 1 (Med1) can significantly affect hepatocyte proliferation and differentiation. Acting as a tumor suppressor, microRNA-637 (hsa-miR-637) can inhibit...

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Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice

Acetaminophen (APAP) overdose can cause liver injury and liver failure, which is one of the most common causes of drug-induced liver injury in the United States. Pharmacological activation of autophagy...

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Ulcerative colitis triggered by pegylated interferon alpha-2b in a patient with chronic hepatitis B: A case report and literature review

Interferon (IFN) is a multifaceted immunomodulator that is effective against many diseases, including chronic hepatitis B and chronic hepatitis C infection. IFN defends against viral infection, but...

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