Indocyanine green fluorescence imaging: A novel technique in liver transplantation
December 2021
Indocyanine green (ICG) is a fluorescent dye that is widely used in hepatobiliary surgery for fluorescence contrast. ICG is selectively absorbed by the liver after intravenous injection and then secreted...
Share article
Correlation of effective hepatic blood flow with liver pathology in patients with hepatitis B virus
December 2021
Effective hepatic blood flow (EHBF) decreases with liver disease progression, and identifying liver pathology is critical for patients with liver disease. This study was designed to elucidate the correlation...
Share article
Liver-specific microRNA-185 knockout promotes cholesterol dysregulation in mice
December 2021
The liver plays a key role in regulating whole body cholesterol homeostasis. Hepatic cholesterol accumulation causes liver injury in fatty liver disease and hypercholesterolemia increases the risk of...
Share article
Wu Mengchao: A blade warrior against liver cancer☆
Available online 7 November 2021
Share article
Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease
September 2021
Bile acids are a family of atypical steroids generated at the interface of liver-intestinal microbiota acting on a ubiquitously expressed family of membrane and nuclear receptors known as bile acid...
Share article
Bile acid metabolism and bile acid receptor signaling in metabolic diseases and therapy
September 2021
Share article
Gut microbiome in liver pathophysiology and cholestatic liver disease
September 2021
An increasing amount of evidence has shown critical roles of gut microbiome in host pathophysiology. The gut and the liver are anatomically and physiologically connected. Given the critical role of...
Share article
Bile acid receptors and signaling crosstalk in the liver, gut and brain
September 2021
Bile acids are physiological detergents derived from cholesterol that aid in digestion and nutrient absorption, and they play roles in glucose, lipid, and energy metabolism and in gut microbiome and...
Share article
Bile acids and metabolic surgery
September 2021
The epidemic of obesity and its co-mortalities has reached an alarming level worldwide. Currently, metabolic surgeries, especially the Roux-en-Y gastric bypass and vertical sleeve gastrectomy, are the...
Share article
Farnesoid X receptor and fibroblast growth factor 15/19 as pharmacological targets
September 2021
The farnesoid X receptor (FXR) is a nuclear receptor and transcriptional regulator activated by bile acids or synthetic FXR agonists. FXR is expressed highly in the liver and intestine where modulation...
Share article
Metformin alleviates cholestasis-associated nephropathy through regulating oxidative stress and mitochondrial function
September 2021
Cholestasis-associated renal injury or cholemic nephropathy (CN) is a serious clinical problem. Previous studies mentioned that oxidative stress and mitochondrial impairment play a role in CN. There...
Share article
Mitigation of cholestasis-associated hepatic and renal injury by edaravone treatment: Evaluation of its effects on oxidative stress and mitochondrial function
September 2021
The liver is the primary organ affected by cholestasis, and complications such as renal injury, renal failure, and the need for renal transplantation are associated with cholestatic liver disease. There...
Share article
Expert consensus on perioperative management of liver transplantation in adults with acute-on-chronic liver failure
June 2021
Acute-on-chronic liver failure (ACLF) is a syndrome in which acute liver failure with extrahepatic organ failure occurs on chronic liver disease. Recently, liver transplantation is the only effective...
Share article
Mesenchymal stem cells therapy for acute liver failure: Recent advances and future perspectives
June 2021
Acute liver failure (ALF) is a life-threatening disease characterized by the rapid development of hepatocyte death and a systemic inflammatory response, which leads to high mortality. Despite the prevention...
Share article
Clinical perspectives of isoniazid-induced liver injury
June 2021
Isoniazid (INH) is a synthetic anti-mycobacterial agent used to treat active or latent tuberculosis (TB). INH has been in clinical use for nearly 70 years and remains broadly utilized at the front line...
Share article
Novel organoid model in drug screening: Past, present, and future
June 2021
Advances in the field of stem cells have led to the development of a technology called organoids. Organoids are cell cluster structures formed by the cultivation of stem cells in a three-dimensional...
Share article
Vitamins and non-alcoholic fatty liver disease: A molecular insight
June 2021
The incidence of non-alcoholic fatty liver disease (NAFLD) is rising rapidly across the globe. NAFLD pathogenesis is largely driven by an imbalance in hepatic energy metabolism, and at present, there...
Share article
Hsa-miR-637 inhibits human hepatocyte proliferation by targeting Med1-interacting proteins
June 2021
Recent studies have shown that mediator complex subunit 1 (Med1) can significantly affect hepatocyte proliferation and differentiation. Acting as a tumor suppressor, microRNA-637 (hsa-miR-637) can inhibit...
Share article
Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice
June 2021
Acetaminophen (APAP) overdose can cause liver injury and liver failure, which is one of the most common causes of drug-induced liver injury in the United States. Pharmacological activation of autophagy...
Share article
Ulcerative colitis triggered by pegylated interferon alpha-2b in a patient with chronic hepatitis B: A case report and literature review
June 2021
Interferon (IFN) is a multifaceted immunomodulator that is effective against many diseases, including chronic hepatitis B and chronic hepatitis C infection. IFN defends against viral infection, but...
Share article
