Exosomes as mediators of tumor immune escape and immunotherapy in hepatocellular carcinoma
Available online 15 August 2022
Hepatocellular carcinoma (HCC), a typical inflammatory-related cancer, mainly occurs in patients with chronic liver diseases. Moreover, the liver is an immunologically privileged apparatus with multiple...
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Dynactin 2 acts as an oncogene in hepatocellular carcinoma through promoting cell cycle progression
Available online 11 August 2022
Dynactin (DCTN) can activate cytoplasmic dynein and drive intracellular organelle transport containing six family members (DCTN1 to DCTN6). The DCTN family has been studied as cancer-related genes or...
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Glycogen accumulation drives hepatocarcinogenesis by targeting the Hippo signaling pathway
Available online 1 August 2022
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Heterogeneous population of macrophages in the development of non-alcoholic fatty liver disease☆
Available online 1 July 2022
Non-alcoholic fatty liver disease (NAFLD) is characterized by a spectrum of hepatic diseases, including fatty liver, non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. NAFLD is...
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Camrelizumab (SHR-1210) treatment for recurrent hepatocellular carcinoma after liver transplant: A report of two cases
June 2022
Immune checkpoint inhibitors are generally contraindicated for post-transplant patients. However, we report two patients with metastatic hepatocellular carcinoma (HCC) treated with camrelizumab (SHR-1210),...
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Protective effects of Longhu Rendan on chronic liver injury and fibrosis in mice
June 2022
Liver fibrosis resulting from persistent liver injury represents a major healthcare problem globally. Traditional Chinese medicine has played an essential role in the treatment of liver fibrosis in...
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Chinese expert consensus on evaluation of donor and donor liver for split liver transplantation
June 2022
With the advent of the era of organ donation after citizen's death, split liver transplantation (SLT) can effectively increase the supply of donor livers and shorten the transplantation wait time for...
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Expert consensus on the role of hematological markers in the early clinical screening of hepatocellular carcinoma
June 2022
The disease burden of hepatocellular carcinoma (HCC) in China is heavy, and the prognosis is still unfavourable. Therefore, early screening of high-risk groups of HCC through simple methods is the key...
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Effects of intestine-specific deletion of fibroblast growth factor 15 on alcoholic liver disease development in mice
June 2022
Alcoholic liver disease (ALD) is an important and growing cause for the development of chronic liver diseases in the world. Bile acid (BA) levels are increased in patients with ALD and dysregulation...
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Non-alcoholic fatty liver disease development: A multifactorial pathogenic phenomena
June 2022
Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of excessive intrahepatic fat, is a leading metabolic disorder also considered as the hepatic manifestation of metabolic...
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Diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria: A case report
June 2022
Erythropoietic protoporphyria (EPP) is a rare inherited disease caused by partial deficiency activity of the enzyme ferrochelatase (FECH), resulting in excessive accumulation of protoporphyrin IX in...
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Quantification of liver fat deposition in obese and diabetic patients: A pilot study on the correlation with myocardium and periapical fat content
June 2022
Non-alcoholic fatty liver disease (NAFLD) is a worldwide health problem, which associated with systemic health problems and causes a higher risk of all-cause mortality. The leading causes of death in...
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Impact of antibiotics on the efficacy of immune checkpoint inhibitors in the treatment of primary liver cancer
Available online 2 June 2022
Immune checkpoint inhibitors (ICIs) are widely used in the treatment of liver cancer. However, the interaction with other drugs may change the efficacy of ICIs. Few studies investigated the effects...
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Clinical outcome of Yttrium-90 selective internal radiation therapy (Y-90 SIRT) in unresectable hepatocellular carcinoma: Experience from a tertiary care center
March 2022
Whereas Yttrium-90 selective internal radiation therapy (Y-90 SIRT) was shown to improve local tumor control in non-Asian population, the efficacy of this therapy for Asian population in real-world...
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Immune cells in alcohol-related liver disease
March 2022
Alcohol-related liver disease (ALD), which is caused by excessive alcohol consumption, is one of the most common types of liver disease and a primary cause of hepatic injury, with a disease spectrum...
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Recent insights into the pathogeneses and therapeutic targets of liver diseases: Summary of the 4th Chinese American liver Society/Society of Chinese Bioscientists in America Hepatology Division Symposium in 2021
March 2022
The 4th Chinese American Liver Society (CALS)/Society of Chinese Bioscientists in America (SCBA) Hepatology Division Annual Symposium was held virtually on October 29–30, 2021. The goal of the CALS...
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Plasma angiopoietin 2 as a novel prognostic biomarker in alcohol-related cirrhosis and hepatitis
March 2022
Severe alcoholic hepatitis (SAH), the most florid form of alcohol-related liver disease (ALD), has a mortality rate of 16% at 28 days. The angiopoietin-Tie 2 system regulates angiogenesis and inflammation,...
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Risk factors for very low-level viremia in patients with chronic hepatitis B virus infection: A single-center retrospective study
March 2022
Several effective antiviral drugs are now available; however, the risk of liver-related complications is still present. Low-level viremia (LLV), defined as a hepatitis B virus (HBV) deoxyribonucleic...
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Portopulmonary hypertension: Current developments and future perspectives
March 2022
Portopulmonary hypertension (POPH) is a severe pulmonary vascular disease secondary to portal hypertension and a subset of Group 1 pulmonary hypertension (PH). The pathological changes of POPH are indistinguishable...
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Marked elevation of serum alpha-fetoprotein following Clonorchis sinensis infection: A rare case report
March 2022
Clonorchiasis, also known as the liver fluke disease, is caused by eating raw freshwater fish or shrimps that contain Clonorchis sinensis cyst larvae, which mainly involves the hepatobiliary system....
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The clinical implication of gamma-glutamyl transpeptidase in COVID-19
December 2021
Coronavirus disease 2019 (COVID-19) is a life-threatening disease that predominantly causes respiratory failure. The impact of COVID-19 on other organs remains elusive. Herein, we aimed to investigate...
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Fructooligosaccharides enhance the therapeutic effect of xiao-zhi-fang on non-alcoholic fatty liver disease via regulating intestinal flora
December 2021
Non-alcoholic fatty liver disease (NAFLD) is a frequently occurring clinical disease, which could be treated by traditional Chinese medicine. However, the effects and mechanisms of xiao-zhi-fang (XZF)...
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Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
December 2021
Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of...
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A clinically relevant combination treatment with doxorubicin and cyclophosphamide does not induce hepatotoxicity in C57BL/6J mice
December 2021
Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity. A combination chemotherapy regimen of doxorubicin (DOX) and cyclophosphamide (CPS) is employed in treatment...
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Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis
December 2021
Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics. We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography...
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